(e,e,e,e)-squalene

(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.

Cross Reference

Introduction

To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (e,e,e,e)-squalene?

(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene

MeSH term MeSH ID Detail
Pain D010146 64 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Parkinson Disease D010300 53 associated lipids
Precancerous Conditions D011230 48 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Psoriasis D011565 47 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Leukemia P388 D007941 43 associated lipids
Per page 10 20 50 100 | Total 84

PubChem Associated disorders and diseases

What pathways are associated with (e,e,e,e)-squalene

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with (e,e,e,e)-squalene?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (e,e,e,e)-squalene?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with (e,e,e,e)-squalene

Download all related citations
Per page 10 20 50 100 | Total 1766
Authors Title Published Journal PubMed Link
Rastrelli L et al. Rate of degradation of alpha-tocopherol, squalene, phenolics, and polyunsaturated fatty acids in olive oil during different storage conditions. 2002 J. Agric. Food Chem. pmid:12236680
Gylling H and Miettinen TA Inheritance of cholesterol metabolism of probands with high or low cholesterol absorption. 2002 J. Lipid Res. pmid:12235179
Wentzinger LF et al. Inhibition of squalene synthase and squalene epoxidase in tobacco cells triggers an up-regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase. 2002 Plant Physiol. pmid:12226513
Yoo YC et al. Inhibitory effect of BCG cell-wall skeletons (BCG-CWS) emulsified in squalane on tumor growth and metastasis in mice. 2002 Arch. Pharm. Res. pmid:12214866
Skeiky YA et al. Protective efficacy of a tandemly linked, multi-subunit recombinant leishmanial vaccine (Leish-111f) formulated in MPL adjuvant. 2002 Vaccine pmid:12213399
Rontani JF et al. Aerobic and anaerobic metabolism of squalene by a denitrifying bacterium isolated from marine sediment. 2002 Arch. Microbiol. pmid:12209261
Hess BA Concomitant C-ring Expansion and D-ring formation in lanosterol biosynthesis from squalene without violation of Markovnikov's rule. 2002 J. Am. Chem. Soc. pmid:12197724
Connolly JD and Hill RA Triterpenoids. 2002 Nat Prod Rep pmid:12195814
Matyas GR et al. Induction and detection of antibodies to squalene. II. Optimization of the assay for murine antibodies. 2002 J. Immunol. Methods pmid:12165433
Blagg BS et al. Recombinant squalene synthase. A mechanism for the rearrangement of presqualene diphosphate to squalene. 2002 J. Am. Chem. Soc. pmid:12137537
Jarstfer MB et al. Recombinant squalene synthase. Synthesis of non-head-to-tail isoprenoids in the absence of NADPH. 2002 J. Am. Chem. Soc. pmid:12137536
Pérez-Camino MC et al. Determination of esters of fatty acids with low molecular weight alcohols in olive oils. 2002 J. Agric. Food Chem. pmid:12137504
Asano KG et al. Chemical composition of fingerprints for gender determination. 2002 J. Forensic Sci. pmid:12136987
Asa PB et al. Antibodies to squalene in recipients of anthrax vaccine. 2002 Exp. Mol. Pathol. pmid:12127050
Hoshino T and Ohashi S Importance of the methyl group at C10 of squalene for hopene biosynthesis and novel carbocyclic skeletons with 6/5 + 5/5 + (6) ring system(s). 2002 Org. Lett. pmid:12123374
Morimoto Y et al. Asymmetric total synthesis of highly symmetric squalene-derived cytotoxic polyethers. 2002 Chirality pmid:12112332
Passi S et al. Lipophilic antioxidants in human sebum and aging. 2002 Free Radic. Res. pmid:12069113
Gauci C et al. Molecular cloning of a vaccine antigen against infection with the larval stage of Echinococcus multilocularis. 2002 Infect. Immun. pmid:12065546
Spanggord RJ et al. Development and application of an analytical method for the determination of squalene in formulations of anthrax vaccine adsorbed. 2002 J Pharm Biomed Anal pmid:12062677
Visioli F and Galli C Biological properties of olive oil phytochemicals. 2002 Crit Rev Food Sci Nutr pmid:12058980
Nestel PJ and Kudchodkar B Plasma squalene as an index of cholesterol synthesis. 1975 Clin Sci Mol Med pmid:1204294
Uchino T et al. Effect of squalene monohydroperoxide on cytotoxicity and cytokine release in a three-dimensional human skin model and human epidermal keratinocytes. 2002 Biol. Pharm. Bull. pmid:12033500
Sanina OL and Datsenko ZM [Sterol composition of sarcolemma in normal rabbits and in experimental muscular dystrophy]. 1975 Nov-Dec Ukr Biokhim Zh pmid:1202710
Lewis RW The squalene content of atheromatous plaques. A re-examination. 1975 Nov-Dec Atherosclerosis pmid:1201156
Andersson HC Disorders of post-squalene cholesterol biosynthesis leading to human dysmorphogenesis. 2002 Cell. Mol. Biol. (Noisy-le-grand) pmid:11990452
Holm BC et al. The arthritogenic adjuvant squalene does not accumulate in joints, but gives rise to pathogenic cells in both draining and non-draining lymph nodes. 2002 Clin. Exp. Immunol. pmid:11966758
Metzger P et al. Botryolins A and B, two tetramethylsqualene triethers from the green microalga Botryococcus braunii. 2002 Phytochemistry pmid:11937163
Soják L et al. Gas chromatographic-mass spectrometric characterization of all acyclic C5-C7 alkenes from fluid catalytic cracked gasoline using polydimethylsiloxane and squalane stationary phases. 2002 J Chromatogr A pmid:11873990
Dutton A et al. A novel function of the triterpene squalene in a tritrophic system. 2002 J. Chem. Ecol. pmid:11868668
Armstrong KM and Cukierman S On the origin of closing flickers in gramicidin channels: a new hypothesis. 2002 Biophys. J. pmid:11867449
Bernstein DI et al. Effect of previous or simultaneous immunization with canarypox expressing cytomegalovirus (CMV) glycoprotein B (gB) on response to subunit gB vaccine plus MF59 in healthy CMV-seronegative adults. 2002 J. Infect. Dis. pmid:11865427
Ott G et al. A cationic sub-micron emulsion (MF59/DOTAP) is an effective delivery system for DNA vaccines. 2002 J Control Release pmid:11853914
Mitchell DK et al. Immunogenicity of a recombinant human cytomegalovirus gB vaccine in seronegative toddlers. 2002 Pediatr. Infect. Dis. J. pmid:11840080
Deng X et al. Immunological response of female macaques to the PH-20 sperm protein following injection of recombinant proteins or synthesized peptides. 2002 J. Reprod. Immunol. pmid:11839398
Teshima SI and Kanazawa A Biosynthesis of sterols in a starfish, Laiaster leachii. 1975 Comp. Biochem. Physiol., B pmid:1183195
Beveridge TH et al. Phytosterol content in American ginseng seed oil. 2002 J. Agric. Food Chem. pmid:11829639
Psomiadou E and Tsimidou M Stability of virgin olive oil. 2. Photo-oxidation studies. 2002 J. Agric. Food Chem. pmid:11829635
Psomiadou E and Tsimidou M Stability of virgin olive oil. 1. Autoxidation studies. 2002 J. Agric. Food Chem. pmid:11829634
Saadatzadeh MR et al. Production of the mycelial phase of Malassezia in vitro. 2001 Med. Mycol. pmid:11798054
Corcelli A et al. Lipid-protein stoichiometries in a crystalline biological membrane: NMR quantitative analysis of the lipid extract of the purple membrane. 2002 J. Lipid Res. pmid:11792732
Haralampidis K et al. Biosynthesis of triterpenoid saponins in plants. 2002 Adv. Biochem. Eng. Biotechnol. pmid:11783842
He HP et al. Extraction and purification of squalene from amaranthus grain. 2002 J. Agric. Food Chem. pmid:11782209
Simonen P et al. Acute effects of weight reduction on cholesterol metabolism in obese type 2 diabetes. 2002 Clin. Chim. Acta pmid:11750274
Sawada M et al. Effect of FR194738, a potent inhibitor of squalene epoxidase, on cholesterol metabolism in HepG2 cells. 2001 Eur. J. Pharmacol. pmid:11716837
Milla P et al. Yeast oxidosqualene cyclase (Erg7p) is a major component of lipid particles. 2002 J. Biol. Chem. pmid:11706015
Burkhart CN et al. Cerumen composition by flash pyrolysis-gas chromatography/mass spectrometry. 2001 Otol. Neurotol. pmid:11698786
Radwan SS and Mangold HK Lipids in plant tissue cultures. V. Effect of environmental conditions on the lipids of Glycine soja and Brassica napus cultures. 1975 Chem. Phys. Lipids pmid:1168102
McFarland EJ et al. Human immunodeficiency virus type 1 (HIV-1) gp120-specific antibodies in neonates receiving an HIV-1 recombinant gp120 vaccine. 2001 J. Infect. Dis. pmid:11679925
Davis TA et al. Idiotype vaccination following ABMT can stimulate specific anti-idiotype immune responses in patients with B-cell lymphoma. 2001 Biol. Blood Marrow Transplant. pmid:11669219
Gasparini R et al. Increased immunogenicity of the MF59-adjuvanted influenza vaccine compared to a conventional subunit vaccine in elderly subjects. 2001 Eur. J. Epidemiol. pmid:11599686