(e,e,e,e)-squalene

(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.

Cross Reference

Introduction

To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (e,e,e,e)-squalene?

(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene

MeSH term MeSH ID Detail
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Precancerous Conditions D011230 48 associated lipids
Arthritis D001168 41 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Coronary Disease D003327 70 associated lipids
Acne Vulgaris D000152 35 associated lipids
Occupational Diseases D009784 42 associated lipids
Per page 10 20 50 100 | Total 84

PubChem Associated disorders and diseases

What pathways are associated with (e,e,e,e)-squalene

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with (e,e,e,e)-squalene?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (e,e,e,e)-squalene?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with (e,e,e,e)-squalene

Download all related citations
Per page 10 20 50 100 | Total 1766
Authors Title Published Journal PubMed Link
Byars NE and Allison AC Adjuvant formulation for use in vaccines to elicit both cell-mediated and humoral immunity. 1987 Vaccine pmid:3499713
Higgins DA et al. MF59 adjuvant enhances the immunogenicity of influenza vaccine in both young and old mice. 1996 Vaccine pmid:8782343
Cataldo DM and Van Nest G The adjuvant MF59 increases the immunogenicity and protective efficacy of subunit influenza vaccine in mice. 1997 Vaccine pmid:9364672
Singh M et al. A comparison of biodegradable microparticles and MF59 as systemic adjuvants for recombinant gD from HSV-2. 1998 Vaccine pmid:9795387
Barchfeld GL et al. The adjuvants MF59 and LT-K63 enhance the mucosal and systemic immunogenicity of subunit influenza vaccine administered intranasally in mice. 1999 Vaccine pmid:10067675
Hilgers LA et al. Sulfolipo-cyclodextrin in squalane-in-water as a novel and safe vaccine adjuvant. 1999 Vaccine pmid:9987157
Podda A The adjuvanted influenza vaccines with novel adjuvants: experience with the MF59-adjuvanted vaccine. 2001 Vaccine pmid:11257408
Greer CE et al. The comparison of the effect of LTR72 and MF59 adjuvants on mouse humoral response to intranasal immunisation with human papillomavirus type 6b (HPV-6b) virus-like particles. 2000 Vaccine pmid:11137233
Skeiky YA et al. Protective efficacy of a tandemly linked, multi-subunit recombinant leishmanial vaccine (Leish-111f) formulated in MPL adjuvant. 2002 Vaccine pmid:12213399
Madhun AS et al. An adjuvanted pandemic influenza H1N1 vaccine provides early and long term protection in health care workers. 2010 Vaccine pmid:21034828
Esposito S et al. Immunogenicity, safety and tolerability of monovalent 2009 pandemic influenza A/H1N1 MF59-adjuvanted vaccine in patients with β-thalassemia major. 2010 Vaccine pmid:20888873
Tritto E et al. Mechanism of action of licensed vaccine adjuvants. 2009 Vaccine pmid:19200813
Ansaldi F et al. Adjuvanted seasonal influenza vaccines and perpetual viral metamorphosis: the importance of cross-protection. 2009 Vaccine pmid:19200846
Camilloni B et al. Cross-reactive antibodies in middle-aged and elderly volunteers after MF59-adjuvanted subunit trivalent influenza vaccine against B viruses of the B/Victoria or B/Yamagata lineages. 2009 Vaccine pmid:19410623
Phillips CJ et al. Antibodies to squalene in US Navy Persian Gulf War veterans with chronic multisymptom illness. 2009 Vaccine pmid:19379786
Carmona A et al. Immunogenicity and safety of AS03-adjuvanted 2009 influenza A H1N1 vaccine in children 6-35 months. 2010 Vaccine pmid:20600478
Frey SE et al. Safety and immunogenicity of HCV E1E2 vaccine adjuvanted with MF59 administered to healthy adults. 2010 Vaccine pmid:20619382
Dell'Era L et al. Immunogenicity, safety and tolerability of MF59-adjuvanted seasonal influenza vaccine in children with juvenile idiopathic arthritis. 2012 Vaccine pmid:22138210
Okike IO et al. The immunogenicity of a novel A (H1N1) vaccine in HIV-infected children. 2011 Vaccine pmid:21742005
Guillon C et al. Formulation of HIV-1 Tat and p24 antigens by PLA nanoparticles or MF59 impacts the breadth, but not the magnitude, of serum and faecal antibody responses in rabbits. 2007 Vaccine pmid:17904700
Baldo V et al. MF59-adjuvanted influenza vaccine confers superior immunogenicity in adult subjects (18-60 years of age) with chronic diseases who are at risk of post-influenza complications. 2007 Vaccine pmid:17383057
Bråve A et al. Candidate HIV-1 gp140DeltaV2, Gag and Tat vaccines protect against experimental HIV-1/MuLV challenge. 2007 Vaccine pmid:17707956
Ansaldi F et al. Cross-protection by MF59-adjuvanted influenza vaccine: neutralizing and haemagglutination-inhibiting antibody activity against A(H3N2) drifted influenza viruses. 2008 Vaccine pmid:18294741
O'Hagan DT et al. Cationic microparticles are a potent delivery system for a HCV DNA vaccine. 2004 Vaccine pmid:15542189
Faenzi E et al. One dose of an MF59-adjuvanted pandemic A/H1N1 vaccine recruits pre-existing immune memory and induces the rapid rise of neutralizing antibodies. 2012 Vaccine pmid:22521851
Hatz C et al. A randomised, single-blind, dose-range study to assess the immunogenicity and safety of a cell-culture-derived A/H1N1 influenza vaccine in adult and elderly populations. 2012 Vaccine pmid:22626675
Dey AK et al. Use of a polyanionic carbomer, Carbopol971P, in combination with MF59, improves antibody responses to HIV-1 envelope glycoprotein. 2012 Vaccine pmid:22366638
Reynales H et al. A prospective observational safety study on MF59(®) adjuvanted cell culture-derived vaccine, Celtura(®) during the A/H1N1 (2009) influenza pandemic. 2012 Vaccine pmid:22902681
Yang WH et al. Long-term immunogenicity of an AS03-adjuvanted influenza A(H1N1)pdm09 vaccine in young and elderly adults: an observer-blind, randomized trial. 2013 Vaccine pmid:23856331
Calabro S et al. The adjuvant effect of MF59 is due to the oil-in-water emulsion formulation, none of the individual components induce a comparable adjuvant effect. 2013 Vaccine pmid:23684834
Segura-Velázquez R et al. Influenza vaccine: development of a novel intranasal and subcutaneous recombinant adjuvant. 2013 Vaccine pmid:23746458
Puig-Barberà J et al. MF59-adjuvanted and virosomal influenza vaccines for preventing influenza hospitalization in older people: comparative effectiveness using the Valencia health care information system. 2013 Vaccine pmid:23731629
Rouleau I et al. Increased risk of anaphylaxis following administration of 2009 AS03-adjuvanted monovalent pandemic A/H1N1 (H1N1pdm09) vaccine. 2013 Vaccine pmid:24144473
Vinay TN et al. Toxicity and dose determination of quillaja saponin, aluminum hydroxide and squalene in olive flounder (Paralichthys olivaceus). 2014 Vet. Immunol. Immunopathol. pmid:23570990
Drulak MW et al. Vaccination of seropositive subjects with CHIRON CMV gB subunit vaccine combined with MF59 adjuvant for production of CMV immune globulin. 2000 Viral Immunol. pmid:10733168
Marshall BC and Adler SP Avidity maturation following immunization with two human cytomegalovirus (CMV) vaccines: a live attenuated vaccine (Towne) and a recombinant glycoprotein vaccine (gB/MF59). 2003 Viral Immunol. pmid:14733736
Heinemann L et al. Effective induction of type 1 helper IgG2a and cytotoxic T-cell responses in mice following immunization with human papillomavirus type 16 E2 in MF59. 2008 Viral Immunol. pmid:18476769
Burke B et al. Neutralizing antibody responses to subtype B and C adjuvanted HIV envelope protein vaccination in rabbits. 2009 Virology pmid:19249806
Stephenson I et al. Detection of anti-H5 responses in human sera by HI using horse erythrocytes following MF59-adjuvanted influenza A/Duck/Singapore/97 vaccine. 2004 Virus Res. pmid:15163495
Clouse SD Brassinosteroids. Plant counterparts to animal steroid hormones? 2002 Vitam. Horm. pmid:12481548
Zadák Z et al. [The role of cholesterol and intermediary metabolites of its synthesis in intensive care and parenteral nutrition]. 2000 Vnitr Lek pmid:15637893
PokrovskiÄ­ AA et al. [Method of isolating, identifying and quantitatively determining alkanes, cycloalkanes, monocyclic arenes and squalene in animal organs and tissues]. 1978 Sep-Oct Vopr Pitan pmid:716335
Markelova VF and Levachev MM [Inclusion of C14-acetate in cholesterol and tissue squalene of rats in choline-protein deficiency]. 1967 Nov-Dec Vopr Pitan pmid:5610866
Gonor KV et al. [The influence of a diet with including amaranth oil on antioxidant and immune status in patients with ischemic heart disease and hyperlipoproteidemia]. 2006 Vopr Pitan pmid:17313043
Gonor KV et al. [The influence of diet with including amaranth oil on lipid metabolism in patients with ischemic heart disease and hyperlipoproteidemia]. 2006 Vopr Pitan pmid:16862949
Kulakova SN et al. [Amaranths oil: peculiarities of chemical composition and influence on lipid metabolism by rats]. 2006 Vopr Pitan pmid:16862953
Palamarchuk VI et al. [Content of squalene and sterols in tissues of the hemopoietic system in normal rats and in experimental leukemia]. 1983 May-Jun Vopr. Med. Khim. pmid:6880121
Kozlov VG and Viktorova EG [Evaluation of the efficiency and reactogenicity of emulsion-based adjuvant systems in the manufacture of polyclonal enteroviral diagnostic sera]. 2011 Mar-Apr Vopr. Virusol. pmid:21545042
Zhao M et al. [Research progress on the squalene synthase]. 2003 Wei Sheng Wu Xue Bao pmid:16281569
Lynen F [The biochemical basis of the biosynthesis of cholesterol and fatty acids]. 1966 Wien. Klin. Wochenschr. pmid:4296920
Bakalar B et al. Changes in cholesterol and its precursors during the first days after major trauma. 2003 Wien. Klin. Wochenschr. pmid:14743581
Global Advisory Committee on Vaccine Safety, 6-7 June 2006. 2006 Wkly. Epidemiol. Rec. pmid:16841398
Richter E et al. Stimulation of the faecal excretion of 2,4,5,2',4',5'-hexachlorobiphenyl in rats by squalane. 1983 Xenobiotica pmid:6415933
Hu JJ et al. [Antibody production and its neutralization of Abeta42's cytoxicity in BALB/c mice induced by Abeta42 and its subunit vaccines]. 2004 Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi pmid:15191720
Ikekawa T et al. [Studies on antitumor activity of squalene and its related compounds]. 1986 Yakugaku Zasshi pmid:3772729
Tsai TF MF59 adjuvanted seasonal and pandemic influenza vaccines. 2011 Yakugaku Zasshi pmid:22129867
Abe I [Engineering of squalene cyclizing enzymes]. 2008 Yakugaku Zasshi pmid:18670176
Zhang Y et al. [Chemical constituents from the mangrove plant Ceriops tagal]. 2005 Yao Xue Xue Bao pmid:16408813
Sondergaard E et al. Alimentary production of gallstones in hamsters. 28. Influence of isomerized squalene on gallstone production. 1974 Z Ernahrungswiss pmid:4450595
Dam H et al. Alimentary production of gallstones in hamsters. 27. Influence of supplementation of the gallstone producing diet with squalene, cholesterol, certain other sterols, fish oil fatty acid ethyl esters, and modification of the basal diet on gallstone production and levels of cholesterol in serum and liver. 1974 Z Ernahrungswiss pmid:4615449
Kipping D [Observations on skin surface fats]. 1965 Z Haut Geschlechtskr pmid:5860995
Gloor M [The significance of physiological and biochemical deviations from the norm on the skin surface for infectious skin diseases (proceedings)]. 1976 Z. Hautkr. pmid:13544
de la Puerta R et al. Effect of minor components of virgin olive oil on topical antiinflammatory assays. 2000 Sep-Oct Z. Naturforsch., C, J. Biosci. pmid:11098836
Kopena R et al. Lipophilic compounds from the femoral gland secretions of male Hungarian green lizards, Lacerta viridis. 2009 May-Jun Z. Naturforsch., C, J. Biosci. pmid:19678551
Liu Y et al. [Researches on influence of squalene synthase gene polymorphism on catalytic efficiency of its encode enzyme in Glycyrrhiza uralensis]. 2012 Zhongguo Zhong Yao Za Zhi pmid:23627178
Li RC et al. [Study on the safety and immunogenicity of MF59-adjuvanted influenza subunit vaccine in Chinese elderly]. 2008 Zhonghua Liu Xing Bing Xue Za Zhi pmid:19040034