| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pain | D010146 | 64 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
| Metabolism, Inborn Errors | D008661 | 46 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
(e,e,e,e)-squalene
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
Cross Reference
Introduction
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (e,e,e,e)-squalene?
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
PubChem Associated disorders and diseases
What pathways are associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (e,e,e,e)-squalene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with (e,e,e,e)-squalene?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with (e,e,e,e)-squalene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Corey EJ and Ortiz de Montellano PR | Enzymic synthesis of beta-amyrin from 2,3-oxidosqualene. | 1967 | J. Am. Chem. Soc. | pmid:6042774 |
| van Tamelen EE et al. | On the mechanism of lanosterol biosynthesis from squalene 2,3-oxide. | 1967 | J. Am. Chem. Soc. | pmid:6042776 |
| Corey EJ et al. | 2,3-iminosqualene, a potent inhibitor of the enzymic cyclization of 2,3-oxidosqualene to sterols. | 1967 | J. Am. Chem. Soc. | pmid:6043808 |
| Young TE and Maggs RJ | The use of a moving wire detector system for the study of liquid chromatographic columns. | 1967 May-Jun | Anal. Chim. Acta | pmid:6045413 |
| Corey EJ and Gross SK | Formation of sterols by the action of 2,3-oxidosqualene-sterol cyclase on the factitious substrates 2,3:22,23-dioxidosqualene and 2,3-oxido-22,23-dihydrosqualene. | 1967 | J. Am. Chem. Soc. | pmid:6046552 |
| Rao KS and Olson RE | The effect of excessive vitamin A upon the metabolism of isoprenoid compounds in rat liver. | 1967 | Biochim. Biophys. Acta | pmid:6049507 |
| Arffmann E and Glavind J | Studies by the newt test on carcinogenic properties of rats. | 1967 | Acta Pathol Microbiol Scand | pmid:6050372 |
| Willett JD et al. | Squalene-2,3oxide, an intermediate in the enzymatic conversion of squalene to lanosterol and cholesterol. | 1967 | J. Biol. Chem. | pmid:6061706 |
| van Tamelen EE et al. | Enzymic cyclization of trans,trans,trans-18,19-dihydrosqualene 2,3-oxide. | 1967 | J. Am. Chem. Soc. | pmid:6064361 |
| Grob EC and Csupor L | [Information on the leaf lipids of Acer platanoides L. during autumn yellowing]. | 1967 | Experientia | pmid:6077859 |
| Cain CE et al. | Hydrocarbons from human meninges and meningiomas. | 1967 | Biochim. Biophys. Acta | pmid:6078120 |
| Eilenberg H and Shechter I | A possible regulatory role of squalene epoxidase in Chinese hamster ovary cells. | 1984 | Lipids | pmid:6087072 |
| Cenedella RJ | Concentration-dependent effects of AY-9944 and U18666A on sterol synthesis in brain. Variable sensitivities of metabolic steps. | 1980 | Biochem. Pharmacol. | pmid:6159896 |
| Cicchini T et al. | [The importance of man, mouse and rat skin surface lipid fractions on the "in vitro" penetration of "Schistosoma mansoni" cercariae (author's transl)]. | 1977 Sep-Oct | Ann Sclavo | pmid:616258 |
| Cherayil GD et al. | Abnormal lipid composition of fat tissue in human mesenteric panniculitis. | 1981 | Lipids | pmid:6163941 |
| Ohkido M et al. | Lipid peroxide of human skin. | 1980 | Curr. Probl. Dermatol. | pmid:6165521 |
| Lay JP et al. | Metabolism of beta-hexachlorocyclohexane-14C in rats following low dosing in the daily diet. | 1981 | J Environ Sci Health B | pmid:6166652 |
| Richter E et al. | Excretion of beta-hexachlorocyclohexane by the rat as influenced by oral paraffin, squalane, and Lutrol E 400. | 1981 | Ecotoxicol. Environ. Saf. | pmid:6170505 |
| Matsuo I et al. | Mechanism of skin surface lipid peroxidation. | 1983 | Curr. Probl. Dermatol. | pmid:6197240 |
| Stewart ME et al. | Suppression of sebum secretion with 13-cis-retinoic acid: effect on individual skin surface lipids and implications for their anatomic origin. | 1984 | J. Invest. Dermatol. | pmid:6228612 |
| Bachman D et al. | Effect of bacille Calmette-Guerin immunotherapy on feline sarcoma virus-induced neoplasms in the cat. | 1982 | Am. J. Vet. Res. | pmid:6280529 |
| Tilvis RS et al. | Release of newly synthesized squalene, methyl sterols and cholesterol from human adipocytes in the presence of lipoproteins. | 1978 | Scand. J. Clin. Lab. Invest. | pmid:628820 |
| Pinto WJ and Nes WR | Stereochemical specificity for sterols in Saccharomyces cerevisiae. | 1983 | J. Biol. Chem. | pmid:6339498 |
| Pinto WJ et al. | Stereochemically distinct roles for sterol in Saccharomyces cerevisiae. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6340686 |
| Jahnke L and Klein HP | Oxygen requirements for formation and activity of the squalene epoxidase in Saccharomyces cerevisiae. | 1983 | J. Bacteriol. | pmid:6348021 |
| Ryder NS et al. | Effect of the antimycotic drug naftifine on growth of and sterol biosynthesis in Candida albicans. | 1984 | Antimicrob. Agents Chemother. | pmid:6375557 |
| Wood SG and Gottlieb D | Evidence from mycelial studies for differences in the sterol biosynthetic pathway of Rhizoctonia solani and Phytophthora cinnamomi. | 1978 | Biochem. J. | pmid:637849 |
| Wood SG and Gottlieb D | Evidence from cell-free systems for differences in the sterol biosynthetic pathway of Rhizoctonia solani and Phytophthora cinnamomi. | 1978 | Biochem. J. | pmid:637850 |
| Wielgosz GJ and Armstrong DT | Effects of prolactin, progesterone, and 17beta-hydroxy-5alpha-androstan-3-one on squalene production by the preputial gland of the immature female rat. | 1978 | Can. J. Physiol. Pharmacol. | pmid:638868 |
| Takeuchi N et al. | Impairment of hepatic cholesterol synthesis from squalene and the function of hepatic sterol carrier protein system by ageing. | 1978 | Exp. Gerontol. | pmid:639893 |
| Richter E et al. | Stimulation of the faecal excretion of 2,4,5,2',4',5'-hexachlorobiphenyl in rats by squalane. | 1983 | Xenobiotica | pmid:6415933 |
| Scott MT et al. | Adjuvant requirements for protective immunization of mice using a Trypanosoma cruzi 90K cell surface glycoprotein. | 1984 | Int. Arch. Allergy Appl. Immunol. | pmid:6429057 |
| Chen HW and Leonard DA | Chloroquine inhibits cyclization of squalene oxide to lanosterol in mammalian cells. | 1984 | J. Biol. Chem. | pmid:6429139 |
| Strauss JS et al. | The effect of marked inhibition of sebum production with 13cis-retinoic acid on skin surface lipid composition. | 1980 | J. Invest. Dermatol. | pmid:6444323 |
| Bhavnani BR | Oestrogen biosynthesis in the pregnant mare. | 1981 | J. Endocrinol. | pmid:6453917 |
| Miettinen TA | Cholesterol and bile acid synthesis in two families with homozygous and heterozygous hypercholesterolemia. | 1984 Jul-Aug | Arteriosclerosis | pmid:6466195 |
| Arce V et al. | The in vivo incorporation of acetate into different non-saponifiable lipids by neonatal chick tissues. | 1984 | Comp. Biochem. Physiol., B | pmid:6478791 |
| Chin J and Bloch K | Role of supernatant protein factor and anionic phospholipid in squalene uptake and conversion by microsomes. | 1984 | J. Biol. Chem. | pmid:6480582 |
| Ohsawa K et al. | The possible role of squalene and its peroxide of the sebum in the occurrence of sunburn and protection from the damage caused by U.V. irradiation. | 1984 | J Toxicol Sci | pmid:6481825 |
| Schroeder F et al. | Correlation of tumor metastasis with sterol carrier protein and plasma membrane sterol levels. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6497882 |
| Peyronel D et al. | Fatty acid and squalene compositions of Mediterranean Centrophorus SPP egg and liver oils in relation to age. | 1984 | Lipids | pmid:6503627 |
| Linares A et al. | Squalene, lanosterol and cholesterol synthesis from acetate in neonatal chick tissues. | 1984 | Rev. Esp. Fisiol. | pmid:6531508 |
| Kajiyama G et al. | Serum squalene in patients with gallstones. | 1983 | Hiroshima J. Med. Sci. | pmid:6618897 |
| Strandberg TE | Sterol synthesis from biliary squalene in the jejunal mucosa of the rat in vivo. | 1983 | Lipids | pmid:6621260 |
| Bell FP and Hubert EV | Evidence that chlorpromazine inhibits sterologenesis at post-HMGCoA reductase sites in rat liver, in vitro. | 1983 | Lipids | pmid:6633175 |
| Rahier A et al. | Inhibition of 2,3-oxidosqualene: beta-amyrin-cyclase, S-adenosyl-L-methionine: cycloartenol C-24-methyltransferase and cycloeucalenol: obtusifoliol isomerase by rationally designed molecules containing a tertiary amine function. | 1983 | Biochem. Soc. Trans. | pmid:6642064 |
| Aguilera JA et al. | Incorporation of mevalonate into squalene, lanosterol and cholesterol by different neonatal chick tissues. | 1983 | Int. J. Biochem. | pmid:6653866 |
| Zaaijer D and van der Horst CJ | Cyclic changes in hormones, carbohydrates and indole metabolism in cervical mucus of normal, fertilizing cows and the relationship with non-fertility. | 1983 | Cytobios | pmid:6684538 |
| Dykes PJ et al. | Analysis of the non-ionic detergent-soluble lipids of human stratum corneum. | 1984 | Br. J. Dermatol. | pmid:6696844 |
| Yachnin S and Mannickarottu V | Increased 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol biosynthesis in freshly isolated hairy cell leukemia cells. | 1984 | Blood | pmid:6696995 |