| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pain | D010146 | 64 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
| Metabolism, Inborn Errors | D008661 | 46 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
(e,e,e,e)-squalene
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
Cross Reference
Introduction
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (e,e,e,e)-squalene?
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
PubChem Associated disorders and diseases
What pathways are associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (e,e,e,e)-squalene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with (e,e,e,e)-squalene?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with (e,e,e,e)-squalene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Michael-Jubeli R et al. | High-temperature gas chromatography-mass spectrometry for skin surface lipids profiling. | 2011 | J. Lipid Res. | pmid:20952798 |
| Lama-Muñoz A et al. | New hydrothermal treatment of alperujo enhances the content of bioactive minor components in crude pomace olive oil. | 2011 | J. Agric. Food Chem. | pmid:21265536 |
| Brasser AJ et al. | Presence of wax esters and squalene in human saliva. | 2011 | Arch. Oral Biol. | pmid:21247555 |
| Arguedas A et al. | Assessment of the safety, tolerability and kinetics of the immune response to A/H1N1v vaccine formulations with and without adjuvant in healthy pediatric subjects from 3 through 17 years of age. | 2011 | Hum Vaccin | pmid:21285531 |
| Manuel O et al. | Humoral response to the influenza A H1N1/09 monovalent AS03-adjuvanted vaccine in immunocompromised patients. | 2011 | Clin. Infect. Dis. | pmid:21288852 |
| Alghisi F et al. | Immunogenicity and safety profile of the monovalent A/H1N1 MF59-adjuvanted vaccine in patients affected by cystic fibrosis. | 2011 | Thorax | pmid:21228426 |
| Decaro N et al. | Immunogenicity and protective efficacy in dogs of an MF59â„¢-adjuvanted vaccine against recombinant canine/porcine coronavirus. | 2011 | Vaccine | pmid:21272607 |
| Arias JL et al. | Squalene based nanocomposites: a new platform for the design of multifunctional pharmaceutical theragnostics. | 2011 | ACS Nano | pmid:21275408 |
| van den Brand JM et al. | Efficacy of vaccination with different combinations of MF59-adjuvanted and nonadjuvanted seasonal and pandemic influenza vaccines against pandemic H1N1 (2009) influenza virus infection in ferrets. | 2011 | J. Virol. | pmid:21209108 |
| Calabro S et al. | Vaccine adjuvants alum and MF59 induce rapid recruitment of neutrophils and monocytes that participate in antigen transport to draining lymph nodes. | 2011 | Vaccine | pmid:21215831 |
| Javelle E et al. | Delayed focal lipoatrophy after AS03-adjuvanted influenza A (H1N1) 2009 vaccine. | 2011 | Vaccine | pmid:21172376 |
| Montagnani S et al. | Autoimmune hemolytic anemia following MF59-adjuvanted influenza vaccine administration: a report of two cases. | 2011 | Ann Pharmacother | pmid:21189364 |
| Esposito S et al. | Pandemic influenza A/H1N1 vaccine administered sequentially or simultaneously with seasonal influenza vaccine to HIV-infected children and adolescents. | 2011 | Vaccine | pmid:21199699 |
| Lopez P et al. | Combined, concurrent, and sequential administration of seasonal influenza and MF59-adjuvanted A/H5N1 vaccines: a phase II randomized, controlled trial of immunogenicity and safety in healthy adults. | 2011 | J. Infect. Dis. | pmid:21606530 |
| Cen-Pacheco F et al. | Cytotoxic oxasqualenoids from the red alga Laurencia viridis. | 2011 | Eur J Med Chem | pmid:21616566 |
| Raouane M et al. | Synthesis, characterization, and in vivo delivery of siRNA-squalene nanoparticles targeting fusion oncogene in papillary thyroid carcinoma. | 2011 | J. Med. Chem. | pmid:21561161 |
| Nowosielski M and Hoffmann M | Do the substituent effects affect conformational freedom of squalene in hopene biosynthesis? | 2011 | J Mol Model | pmid:21562825 |
| Hernández-GarcÃa I et al. | [Adverse events after administration of A/H1N1 vaccine to patients]. | 2011 | Med Clin (Barc) | pmid:20199781 |
| Andrews NJ et al. | Predictors of immune response and reactogenicity to AS03B-adjuvanted split virion and non-adjuvanted whole virion H1N1 (2009) pandemic influenza vaccines. | 2011 | Vaccine | pmid:21875635 |
| Vesikari T et al. | Oil-in-water emulsion adjuvant with influenza vaccine in young children. | 2011 | N. Engl. J. Med. | pmid:21995388 |
| Bernstein DI | Vaccines for cytomegalovirus. | 2011 | Infect Disord Drug Targets | pmid:22309618 |
| Fox CB et al. | Effects of emulsifier concentration, composition, and order of addition in squalene-phosphatidylcholine oil-in-water emulsions. | 2011 | Pharm Dev Technol | pmid:20550484 |
| Fabbiani M et al. | Immune response to influenza A (H1N1)v monovalent MF59-adjuvanted vaccine in HIV-infected patients. | 2011 | Vaccine | pmid:21349364 |
| Gill S et al. | Cholesterol-dependent degradation of squalene monooxygenase, a control point in cholesterol synthesis beyond HMG-CoA reductase. | 2011 | Cell Metab. | pmid:21356516 |
| Niehaus TD et al. | Identification of unique mechanisms for triterpene biosynthesis in Botryococcus braunii. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21746901 |
| Kaya K et al. | Thraustochytrid Aurantiochytrium sp. 18W-13a accummulates high amounts of squalene. | 2011 | Biosci. Biotechnol. Biochem. | pmid:22056449 |
| Cheong HJ et al. | Immunogenicity and safety of the influenza A/H1N1 2009 inactivated split-virus vaccine in young and older adults: MF59-adjuvanted vaccine versus nonadjuvanted vaccine. | 2011 | Clin. Vaccine Immunol. | pmid:21715575 |
| Soto G et al. | Acetoacetyl-CoA thiolase regulates the mevalonate pathway during abiotic stress adaptation. | 2011 | J. Exp. Bot. | pmid:21908473 |
| Celia C et al. | Gemcitabine-loaded innovative nanocarriers vs GEMZAR: biodistribution, pharmacokinetic features and in vivo antitumor activity. | 2011 | Expert Opin Drug Deliv | pmid:22077480 |
| Tsai TF | MF59 adjuvanted seasonal and pandemic influenza vaccines. | 2011 | Yakugaku Zasshi | pmid:22129867 |
| Puig-Barberà J et al. | MF59™-adjuvanted seasonal influenza vaccine in young children. | 2011 | Expert Rev Vaccines | pmid:22043952 |
| Viganò A et al. | Long-term immunogenicity after one and two doses of a monovalent MF59-adjuvanted A/H1N1 Influenza virus vaccine coadministered with the seasonal 2009-2010 nonadjuvanted Influenza virus vaccine in HIV-infected children, adolescents, and young adults in a randomized controlled trial. | 2011 | Clin. Vaccine Immunol. | pmid:21795458 |
| Huijskens E et al. | Immunogenicity, boostability, and sustainability of the immune response after vaccination against Influenza A virus (H1N1) 2009 in a healthy population. | 2011 | Clin. Vaccine Immunol. | pmid:21795459 |
| Pollard AJ and Hill AV | Antibody repertoire: embracing diversity. | 2011 | Sci Transl Med | pmid:21795586 |
| Okike IO et al. | The immunogenicity of a novel A (H1N1) vaccine in HIV-infected children. | 2011 | Vaccine | pmid:21742005 |
| Kowert BA and Watson MB | Diffusion of organic solutes in squalane. | 2011 | J Phys Chem B | pmid:21780767 |
| Bildstein L et al. | Interaction of an amphiphilic squalenoyl prodrug of gemcitabine with cellular membranes. | 2011 | Eur J Pharm Biopharm | pmid:21784150 |
| Della Cioppa G et al. | Trivalent and quadrivalent MF59(®)-adjuvanted influenza vaccine in young children: a dose- and schedule-finding study. | 2011 | Vaccine | pmid:21906647 |
| Fox CB et al. | Immunomodulatory and physical effects of oil composition in vaccine adjuvant emulsions. | 2011 | Vaccine | pmid:21906648 |
| Zuccotti GV et al. | Long-lasting immunogenicity and safety of a 2009 pandemic influenza A(H1N1) MF59-adjuvanted vaccine when co-administered with a 2009-2010 seasonal influenza vaccine in young patients with type 1 diabetes mellitus. | 2011 | Diabet. Med. | pmid:21916971 |
| Meyer K et al. | A weak neutralizing antibody response to hepatitis C virus envelope glycoprotein enhances virus infection. | 2011 | PLoS ONE | pmid:21887300 |
| Broeders NE et al. | Influenza A/H1N1 vaccine in patients treated by kidney transplant or dialysis: a cohort study. | 2011 | Clin J Am Soc Nephrol | pmid:21921153 |
| Achiraman S et al. | Increased squalene concentrations in the clitoral gland during the estrous cycle in rats: an estrus-indicating scent mark? | 2011 | Theriogenology | pmid:21924481 |
| Brito LA et al. | An alternative renewable source of squalene for use in emulsion adjuvants. | 2011 | Vaccine | pmid:21723355 |
| Weyermann C et al. | Initial results on the composition of fingerprints and its evolution as a function of time by GC/MS analysis. | 2011 | J. Forensic Sci. | pmid:20707835 |
| Wu J et al. | Superior protection provided by a single dose of MF59-adjuvanted whole inactivated H5N1 influenza vaccine in type 1 diabetic mice. | 2011 | Arch. Virol. | pmid:21110049 |
| Packwood DM and Phillips LF | A stochastic, local mode study of neon-liquid surface collision dynamics. | 2011 | Phys Chem Chem Phys | pmid:21042647 |
| Andrews N et al. | Age-specific effectiveness of an oil-in-water adjuvanted pandemic (H1N1) 2009 vaccine against confirmed infection in high risk groups in England. | 2011 | J. Infect. Dis. | pmid:21148494 |
| Kajaste-Rudnitski A et al. | Induction of protective antibody response by MF59-adjuvanted 2009 pandemic A/H1N1v influenza vaccine in HIV-1-infected individuals. | 2011 | AIDS | pmid:21150561 |
| Launay O et al. | Safety and immunogenicity of a monovalent 2009 influenza A/H1N1v vaccine adjuvanted with AS03A or unadjuvanted in HIV-infected adults: a randomized, controlled trial. | 2011 | J. Infect. Dis. | pmid:21628666 |
| Piccialli V et al. | Isolation of a bis-iodurated tetra-THF as a trace product from the oxidation of squalene with RuOâ‚„ and its double ring expansion to a novel bis-THF-bis-THP compound. | 2011 | Molecules | pmid:21709619 |
| Iannazzo S | Pharmacoeconomic evaluation of the MF59--adjuvanted influenza vaccine in the elderly population in Italy. | 2011 | J Prev Med Hyg | pmid:21710816 |
| Seubert A et al. | Adjuvanticity of the oil-in-water emulsion MF59 is independent of Nlrp3 inflammasome but requires the adaptor protein MyD88. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21690334 |
| Khurana S et al. | MF59 adjuvant enhances diversity and affinity of antibody-mediated immune response to pandemic influenza vaccines. | 2011 | Sci Transl Med | pmid:21632986 |
| Zhang LW et al. | Oil components modulate the skin delivery of 5-aminolevulinic acid and its ester prodrug from oil-in-water and water-in-oil nanoemulsions. | 2011 | Int J Nanomedicine | pmid:21556344 |
| Meier S et al. | Antibody responses to natural influenza A/H1N1/09 disease or following immunization with adjuvanted vaccines, in immunocompetent and immunocompromised children. | 2011 | Vaccine | pmid:21419775 |
| Réjiba S et al. | Squalenoyl gemcitabine nanomedicine overcomes the low efficacy of gemcitabine therapy in pancreatic cancer. | 2011 | Nanomedicine | pmid:21419876 |
| Banzhoff A et al. | Passive surveillance of adverse events of an MF59-adjuvanted H1N1v vaccine during the pandemic mass vaccinations. | 2011 | Hum Vaccin | pmid:21422814 |
| Parretta E et al. | Italian post-marketing surveillance for adverse event reports after MF59-adjuvanted H1N1v vaccination. | 2011 | Vaccine | pmid:21406267 |
| Ambike A et al. | Interaction of self-assembled squalenoyl gemcitabine nanoparticles with phospholipid-cholesterol monolayers mimicking a biomembrane. | 2011 | Langmuir | pmid:21413743 |
| Gao J et al. | Laser-induced acoustic desorption/atmospheric pressure chemical ionization mass spectrometry. | 2011 | J. Am. Soc. Mass Spectrom. | pmid:21472571 |
| Weschler CJ et al. | Squalene and cholesterol in dust from danish homes and daycare centers. | 2011 | Environ. Sci. Technol. | pmid:21476540 |
| Cauda V et al. | "Liquid-phase calcination" of colloidal mesoporous silica nanoparticles in high-boiling solvents. | 2011 | J. Am. Chem. Soc. | pmid:21480591 |
| Griffiths PD et al. | Cytomegalovirus glycoprotein-B vaccine with MF59 adjuvant in transplant recipients: a phase 2 randomised placebo-controlled trial. | 2011 | Lancet | pmid:21481708 |
| Liu CL et al. | The direct observation of secondary radical chain chemistry in the heterogeneous reaction of chlorine atoms with submicron squalane droplets. | 2011 | Phys Chem Chem Phys | pmid:21455529 |
| Inagaki YS et al. | Investigation of the potential for triterpene synthesis in rice through genome mining and metabolic engineering. | 2011 | New Phytol. | pmid:21501172 |
| Garcia-Sicilia J et al. | Immunogenicity and safety of AS03-adjuvanted H1N1 pandemic vaccines in children and adolescents. | 2011 | Vaccine | pmid:21504774 |
| O'Hagan DT et al. | MF59 adjuvant: the best insurance against influenza strain diversity. | 2011 | Expert Rev Vaccines | pmid:21506643 |
| Esposito S et al. | Immunogenicity, safety and tolerability of monovalent 2009 pandemic influenza A/H1N1 MF59-adjuvanted vaccine in children and adolescents with Williams or Cornelia De Lange syndrome. | 2011 | Hum Vaccin | pmid:21508673 |
| AÄimoviÄ J et al. | Circadian rhythm of cholesterol synthesis in mouse liver: a statistical analysis of the post-squalene metabolites in wild-type and Crem-knock-out mice. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21531203 |
| Siedenburg G and Jendrossek D | Squalene-hopene cyclases. | 2011 | Appl. Environ. Microbiol. | pmid:21531832 |
| Tsai TF et al. | Explorations of clinical trials and pharmacovigilance databases of MF59®-adjuvanted influenza vaccines for associated cases of narcolepsy. | 2011 | Scand. J. Infect. Dis. | pmid:21534891 |
| Esposito S et al. | Influenza A/H1N1 MF59-adjuvanted vaccine in preterm and term children aged 6 to 23 months. | 2011 | Pediatrics | pmid:21464195 |
| Esposito S et al. | An open-label, randomized clinical trial assessing immunogenicity, safety and tolerability of pandemic influenza A/H1N1 MF59-adjuvanted vaccine administered sequentially or simultaneously with seasonal virosomal-adjuvanted influenza vaccine to paediatric kidney transplant recipients. | 2011 | Nephrol. Dial. Transplant. | pmid:20974645 |
| Montana M et al. | Safety review: squalene and thimerosal in vaccines. | 2010 Nov-Dec | Therapie | pmid:21176760 |
| Voyron S et al. | Antifungal activity of bis-azasqualenes, inhibitors of oxidosqualene cyclase. | 2010 | Mycoses | pmid:19549106 |
| van Himbergen TM et al. | Familial combined hyperlipidemia is associated with alterations in the cholesterol synthesis pathway. | 2010 | Arterioscler. Thromb. Vasc. Biol. | pmid:19834104 |
| Keitel W et al. | Dose ranging of adjuvant and antigen in a cell culture H5N1 influenza vaccine: safety and immunogenicity of a phase 1/2 clinical trial. | 2010 | Vaccine | pmid:19835829 |
| Brunner R et al. | The ABC of clinical and experimental adjuvants--a brief overview. | 2010 | Immunol. Lett. | pmid:19895847 |
| Eroglu E and Melis A | Extracellular terpenoid hydrocarbon extraction and quantitation from the green microalgae Botryococcus braunii var. Showa. | 2010 | Bioresour. Technol. | pmid:20005092 |
| Kalvodova L | Squalene-based oil-in-water emulsion adjuvants perturb metabolism of neutral lipids and enhance lipid droplet formation. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20018176 |
| Kimura M et al. | Protostadienol synthase from Aspergillus fumigatus: functional conversion into lanosterol synthase. | 2010 | Biochem. Biophys. Res. Commun. | pmid:19951700 |
| Waddington CS et al. | Safety and immunogenicity of AS03B adjuvanted split virion versus non-adjuvanted whole virion H1N1 influenza vaccine in UK children aged 6 months-12 years: open label, randomised, parallel group, multicentre study. | 2010 | BMJ | pmid:20508026 |
| Beck F et al. | Queries about vaccines containing squalene. | 2010 | Immunol. Cell Biol. | pmid:20157330 |
| Gerpe A et al. | Naftifine-analogues as anti-Trypanosoma cruzi agents. | 2010 | Eur J Med Chem | pmid:20163894 |
| Warleta F et al. | Squalene protects against oxidative DNA damage in MCF10A human mammary epithelial cells but not in MCF7 and MDA-MB-231 human breast cancer cells. | 2010 | Food Chem. Toxicol. | pmid:20138105 |
| Sugihara N et al. | Novel fractionation method for squalene and phytosterols contained in the deodorization distillate of rice bran oil. | 2010 | J Oleo Sci | pmid:20103978 |
| Chen CC et al. | Effects of lipophilic emulsifiers on the oral administration of lovastatin from nanostructured lipid carriers: physicochemical characterization and pharmacokinetics. | 2010 | Eur J Pharm Biopharm | pmid:20060469 |
| Spanova M et al. | Effect of lipid particle biogenesis on the subcellular distribution of squalene in the yeast Saccharomyces cerevisiae. | 2010 | J. Biol. Chem. | pmid:20032462 |
| Tsai T et al. | Exposure to MF59-adjuvanted influenza vaccines during pregnancy--a retrospective analysis. | 2010 | Vaccine | pmid:19969117 |
| Pietrella D et al. | A beta-glucan-conjugate vaccine and anti-beta-glucan antibodies are effective against murine vaginal candidiasis as assessed by a novel in vivo imaging technique. | 2010 | Vaccine | pmid:20038431 |
| Gasparini R et al. | Impact of prior or concomitant seasonal influenza vaccination on MF59-adjuvanted H1N1v vaccine (Focetria) in adult and elderly subjects. | 2010 | Int. J. Clin. Pract. | pmid:20039974 |
| De Luca C and Valacchi G | Surface lipids as multifunctional mediators of skin responses to environmental stimuli. | 2010 | Mediators Inflamm. | pmid:20981292 |
| Bildstein L et al. | Transmembrane diffusion of gemcitabine by a nanoparticulate squalenoyl prodrug: an original drug delivery pathway. | 2010 | J Control Release | pmid:20691740 |
| Weiss TL et al. | Raman spectroscopy analysis of botryococcene hydrocarbons from the green microalga Botryococcus braunii. | 2010 | J. Biol. Chem. | pmid:20705610 |
| Nakagawa K et al. | gamma-Tocotrienol reduces squalene hydroperoxide-induced inflammatory responses in HaCaT keratinocytes. | 2010 | Lipids | pmid:20714817 |
| Black S et al. | Safety of MF59-adjuvanted versus non-adjuvanted influenza vaccines in children and adolescents: an integrated analysis. | 2010 | Vaccine | pmid:20813217 |
| Vesikari T et al. | Immunogenicity and safety of MF59-adjuvanted H5N1 influenza vaccine from infancy to adolescence. | 2010 | Pediatrics | pmid:20819892 |
| Pili B et al. | Liposomal squalenoyl-gemcitabine: formulation, characterization and anticancer activity evaluation. | 2010 | Nanoscale | pmid:20820745 |
| Beran J et al. | A phase III, randomized, open-label study to assess the tolerability and immunogenicity of an H5N1 influenza vaccine administered to healthy adults with a 1-, 2-, 3-, or 6-week interval between first and second doses. | 2010 | Clin Ther | pmid:21316535 |