(e,e,e,e)-squalene

(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.

Cross Reference

Introduction

To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (e,e,e,e)-squalene?

(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene

MeSH term MeSH ID Detail
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Edema D004487 152 associated lipids
Exostoses, Multiple Hereditary D005097 3 associated lipids
Fasciitis D005208 2 associated lipids
Fatigue D005221 10 associated lipids
Fibrosarcoma D005354 8 associated lipids
Gallbladder Diseases D005705 3 associated lipids
Hemolysis D006461 131 associated lipids
Hepatitis D006505 11 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with (e,e,e,e)-squalene

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with (e,e,e,e)-squalene?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (e,e,e,e)-squalene?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with (e,e,e,e)-squalene

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Per page 10 20 50 100 | Total 1766
Authors Title Published Journal PubMed Link
POPJAK G et al. Mechanism of squalene biosynthesis from mevalonate and farnesyl pyrophosphate. 1961 Biochem. Biophys. Res. Commun. pmid:13737103
POPJAK G et al. Studies on the biosynthesis of cholesterol. XV. Mechanism of squalene biosynthesis from farnesyl pyrophosphate and from mevalonate. 1961 J. Biol. Chem. pmid:13737104
CAPSTACK E et al. The biosynthesis of squalene in germinating seeds of Pisum sativum. 1962 Biochemistry pmid:14018475
ALAM SQ et al. Detection and estimation of squalene in leaves. 1962 Nature pmid:13860005
GOSSELIN L et al. Particulate enzyme system for the synthesis of squalene from 2-(14C)-mevalonic acid. 1962 Nature pmid:13900654
GOSSELIN L Utilization of (2-14C) mevalonic acid by rat liver cell fraction: evidence for an attachment of a squalene precursor to a cellular component insoluble at acid pH. 1962 Arch. Int. Physiol. Biochim. pmid:13900655
CHILDS CR and BLOCH K Further observations on the biosynthesis of squalene. 1962 J. Biol. Chem. pmid:13878983
HOLMES WL and STACK E Gas chromatography of squalene, sterols and bile acid methyl esters. 1962 Biochim. Biophys. Acta pmid:13908533
POPJAK G et al. Studies on the biosynthesis of cholesterol. XVI. Chemical synthesis of 1-H2-3-2-C-14- and 1-D2-2-C-14-trans-trans-farnesyl pyrophosphate and their utilization in squalene biosynthesis. 1962 J. Biol. Chem. pmid:14487886
POPJAK G et al. Sterospecificity of hydrogen transfer from reduced triphosphopyridine nucleotide to squalene during its synthesis from farnesyl pyrophosphate. 1962 Biochem. Biophys. Res. Commun. pmid:14487887
ROTHBLAT GH et al. A quantitative colorimetric assay for squalene. 1962 Anal. Biochem. pmid:14494417
HORLICK L and AVIGAN J STEROLS OF SKIN IN THE NORMAL AND TRIPARANOL-TREATED RAT. 1963 J. Lipid Res. pmid:14168146
LUPIEN PJ et al. EFFECT OF AN ANTIBIOTIC ON LIPID FRACTIONS IN PLASMS AND EGG YOLK OF LAYING HENS. 1963 Can J Biochem Physiol pmid:14083981
GRIESEMER RD and THOMAS RW LIPOGENESIS IN HUMAN SKIN. II. THE EFFECT OF PHYSICAL AND CHEMICAL FACTORS ON IN VITRO LIPOGENESIS FROM ACETATE. 1963 J. Invest. Dermatol. pmid:14059599
LIBERTI A et al. ISOTOPIC EFFECTS IN GAS-LIQUID CHROMATOGRAPHY. I. GAS CHROMATOGRAPHIC BEHAVIOUR OF BENZENE AND PERDEUTEROBENZENE. 1963 J. Chromatogr. pmid:14066512
GRIESEMER RD and THOMAS RW LIPOGENESIS IN HUMAN SKIN. III. VARIATION WITH BODY SITE. 1963 J. Invest. Dermatol. pmid:14066602
PROSTENIK M and MUNK-WEINERT M The isolation of squalene from human brain. 1963 Biochim. Biophys. Acta pmid:13986372
BURGESS TL and WILSON JD Studies on hormonal regulation of squalene synthesis in preputial gland and skin of the rat. 1963 Proc. Soc. Exp. Biol. Med. pmid:14016990
CALTABIANO S and SPREMOLLA G [Histological and humoral aspects of experimental atherosclerosis induced by squalene in rabbits treated with triparanol]. 1963 Arch Sci Med (Torino) pmid:14017944
CARAVACA J et al. Inhibition of squalene and cholesterol biosynthesis by hepatocatalase (Caperase). 1963 Biochem. Biophys. Res. Commun. pmid:14018515
CORNFORTH JW et al. Stereospecific insertion of hydrogen atom into squalene from reduced nicotinamide-adenine dinucleotides. 1963 Biochem. Biophys. Res. Commun. pmid:14023096
GAYLOR JL Biosynthesis of skin sterols. III. Conversion of squalene to sterols by rat skin. 1963 J. Biol. Chem. pmid:13946923
GAYLOR JL Biosynthesis of skin sterols. V. Effect of arsenite inhibition and the accumulation of labeled lanosta-7, 24-dien-3 beta-ol in rat skin. 1963 Arch. Biochem. Biophys. pmid:13946925
JACHYMCZYK W [Biosynthesis of triterpenoid compounds]. 1963 Postepy Biochem. pmid:13957182
BEELER DA et al. The biosynthesis of squalene from mevalonic acid-2-C-14 and farnesyl pyrophosphate-4,8,12-C-14 by carrot and tomato enzymes. 1963 Arch. Biochem. Biophys. pmid:13970235
SAMUELSSON B and GOODMAN DS Stereochemistry of the hydrogen transfer to squalene during its biosynthesis from farnesyl pyrophosphate. 1963 Biochem. Biophys. Res. Commun. pmid:13976173
Malathi P and Ganguly J Studies on metabolism of vitamin A. 8. Effect of ascorbate on isoprenoid metabolism in vitamin A-deficient rats. 1964 Biochem. J. pmid:5837438
GOODMAN DS SQUALENE IN HUMAN AND RAT BLOOD PLASMA. 1964 J. Clin. Invest. pmid:14192529
SALOKANGAS RA et al. TERPENE METABOLISM IN THE RAT TESTIS. I. THE CONVERSION OF ISOPENTENYL PYROPHOSPHATE TO SQUALENE AND STEROLS. 1964 Biochemistry pmid:14211625
MCCARTHY MJ et al. COMPOSITION OF MOLECULAR DISTILLATES OF BUTTER OIL: ISOLATION AND IDENTIFICATION OF COMPONENTS OTHER THAN GLYCERIDES. 1964 J. Lipid Res. pmid:14221107
TSAI SC et al. TESTICULAR STEROLS. 1. INCORPORATION OF MEVALONATE AND ACETATE INTO STEROLS BY TESTICULAR TISSUE FROM RATS. 1964 Arch. Biochem. Biophys. pmid:14186739
VAN DEN OORD A THE ABSENCE OF CHOLESTEROL SYNTHESIS IN THE CRAB, CANCER PAGURUS L. 1964 Comp. Biochem. Physiol. pmid:14246359
DILLER ER and HARVEY OA INTERRELATIONSHIP OF STEROL AND FATTY ACID BIOSYNTHESIS IN RAT LIVER SLICES AS RELATED TO DIETARY LIPID. 1964 Biochemistry pmid:14269326
SAMUELSSON B and GOODMAN DS STEREOCHEMISTRY AT THE CENTER OF SQUALENE DURING ITS BIOSYNTHESIS FROM FARNESYL PYROPHOSPHATE AND SUBSEQUENT CONVERSION TO CHOLESTEROL. 1964 J. Biol. Chem. pmid:14114881
ALEXANDER GJ and ALEXANDER RB INHIBITION OF CHOLESTEROL SYNTHESIS IN VIVO BY A CONVULSANT, METRAZOL. 1964 Proc. Soc. Exp. Biol. Med. pmid:14117448
BROOKS SC and GODEFROI VC QUANITITATIVE COLLECTION OF MICRO AMOUNTS OF STEROIDS FROM GAS-LIQUID CHROMATOGRAPHY. 1964 Anal. Biochem. pmid:14134426
LUCY JA and DINGLE JT FAT-SOLUBLE VITAMINS AND BIOLOGICAL MEMBRANES. 1964 Nature pmid:14222261
Krishna G et al. An enzyme-bound intermediate in the conversion of farnesyl pyrophosphate to squalene. 1964 Biochem. Biophys. Res. Commun. pmid:4284347
Gosselin L [Utilization of farnesyl pyrophosphate by rat liver microsomes in the absence of nicotinamide adenine dinucleotides]. 1964 Arch. Int. Physiol. Biochim. pmid:4157959
Paroli E [Effect of beta-carotene and of squalene on analgesia and respiratory depression caused by morphine]. 1964 Boll. Soc. Ital. Biol. Sper. pmid:5877121
Van Leusden H and Villee CA The de novo synthesis of sterols and steroids from acetate by preparations of human term placenta. 1965 Steroids pmid:5857495
Kipping D [Observations on skin surface fats]. 1965 Z Haut Geschlechtskr pmid:5860995
KARLSON P [NOBEL PRIZE FOR MEDICINE AND PHYSIOLOGY IN 1964]. 1965 Dtsch. Med. Wochenschr. pmid:14238764
CORNFORTH JW et al. THE MIGRATION AND ELIMINATION OF HYDROGEN DURING BIOSYNTHESIS OF CHOLESTEROL FROM SQUALENE. 1965 J. Am. Chem. Soc. pmid:14329430
DIPLOCK AT et al. VITAMIN A AND ISOPRENOID SYNTHESIS IN THE RAT. 1965 Biochem. J. pmid:14333548
Stone KJ and Hemming FW The incorporation of [2-14C, 4R-3H1] mevalonate and [2-14C, 4S-3H1] mevalonate into squalene, ubiquinone and ergosterol of Aspergillus fumigatus Fresenius. 1965 Biochem. J. pmid:4284430
Dalidowicz JE and McDonald HJ Site of the in vitro inhibition of cholesterol biosynthesis by tolbutamide and phenethylbiguanide. 1965 Biochemistry pmid:4284598
Gosselin L and Duvivier J [On the utilization of C14-2-mevalonic acid by cell fractions of bovine adrenal gland homogenates]. 1965 Arch. Int. Physiol. Biochim. pmid:4158100
Garbuzov AG et al. [The presence of squalene in the human aorta]. 1965 Arkh. Patol. pmid:5881137
Goodwin TW and Williams RJ A mechanism for the biosynthesis of alpha-carotene. 1965 Biochem. J. pmid:5881648