(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Burke B et al. | Neutralizing antibody responses to subtype B and C adjuvanted HIV envelope protein vaccination in rabbits. | 2009 | Virology | pmid:19249806 |
Baudner BC et al. | MF59 emulsion is an effective delivery system for a synthetic TLR4 agonist (E6020). | 2009 | Pharm. Res. | pmid:19255727 |
Herchi W et al. | Characterization and quantification of the aliphatic hydrocarbon fraction during linseed development ( Linum usitatissimum L.). | 2009 | J. Agric. Food Chem. | pmid:19492811 |
Cho S et al. | High-dose squalene ingestion increases type I procollagen and decreases ultraviolet-induced DNA damage in human skin in vivo but is associated with transient adverse effects. | 2009 | Clin. Exp. Dermatol. | pmid:19522983 |
Petrick L and Dubowski Y | Heterogeneous oxidation of squalene film by ozone under various indoor conditions. | 2009 | Indoor Air | pmid:19500173 |
Vesikari T et al. | MF59-adjuvanted influenza vaccine (FLUAD) in children: safety and immunogenicity following a second year seasonal vaccination. | 2009 | Vaccine | pmid:19840662 |
Kim ES et al. | Squalene-induced exogenous lipoid pneumonia in an infant. | 2009 | Pediatr Int | pmid:19799746 |
Tagliabue A and Rappuoli R | Vaccine adjuvants: the dream becomes real. | 2008 Sep-Oct | Hum Vaccin | pmid:18682690 |
Zolot AM et al. | Quantum-state resolved reactive scattering at the gas-liquid interface: F+squalane (C30H62) dynamics via high-resolution infrared absorption of nascent HF(v,J). | 2008 | J Chem Phys | pmid:19026079 |
Li RC et al. | [Study on the safety and immunogenicity of MF59-adjuvanted influenza subunit vaccine in Chinese elderly]. | 2008 | Zhonghua Liu Xing Bing Xue Za Zhi | pmid:19040034 |
Wu TK et al. | Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase: a chemistry-biology interdisciplinary study of the protein's structure-function-reaction mechanism relationships. | 2008 | Chem Rec | pmid:18956480 |
Shimizu Y et al. | [Innovation of vaccine adjuvants]. | 2008 | Nippon Rinsho | pmid:18939490 |
Barra A et al. | Chemical characterization and DNA tracking of Sardinian botargo by Mugil cephalus from different geographical origins. | 2008 | J. Agric. Food Chem. | pmid:18942834 |
Lin Y et al. | Induction of broad CD4+ and CD8+ T-cell responses and cross-neutralizing antibodies against hepatitis C virus by vaccination with Th1-adjuvanted polypeptides followed by defective alphaviral particles expressing envelope glycoproteins gpE1 and gpE2 and nonstructural proteins 3, 4, and 5. | 2008 | J. Virol. | pmid:18508900 |
Reddy LH et al. | Squalenoylation favorably modifies the in vivo pharmacokinetics and biodistribution of gemcitabine in mice. | 2008 | Drug Metab. Dispos. | pmid:18474674 |
Heinemann L et al. | Effective induction of type 1 helper IgG2a and cytotoxic T-cell responses in mice following immunization with human papillomavirus type 16 E2 in MF59. | 2008 | Viral Immunol. | pmid:18476769 |
Winne JM et al. | Nonenzymic polycyclization of analogues of oxidosqualene with a preformed C-ring. | 2008 | Org. Biomol. Chem. | pmid:18480904 |
Arias JL et al. | Magnetoresponsive squalenoyl gemcitabine composite nanoparticles for cancer active targeting. | 2008 | Langmuir | pmid:18540685 |
Sotiroudis TG and Kyrtopoulos SA | Anticarcinogenic compounds of olive oil and related biomarkers. | 2008 | Eur J Nutr | pmid:18458836 |
Tong R and McDonald FE | Mimicking biosynthesis: total synthesis of the triterpene natural product abudinol B from a squalene-like precursor. | 2008 | Angew. Chem. Int. Ed. Engl. | pmid:18459096 |
Shahiwala A and Amiji MM | Enhanced mucosal and systemic immune response with squalane oil-containing multiple emulsions upon intranasal and oral administration in mice. | 2008 | J Drug Target | pmid:18446609 |
Schultze V et al. | Safety of MF59 adjuvant. | 2008 | Vaccine | pmid:18462843 |
Zhang JX et al. | Sex- and gonad-affecting scent compounds and 3 male pheromones in the rat. | 2008 | Chem. Senses | pmid:18515819 |
Metzger P et al. | Braunicetals: acetals from condensation of macrocyclic aldehydes and terpene diols in Botryococcus braunii. | 2008 | Phytochemistry | pmid:18639308 |
Catalán J et al. | The photophysics of all-trans polyenes from ttbP5, a nonphotolabile pentaene. | 2008 | J Chem Phys | pmid:18624481 |
Mosca F et al. | Molecular and cellular signatures of human vaccine adjuvants. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18650390 |
Peri A and Serio M | Neuroprotective effects of the Alzheimer's disease-related gene seladin-1. | 2008 | J. Mol. Endocrinol. | pmid:18768664 |
Kürti L et al. | Conformational energetics of cationic backbone rearrangements in triterpenoid biosynthesis provide an insight into enzymatic control of product. | 2008 | J. Am. Chem. Soc. | pmid:18558677 |
Abe I | [Engineering of squalene cyclizing enzymes]. | 2008 | Yakugaku Zasshi | pmid:18670176 |
Noro JC et al. | Tetrahdroxysqualene from Rhus taitensis shows antimycobacterial activity against Mycobacterium tuberculosis. | 2008 | J. Nat. Prod. | pmid:18710283 |
Tachi M and Iwamori M | Mass spectrometric characterization of cholesterol esters and wax esters in epidermis of fetal, adult and keloidal human skin. | 2008 | Exp. Dermatol. | pmid:17979971 |
Das B et al. | Squalene selectively protects mouse bone marrow progenitors against cisplatin and carboplatin-induced cytotoxicity in vivo without protecting tumor growth. | 2008 | Neoplasia | pmid:18813359 |
Huber VC and McCullers JA | Vaccines against pandemic influenza: what can be done before the next pandemic? | 2008 | Pediatr. Infect. Dis. J. | pmid:18820570 |
Nováková Z et al. | Membrane proteins and squalene-hydrosqualene profile in methanoarchaeon Methanothermobacter thermautotrophicus resistant to N,N'-dicyclohexylcarbodiimide. | 2008 | Folia Microbiol. (Praha) | pmid:18661300 |
Morimoto Y | The role of chemical synthesis in structure elucidation of oxasqualenoids. | 2008 | Org. Biomol. Chem. | pmid:18452003 |
Radosević K et al. | Antibody and T-cell responses to a virosomal adjuvanted H9N2 avian influenza vaccine: impact of distinct additional adjuvants. | 2008 | Vaccine | pmid:18514980 |
Gerpe A et al. | Heteroallyl-containing 5-nitrofuranes as new anti-Trypanosoma cruzi agents with a dual mechanism of action. | 2008 | Bioorg. Med. Chem. | pmid:17981471 |
Durando P et al. | Safety and immunogenicity of two influenza virus subunit vaccines, with or without MF59 adjuvant, administered to human immunodeficiency virus type 1-seropositive and -seronegative adults. | 2008 | Clin. Vaccine Immunol. | pmid:18003811 |
Pelle E et al. | Identification of histamine receptors and reduction of squalene levels by an antihistamine in sebocytes. | 2008 | J. Invest. Dermatol. | pmid:18007585 |
Miettinen TA et al. | Synthesis and absorption of cholesterol in Finnish boys by serum non-cholesterol sterols: the cardiovascular risk in Young Finns Study. | 2008 | Atherosclerosis | pmid:18178213 |
Wack A et al. | Combination adjuvants for the induction of potent, long-lasting antibody and T-cell responses to influenza vaccine in mice. | 2008 | Vaccine | pmid:18162266 |
Zhang W et al. | Feeding with supplemental squalene enhances the productive performance in boars. | 2008 | Anim. Reprod. Sci. | pmid:18164149 |
Couvreur P et al. | Discovery of new hexagonal supramolecular nanostructures formed by squalenoylation of an anticancer nucleoside analogue. | 2008 | Small | pmid:18247384 |
Reddy LH et al. | Preclinical toxicology (subacute and acute) and efficacy of a new squalenoyl gemcitabine anticancer nanomedicine. | 2008 | J. Pharmacol. Exp. Ther. | pmid:18258784 |
Bernstein DI et al. | Effects of adjuvants on the safety and immunogenicity of an avian influenza H5N1 vaccine in adults. | 2008 | J. Infect. Dis. | pmid:18260764 |
Simonen P et al. | The validity of serum squalene and non-cholesterol sterols as surrogate markers of cholesterol synthesis and absorption in type 2 diabetes. | 2008 | Atherosclerosis | pmid:17875306 |
Babiychuk E et al. | Allelic mutant series reveal distinct functions for Arabidopsis cycloartenol synthase 1 in cell viability and plastid biogenesis. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18287026 |
Ansaldi F et al. | Cross-protection by MF59-adjuvanted influenza vaccine: neutralizing and haemagglutination-inhibiting antibody activity against A(H3N2) drifted influenza viruses. | 2008 | Vaccine | pmid:18294741 |
Kwon SM et al. | In vivo time-dependent gene expression of cationic lipid-based emulsion as a stable and biocompatible non-viral gene carrier. | 2008 | J Control Release | pmid:18384902 |
Kanaji N et al. | Positron emission tomography-positive squalene-induced lipoid pneumonia confirmed by gas chromatography-mass spectrometry of bronchoalveolar lavage fluid. | 2008 | Am. J. Med. Sci. | pmid:18414072 |