| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pain | D010146 | 64 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
| Metabolism, Inborn Errors | D008661 | 46 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
(e,e,e,e)-squalene
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
Cross Reference
Introduction
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (e,e,e,e)-squalene?
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
PubChem Associated disorders and diseases
What pathways are associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (e,e,e,e)-squalene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with (e,e,e,e)-squalene?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with (e,e,e,e)-squalene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Vanhanen HT and Miettinen TA | Cholesterol absorption and synthesis during pravastatin, gemfibrozil and their combination. | 1995 | Atherosclerosis | pmid:7661873 |
| Gylling H et al. | Postprandial vitamin A and squalene clearances and cholesterol synthesis off and on lovastatin treatment in type III hyperlipoproteinemia. | 1995 | Atherosclerosis | pmid:7669084 |
| Kerwin JL et al. | Isoprenoid-mediated changes in the glycerophospholipid molecular species of the sterol auxotrophic fungus Lagenidium giganteum. | 1995 | Microbiology (Reading, Engl.) | pmid:7704271 |
| Fliesler SJ et al. | Isoprenoid lipid metabolism in the retina: dynamics of squalene and cholesterol incorporation and turnover in frog rod outer segment membranes. | 1995 | Exp. Eye Res. | pmid:7720806 |
| Houston L et al. | Response of guinea pigs to a vaccine containing a new adjuvant (SAF) and gram-negative bacteria. | 1995 | Lab. Anim. Sci. | pmid:7752616 |
| Langenberg AG et al. | A recombinant glycoprotein vaccine for herpes simplex virus type 2: safety and immunogenicity [corrected]. | 1995 | Ann. Intern. Med. | pmid:7755223 |
| Yamamoto A et al. | Impaired water barrier function in acne vulgaris. | 1995 | Arch. Dermatol. Res. | pmid:7763094 |
| Kamimura N et al. | Construction of squalene-accumulating Saccharomyces cerevisiae mutants by gene disruption through homologous recombination. | 1994 | Appl. Microbiol. Biotechnol. | pmid:7765777 |
| Lees ND et al. | Cloning of the late genes in the ergosterol biosynthetic pathway of Saccharomyces cerevisiae--a review. | 1995 | Lipids | pmid:7791529 |
| Abe I and Prestwich GD | Identification of the active site of vertebrate oxidosqualene cyclase. | 1995 | Lipids | pmid:7791531 |
| Cattel L et al. | 2,3-Oxidosqualene cyclase: from azasqualenes to new site-directed inhibitors. | 1995 | Lipids | pmid:7791532 |
| Balliano G et al. | Inhibition of sterol biosynthesis in Saccharomyces cerevisiae and Candida albicans by 22,23-epoxy-2-aza-2,3-dihydrosqualene and the corresponding N-oxide. | 1994 | Antimicrob. Agents Chemother. | pmid:7810997 |
| Rabiskova M et al. | The influence of surface properties on uptake of oil into complex coacervate microcapsules. | 1994 | J. Pharm. Pharmacol. | pmid:7815274 |
| Someya K et al. | The antioxidant effect of palm fruit carotene on skin lipid peroxidation in guinea pigs as estimated by chemiluminescence-HPLC method. | 1994 | J. Nutr. Sci. Vitaminol. | pmid:7844638 |
| Fujita H and Matsuo I | In vitro phototoxic activities of new quinolone antibacterial agents: lipid peroxidative potentials. | 1994 | Photodermatol Photoimmunol Photomed | pmid:7880759 |
| Boutaud O et al. | Retention of the label during the conversion of [3-3H] squalene into (3S)-2,3-oxidosqualene catalyzed by mammalian squalene oxidase. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7887959 |
| Coates RM | Biogenetic-type rearrangements of terpenes. | 1976 | Fortschr Chem Org Naturst | pmid:791779 |
| Valensi JP et al. | Systemic cytokine profiles in BALB/c mice immunized with trivalent influenza vaccine containing MF59 oil emulsion and other advanced adjuvants. | 1994 | J. Immunol. | pmid:7930610 |
| Kahn JO et al. | Clinical and immunologic responses to human immunodeficiency virus (HIV) type 1SF2 gp120 subunit vaccine combined with MF59 adjuvant with or without muramyl tripeptide dipalmitoyl phosphatidylethanolamine in non-HIV-infected human volunteers. | 1994 | J. Infect. Dis. | pmid:7963729 |
| Hoffman SL et al. | Safety, immunogenicity, and efficacy of a malaria sporozoite vaccine administered with monophosphoryl lipid A, cell wall skeleton of mycobacteria, and squalane as adjuvant. | 1994 | Am. J. Trop. Med. Hyg. | pmid:7985753 |
| Wieland B et al. | Genetic and biochemical analyses of the biosynthesis of the yellow carotenoid 4,4'-diaponeurosporene of Staphylococcus aureus. | 1994 | J. Bacteriol. | pmid:8002598 |
| Ortiz de Montellano PR and Boparai AS | The squalene synthetase active site. Catalytic acceptance of 7- and 11- demethylfarnesyl pyrophosphates. | 1976 | Biochem. Biophys. Res. Commun. | pmid:800341 |
| Pogliani L et al. | An NMR and molecular mechanics study of squalene and squalene derivatives. | 1994 | Chem. Phys. Lipids | pmid:8013054 |
| Giron MD et al. | Mevalonate-mediated suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase function in alpha-toxin-perforated cells. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8022795 |
| Dollis D and Schuber F | Effects of a 2,3-oxidosqualene-lanosterol cyclase inhibitor 2,3:22,23-dioxidosqualene and 24,25-epoxycholesterol on the regulation of cholesterol biosynthesis in human hepatoma cell line HepG2. | 1994 | Biochem. Pharmacol. | pmid:8043030 |
| Gylling H and Miettinen TA | Postabsorptive metabolism of dietary squalene. | 1994 | Atherosclerosis | pmid:8060377 |
| Tulliez J et al. | [The effect of prolonged injestion of paraffin oil in pigs: selective retention and interference with cholesterol metabolism]. | 1975 | C.R. Hebd. Seances Acad. Sci., Ser. D, Sci. Nat. | pmid:807414 |
| Domnas A et al. | Squalene metabolism in two species of Lagenidium. | 1994 | Can. J. Microbiol. | pmid:8076247 |
| Sunthornandh P and Ratanabanangkoon K | A comparative study of three vehicles on antibody responses against elapid snake neurotoxin immunogens. | 1994 | Toxicon | pmid:8079368 |
| Hilgers LA et al. | A novel non-mineral oil-based adjuvant. I. Efficacy of a synthetic sulfolipopolysaccharide in a squalane-in-water emulsion in laboratory animals. | 1994 | Vaccine | pmid:8085385 |
| Hilgers LA et al. | A novel non-mineral oil-based adjuvant. II. Efficacy of a synthetic sulfolipopolysaccharide in a squalane-in-water emulsion in pigs. | 1994 | Vaccine | pmid:8085386 |
| Abe I | [Bioorganic chemistry of squalene cyclase]. | 1994 | Tanpakushitsu Kakusan Koso | pmid:8090933 |
| Ren Z and Gould MN | Inhibition of ubiquinone and cholesterol synthesis by the monoterpene perillyl alcohol. | 1994 | Cancer Lett. | pmid:8149348 |
| Mookhtiar KA et al. | Yeast squalene synthase. A mechanism for addition of substrates and activation by NADPH. | 1994 | J. Biol. Chem. | pmid:8157649 |
| Byars NE et al. | Vaccinating guinea pigs with recombinant glycoprotein D of herpes simplex virus in an efficacious adjuvant formulation elicits protection against vaginal infection. | 1994 | Vaccine | pmid:8165851 |
| Inoue H et al. | Phosphorylation of farnesol by a cell-free system from Botryococcus braunii. | 1994 | Biochem. Biophys. Res. Commun. | pmid:8179579 |
| Ohkawa S et al. | Immune responses induced by prototype vaccines for AIDS in rhesus monkeys. | 1994 | AIDS Res. Hum. Retroviruses | pmid:8179961 |
| Corsini A et al. | Relationship between mevalonate pathway and arterial myocyte proliferation: in vitro studies with inhibitors of HMG-CoA reductase. | 1993 | Atherosclerosis | pmid:8216498 |
| Beck FW and Whitehouse MW | Modifications in the establishment of allergic encephalomyelitis (EAE) in rats; an imporved assay for immunosuppressant drugs. | 1976 | Agents Actions | pmid:822699 |
| Ciosek CP et al. | Lipophilic 1,1-bisphosphonates are potent squalene synthase inhibitors and orally active cholesterol lowering agents in vivo. | 1993 | J. Biol. Chem. | pmid:8227045 |
| Vanhanen HT et al. | Serum cholesterol, cholesterol precursors, and plant sterols in hypercholesterolemic subjects with different apoE phenotypes during dietary sitostanol ester treatment. | 1993 | J. Lipid Res. | pmid:8228636 |
| Balliano G et al. | 3-Carboxy-4-nitrophenyl-dithio-1,1',2-trisnorsqualene: a site-directed inactivator of yeast oxidosqualene cyclase. | 1993 | Lipids | pmid:8246689 |
| Ernst J et al. | The crystal structure of squalene. | 1976 | Angew. Chem. Int. Ed. Engl. | pmid:827944 |
| Florin-Christensen M et al. | Occurrence of specific sterols in Pneumocystis carinii. | 1994 | Biochem. Biophys. Res. Commun. | pmid:8292026 |
| Phleger CF et al. | Membrane biosynthesis in swimbladders of deep sea fishes Coryphaenoides acrolepis and Antimora rostrata. | 1977 | Comp. Biochem. Physiol., B | pmid:830467 |
| Mercer EI | Inhibitors of sterol biosynthesis and their applications. | 1993 | Prog. Lipid Res. | pmid:8309949 |
| Miettinen TA and Vanhanen H | Serum concentration and metabolism of cholesterol during rapeseed oil and squalene feeding. | 1994 | Am. J. Clin. Nutr. | pmid:8310985 |
| Storm HM et al. | Radioprotection of mice by dietary squalene. | 1993 | Lipids | pmid:8355581 |
| Lohner K et al. | Squalene promotes the formation of non-bilayer structures in phospholipid model membranes. | 1993 | Biochim. Biophys. Acta | pmid:8399307 |
| Kawakami T et al. | Squalane as a possible carrier of bone morphogenetic protein. | 1993 | Biomaterials | pmid:8399948 |