(e,e,e,e)-squalene

(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.

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Introduction

To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (e,e,e,e)-squalene?

(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene

MeSH term MeSH ID Detail
Pain D010146 64 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Parkinson Disease D010300 53 associated lipids
Precancerous Conditions D011230 48 associated lipids
Psoriasis D011565 47 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Leukemia P388 D007941 43 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with (e,e,e,e)-squalene

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with (e,e,e,e)-squalene?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (e,e,e,e)-squalene?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with (e,e,e,e)-squalene

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Authors Title Published Journal PubMed Link
Chiba K et al. Skin roughness and wrinkle formation induced by repeated application of squalene-monohydroperoxide to the hairless mouse. 1999 Exp. Dermatol. pmid:10597136
Kawada A et al. In vitro phototoxicity of new quinolones: production of active oxygen species and photosensitized lipid peroxidation. 1999 Photodermatol Photoimmunol Photomed pmid:10599972
Hoshino T et al. New cyclization mechanism for squalene: a ring-expansion step for the five-membered C-ring intermediate in hopene biosynthesis. 1999 Biosci. Biotechnol. Biochem. pmid:10635573
Gajkowska B et al. The experimental squalene encephaloneuropathy in the rat. 1999 Exp. Toxicol. Pathol. pmid:10048717
Dupuis M et al. Distribution of adjuvant MF59 and antigen gD2 after intramuscular injection in mice. 1999 Vaccine pmid:10519932
Milla P et al. 19-Azasqualene-2,3-epoxide and its N-oxide: metabolic fate and inhibitory effect on sterol biosynthesis in Saccharomyces cerevisiae. 1999 Lipids pmid:10478925
Zhang L et al. The preventive effects of incomplete Freund's adjuvant and other vehicles on the development of adjuvant-induced arthritis in Lewis rats. 1999 Immunology pmid:10540226
Ceruti M et al. 29-Methylidene-2,3-oxidosqualene derivatives as stereospecific mechanism-based inhibitors of liver and yeast oxidosqualene cyclase. 1998 J. Med. Chem. pmid:9484504
O'Hagan DT Recent advances in vaccine adjuvants for systemic and mucosal administration. 1998 J. Pharm. Pharmacol. pmid:9504429
Sato T et al. Overexpression of squalene-hopene cyclase by the pET vector in Escherichia coli and first identification of tryptophan and aspartic acid residues inside the QW motif as active sites. 1998 Biosci. Biotechnol. Biochem. pmid:9532806
Rao CV et al. Chemopreventive effect of squalene on colon cancer. 1998 Carcinogenesis pmid:9498278
Zheng YF et al. Inhibition kinetics and affinity labeling of bacterial squalene:hopene cyclase by thia-substituted analogues of 2, 3-oxidosqualene. 1998 Biochemistry pmid:9558334
Lopez D et al. Compensatory responses to inhibition of hepatic squalene synthase. 1998 Arch. Biochem. Biophys. pmid:9514656
Basáñez G et al. Effect of single chain lipids on phospholipase C-promoted vesicle fusion. A test for the stalk hypothesis of membrane fusion. 1998 Biochemistry pmid:9521711
Bibikova MV and Bondareva NS [Drugs of microbial origin for treatment of atherosclerosis]. 1998 Antibiot. Khimioter. pmid:9777104
Kushiro T et al. Beta-amyrin synthase--cloning of oxidosqualene cyclase that catalyzes the formation of the most popular triterpene among higher plants. 1998 Eur. J. Biochem. pmid:9746369
Michikawa M and Yanagisawa K Apolipoprotein E4 induces neuronal cell death under conditions of suppressed de novo cholesterol synthesis. 1998 J. Neurosci. Res. pmid:9778150
Saenz MT et al. Cytostatic activity of some compounds from the unsaponifiable fraction obtained from virgin olive oil. 1998 Farmaco pmid:9786644
Schedin S et al. Alterations in the biosynthesis of cholesterol, dolichol and dolichyl-P in the genetic cholesterol homeostasis disorder, Niemann-Pick type C disease. 1998 Biochim. Biophys. Acta pmid:9795206
Smith TJ et al. Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis by dietary olive oil and squalene. 1998 Carcinogenesis pmid:9600360
Singh M et al. A comparison of biodegradable microparticles and MF59 as systemic adjuvants for recombinant gD from HSV-2. 1998 Vaccine pmid:9795387
Sajbidor J et al. Influence of new fenpropimorph fungicides on the growth and sterol composition in Saccharomyces cerevisiae: relationship between structure and activity. 1998 J. Pharm. Pharmacol. pmid:9600722
Joshi MK et al. Importance of specific native lipids in controlling the photocycle of bacteriorhodopsin. 1998 Biochemistry pmid:9772173
Nesburn AB et al. Local periocular vaccination protects against eye disease more effectively than systemic vaccination following primary ocular herpes simplex virus infection in rabbits. 1998 J. Virol. pmid:9733807
Cattel L and Ceruti M Inhibitors of 2,3-oxidosqualene cyclase as tools for studying the mechanism and function of the enzyme. 1998 Crit. Rev. Biochem. Mol. Biol. pmid:9827705
Weldon MK et al. Surface enhanced Raman spectroscopic monitor of P. acnes lipid hydrolysis in vitro. 1998 J. Lipid Res. pmid:9741703
Fernández JJ et al. Evaluation of the cytotoxic activity of polyethers isolated from Laurencia. 1998 Bioorg. Med. Chem. pmid:9925286
Nakano M et al. Useful 1O2 (1delta g) generator, 3-(4'-methyl-1'-naphthyl)-propionic acid, 1',4'-endoperoxide (NEPO), for dioxygenation of squalence (a skin surface lipid) in an organic solvent and bacterial killing in aqueous medium. 1998 FEBS Lett. pmid:9710240
Perzl M et al. Cloning of conserved genes from Zymomonas mobilis and Bradyrhizobium japonicum that function in the biosynthesis of hopanoid lipids. 1998 Biochim. Biophys. Acta pmid:9714766
Hagiwara T et al. Determination of lycopene, alpha-carotene and beta-carotene in serum by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry with selected-ion monitoring. 1998 J. Chromatogr. B Biomed. Sci. Appl. pmid:9653948
Dupuis M et al. Dendritic cells internalize vaccine adjuvant after intramuscular injection. 1998 Cell. Immunol. pmid:9637761
Mansfield PD et al. The effects of four, commercial ceruminolytic agents on the middle ear. 1997 Nov-Dec J Am Anim Hosp Assoc pmid:9358414
Law S et al. Skin surface lipids inhibit adherence of Candida albicans to stratum corneum. 1997 Dermatology (Basel) pmid:9407165
Grieveson LA et al. A simplified squalene epoxidase assay based on an HPLC separation and time-dependent UV/visible determination of squalene. 1997 Anal. Biochem. pmid:9324936
Kribii R et al. Cloning and characterization of the Arabidopsis thaliana SQS1 gene encoding squalene synthase--involvement of the C-terminal region of the enzyme in the channeling of squalene through the sterol pathway. 1997 Eur. J. Biochem. pmid:9363754
Cataldo DM and Van Nest G The adjuvant MF59 increases the immunogenicity and protective efficacy of subunit influenza vaccine in mice. 1997 Vaccine pmid:9364672
Tomasi M et al. Strong mucosal adjuvanticity of cholera toxin within lipid particles of a new multiple emulsion delivery system for oral immunization. 1997 Eur. J. Immunol. pmid:9368632
Salamon Z et al. Coupled plasmon-waveguide resonators: a new spectroscopic tool for probing proteolipid film structure and properties. 1997 Biophys. J. pmid:9370473
Toews AD et al. Tellurium causes dose-dependent coordinate down-regulation of myelin gene expression. 1997 Brain Res. Mol. Brain Res. pmid:9387870
Fliesler SJ et al. Squalene is localized to the plasma membrane in bovine retinal rod outer segments. 1997 Exp. Eye Res. pmid:9176062
Donald KA et al. Effects of overproduction of the catalytic domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase on squalene synthesis in Saccharomyces cerevisiae. 1997 Appl. Environ. Microbiol. pmid:9292983
Wendt KU et al. Structure and function of a squalene cyclase. 1997 Science pmid:9295270
Barnett SW et al. Vaccination with HIV-1 gp120 DNA induces immune responses that are boosted by a recombinant gp120 protein subunit. 1997 Vaccine pmid:9234536
Cenedella RJ Posttranscriptional regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in lens epithelial cells by mevalonate-derived nonsterols. 1997 Exp. Eye Res. pmid:9237866
Flint OP et al. Inhibition of cholesterol synthesis by squalene synthase inhibitors does not induce myotoxicity in vitro. 1997 Toxicol. Appl. Pharmacol. pmid:9221828
Kawakami T et al. Evaluation of heterotopic bone formation induced by squalane and bone morphogenetic protein composite. 1997 Clin. Orthop. Relat. Res. pmid:9137198
Kushiro T et al. In vitro conversion of 2,3-oxidosqualene into dammarenediol by Panax ginseng microsomes. 1997 Biol. Pharm. Bull. pmid:9084891
Perzl M et al. Squalene-hopene cyclase from Bradyrhizobium japonicum: cloning, expression, sequence analysis and comparison to other triterpenoid cyclases. 1997 Microbiology (Reading, Engl.) pmid:9141686
Granoff DM et al. MF59 adjuvant enhances antibody responses of infant baboons immunized with Haemophilus influenzae type b and Neisseria meningitidis group C oligosaccharide-CRM197 conjugate vaccine. 1997 Infect. Immun. pmid:9125551
Eisele B et al. Effects of a novel 2,3-oxidosqualene cyclase inhibitor on cholesterol biosynthesis and lipid metabolism in vivo. 1997 J. Lipid Res. pmid:9101437
Stach D et al. Synthesis and inhibition studies of sulfur-substituted squalene oxide analogues as mechanism-based inhibitors of 2,3-oxidosqualene-lanosterol cyclase. 1997 J. Med. Chem. pmid:9003518
Baum CL et al. Sterol carrier protein-2 overexpression enhances sterol cycling and inhibits cholesterol ester synthesis and high density lipoprotein cholesterol secretion. 1997 J. Biol. Chem. pmid:9045674
O'Hagan DT et al. Recent advances in vaccine adjuvants: the development of MF59 emulsion and polymeric microparticles. 1997 Mol Med Today pmid:9060004
Stoskopf MK et al. The impact of water temperature on core body temperature of North American river otters (Lutra canadensis) during simulated oil spill recovery washing protocols. 1997 J. Zoo Wildl. Med. pmid:9523634
Uusitupa MI et al. Lathosterol and other non-cholesterol sterols during treatment of hypercholesterolaemia with beta-glucan-rich oat bran. 1997 Eur J Clin Nutr pmid:9306087
Morand OH et al. Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin. 1997 J. Lipid Res. pmid:9162756
Kuchta T et al. Inhibition of ergosterol biosynthesis is not accompanied by a change in fatty acid composition in Saccharomyces cerevisiae treated with the antifungal agent 6-amino-2-n-pentylthiobenzothiazole. 1997 FEMS Microbiol. Lett. pmid:9163904
Newmark HL Squalene, olive oil, and cancer risk: a review and hypothesis. 1997 Cancer Epidemiol. Biomarkers Prev. pmid:9419410
Smiałek M et al. Experimental squalene encephaloneuropathy in the rat. 1997 Folia Neuropathol pmid:9833408
Hamdan JS and Casali AK Effect of amphotericin B on the lipids of yeast cells of Sporothrix schenckii. 1996-1997 Mycopathologia pmid:9276941
Airaudi D et al. In vitro susceptibility of fungi to acyclic inhibitors of 2,3-oxidosqualene cyclases. 1996 Jan-Feb Mycoses pmid:8786759
Bonté F et al. Simarouba amara extract increases human skin keratinocyte differentiation. 1996 J Ethnopharmacol pmid:8844461
Traquina P et al. MF59 adjuvant enhances the antibody response to recombinant hepatitis B surface antigen vaccine in primates. 1996 J. Infect. Dis. pmid:8940205
Rangel H et al. Naturally azole-resistant Leishmania braziliensis promastigotes are rendered susceptible in the presence of terbinafine: comparative study with azole-susceptible Leishmania mexicana promastigotes. 1996 Antimicrob. Agents Chemother. pmid:9124841
Gylling H et al. Delayed postprandial retinyl palmitate and squalene removal in a patient heterozygous for apolipoprotein A-IFIN mutation (Leu 159-->Arg) and low HDL cholesterol level without coronary artery disease. 1996 Atherosclerosis pmid:9125314
Fujie T et al. Culture of cells derived from the human sebaceous gland under serum-free conditions without a biological feeder layer or specific matrices. 1996 Arch. Dermatol. Res. pmid:8931874
Grimes DS et al. Sunlight, cholesterol and coronary heart disease. 1996 QJM pmid:8935479
Krisans SK Cell compartmentalization of cholesterol biosynthesis. 1996 Ann. N. Y. Acad. Sci. pmid:8993542
Nikkilä K et al. Serum squalene and noncholesterol sterols before and after delivery in normal and cholestatic pregnancy. 1996 J. Lipid Res. pmid:9017519
Keefer MC et al. Safety and immunogenicity of Env 2-3, a human immunodeficiency virus type 1 candidate vaccine, in combination with a novel adjuvant, MTP-PE/MF59. NIAID AIDS Vaccine Evaluation Group. 1996 AIDS Res. Hum. Retroviruses pmid:8744579
Dracheva S et al. Chemical and functional studies on the importance of purple membrane lipids in bacteriorhodopsin photocycle behavior. 1996 FEBS Lett. pmid:8612754
Ito T et al. Hepatic cholesterol metabolism in patients with cholesterol gallstones: enhanced intracellular transport of cholesterol. 1996 Gastroenterology pmid:8613070
Chan C et al. The squalestatins: decarboxy and 4-deoxy analogues as potent squalene synthase inhibitors. 1996 J. Med. Chem. pmid:8568810
Miquel K et al. Farnesol and geranylgeraniol induce actin cytoskeleton disorganization and apoptosis in A549 lung adenocarcinoma cells. 1996 Biochem. Biophys. Res. Commun. pmid:8780704
Higgins DA et al. MF59 adjuvant enhances the immunogenicity of influenza vaccine in both young and old mice. 1996 Vaccine pmid:8782343
Mark M et al. Effects of a novel 2,3-oxidosqualene cyclase inhibitor on the regulation of cholesterol biosynthesis in HepG2 cells. 1996 J. Lipid Res. pmid:8820110
Arthington-Skaggs BA et al. Positive and negative regulation of a sterol biosynthetic gene (ERG3) in the post-squalene portion of the yeast ergosterol pathway. 1996 FEBS Lett. pmid:8772195
Gylling H et al. The metabolism of cholestanol in primary biliary cirrhosis. 1996 J. Hepatol. pmid:8738731
Chan P et al. Effectiveness and safety of low-dose pravastatin and squalene, alone and in combination, in elderly patients with hypercholesterolemia. 1996 J Clin Pharmacol pmid:8739021
Yoshino S Oral administration of type II collagen suppresses non-specifically induced chronic arthritis in rats. 1996 Biomed. Pharmacother. pmid:8672728
Barth MM et al. Structural and stereoelectronic requirements for the inhibition of mammalian 2,3-oxidosqualene cyclase by substituted isoquinoline derivatives. 1996 J. Med. Chem. pmid:8691425
Fan SR et al. Squalene inhibits sodium arsenite-induced sister chromatid exchanges and micronuclei in Chinese hamster ovary-K1 cells. 1996 Mutat. Res. pmid:8692222
Airaudi D et al. Preliminary screening of some squalenoid derivatives for toxicity towards dermatophytes. 1995 Jul-Aug Mycoses pmid:8559196
Gylling H et al. Postprandial vitamin A and squalene clearances and cholesterol synthesis off and on lovastatin treatment in type III hyperlipoproteinemia. 1995 Atherosclerosis pmid:7669084
Lees ND et al. Cloning of the late genes in the ergosterol biosynthetic pathway of Saccharomyces cerevisiae--a review. 1995 Lipids pmid:7791529
Abe I and Prestwich GD Identification of the active site of vertebrate oxidosqualene cyclase. 1995 Lipids pmid:7791531
Cattel L et al. 2,3-Oxidosqualene cyclase: from azasqualenes to new site-directed inhibitors. 1995 Lipids pmid:7791532
Houston L et al. Response of guinea pigs to a vaccine containing a new adjuvant (SAF) and gram-negative bacteria. 1995 Lab. Anim. Sci. pmid:7752616
Langenberg AG et al. A recombinant glycoprotein vaccine for herpes simplex virus type 2: safety and immunogenicity [corrected]. 1995 Ann. Intern. Med. pmid:7755223
Yamamoto A et al. Impaired water barrier function in acne vulgaris. 1995 Arch. Dermatol. Res. pmid:7763094
Vanhanen HT and Miettinen TA Cholesterol absorption and synthesis during pravastatin, gemfibrozil and their combination. 1995 Atherosclerosis pmid:7661873
Fliesler SJ et al. Isoprenoid lipid metabolism in the retina: dynamics of squalene and cholesterol incorporation and turnover in frog rod outer segment membranes. 1995 Exp. Eye Res. pmid:7720806
Kerwin JL et al. Isoprenoid-mediated changes in the glycerophospholipid molecular species of the sterol auxotrophic fungus Lagenidium giganteum. 1995 Microbiology (Reading, Engl.) pmid:7704271
Ott G et al. Enhancement of humoral response against human influenza vaccine with the simple submicron oil/water emulsion adjuvant MF59. 1995 Vaccine pmid:8578842
Piretti MV et al. Simultaneous reversed-phase high-performance liquid chromatographic separation of non-polar isoprenoid lipids and their determination. 1995 J. Chromatogr. B, Biomed. Appl. pmid:8788146
Socaciu C et al. In vitro yeast (Saccharomyces cerevisiae) presqualene and squalene synthesis related to substrate and cofactor availability. 1995 C. R. Acad. Sci. III, Sci. Vie pmid:8521075
Robuccio JA et al. Comparison of the effects of five adjuvants on the antibody response to influenza virus antigen in guinea pigs. 1995 Lab. Anim. Sci. pmid:7474883
Lewis D et al. Enzyme inhibition during the conversion of squalene to cholesterol. 1995 Steroids pmid:7482633
Pittler SJ et al. In vivo requirement of protein prenylation for maintenance of retinal cytoarchitecture and photoreceptor structure. 1995 J. Cell Biol. pmid:7615641
Viola F et al. Inhibition of 2,3-oxidosqualene cyclase and sterol biosynthesis by 10- and 19-azasqualene derivatives. 1995 Biochem. Pharmacol. pmid:7575639