(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Downing DT et al. | Changes in skin surface lipid composition induced by severe caloric restriction in man. | 1972 | Am. J. Clin. Nutr. | pmid:5010536 |
Gibbons GF and Mitropoulos KA | Inhibition of cholesterol biosynthesis by carbon monoxide: accumulation of lanosterol and 24,25-dihydrolanosterol. | 1972 | Biochem. J. | pmid:5073750 |
Edkins E and Hansen IA | Wax esters secreted by the uropygial glands of some Australian waterfowl, including the magpie goose. | 1972 | Comp. Biochem. Physiol., B | pmid:5075378 |
Cotterill JA et al. | Age and sex variation in skin surface lipid composition and sebum excretion rate. | 1972 | Br. J. Dermatol. | pmid:5077864 |
Slakey LL et al. | The effect of starvation and re-feeding on the rates of synthesis and degradation of enzyms effecting intermediate reactions in the synthesis of cholesterol and fatty acids in rat liver. | 1972 | Biochem. J. | pmid:5085557 |
Stone KJ and Strominger JL | Inhibition of sterol biosynthesis by bacitracin. | 1972 | Proc. Natl. Acad. Sci. U.S.A. | pmid:4338587 |
Qureshi AA et al. | Squalene synthetase. I. Dissociation and reassociation of enzyme complex. | 1972 | Biochem. Biophys. Res. Commun. | pmid:4341049 |
Malhotra HC and Nes WR | The conversion of mevalonate to 24-methylenecycloartanol by a cell-free enzyme preparation from nonphotosynthetic tissue. | 1972 | J. Biol. Chem. | pmid:4651646 |
Heintz R et al. | Plant sterol metabolism. Demonstration and identification of a biosynthetic intermediate between farnesyl PP and squalene in a higher plant. | 1972 | Biochem. Biophys. Res. Commun. | pmid:4344813 |
Atkin SD et al. | The isolation of 2,3-oxidosqualene from the liver of rats treated with 1-dodecylimidazole, a novel hypocholesterolaemic agent. | 1972 | Biochem. J. | pmid:4655417 |
Gloor M et al. | [Skin surface lipids: qualitative and quantitative determination in patients with acne vulgaris and controls. I]. | 1972 | Arch Dermatol Forsch | pmid:4260600 |
Gloor M et al. | [Influence of skin surface lipids on the result of Burckhardt's alkali resistance determination]. | 1972 | Berufsdermatosen | pmid:4262349 |
Cotterill JA et al. | Further observations on the pathogenesis of acne. | 1972 | Br Med J | pmid:4262616 |
Gloor M et al. | Quantity and composition of skin surface lipids and alkaline-resistance in subjects with contact allergy and in healthy controls. | 1972 | Arch Dermatol Forsch | pmid:4264242 |
Tronnier H | [Methodological problems in exogenous and endogenous influencing on the skin surface]. | 1972 | Arch Dermatol Forsch | pmid:4265238 |
Ramsey RB et al. | Distribution of alkanes in normal and atherosclerotic rabbit aortas. | 1972 May-Jun | Atherosclerosis | pmid:5051654 |
Ritter MC and Dempsey ME | Squalene and sterol carrier protein: structural properties, lipid-binding, and function in cholesterol biosynthesis. | 1973 | Proc. Natl. Acad. Sci. U.S.A. | pmid:4509660 |
Terakado M et al. | Effects of arsenite on incorporation of mevalonate-2-14C into squalene-14C in rabbit dental pulp. | 1973 | J Nihon Univ Sch Dent | pmid:4517364 |
Anding C et al. | [Comparative cyclization of 2,3 epoxide of methylene-22-dihydro-22-squalene in cell-free systems extracted from animal and higher plant tissues]. | 1973 | C.R. Hebd. Seances Acad. Sci., Ser. D, Sci. Nat. | pmid:4632903 |
Ruzicka L | In the borderland between bioorganic chemistry and biochemistry. | 1973 | Annu. Rev. Biochem. | pmid:4600996 |
Bose AK and Hungund BL | The role of glycine in the biosynthesis of steroids. | 1973 | Experientia | pmid:4582087 |
David MH and Kirsop BH | A correlation between oxygen requirements and the products of sterol synthesis in strains of Saccharomyces cerevisiae. | 1973 | J. Gen. Microbiol. | pmid:4584066 |
Clark RP and Shirley SG | Identification of skin in airborne particulate matter. | 1973 | Nature | pmid:4585846 |
Johnson RC and Shah SN | Evidence for the participation of two soluble noncatalytic proteins in hepatic microsomal cholesterol synthesis. | 1973 | Biochem. Biophys. Res. Commun. | pmid:4741538 |
Egwim PO and Kummerow FA | In vitro hepatic cholesterogenesis in rats fed corn oil and fat-free diets. | 1973 | Life Sci. II | pmid:4708203 |
Bojesen E et al. | Sterol biosynthesis in vitro of rat renal inner medulla. | 1973 | Biochim. Biophys. Acta | pmid:4713153 |
Shah SN | Regulation of hepatic cholesterol synthesis from mevalonate in suckling and weaned rats. | 1973 | Lipids | pmid:4713377 |
Phleger CF et al. | Pressure effect on squalene-2,3-oxide cyclization in fish. | 1973 | Comp. Biochem. Physiol., B | pmid:4719990 |
van Leusden HA et al. | Lack of squalene and lanosterol synthesis by the perfused human placenta at term. | 1973 | J. Steroid Biochem. | pmid:4747979 |
Farrington JW et al. | Intercalibration of analyses of recently biosynthesized hydrocarbons and petroleum hydrocarbons in marine lipids. | 1973 | Bull Environ Contam Toxicol | pmid:4753263 |
Murakami S | Isolation and analysis of squalene alcohols from rat preputial glands. | 1973 | Kobe J Med Sci | pmid:4764042 |
Qureshi AA et al. | Squalene synthetase. II. Purification and properties of bakers' yeast enzyme. | 1973 | J. Biol. Chem. | pmid:4348552 |
Beytia E et al. | Squalene synthetase. 3. Mechanism of the reaction. | 1973 | J. Biol. Chem. | pmid:4348553 |
Slakey LL et al. | Occurrence of the enzymes effecting the conversion of acetyl CoA to squalene in homogenates of hog aorta. | 1973 | J. Lipid Res. | pmid:4351784 |
Morris PW and Gorski J | Control of steroidogenesis in pre-ovulatory cells. Luteinizing hormone stimulation of (14C)-acetate incorporation into sterols. | 1973 | J. Biol. Chem. | pmid:4355508 |
Derksen A and Cohen P | Extensive incorporation of (2-14C) mevalonic acid into cholesterol precursors by human platelets in vitro. | 1973 | J. Biol. Chem. | pmid:4355579 |
Inomata N | [Symposium I: aging and the activity of the sebaceous glands]. | 1973 | Nihon Hifuka Gakkai Zasshi | pmid:4546667 |
Faulkner DJ and Petersen MR | Application of the claisen rearrangement to the synthesis of trans trisubstituted olefinic bonds. Synthesis of squalene and insect juvenile hormone. | 1973 | J. Am. Chem. Soc. | pmid:4687674 |
Caspi E et al. | Mechanism of squalene cyclization: the chiral origin of the C-7 and C-15 hydrogen atoms of fusidic acid. | 1973 | J. Steroid Biochem. | pmid:4795867 |
Ebersole RC et al. | Mechanism of oxidative cyclization of squalene. Evidence for cyclization of squalene from either end of the squalene molecule in the in vivo biosynthesis of fusidic acid by Fusidium coccineum. | 1973 | J. Am. Chem. Soc. | pmid:4796972 |
Kellum RE et al. | Human sebaceous gland lipids: in vitro incubations with 14C-labelled compounds. | 1973 | J. Invest. Dermatol. | pmid:4684160 |
Tabacik C et al. | The squalene epoxidase-cyclase activity of human term placenta. | 1973 | FEBS Lett. | pmid:4747843 |
Bhavani BR and Short RV | Formation of steroids by the pregnant mare. 3. Metabolism of 14C-squalene and 3H-dehydroisoandrosterone injected into the fetal circulation. | 1973 | Endocrinology | pmid:4267110 |
Williams M et al. | The effect of local temperature changes on sebum excretion rate and forehead surface lipid composition. | 1973 | Br. J. Dermatol. | pmid:4270005 |
Gloor M et al. | [Composition of skin surface lipids in persons with seborrhoea sicca and seborrhoea oleosa (author's transl)]. | 1973 | Arch Dermatol Forsch | pmid:4270568 |
Cunliffe WJ et al. | Tetracycline and acne vulgaris: a clinical and laboratory investigation. | 1973 | Br Med J | pmid:4271323 |
Cotterill JA et al. | Variation in skin surface lipid composition and sebum excretion rate with time. | 1973 | Acta Derm. Venereol. | pmid:4127454 |
Voogt PA | Investigations of the capacity of synthesizing 3 beta-sterols in mollusca. X. Biosynthesis and composition of 3 beta-sterols in Cephalopoda. | 1973 | Arch. Int. Physiol. Biochim. | pmid:4127479 |
Qureshi AA et al. | Biosynthesis of prelycopersene pyrophosphate and lycopersene by squalene synthetase. | 1973 | J. Biol. Chem. | pmid:4144543 |
Kawaguchi A et al. | Subcellular distribution of sesterterpene- and sterol-biosynthesizing activities in Cochliobolus heterostrophus. | 1973 | Biochim. Biophys. Acta | pmid:4120185 |