| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
(e,e,e,e)-squalene
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
Cross Reference
Introduction
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (e,e,e,e)-squalene?
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
PubChem Associated disorders and diseases
What pathways are associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (e,e,e,e)-squalene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with (e,e,e,e)-squalene?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with (e,e,e,e)-squalene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Johnson RC and Shah SN | Microsomal synthesis of cholesterol from squalene, Lanosterol, and desmosterol. Evidence for the presence of two noncatalytic activator proteins in the 105,000 g supernatant fraction from brain, heart, and kidney. | 1974 | Arch. Biochem. Biophys. | pmid:4460877 |
| TSAI SC et al. | TESTICULAR STEROLS. 1. INCORPORATION OF MEVALONATE AND ACETATE INTO STEROLS BY TESTICULAR TISSUE FROM RATS. | 1964 | Arch. Biochem. Biophys. | pmid:14186739 |
| Krishna G et al. | Enzymic conversion of farnesyl pyrophosphate to squalene. | 1966 | Arch. Biochem. Biophys. | pmid:4380977 |
| Trocha PJ and Sprinson DB | Location and regulation of early enzymes of sterol biosynthesis in yeast. | 1976 | Arch. Biochem. Biophys. | pmid:7207 |
| Oesch F et al. | Substrate specificity of hepatic epoxide hydrase in microsomes and in a purified preparation: evidence for homologous enzymes. | 1971 | Arch. Biochem. Biophys. | pmid:5117530 |
| Sasiak K and Rilling HC | Purification to homogeneity and some properties of squalene synthetase. | 1988 | Arch. Biochem. Biophys. | pmid:3277535 |
| GAYLOR JL | Biosynthesis of skin sterols. V. Effect of arsenite inhibition and the accumulation of labeled lanosta-7, 24-dien-3 beta-ol in rat skin. | 1963 | Arch. Biochem. Biophys. | pmid:13946925 |
| BEELER DA et al. | The biosynthesis of squalene from mevalonic acid-2-C-14 and farnesyl pyrophosphate-4,8,12-C-14 by carrot and tomato enzymes. | 1963 | Arch. Biochem. Biophys. | pmid:13970235 |
| Godinez MH et al. | The biosynthesis of isoprenoid lipids including ubiquinone in muscle from normal and genetically dystrophic mice. | 1970 | Arch. Biochem. Biophys. | pmid:5460184 |
| POPJAK G | Biosynthesis of squalene and cholesterol in vitro from acetate-1-C14. | 1954 | Arch. Biochem. Biophys. | pmid:13125576 |