Chiba K et al. |
Skin roughness and wrinkle formation induced by repeated application of squalene-monohydroperoxide to the hairless mouse. |
1999 |
Exp. Dermatol. |
pmid:10597136
|
Kawada A et al. |
In vitro phototoxicity of new quinolones: production of active oxygen species and photosensitized lipid peroxidation. |
1999 |
Photodermatol Photoimmunol Photomed |
pmid:10599972
|
Hoshino T et al. |
New cyclization mechanism for squalene: a ring-expansion step for the five-membered C-ring intermediate in hopene biosynthesis. |
1999 |
Biosci. Biotechnol. Biochem. |
pmid:10635573
|
Gajkowska B et al. |
The experimental squalene encephaloneuropathy in the rat. |
1999 |
Exp. Toxicol. Pathol. |
pmid:10048717
|
Dupuis M et al. |
Distribution of adjuvant MF59 and antigen gD2 after intramuscular injection in mice. |
1999 |
Vaccine |
pmid:10519932
|
Milla P et al. |
19-Azasqualene-2,3-epoxide and its N-oxide: metabolic fate and inhibitory effect on sterol biosynthesis in Saccharomyces cerevisiae. |
1999 |
Lipids |
pmid:10478925
|
Zhang L et al. |
The preventive effects of incomplete Freund's adjuvant and other vehicles on the development of adjuvant-induced arthritis in Lewis rats. |
1999 |
Immunology |
pmid:10540226
|
Ceruti M et al. |
29-Methylidene-2,3-oxidosqualene derivatives as stereospecific mechanism-based inhibitors of liver and yeast oxidosqualene cyclase. |
1998 |
J. Med. Chem. |
pmid:9484504
|
O'Hagan DT |
Recent advances in vaccine adjuvants for systemic and mucosal administration. |
1998 |
J. Pharm. Pharmacol. |
pmid:9504429
|
Sato T et al. |
Overexpression of squalene-hopene cyclase by the pET vector in Escherichia coli and first identification of tryptophan and aspartic acid residues inside the QW motif as active sites. |
1998 |
Biosci. Biotechnol. Biochem. |
pmid:9532806
|
Rao CV et al. |
Chemopreventive effect of squalene on colon cancer. |
1998 |
Carcinogenesis |
pmid:9498278
|
Zheng YF et al. |
Inhibition kinetics and affinity labeling of bacterial squalene:hopene cyclase by thia-substituted analogues of 2, 3-oxidosqualene. |
1998 |
Biochemistry |
pmid:9558334
|
Lopez D et al. |
Compensatory responses to inhibition of hepatic squalene synthase. |
1998 |
Arch. Biochem. Biophys. |
pmid:9514656
|
Basáñez G et al. |
Effect of single chain lipids on phospholipase C-promoted vesicle fusion. A test for the stalk hypothesis of membrane fusion. |
1998 |
Biochemistry |
pmid:9521711
|
Bibikova MV and Bondareva NS |
[Drugs of microbial origin for treatment of atherosclerosis]. |
1998 |
Antibiot. Khimioter. |
pmid:9777104
|
Kushiro T et al. |
Beta-amyrin synthase--cloning of oxidosqualene cyclase that catalyzes the formation of the most popular triterpene among higher plants. |
1998 |
Eur. J. Biochem. |
pmid:9746369
|
Michikawa M and Yanagisawa K |
Apolipoprotein E4 induces neuronal cell death under conditions of suppressed de novo cholesterol synthesis. |
1998 |
J. Neurosci. Res. |
pmid:9778150
|
Saenz MT et al. |
Cytostatic activity of some compounds from the unsaponifiable fraction obtained from virgin olive oil. |
1998 |
Farmaco |
pmid:9786644
|
Schedin S et al. |
Alterations in the biosynthesis of cholesterol, dolichol and dolichyl-P in the genetic cholesterol homeostasis disorder, Niemann-Pick type C disease. |
1998 |
Biochim. Biophys. Acta |
pmid:9795206
|
Smith TJ et al. |
Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis by dietary olive oil and squalene. |
1998 |
Carcinogenesis |
pmid:9600360
|
Singh M et al. |
A comparison of biodegradable microparticles and MF59 as systemic adjuvants for recombinant gD from HSV-2. |
1998 |
Vaccine |
pmid:9795387
|
Sajbidor J et al. |
Influence of new fenpropimorph fungicides on the growth and sterol composition in Saccharomyces cerevisiae: relationship between structure and activity. |
1998 |
J. Pharm. Pharmacol. |
pmid:9600722
|
Joshi MK et al. |
Importance of specific native lipids in controlling the photocycle of bacteriorhodopsin. |
1998 |
Biochemistry |
pmid:9772173
|
Nesburn AB et al. |
Local periocular vaccination protects against eye disease more effectively than systemic vaccination following primary ocular herpes simplex virus infection in rabbits. |
1998 |
J. Virol. |
pmid:9733807
|
Cattel L and Ceruti M |
Inhibitors of 2,3-oxidosqualene cyclase as tools for studying the mechanism and function of the enzyme. |
1998 |
Crit. Rev. Biochem. Mol. Biol. |
pmid:9827705
|
Weldon MK et al. |
Surface enhanced Raman spectroscopic monitor of P. acnes lipid hydrolysis in vitro. |
1998 |
J. Lipid Res. |
pmid:9741703
|
Fernández JJ et al. |
Evaluation of the cytotoxic activity of polyethers isolated from Laurencia. |
1998 |
Bioorg. Med. Chem. |
pmid:9925286
|
Nakano M et al. |
Useful 1O2 (1delta g) generator, 3-(4'-methyl-1'-naphthyl)-propionic acid, 1',4'-endoperoxide (NEPO), for dioxygenation of squalence (a skin surface lipid) in an organic solvent and bacterial killing in aqueous medium. |
1998 |
FEBS Lett. |
pmid:9710240
|
Perzl M et al. |
Cloning of conserved genes from Zymomonas mobilis and Bradyrhizobium japonicum that function in the biosynthesis of hopanoid lipids. |
1998 |
Biochim. Biophys. Acta |
pmid:9714766
|
Hagiwara T et al. |
Determination of lycopene, alpha-carotene and beta-carotene in serum by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry with selected-ion monitoring. |
1998 |
J. Chromatogr. B Biomed. Sci. Appl. |
pmid:9653948
|
Dupuis M et al. |
Dendritic cells internalize vaccine adjuvant after intramuscular injection. |
1998 |
Cell. Immunol. |
pmid:9637761
|
Mansfield PD et al. |
The effects of four, commercial ceruminolytic agents on the middle ear. |
1997 Nov-Dec |
J Am Anim Hosp Assoc |
pmid:9358414
|
Law S et al. |
Skin surface lipids inhibit adherence of Candida albicans to stratum corneum. |
1997 |
Dermatology (Basel) |
pmid:9407165
|
Grieveson LA et al. |
A simplified squalene epoxidase assay based on an HPLC separation and time-dependent UV/visible determination of squalene. |
1997 |
Anal. Biochem. |
pmid:9324936
|
Kribii R et al. |
Cloning and characterization of the Arabidopsis thaliana SQS1 gene encoding squalene synthase--involvement of the C-terminal region of the enzyme in the channeling of squalene through the sterol pathway. |
1997 |
Eur. J. Biochem. |
pmid:9363754
|
Cataldo DM and Van Nest G |
The adjuvant MF59 increases the immunogenicity and protective efficacy of subunit influenza vaccine in mice. |
1997 |
Vaccine |
pmid:9364672
|
Tomasi M et al. |
Strong mucosal adjuvanticity of cholera toxin within lipid particles of a new multiple emulsion delivery system for oral immunization. |
1997 |
Eur. J. Immunol. |
pmid:9368632
|
Salamon Z et al. |
Coupled plasmon-waveguide resonators: a new spectroscopic tool for probing proteolipid film structure and properties. |
1997 |
Biophys. J. |
pmid:9370473
|
Toews AD et al. |
Tellurium causes dose-dependent coordinate down-regulation of myelin gene expression. |
1997 |
Brain Res. Mol. Brain Res. |
pmid:9387870
|
Fliesler SJ et al. |
Squalene is localized to the plasma membrane in bovine retinal rod outer segments. |
1997 |
Exp. Eye Res. |
pmid:9176062
|
Donald KA et al. |
Effects of overproduction of the catalytic domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase on squalene synthesis in Saccharomyces cerevisiae. |
1997 |
Appl. Environ. Microbiol. |
pmid:9292983
|
Wendt KU et al. |
Structure and function of a squalene cyclase. |
1997 |
Science |
pmid:9295270
|
Barnett SW et al. |
Vaccination with HIV-1 gp120 DNA induces immune responses that are boosted by a recombinant gp120 protein subunit. |
1997 |
Vaccine |
pmid:9234536
|
Cenedella RJ |
Posttranscriptional regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in lens epithelial cells by mevalonate-derived nonsterols. |
1997 |
Exp. Eye Res. |
pmid:9237866
|
Flint OP et al. |
Inhibition of cholesterol synthesis by squalene synthase inhibitors does not induce myotoxicity in vitro. |
1997 |
Toxicol. Appl. Pharmacol. |
pmid:9221828
|
Kawakami T et al. |
Evaluation of heterotopic bone formation induced by squalane and bone morphogenetic protein composite. |
1997 |
Clin. Orthop. Relat. Res. |
pmid:9137198
|
Kushiro T et al. |
In vitro conversion of 2,3-oxidosqualene into dammarenediol by Panax ginseng microsomes. |
1997 |
Biol. Pharm. Bull. |
pmid:9084891
|
Perzl M et al. |
Squalene-hopene cyclase from Bradyrhizobium japonicum: cloning, expression, sequence analysis and comparison to other triterpenoid cyclases. |
1997 |
Microbiology (Reading, Engl.) |
pmid:9141686
|
Granoff DM et al. |
MF59 adjuvant enhances antibody responses of infant baboons immunized with Haemophilus influenzae type b and Neisseria meningitidis group C oligosaccharide-CRM197 conjugate vaccine. |
1997 |
Infect. Immun. |
pmid:9125551
|
Eisele B et al. |
Effects of a novel 2,3-oxidosqualene cyclase inhibitor on cholesterol biosynthesis and lipid metabolism in vivo. |
1997 |
J. Lipid Res. |
pmid:9101437
|
Stach D et al. |
Synthesis and inhibition studies of sulfur-substituted squalene oxide analogues as mechanism-based inhibitors of 2,3-oxidosqualene-lanosterol cyclase. |
1997 |
J. Med. Chem. |
pmid:9003518
|
Baum CL et al. |
Sterol carrier protein-2 overexpression enhances sterol cycling and inhibits cholesterol ester synthesis and high density lipoprotein cholesterol secretion. |
1997 |
J. Biol. Chem. |
pmid:9045674
|
O'Hagan DT et al. |
Recent advances in vaccine adjuvants: the development of MF59 emulsion and polymeric microparticles. |
1997 |
Mol Med Today |
pmid:9060004
|
Stoskopf MK et al. |
The impact of water temperature on core body temperature of North American river otters (Lutra canadensis) during simulated oil spill recovery washing protocols. |
1997 |
J. Zoo Wildl. Med. |
pmid:9523634
|
Uusitupa MI et al. |
Lathosterol and other non-cholesterol sterols during treatment of hypercholesterolaemia with beta-glucan-rich oat bran. |
1997 |
Eur J Clin Nutr |
pmid:9306087
|
Morand OH et al. |
Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin. |
1997 |
J. Lipid Res. |
pmid:9162756
|
Kuchta T et al. |
Inhibition of ergosterol biosynthesis is not accompanied by a change in fatty acid composition in Saccharomyces cerevisiae treated with the antifungal agent 6-amino-2-n-pentylthiobenzothiazole. |
1997 |
FEMS Microbiol. Lett. |
pmid:9163904
|
Newmark HL |
Squalene, olive oil, and cancer risk: a review and hypothesis. |
1997 |
Cancer Epidemiol. Biomarkers Prev. |
pmid:9419410
|
Smiałek M et al. |
Experimental squalene encephaloneuropathy in the rat. |
1997 |
Folia Neuropathol |
pmid:9833408
|
Hamdan JS and Casali AK |
Effect of amphotericin B on the lipids of yeast cells of Sporothrix schenckii. |
1996-1997 |
Mycopathologia |
pmid:9276941
|
Airaudi D et al. |
In vitro susceptibility of fungi to acyclic inhibitors of 2,3-oxidosqualene cyclases. |
1996 Jan-Feb |
Mycoses |
pmid:8786759
|
Bonté F et al. |
Simarouba amara extract increases human skin keratinocyte differentiation. |
1996 |
J Ethnopharmacol |
pmid:8844461
|
Traquina P et al. |
MF59 adjuvant enhances the antibody response to recombinant hepatitis B surface antigen vaccine in primates. |
1996 |
J. Infect. Dis. |
pmid:8940205
|
Rangel H et al. |
Naturally azole-resistant Leishmania braziliensis promastigotes are rendered susceptible in the presence of terbinafine: comparative study with azole-susceptible Leishmania mexicana promastigotes. |
1996 |
Antimicrob. Agents Chemother. |
pmid:9124841
|
Gylling H et al. |
Delayed postprandial retinyl palmitate and squalene removal in a patient heterozygous for apolipoprotein A-IFIN mutation (Leu 159-->Arg) and low HDL cholesterol level without coronary artery disease. |
1996 |
Atherosclerosis |
pmid:9125314
|
Fujie T et al. |
Culture of cells derived from the human sebaceous gland under serum-free conditions without a biological feeder layer or specific matrices. |
1996 |
Arch. Dermatol. Res. |
pmid:8931874
|
Grimes DS et al. |
Sunlight, cholesterol and coronary heart disease. |
1996 |
QJM |
pmid:8935479
|
Krisans SK |
Cell compartmentalization of cholesterol biosynthesis. |
1996 |
Ann. N. Y. Acad. Sci. |
pmid:8993542
|
Nikkilä K et al. |
Serum squalene and noncholesterol sterols before and after delivery in normal and cholestatic pregnancy. |
1996 |
J. Lipid Res. |
pmid:9017519
|
Keefer MC et al. |
Safety and immunogenicity of Env 2-3, a human immunodeficiency virus type 1 candidate vaccine, in combination with a novel adjuvant, MTP-PE/MF59. NIAID AIDS Vaccine Evaluation Group. |
1996 |
AIDS Res. Hum. Retroviruses |
pmid:8744579
|
Dracheva S et al. |
Chemical and functional studies on the importance of purple membrane lipids in bacteriorhodopsin photocycle behavior. |
1996 |
FEBS Lett. |
pmid:8612754
|
Ito T et al. |
Hepatic cholesterol metabolism in patients with cholesterol gallstones: enhanced intracellular transport of cholesterol. |
1996 |
Gastroenterology |
pmid:8613070
|
Chan C et al. |
The squalestatins: decarboxy and 4-deoxy analogues as potent squalene synthase inhibitors. |
1996 |
J. Med. Chem. |
pmid:8568810
|
Miquel K et al. |
Farnesol and geranylgeraniol induce actin cytoskeleton disorganization and apoptosis in A549 lung adenocarcinoma cells. |
1996 |
Biochem. Biophys. Res. Commun. |
pmid:8780704
|
Higgins DA et al. |
MF59 adjuvant enhances the immunogenicity of influenza vaccine in both young and old mice. |
1996 |
Vaccine |
pmid:8782343
|
Mark M et al. |
Effects of a novel 2,3-oxidosqualene cyclase inhibitor on the regulation of cholesterol biosynthesis in HepG2 cells. |
1996 |
J. Lipid Res. |
pmid:8820110
|
Arthington-Skaggs BA et al. |
Positive and negative regulation of a sterol biosynthetic gene (ERG3) in the post-squalene portion of the yeast ergosterol pathway. |
1996 |
FEBS Lett. |
pmid:8772195
|
Gylling H et al. |
The metabolism of cholestanol in primary biliary cirrhosis. |
1996 |
J. Hepatol. |
pmid:8738731
|
Chan P et al. |
Effectiveness and safety of low-dose pravastatin and squalene, alone and in combination, in elderly patients with hypercholesterolemia. |
1996 |
J Clin Pharmacol |
pmid:8739021
|
Yoshino S |
Oral administration of type II collagen suppresses non-specifically induced chronic arthritis in rats. |
1996 |
Biomed. Pharmacother. |
pmid:8672728
|
Barth MM et al. |
Structural and stereoelectronic requirements for the inhibition of mammalian 2,3-oxidosqualene cyclase by substituted isoquinoline derivatives. |
1996 |
J. Med. Chem. |
pmid:8691425
|
Fan SR et al. |
Squalene inhibits sodium arsenite-induced sister chromatid exchanges and micronuclei in Chinese hamster ovary-K1 cells. |
1996 |
Mutat. Res. |
pmid:8692222
|
Airaudi D et al. |
Preliminary screening of some squalenoid derivatives for toxicity towards dermatophytes. |
1995 Jul-Aug |
Mycoses |
pmid:8559196
|
Gylling H et al. |
Postprandial vitamin A and squalene clearances and cholesterol synthesis off and on lovastatin treatment in type III hyperlipoproteinemia. |
1995 |
Atherosclerosis |
pmid:7669084
|
Lees ND et al. |
Cloning of the late genes in the ergosterol biosynthetic pathway of Saccharomyces cerevisiae--a review. |
1995 |
Lipids |
pmid:7791529
|
Abe I and Prestwich GD |
Identification of the active site of vertebrate oxidosqualene cyclase. |
1995 |
Lipids |
pmid:7791531
|
Cattel L et al. |
2,3-Oxidosqualene cyclase: from azasqualenes to new site-directed inhibitors. |
1995 |
Lipids |
pmid:7791532
|
Houston L et al. |
Response of guinea pigs to a vaccine containing a new adjuvant (SAF) and gram-negative bacteria. |
1995 |
Lab. Anim. Sci. |
pmid:7752616
|
Langenberg AG et al. |
A recombinant glycoprotein vaccine for herpes simplex virus type 2: safety and immunogenicity [corrected]. |
1995 |
Ann. Intern. Med. |
pmid:7755223
|
Yamamoto A et al. |
Impaired water barrier function in acne vulgaris. |
1995 |
Arch. Dermatol. Res. |
pmid:7763094
|
Vanhanen HT and Miettinen TA |
Cholesterol absorption and synthesis during pravastatin, gemfibrozil and their combination. |
1995 |
Atherosclerosis |
pmid:7661873
|
Fliesler SJ et al. |
Isoprenoid lipid metabolism in the retina: dynamics of squalene and cholesterol incorporation and turnover in frog rod outer segment membranes. |
1995 |
Exp. Eye Res. |
pmid:7720806
|
Kerwin JL et al. |
Isoprenoid-mediated changes in the glycerophospholipid molecular species of the sterol auxotrophic fungus Lagenidium giganteum. |
1995 |
Microbiology (Reading, Engl.) |
pmid:7704271
|
Ott G et al. |
Enhancement of humoral response against human influenza vaccine with the simple submicron oil/water emulsion adjuvant MF59. |
1995 |
Vaccine |
pmid:8578842
|
Piretti MV et al. |
Simultaneous reversed-phase high-performance liquid chromatographic separation of non-polar isoprenoid lipids and their determination. |
1995 |
J. Chromatogr. B, Biomed. Appl. |
pmid:8788146
|
Socaciu C et al. |
In vitro yeast (Saccharomyces cerevisiae) presqualene and squalene synthesis related to substrate and cofactor availability. |
1995 |
C. R. Acad. Sci. III, Sci. Vie |
pmid:8521075
|
Robuccio JA et al. |
Comparison of the effects of five adjuvants on the antibody response to influenza virus antigen in guinea pigs. |
1995 |
Lab. Anim. Sci. |
pmid:7474883
|
Lewis D et al. |
Enzyme inhibition during the conversion of squalene to cholesterol. |
1995 |
Steroids |
pmid:7482633
|
Pittler SJ et al. |
In vivo requirement of protein prenylation for maintenance of retinal cytoarchitecture and photoreceptor structure. |
1995 |
J. Cell Biol. |
pmid:7615641
|
Viola F et al. |
Inhibition of 2,3-oxidosqualene cyclase and sterol biosynthesis by 10- and 19-azasqualene derivatives. |
1995 |
Biochem. Pharmacol. |
pmid:7575639
|