| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Exostoses, Multiple Hereditary | D005097 | 3 associated lipids |
| Fasciitis | D005208 | 2 associated lipids |
| Fatigue | D005221 | 10 associated lipids |
| Fibrosarcoma | D005354 | 8 associated lipids |
| Gallbladder Diseases | D005705 | 3 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Hepatitis | D006505 | 11 associated lipids |
(e,e,e,e)-squalene
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
Cross Reference
Introduction
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (e,e,e,e)-squalene?
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
PubChem Associated disorders and diseases
What pathways are associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (e,e,e,e)-squalene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with (e,e,e,e)-squalene?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with (e,e,e,e)-squalene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Miettinen TA and Gylling H | Cholesterol synthesis and absorption in coronary patients with lipid triad and isolated high LDL cholesterol in a 4S subgroup. | 2003 | Atherosclerosis | pmid:12801618 |
| Rontani JF et al. | Production of a polyunsaturated isoprenoid wax ester during aerobic metabolism of squalene by Marinobacter squalenivorans sp. nov. | 2003 | Appl. Environ. Microbiol. | pmid:12839795 |
| Zhang L et al. | Proopiomelanocortin peptides and sebogenesis. | 2003 | Ann. N. Y. Acad. Sci. | pmid:12851311 |
| Satoh M et al. | Induction of lupus autoantibodies by adjuvants. | 2003 | J. Autoimmun. | pmid:12892730 |
| Podda A and Del Giudice G | MF59-adjuvanted vaccines: increased immunogenicity with an optimal safety profile. | 2003 | Expert Rev Vaccines | pmid:12899571 |
| Iorio AM et al. | Antibody responses and HIV-1 viral load in HIV-1-seropositive subjects immunised with either the MF59-adjuvanted influenza vaccine or a conventional non-adjuvanted subunit vaccine during highly active antiretroviral therapy. | 2003 | Vaccine | pmid:12922092 |
| Catalán CA et al. | A linear sesterterpene, two squalene derivatives and two peptide derivatives from Croton hieronymi. | 2003 | Phytochemistry | pmid:12943786 |
| DALE J | Dehydrogenation of squalene with N-bromosuccinimide. | 1952 | Arch. Biochem. Biophys. | pmid:13008464 |
| Pye RJ et al. | Skin surface lipid composition in rosacea. | 1976 | Br. J. Dermatol. | pmid:130159 |
| Cooper MF et al. | Sebaceous lipogenesis in human skin. Variability with age and with severity of acne. | 1976 | Br. J. Dermatol. | pmid:130160 |
| NICOLAIDES N and ROTHMAN S | Studies on the chemical composition of human hair fat. I. The squalene-cholesterol relationship in children and adults. | 1952 | J. Invest. Dermatol. | pmid:13023010 |
| LANGDON RG and BLOCH K | The biosynthesis of squalene. | 1953 | J. Biol. Chem. | pmid:13034767 |
| LANGDON RG and BLOCH K | The utilization of squalene in the biosynthesis of cholesterol. | 1953 | J. Biol. Chem. | pmid:13034768 |
| WHEATLEY VR | Studies of sebum. IV. The estimation of squalene in sebum and sebum-like materials. | 1953 | Biochem. J. | pmid:13115346 |
| POPJAK G | Biosynthesis of squalene and cholesterol in vitro from acetate-1-C14. | 1954 | Arch. Biochem. Biophys. | pmid:13125576 |
| Bogan BW et al. | Alkanindiges illinoisensis gen. nov., sp. nov., an obligately hydrocarbonoclastic, aerobic squalane-degrading bacterium isolated from oilfield soils. | 2003 | Int. J. Syst. Evol. Microbiol. | pmid:13130023 |
| SCHWENK E et al. | Studies on the biosynthesis of cholesterol. VI. Companions of cholesterol-C14 in liver perfusions, including squalene-C14 as possible precursors in its biosynthesis. | 1954 | Arch. Biochem. Biophys. | pmid:13139684 |
| EIDINOFF ML et al. | The biosynthesis of squalene from acetate in man. | 1954 | J. Clin. Invest. | pmid:13143078 |
| SQUALENE, a precursor of cholesterol. | 1954 | Nutr. Rev. | pmid:13166142 | |
| CORNFORTH JW and POPJAK G | Studies on the biosynthesis of cholesterol. 3. Distribution of 14C in squalene biosynthesized from [Me-14C]acetate. | 1954 | Biochem. J. | pmid:13208629 |
| Van Sickle WA et al. | Inhibition of cholesterol synthesis by cyclopropylamine derivatives of squalene in human hepatoblastoma cells in culture. | 1992 | Lipids | pmid:1326069 |
| RABINOWITZ JL et al. | Branched chain acids in the biosynthesis of squalene and cholesterol. | 1955 | Fed. Proc. | pmid:13262139 |
| DICKHART W | The squalene contents of various oils. | 1955 | Am J Pharm Sci Support Public Health | pmid:13275573 |
| SQUALENE and cholesterol synthesis in the human skin. | 1956 | Nutr. Rev. | pmid:13309889 | |
| Murakoshi M et al. | Inhibition by squalene of the tumor-promoting activity of 12-O-tetradecanoylphorbol-13-acetate in mouse-skin carcinogenesis. | 1992 | Int. J. Cancer | pmid:1334056 |
| DITURI F et al. | Terpenoid intermediates in the biosynthesis of cholesterol. | 1956 | J. Biol. Chem. | pmid:13345809 |
| VILLALBA GOMEZ GM | [Squalene index]. | 1956 May-Aug | Rev Sanid Asist Soc | pmid:13379961 |
| Fujita H and Matsuo I | Type I lipid photo-oxidation by the nonsteroidal anti-inflammatory drug suprofen: a possible key to its photosensitivity. | 1992-1993 Oct | Photodermatol Photoimmunol Photomed | pmid:1342189 |
| BOUGHTON B et al. | Studies of sebum. VIII. Observations on the squalene and cholesterol content and the possible functions of squalene in human sebum. | 1957 | Biochem. J. | pmid:13426103 |
| HELLER JH et al. | Squalene content of various shark livers. | 1957 | Nature | pmid:13430738 |
| TCHEN TT and BLOCH K | On the conversion of squalene to lanosterol in vitro. | 1957 | J. Biol. Chem. | pmid:13438881 |
| TCHEN TT and BLOCH K | On the mechanism of enzymatic cyclization of squalene. | 1957 | J. Biol. Chem. | pmid:13438882 |
| SOBEL H et al. | Determinations of squalene in sebum from the forehead of patients with skin cancer. | 1957 | J. Invest. Dermatol. | pmid:13491890 |
| DITURI F et al. | Precursors of squalene and cholesterol. | 1957 | J. Biol. Chem. | pmid:13502345 |
| CORNFORTH JW et al. | Studies on the biosynthesis of cholesterol. 5. Biosynthesis of squalene from DL-3-hydroxy-3-methyl [2-14C] pentano-5-lactone. | 1958 | Biochem. J. | pmid:13535596 |
| WOLFF RE and GODEFROY N | [Transformation of synthetic squalene (11, 1414C) to cholesterol in rats]. | 1958 | C. R. Hebd. Seances Acad. Sci. | pmid:13537384 |
| WOLFF RE and PICHAT L | [Synthesis of 11,14-C14-squalene]. | 1958 | C. R. Hebd. Seances Acad. Sci. | pmid:13537435 |
| EIDINOFF ML et al. | Cholesterol biosynthesis: studies related to the metabolic role of squalene. | 1958 | J. Clin. Invest. | pmid:13539207 |
| Gloor M | [The significance of physiological and biochemical deviations from the norm on the skin surface for infectious skin diseases (proceedings)]. | 1976 | Z. Hautkr. | pmid:13544 |
| POPJAK G et al. | Studies on the biosynthesis of cholesterol. 6. Coenzyme requirements of liver enzymes for synthesis of squalene and of sterol from DL-3-hydroxy-3-methyl-[2-14C] pentano-5-lactone. | 1958 | Biochem. J. | pmid:13546172 |
| LOUD AV and BUCHER NL | The turnover of squalene in relation to the biosynthesis of cholesterol. | 1958 | J. Biol. Chem. | pmid:13563436 |
| MARKLEY K and GURIN S | Decarboxylation of mevalonic acid and conversion to squalene; enzyme fractionation and cofactors. | 1959 | Biochim. Biophys. Acta | pmid:13628647 |
| RILLING HC and BLOCH K | On the mechanism of squaiene biogenesis from mevalonic acid. | 1959 | J. Biol. Chem. | pmid:13654391 |
| Kushwaha SC and Kates M | Lipid composition of Neurospora crassa. | 1976 | Lipids | pmid:136584 |
| ANDERSON DG et al. | The conversion of farnesyl pyrophosphate to squalene by soluble extracts of microsomes. | 1960 | Biochem. Biophys. Res. Commun. | pmid:13683185 |
| GAYLOR JL | Anaerobic conversion of acetate to squalene by rat skin. | 1961 | Proc. Soc. Exp. Biol. Med. | pmid:13704081 |
| GOODMAN DS | Studies on the conversion of squalene to sterol with rat liver enzymes. | 1961 | J. Biol. Chem. | pmid:13707027 |
| GOSSELIN L and PODBER-WAGNER E | [New observations on the particles interfering in the biosynthesis of squalene from mevalonic acid]. | 1961 | Arch. Int. Physiol. Biochim. | pmid:13707370 |
| Cooper MF et al. | Sebaceous lipogenesis and androgen metabolism in acne. | 1976 | Biochem. Soc. Trans. | pmid:137154 |
| PATTERSON JF | Biosynthesis of squalene by rat preputial gland. | 1960 | Proc. Soc. Exp. Biol. Med. | pmid:13733368 |