(e,e,e,e)-squalene

(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.

Cross Reference

Introduction

To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (e,e,e,e)-squalene?

(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene

MeSH term MeSH ID Detail
Niemann-Pick Diseases D009542 25 associated lipids
Hyperlipoproteinemia Type III D006952 4 associated lipids
Photosensitivity Disorders D010787 8 associated lipids
Hyperlipoproteinemias D006951 15 associated lipids
Parkinson Disease D010300 53 associated lipids
Celiac Disease D002446 16 associated lipids
Keloid D007627 12 associated lipids
Influenza, Human D007251 11 associated lipids
Leukemia, Hairy Cell D007943 5 associated lipids
Gallbladder Diseases D005705 3 associated lipids
Micronuclei, Chromosome-Defective D048629 33 associated lipids
Xanthomatosis D014973 17 associated lipids
Atherosclerosis D050197 85 associated lipids
Ossification, Heterotopic D009999 2 associated lipids
Fatigue D005221 10 associated lipids
Keratitis, Herpetic D016849 5 associated lipids
Rosacea D012393 13 associated lipids
Parasitemia D018512 5 associated lipids
Lipodystrophy D008060 4 associated lipids
Exostoses, Multiple Hereditary D005097 3 associated lipids
Tinea Versicolor D014010 5 associated lipids
Parvoviridae Infections D010322 4 associated lipids
Lymphoma, B-Cell D016393 24 associated lipids
Chronic Disease D002908 7 associated lipids
Simian Acquired Immunodeficiency Syndrome D016097 4 associated lipids
Coronavirus Infections D018352 4 associated lipids
Viremia D014766 4 associated lipids
Alopecia Areata D000506 6 associated lipids
Scalp Dermatoses D012536 11 associated lipids
Fasciitis D005208 2 associated lipids
Pneumonia, Lipid D011017 2 associated lipids
Persian Gulf Syndrome D018923 1 associated lipids
Steatorrhea D045602 2 associated lipids
Hemorrhagic Septicemia, Viral D031941 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with (e,e,e,e)-squalene

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with (e,e,e,e)-squalene?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (e,e,e,e)-squalene?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with (e,e,e,e)-squalene

Download all related citations
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Authors Title Published Journal PubMed Link
CORNFORTH JW et al. Studies on the biosynthesis of cholesterol. 5. Biosynthesis of squalene from DL-3-hydroxy-3-methyl [2-14C] pentano-5-lactone. 1958 Biochem. J. pmid:13535596
WOLFF RE and GODEFROY N [Transformation of synthetic squalene (11, 1414C) to cholesterol in rats]. 1958 C. R. Hebd. Seances Acad. Sci. pmid:13537384
WOLFF RE and PICHAT L [Synthesis of 11,14-C14-squalene]. 1958 C. R. Hebd. Seances Acad. Sci. pmid:13537435
LOUD AV and BUCHER NL The turnover of squalene in relation to the biosynthesis of cholesterol. 1958 J. Biol. Chem. pmid:13563436
WITTING LA and PORTER JW Intermediates in the conversion of mevalonic acid to squalene by a rat liver enzyme system. 1959 J. Biol. Chem. pmid:13845505
KROENING F [On the induction of leukemia in C57B1 mice following painting of the dorsal part of the skin with short-chain fatty acids, fatty acid esters and with squalene]. 1959 Acta Unio Int Contra Cancrum pmid:13848508
NICHOLAS HJ and THOMAS BE Intracerebral incorporation of [2-14C]mevalonic acid into adult rat brain squalene and cholesterol. 1959 Biochim. Biophys. Acta pmid:13854106
MARKLEY K and GURIN S Decarboxylation of mevalonic acid and conversion to squalene; enzyme fractionation and cofactors. 1959 Biochim. Biophys. Acta pmid:13628647
RILLING HC and BLOCH K On the mechanism of squaiene biogenesis from mevalonic acid. 1959 J. Biol. Chem. pmid:13654391
WOOTTON JM and WRIGHT LD Biosynthesis of squalene by the annelid Lumbricus terrestris. 1960 Nature pmid:13786660