(e,e,e,e)-squalene

(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.

Cross Reference

Introduction

To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (e,e,e,e)-squalene?

(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene

MeSH term MeSH ID Detail
Niemann-Pick Diseases D009542 25 associated lipids
Dermatitis, Occupational D009783 12 associated lipids
Occupational Diseases D009784 42 associated lipids
Ossification, Heterotopic D009999 2 associated lipids
Otitis Media D010033 12 associated lipids
Pain D010146 64 associated lipids
Parkinson Disease D010300 53 associated lipids
Parvoviridae Infections D010322 4 associated lipids
Periodontitis D010518 22 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
Photosensitivity Disorders D010787 8 associated lipids
Pneumonia, Lipid D011017 2 associated lipids
Precancerous Conditions D011230 48 associated lipids
Pregnancy Complications, Infectious D011251 11 associated lipids
Psoriasis D011565 47 associated lipids
Rosacea D012393 13 associated lipids
Scalp Dermatoses D012536 11 associated lipids
Stomach Ulcer D013276 75 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Tinea Versicolor D014010 5 associated lipids
Viremia D014766 4 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Xanthomatosis D014973 17 associated lipids
Weight Gain D015430 101 associated lipids
Simian Acquired Immunodeficiency Syndrome D016097 4 associated lipids
Lymphoma, B-Cell D016393 24 associated lipids
Keratitis, Herpetic D016849 5 associated lipids
Coronavirus Infections D018352 4 associated lipids
Parasitemia D018512 5 associated lipids
Persian Gulf Syndrome D018923 1 associated lipids
Hemorrhagic Septicemia, Viral D031941 1 associated lipids
Steatorrhea D045602 2 associated lipids
Micronuclei, Chromosome-Defective D048629 33 associated lipids
Atherosclerosis D050197 85 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with (e,e,e,e)-squalene

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with (e,e,e,e)-squalene?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (e,e,e,e)-squalene?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with (e,e,e,e)-squalene

Download all related citations
Per page 10 20 50 100 | Total 1766
Authors Title Published Journal PubMed Link
Nguyen HT et al. Molecular characterization of Glycine max squalene synthase genes in seed phytosterol biosynthesis. 2013 Plant Physiol. Biochem. pmid:24036394
Vono M et al. The adjuvant MF59 induces ATP release from muscle that potentiates response to vaccination. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:24324152
Pannkuk EL et al. Sebaceous lipid profiling of bat integumentary tissues: quantitative analysis of free Fatty acids, monoacylglycerides, squalene, and sterols. 2013 Chem. Biodivers. pmid:24327437
Tegenge MA and Mitkus RJ A physiologically-based pharmacokinetic (PBPK) model of squalene-containing adjuvant in human vaccines. 2013 J Pharmacokinet Pharmacodyn pmid:23912214
Rappuoli R Vaccine adjuvants: the future is bright. Interview by Jenaid Rees. 2013 Expert Rev Vaccines pmid:23829664
Trung Bui D et al. Polymer prodrug nanoparticles based on naturally occurring isoprenoid for anticancer therapy. 2013 Biomacromolecules pmid:23829862
Bruun Laursen A [Catastrophic consequences of Pandemrix swine flu vaccine containing squalene]. 2013 Ugeskr. Laeg. pmid:23833781
Mølbak K [Squalene unlikely sinner]. 2013 Ugeskr. Laeg. pmid:23833782
Gefenaite G et al. Effectiveness of A(H1N1)pdm09 influenza vaccine in adults recommended for annual influenza vaccination. 2013 PLoS ONE pmid:23840413
Ueda D et al. Cyclization of squalene from both termini: identification of an onoceroid synthase and enzymatic synthesis of ambrein. 2013 J. Am. Chem. Soc. pmid:24274794