| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Exostoses, Multiple Hereditary | D005097 | 3 associated lipids |
| Fasciitis | D005208 | 2 associated lipids |
| Fatigue | D005221 | 10 associated lipids |
| Fibrosarcoma | D005354 | 8 associated lipids |
| Gallbladder Diseases | D005705 | 3 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Hepatitis | D006505 | 11 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Hyperlipoproteinemia Type II | D006938 | 22 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Hyperlipoproteinemias | D006951 | 15 associated lipids |
| Hyperlipoproteinemia Type III | D006952 | 4 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Influenza, Human | D007251 | 11 associated lipids |
| Keloid | D007627 | 12 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
(e,e,e,e)-squalene
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
Cross Reference
Introduction
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (e,e,e,e)-squalene?
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
PubChem Associated disorders and diseases
What pathways are associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (e,e,e,e)-squalene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with (e,e,e,e)-squalene?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with (e,e,e,e)-squalene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Schulz JG et al. | HMG-CoA reductase inhibition causes neurite loss by interfering with geranylgeranylpyrophosphate synthesis. | 2004 | J. Neurochem. | pmid:15030386 |
| Uchino T et al. | Potent protecting effects of Catuaba (Anemopaegma mirandum) extracts against hydroperoxide-induced cytotoxicity. | 2004 | Toxicol In Vitro | pmid:15046771 |
| Cravotto G et al. | Umbelliferone aminoalkyl derivatives, a new class of squalene-hopene cyclase inhibitors. | 2004 | Eur J Med Chem | pmid:15501540 |
| Ruf BR et al. | Open, randomized study to compare the immunogenicity and reactogenicity of an influenza split vaccine with an MF59-adjuvanted subunit vaccine and a virosome-based subunit vaccine in elderly. | 2004 | Infection | pmid:15293073 |
| Süli J et al. | Experimental squalene adjuvant. I. Preparation and testing of its effectiveness. | 2004 | Vaccine | pmid:15308373 |
| BenÃsek Z et al. | Experimental squalene adjuvant. II. Harmlessness and local reactogenity. | 2004 | Vaccine | pmid:15308374 |
| Nakano S et al. | Squalene-hopene cyclase: insight into the role of the methyl group on the squalene backbone upon the polycyclization cascade. Enzymatic cyclization products of squalene analogs lacking a 26-methyl group and possessing a methyl group at C7 or C11. | 2004 | Org. Biomol. Chem. | pmid:15254628 |
| Pragst F et al. | Wipe-test and patch-test for alcohol misuse based on the concentration ratio of fatty acid ethyl esters and squalene CFAEE/CSQ in skin surface lipids. | 2004 | Forensic Sci. Int. | pmid:15240027 |
| Sabeena Farvin KH et al. | Effect of squalene on tissue defense system in isoproterenol-induced myocardial infarction in rats. | 2004 | Pharmacol. Res. | pmid:15225664 |
| Kuroda Y et al. | Autoimmunity induced by adjuvant hydrocarbon oil components of vaccine. | 2004 | Biomed. Pharmacother. | pmid:15194169 |
| Holm BC et al. | Adjuvant oil induces waves of arthritogenic lymph node cells prior to arthritis onset. | 2004 | Clin. Exp. Immunol. | pmid:15196244 |
| Fukasawa LO et al. | Adjuvant can improve protection induced by OMV vaccine against Neisseria meningitidis serogroups B/C in neonatal mice. | 2004 | FEMS Immunol. Med. Microbiol. | pmid:15196569 |
| Miettinen TA et al. | Low synthesis and high absorption of cholesterol characterize type 1 diabetes. | 2004 | Diabetes Care | pmid:14693966 |
| Kuroda Y et al. | Distinctive patterns of autoimmune response induced by different types of mineral oil. | 2004 | Toxicol. Sci. | pmid:14718649 |
| Auwärter V et al. | Squalene in hair--a natural reference substance for the improved interpretation of fatty acid ethyl ester concentrations with respect to alcohol misuse. | 2004 | Forensic Sci. Int. | pmid:15451087 |
| Banzhoff A et al. | A new MF59-adjuvanted influenza vaccine enhances the immune response in the elderly with chronic diseases: results from an immunogenicity meta-analysis. | 2003 May-Jun | Gerontology | pmid:12679609 |
| Chiba K et al. | Characteristics of skin wrinkling and dermal changes induced by repeated application of squalene monohydroperoxide to hairless mouse skin. | 2003 Jul-Aug | Skin Pharmacol. Appl. Skin Physiol. | pmid:12784064 |
| Ballou WR et al. | Safety and immunogenicity of a recombinant parvovirus B19 vaccine formulated with MF59C.1. | 2003 | J. Infect. Dis. | pmid:12599085 |
| Hess BA | Formation of the C ring in the lanosterol biosynthesis from squalene. | 2003 | Org. Lett. | pmid:12529131 |
| Satoh M et al. | Induction of lupus autoantibodies by adjuvants. | 2003 | J. Autoimmun. | pmid:12892730 |
| Podda A and Del Giudice G | MF59-adjuvanted vaccines: increased immunogenicity with an optimal safety profile. | 2003 | Expert Rev Vaccines | pmid:12899571 |
| Zhang L et al. | Proopiomelanocortin peptides and sebogenesis. | 2003 | Ann. N. Y. Acad. Sci. | pmid:12851311 |
| Iorio AM et al. | Antibody responses and HIV-1 viral load in HIV-1-seropositive subjects immunised with either the MF59-adjuvanted influenza vaccine or a conventional non-adjuvanted subunit vaccine during highly active antiretroviral therapy. | 2003 | Vaccine | pmid:12922092 |
| Rontani JF et al. | Production of a polyunsaturated isoprenoid wax ester during aerobic metabolism of squalene by Marinobacter squalenivorans sp. nov. | 2003 | Appl. Environ. Microbiol. | pmid:12839795 |
| Das B et al. | In vitro cytoprotective activity of squalene on a bone marrow versus neuroblastoma model of cisplatin-induced toxicity. implications in cancer chemotherapy. | 2003 | Eur. J. Cancer | pmid:14602142 |
| Schulz-Gasch T and Stahl M | Mechanistic insights into oxidosqualene cyclizations through homology modeling. | 2003 | J Comput Chem | pmid:12666166 |
| Khallouki F et al. | Consumption of argan oil (Morocco) with its unique profile of fatty acids, tocopherols, squalene, sterols and phenolic compounds should confer valuable cancer chemopreventive effects. | 2003 | Eur. J. Cancer Prev. | pmid:12548113 |
| Saint-Léger D | [Normal and pathologic sebaceous function. Research in a shallow milieu?]. | 2003 | Pathol. Biol. | pmid:14567194 |
| Miettinen TA and Gylling H | Synthesis and absorption markers of cholesterol in serum and lipoproteins during a large dose of statin treatment. | 2003 | Eur. J. Clin. Invest. | pmid:14636301 |
| Rajamani R and Gao J | Balancing kinetic and thermodynamic control: the mechanism of carbocation cyclization by squalene cyclase. | 2003 | J. Am. Chem. Soc. | pmid:14558824 |
| Veen M et al. | Combined overexpression of genes of the ergosterol biosynthetic pathway leads to accumulation of sterols in Saccharomyces cerevisiae. | 2003 | FEMS Yeast Res. | pmid:14554200 |
| Lewis DJ et al. | Rapid and frequent induction of protective immunity exceeding UK recommendations for healthcare settings by MF59-adjuvated hepatitis B vaccine. | 2003 | Commun Dis Public Health | pmid:15067859 |
| Marshall BC and Adler SP | Avidity maturation following immunization with two human cytomegalovirus (CMV) vaccines: a live attenuated vaccine (Towne) and a recombinant glycoprotein vaccine (gB/MF59). | 2003 | Viral Immunol. | pmid:14733736 |
| Hayashi N et al. | Effect of sunlight exposure and aging on skin surface lipids and urate. | 2003 | Exp. Dermatol. | pmid:14756518 |
| He HP et al. | Supercritical carbon dioxide extraction of oil and squalene from amaranthus grain. | 2003 | J. Agric. Food Chem. | pmid:14690374 |
| Passi S et al. | The combined use of oral and topical lipophilic antioxidants increases their levels both in sebum and stratum corneum. | 2003 | Biofactors | pmid:14695946 |
| Worsham DN et al. | Evidence for cholesterol scavenging by Pneumocystis and potential modifications of host-synthesized sterols by the P. carinii SAM:SMT. | 2003 | J. Eukaryot. Microbiol. | pmid:14736216 |
| Bakalar B et al. | Changes in cholesterol and its precursors during the first days after major trauma. | 2003 | Wien. Klin. Wochenschr. | pmid:14743581 |
| Mateos R et al. | Antioxidant effect of phenolic compounds, alpha-tocopherol, and other minor components in virgin olive oil. | 2003 | J. Agric. Food Chem. | pmid:14611189 |
| Stephenson I et al. | Boosting immunity to influenza H5N1 with MF59-adjuvanted H5N3 A/Duck/Singapore/97 vaccine in a primed human population. | 2003 | Vaccine | pmid:12639491 |
| Rocco F et al. | Conjugated methyl sulfide and phenyl sulfide derivatives of oxidosqualene as inhibitors of oxidosqualene and squalene-hopene cyclases. | 2003 | Lipids | pmid:12784859 |
| Ekanayake Mudiyanselage S et al. | Ultraviolet a induces generation of squalene monohydroperoxide isomers in human sebum and skin surface lipids in vitro and in vivo. | 2003 | J. Invest. Dermatol. | pmid:12787115 |
| Madani KA | Effects of trace components of dietary fat on cholesterol metabolism: phytosterols, oxysterols, and squalene. | 2003 | Nutr. Rev. | pmid:12795450 |
| Miettinen TA and Gylling H | Cholesterol synthesis and absorption in coronary patients with lipid triad and isolated high LDL cholesterol in a 4S subgroup. | 2003 | Atherosclerosis | pmid:12801618 |
| Catalán CA et al. | A linear sesterterpene, two squalene derivatives and two peptide derivatives from Croton hieronymi. | 2003 | Phytochemistry | pmid:12943786 |
| Bogan BW et al. | Alkanindiges illinoisensis gen. nov., sp. nov., an obligately hydrocarbonoclastic, aerobic squalane-degrading bacterium isolated from oilfield soils. | 2003 | Int. J. Syst. Evol. Microbiol. | pmid:13130023 |
| Souto ML et al. | The inhibitory effects of squalene-derived triterpenes on protein phosphatase PP2A. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12657259 |
| Luan Z et al. | Statins inhibit secretion of metalloproteinases-1, -2, -3, and -9 from vascular smooth muscle cells and macrophages. | 2003 | Arterioscler. Thromb. Vasc. Biol. | pmid:12663370 |
| Hendler RW et al. | Purple membrane lipid control of bacteriorhodopsin conformational flexibility and photocycle activity. | 2003 | Eur. J. Biochem. | pmid:12709050 |
| Miettinen TA et al. | Serum noncholesterol sterols during inhibition of cholesterol synthesis by statins. | 2003 | J. Lab. Clin. Med. | pmid:12577049 |