(e,e,e,e)-squalene

(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.

Cross Reference

Introduction

To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (e,e,e,e)-squalene?

(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene

MeSH term MeSH ID Detail
Pain D010146 64 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Parkinson Disease D010300 53 associated lipids
Precancerous Conditions D011230 48 associated lipids
Psoriasis D011565 47 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Leukemia P388 D007941 43 associated lipids
Per page 10 20 50 100 | Total 84

PubChem Associated disorders and diseases

What pathways are associated with (e,e,e,e)-squalene

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with (e,e,e,e)-squalene?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (e,e,e,e)-squalene?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with (e,e,e,e)-squalene

Download all related citations
Per page 10 20 50 100 | Total 1766
Authors Title Published Journal PubMed Link
Zambonin CG et al. Laser desorption/ionization time-of-flight mass spectrometry of squalene in oil samples. 2006 Rapid Commun. Mass Spectrom. pmid:16345138
de Roux A et al. Impact of corticosteroids on the immune response to a MF59-adjuvanted influenza vaccine in elderly COPD-patients. 2006 Vaccine pmid:16288937
Singh M et al. A preliminary evaluation of alternative adjuvants to alum using a range of established and new generation vaccine antigens. 2006 Vaccine pmid:16300864
Gonor KV et al. [The influence of diet with including amaranth oil on lipid metabolism in patients with ischemic heart disease and hyperlipoproteidemia]. 2006 Vopr Pitan pmid:16862949
Kulakova SN et al. [Amaranths oil: peculiarities of chemical composition and influence on lipid metabolism by rats]. 2006 Vopr Pitan pmid:16862953
Järvisalo M et al. Cholesterol absorption and synthesis in children with type 1 diabetes. 2006 Diabetes Care pmid:17003310
Del Giudice G et al. Vaccines with the MF59 adjuvant do not stimulate antibody responses against squalene. 2006 Clin. Vaccine Immunol. pmid:16960112
Barrero AF et al. Solid-phase selenium-catalyzed selective allylic chlorination of polyprenoids: facile syntheses of biologically active terpenoids. 2006 J. Org. Chem. pmid:16839173
Global Advisory Committee on Vaccine Safety, 6-7 June 2006. 2006 Wkly. Epidemiol. Rec. pmid:16841398
Vajdy M et al. Hepatitis C virus polyprotein vaccine formulations capable of inducing broad antibody and cellular immune responses. 2006 J. Gen. Virol. pmid:16847121
Nissinen MJ et al. Effects of plant stanol esters supplied in a fat free milieu by pastilles on cholesterol metabolism in colectomized human subjects. 2006 Nutr Metab Cardiovasc Dis pmid:16935701
Kalinova J et al. Distribution of Vitamin E, squalene, epicatechin, and rutin in common buckwheat plants (Fagopyrum esculentum Moench). 2006 J. Agric. Food Chem. pmid:16848513
Piotrowski PC et al. Statins inhibit growth of human endometrial stromal cells independently of cholesterol availability. 2006 Biol. Reprod. pmid:16571871
Del Giudice G et al. An MF59-adjuvanted inactivated influenza vaccine containing A/Panama/1999 (H3N2) induced broader serological protection against heterovariant influenza virus strain A/Fujian/2002 than a subunit and a split influenza vaccine. 2006 Vaccine pmid:16464520
Siirtola A et al. Cholesterol absorption and synthesis in pediatric kidney, liver, and heart transplant recipients. 2006 Transplantation pmid:16477216
Singh DK and Porter TD Inhibition of sterol 4alpha-methyl oxidase is the principal mechanism by which garlic decreases cholesterol synthesis. 2006 J. Nutr. pmid:16484558
Lodeiro S et al. A putative precursor of isomalabaricane triterpenoids from lanosterol synthase mutants. 2006 Org. Lett. pmid:16435854
Matsuda SP et al. Mechanistic insights into triterpene synthesis from quantum mechanical calculations. Detection of systematic errors in B3LYP cyclization energies. 2006 Org. Biomol. Chem. pmid:16446812
Szostak WB and Szostak-Wegierek D [Health properties of shark oil]. 2006 Prz. Lek. pmid:17083160
Morikubo N et al. Cation-pi interaction in the polyolefin cyclization cascade uncovered by incorporating unnatural amino acids into the catalytic sites of squalene cyclase. 2006 J. Am. Chem. Soc. pmid:17017798
Winne JM et al. Application of the B-alkyl suzuki-miyaura cross-coupling reaction to the stereoselective synthesis of analogues of (3S)-oxidosqualene. 2006 Org. Lett. pmid:17020310
Morimoto Y et al. Two-directional synthesis and stereochemical assignment toward a C2 symmetric oxasqualenoid (+)-intricatetraol. 2006 Org. Biomol. Chem. pmid:17036107
Atmar RL et al. Safety and immunogenicity of nonadjuvanted and MF59-adjuvanted influenza A/H9N2 vaccine preparations. 2006 Clin. Infect. Dis. pmid:17029131
Nichol KL and Treanor JJ Vaccines for seasonal and pandemic influenza. 2006 J. Infect. Dis. pmid:17163383
Peltola P et al. Visceral obesity is associated with high levels of serum squalene. 2006 Obesity (Silver Spring) pmid:16899796
Stephenson I et al. Phase I evaluation of intranasal trivalent inactivated influenza vaccine with nontoxigenic Escherichia coli enterotoxin and novel biovector as mucosal adjuvants, using adult volunteers. 2006 J. Virol. pmid:16641287
Suzuki M et al. Lanosterol synthase in dicotyledonous plants. 2006 Plant Cell Physiol. pmid:16531458
Senthilkumar S et al. Attenuation of cyclophosphamide induced toxicity by squalene in experimental rats. 2006 Chem. Biol. Interact. pmid:16554041
Köhler SP et al. Molecular dynamics study to identify the reactive sites of a liquid squalane surface. 2006 J Phys Chem B pmid:16800468
Schneiders MS et al. Manipulation of isoprenoid biosynthesis as a possible therapeutic option in mevalonate kinase deficiency. 2006 Arthritis Rheum. pmid:16802371
Spanggord RJ et al. Enhancement of an analytical method for the determination of squalene in anthrax vaccine adsorbed formulations. 2006 J Pharm Biomed Anal pmid:16762524
Ottaviani M et al. Peroxidated squalene induces the production of inflammatory mediators in HaCaT keratinocytes: a possible role in acne vulgaris. 2006 J. Invest. Dermatol. pmid:16778793
Hallikainen M et al. Postprandial behavior of plasma squalene and non-cholesterol sterols in men with varying cholesterol absorption. 2006 Clin. Chim. Acta pmid:16814761
Zadák Z et al. Polyunsaturated fatty acids, phytosterols and cholesterol metabolism in the Mediterranean diet. 2006 Acta Medica (Hradec Kralove) pmid:16696439
Senthilkumar S et al. Effect of squalene on cyclophosphamide-induced toxicity. 2006 Clin. Chim. Acta pmid:16150433
Farvin KH et al. Cardioprotective effect of squalene on lipid profile in isoprenaline-induced myocardial infarction in rats. 2006 J Med Food pmid:17201641
Gonor KV et al. [The influence of a diet with including amaranth oil on antioxidant and immune status in patients with ischemic heart disease and hyperlipoproteidemia]. 2006 Vopr Pitan pmid:17313043
Gabutti G et al. Safety and immunogenicity of conventional subunit and MF59-adjuvanted influenza vaccines in human immunodeficiency virus-1-seropositive patients. 2005 Jul-Aug J. Int. Med. Res. pmid:16104444
Ekanayake-Mudiyanselage S et al. Vitamin E delivery to human skin by a rinse-off product: penetration of alpha-tocopherol versus wash-out effects of skin surface lipids. 2005 Jan-Feb Skin Pharmacol Physiol pmid:15608499
Cincinelli A et al. Enrichment of organic pollutants in the sea surface microlayer (SML) at Terra Nova Bay, Antarctica: influence of SML on superficial snow composition. 2005 J Environ Monit pmid:16307088
Shan H et al. Enzymatic cyclization of dioxidosqualene to heterocyclic triterpenes. 2005 J. Am. Chem. Soc. pmid:16366544
Zhang Y et al. [Chemical constituents from the mangrove plant Ceriops tagal]. 2005 Yao Xue Xue Bao pmid:16408813
Tanaka H et al. Enzymatic formation of indole-containing unnatural cyclic polyprenoids by bacterial squalene:hopene cyclase. 2005 Org. Lett. pmid:16354088
Wadman M Race is on for flu vaccine. 2005 Nature pmid:16267526
Krüger RH et al. New phenylenediamine antiozonants for commodities based on natural and synthetic rubber. 2005 Food Addit Contam pmid:16227180
Lodeiro S et al. Enzyme redesign: two mutations cooperate to convert cycloartenol synthase into an accurate lanosterol synthase. 2005 J. Am. Chem. Soc. pmid:16218577
Whitehouse MW Prostanoids as friends, not foes: further evidence from the interference by cycloxygenase-inhibitory drugs when inducing tolerance to experimental arthritigens in rats. 2005 Inflammopharmacology pmid:16259716
Iob A et al. Evidence of increased clinical protection of an MF59-adjuvant influenza vaccine compared to a non-adjuvant vaccine among elderly residents of long-term care facilities in Italy. 2005 Epidemiol. Infect. pmid:16050515
Germann M et al. Characterizing sterol defect suppressors uncovers a novel transcriptional signaling pathway regulating zymosterol biosynthesis. 2005 J. Biol. Chem. pmid:16120615
Lau HL et al. Simultaneous quantification of free fatty acids, free sterols, squalene, and acylglycerol molecular species in palm oil by high-temperature gas chromatography--flame ionization detection. 2005 Lipids pmid:16094863
Abe T and Hoshino T Enzymatic cyclizations of squalene analogs with threo- and erythro-diols at the 6,7- or 10,11-positions by recombinant squalene cyclase. Trapping of carbocation intermediates and mechanistic insights into the product and substrate specificities. 2005 Org. Biomol. Chem. pmid:16106294
Choo YM et al. Application of supercritical fluid chromatography in the quantitative analysis of minor components (carotenes, vitamin E, sterols, and squalene) from palm oil. 2005 Lipids pmid:16028723
Hung CF et al. Physicochemical characterization and gene transfection efficiency of lipid emulsions with various co-emulsifiers. 2005 Int J Pharm pmid:15652212
Henryk T et al. [The effect of alcoxyglycerols, squalene and n-3 fatty acid on some innate immunity parameters in healthy people]. 2005 Pol. Merkur. Lekarski pmid:15997638
Blagović B et al. Lipid analysis of the plasma membrane and mitochondria of brewer's yeast. 2005 Folia Microbiol. (Praha) pmid:15954530
Giner JL et al. Detection of 1,2-hydride shifts in the formation of euph-7-ene by the squalene-tetrahymanol cyclase of Tetrahymena pyriformis. 2005 Chem. Commun. (Camb.) pmid:15959594
Kim TW et al. Airway gene transfer using cationic emulsion as a mucosal gene carrier. 2005 J Gene Med pmid:15929068
Lavoie JM and Stevanovic T Variation of chemical composition of the lipophilic extracts from yellow birch (Betula alleghaniensis) foliage. 2005 J. Agric. Food Chem. pmid:15941310
Xiong Q et al. Structure and reactivity of the dammarenyl cation: configurational transmission in triterpene synthesis. 2005 J. Org. Chem. pmid:15989315
Oliaro-Bosso S et al. Analogs of squalene and oxidosqualene inhibit oxidosqualene cyclase of Trypanosoma cruzi expressed in Saccharomyces cerevisiae. 2005 Lipids pmid:16477810
Archer NE et al. Changes in the lipid composition of latent fingerprint residue with time after deposition on a surface. 2005 Forensic Sci. Int. pmid:16182971
Lee KH et al. Squalene aspiration pneumonia in children: radiographic and CT findings as the first clue to diagnosis. 2005 Pediatr Radiol pmid:15806404
Aguilera Y et al. The protective role of squalene in alcohol damage in the chick embryo retina. 2005 Exp. Eye Res. pmid:15781281
Sun S et al. The combination effects of phenolic compounds and fluconazole on the formation of ergosterol in Candida albicans determined by high-performance liquid chromatography/tandem mass spectrometry. 2005 Anal. Biochem. pmid:15582556
Lee HK et al. Photoaffinity labeling identifies the substrate-binding site of mammalian squalene epoxidase. 2004 Biochem. Biophys. Res. Commun. pmid:15013417
Williams DK et al. Analysis of latent fingerprint deposits by infrared microspectroscopy. 2004 Appl Spectrosc pmid:15035712
Kalogeropoulos N and Andrikopoulos NK Squalene in oils and fats from domestic and commercial fryings of potatoes. 2004 Int J Food Sci Nutr pmid:14985184
Tanaka H et al. 1-methylidenesqualene and 25-methylidenesqualene as active-site probes for bacterial squalene:hopene cyclase. 2004 Org. Lett. pmid:14986979
Abe I et al. Enzymatic cyclization of 22,23-dihydro-2,3-oxidosqualene into euph-7-en-3beta-ol and bacchar-12-en-3beta-ol by recombinant beta-amyrin synthase. 2004 J. Am. Chem. Soc. pmid:15025461
Schulz JG et al. HMG-CoA reductase inhibition causes neurite loss by interfering with geranylgeranylpyrophosphate synthesis. 2004 J. Neurochem. pmid:15030386
Uchino T et al. Potent protecting effects of Catuaba (Anemopaegma mirandum) extracts against hydroperoxide-induced cytotoxicity. 2004 Toxicol In Vitro pmid:15046771
Cravotto G et al. Umbelliferone aminoalkyl derivatives, a new class of squalene-hopene cyclase inhibitors. 2004 Eur J Med Chem pmid:15501540
Thoma R et al. Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase. 2004 Nature pmid:15525992
Suzuki M et al. Loss of function of 3-hydroxy-3-methylglutaryl coenzyme A reductase 1 (HMG1) in Arabidopsis leads to dwarfing, early senescence and male sterility, and reduced sterol levels. 2004 Plant J. pmid:14871314
O'Hagan DT et al. Cationic microparticles are a potent delivery system for a HCV DNA vaccine. 2004 Vaccine pmid:15542189
Stephenson I et al. Detection of anti-H5 responses in human sera by HI using horse erythrocytes following MF59-adjuvanted influenza A/Duck/Singapore/97 vaccine. 2004 Virus Res. pmid:15163495
Hu JJ et al. [Antibody production and its neutralization of Abeta42's cytoxicity in BALB/c mice induced by Abeta42 and its subunit vaccines]. 2004 Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi pmid:15191720
Hronská L et al. Low concentrations of the non-ionic detergent Nonidet P-40 interfere with sterol biogenesis and viability of the yeast Saccharomyces cerevisiae. 2004 FEMS Microbiol. Lett. pmid:15336428
Ruf BR et al. Open, randomized study to compare the immunogenicity and reactogenicity of an influenza split vaccine with an MF59-adjuvanted subunit vaccine and a virosome-based subunit vaccine in elderly. 2004 Infection pmid:15293073
Süli J et al. Experimental squalene adjuvant. I. Preparation and testing of its effectiveness. 2004 Vaccine pmid:15308373
Benísek Z et al. Experimental squalene adjuvant. II. Harmlessness and local reactogenity. 2004 Vaccine pmid:15308374
Nakano S et al. Squalene-hopene cyclase: insight into the role of the methyl group on the squalene backbone upon the polycyclization cascade. Enzymatic cyclization products of squalene analogs lacking a 26-methyl group and possessing a methyl group at C7 or C11. 2004 Org. Biomol. Chem. pmid:15254628
Pragst F et al. Wipe-test and patch-test for alcohol misuse based on the concentration ratio of fatty acid ethyl esters and squalene CFAEE/CSQ in skin surface lipids. 2004 Forensic Sci. Int. pmid:15240027
Sabeena Farvin KH et al. Effect of squalene on tissue defense system in isoproterenol-induced myocardial infarction in rats. 2004 Pharmacol. Res. pmid:15225664
Kuroda Y et al. Autoimmunity induced by adjuvant hydrocarbon oil components of vaccine. 2004 Biomed. Pharmacother. pmid:15194169
Holm BC et al. Adjuvant oil induces waves of arthritogenic lymph node cells prior to arthritis onset. 2004 Clin. Exp. Immunol. pmid:15196244
Fukasawa LO et al. Adjuvant can improve protection induced by OMV vaccine against Neisseria meningitidis serogroups B/C in neonatal mice. 2004 FEMS Immunol. Med. Microbiol. pmid:15196569
Shin DH et al. Amaranth squalene reduces serum and liver lipid levels in rats fed a cholesterol diet. 2004 Br. J. Biomed. Sci. pmid:15058737
Ketomäki A et al. Removal of intravenous Intralipid in patients with familial hypercholesterolemia during inhibition of cholesterol absorption and synthesis. 2004 Clin. Chim. Acta pmid:15149875
Fazio GC et al. Genome mining to identify new plant triterpenoids. 2004 J. Am. Chem. Soc. pmid:15125655
Hoshino T et al. Squalene-hopene cyclase: final deprotonation reaction, conformational analysis for the cyclization of (3R,S)-2,3-oxidosqualene and further evidence for the requirement of an isopropylidene moiety both for initiation of the polycyclization cascade and for the formation of the 5-membered E-ring. 2004 Org. Biomol. Chem. pmid:15136801
Matyas GR et al. Detection of antibodies to squalene: III. Naturally occurring antibodies to squalene in humans and mice. 2004 J. Immunol. Methods pmid:15087221
Poralla K Profound insights into squalene cyclization. 2004 Chem. Biol. pmid:15112988
Reinert DJ et al. Conversion of squalene to the pentacarbocyclic hopene. 2004 Chem. Biol. pmid:15113001
Okada S et al. Characterization of botryococcene synthase enzyme activity, a squalene synthase-like activity from the green microalga Botryococcus braunii, Race B. 2004 Arch. Biochem. Biophys. pmid:14725863
Xu R et al. On the origins of triterpenoid skeletal diversity. 2004 Phytochemistry pmid:14751299
Kawaki H The interaction of monosubstituted benzenes with the stationary liquid in gas liquid chromatography. 2004 Chem. Pharm. Bull. pmid:14758007
Miettinen TA et al. Low synthesis and high absorption of cholesterol characterize type 1 diabetes. 2004 Diabetes Care pmid:14693966
Kuroda Y et al. Distinctive patterns of autoimmune response induced by different types of mineral oil. 2004 Toxicol. Sci. pmid:14718649
Auwärter V et al. Squalene in hair--a natural reference substance for the improved interpretation of fatty acid ethyl ester concentrations with respect to alcohol misuse. 2004 Forensic Sci. Int. pmid:15451087