| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Exostoses, Multiple Hereditary | D005097 | 3 associated lipids |
| Fasciitis | D005208 | 2 associated lipids |
| Fatigue | D005221 | 10 associated lipids |
| Fibrosarcoma | D005354 | 8 associated lipids |
| Gallbladder Diseases | D005705 | 3 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Hepatitis | D006505 | 11 associated lipids |
(e,e,e,e)-squalene
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
Cross Reference
Introduction
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (e,e,e,e)-squalene?
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
PubChem Associated disorders and diseases
What pathways are associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (e,e,e,e)-squalene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with (e,e,e,e)-squalene?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with (e,e,e,e)-squalene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bird CW et al. | Steroids and squalene in Methylococcus capsulatus grown on methane. | 1971 | Nature | pmid:4929985 |
| van Leusden HA et al. | Squalene and lanosterol synthesis in the foeto-placental unit at midgestation. | 1971 | Acta Endocrinol. | pmid:5108099 |
| Taylor RF and Ikawa M | Gas chromatography of carotenoids. | 1971 | Anal. Biochem. | pmid:5130948 |
| Boguslawski W and Zelewski L | Inhibition of cholesterol biosynthesis by the respiratory chain inhibitors in human placenta and in rat liver. | 1971 | Biochem. Pharmacol. | pmid:5132889 |
| Wells JW | Steroids in the pineal gland of the domestic fowl (Gallus domesticus): cholesterol and its biosynthesis. | 1971 | Comp. Biochem. Physiol., B | pmid:5133342 |
| van Tamelen EE et al. | Formation of A-B cis- and trans-19-norlanosterols by enzymic cyclization of 6'-norsqualene 2,3-oxide. | 1971 | J. Am. Chem. Soc. | pmid:5135874 |
| Chida N and Okamura T | Increased cholesterol-biosynthesis in familial hypercholesterolemia. | 1971 | Tohoku J. Exp. Med. | pmid:5140375 |
| Ramsey RB et al. | The biosynthesis of cholesterol and other sterols by brain tissue. Distribution in subcellular fractions as a function of time after intracerebral injection of [2-14C]-mevalonic acid. | 1971 | J. Neurochem. | pmid:5092868 |
| Tamelen EE and Schwartz MA | Mechanism of presqualene pyrophosphate-squalene biosynthesis. | 1971 | J. Am. Chem. Soc. | pmid:4323745 |
| Rilling HC et al. | Studies on the mechanism of squalene biosynthesis. Presqualene pyrophosphate, stereochemistry and a mechanism for its conversion to squalene. | 1971 | J. Am. Chem. Soc. | pmid:4323746 |
| Summerly R and Woodbury S | The in vitro incorporation of 14 C-acetate into the isolated sebaceous glands and appendage-freed epidermis of human skin. A technique for the study of lipid synthesis in the isolated sebaceous gland. | 1971 | Br. J. Dermatol. | pmid:4257140 |
| Cuncliffe WJ et al. | Skin surface lipids in acne. | 1971 | Br. J. Dermatol. | pmid:4257142 |
| Peter G and Peter R | [Studies on the composition of palmar skin surface fat in relation to age and its biochemical bases]. | 1971 | Arch Dermatol Forsch | pmid:5571755 |
| Ramsey RB et al. | The biosynthesis of cholesterol and other sterols by brain tissue. I. Subcellular biosynthesis in vitro. | 1971 | Lipids | pmid:5574907 |
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| Gaskin F and Clayton RB | An interstrain difference in cholesterol synthesis in vitro in mice, dependent upon a difference in endogenous NADPH-generating capacity. | 1972 | J. Lipid Res. | pmid:4400581 |
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| Dugan RE and Porter JW | Hog liver squalene synthetase: the partial purification of the particulate enzyme and kinetic analysis of the reaction. | 1972 | Arch. Biochem. Biophys. | pmid:4403691 |
| Walton MJ and Pennock JF | Some studies on the biosynthesis of ubiguinone, isoprenoid alcohols, squalene and sterols by marine invertebrates. | 1972 | Biochem. J. | pmid:4403925 |
| Qureshi AA et al. | Lycopersene and prelycopersene pyrophosphate. Intermediates in carotene biosynthesis. | 1972 | J. Biol. Chem. | pmid:4403969 |
| Green TR and Baisted DJ | Development of the activities of enzymes of the isoprenoid pathway during early stages of pea-seed germination. | 1972 | Biochem. J. | pmid:4348263 |
| Nitchuk WM and Ainsworth L | The de novo synthesis of sterols and cholesterol from acetate-1- 14 C by sheep and pig placental and fetal liver slices in vitro. | 1972 | Steroids | pmid:5028884 |
| Ramsey RB et al. | The biosynthesis of cholesterol and other sterols by brain tissue. Distribution in subcellular fractions as a function of time after intracerebral injection into developing brain of (2- 14 C)mevalonic. | 1972 | J. Neurochem. | pmid:5009889 |
| Downing DT et al. | Changes in skin surface lipid composition induced by severe caloric restriction in man. | 1972 | Am. J. Clin. Nutr. | pmid:5010536 |
| Gibbons GF and Mitropoulos KA | Inhibition of cholesterol biosynthesis by carbon monoxide: accumulation of lanosterol and 24,25-dihydrolanosterol. | 1972 | Biochem. J. | pmid:5073750 |
| Edkins E and Hansen IA | Wax esters secreted by the uropygial glands of some Australian waterfowl, including the magpie goose. | 1972 | Comp. Biochem. Physiol., B | pmid:5075378 |
| Cotterill JA et al. | Age and sex variation in skin surface lipid composition and sebum excretion rate. | 1972 | Br. J. Dermatol. | pmid:5077864 |
| Slakey LL et al. | The effect of starvation and re-feeding on the rates of synthesis and degradation of enzyms effecting intermediate reactions in the synthesis of cholesterol and fatty acids in rat liver. | 1972 | Biochem. J. | pmid:5085557 |
| Ramsey RB et al. | Formation of methyl sterols in brain cholesterol biosynthesis. Sterol formation in vitro in actively myelinating rat brain. | 1972 | J. Biol. Chem. | pmid:5030627 |
| Bazzano G and Bazzano GS | Hypocholesterolemic effect of -ketoglutarate in the Mongolian gerbil. | 1972 | Proc. Soc. Exp. Biol. Med. | pmid:5033114 |
| Tai HH and Bloch K | Squalene epoxidase of rat liver. | 1972 | J. Biol. Chem. | pmid:5033388 |
| Kramer JK et al. | Structure ditermination of the squalene, dihydrosqualene and tetrahydrosqualene in Halobacterium cutirubrum. | 1972 | Biochim. Biophys. Acta | pmid:5037322 |
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| Ogura K et al. | Enzymic formation of squalene homologs from farnesyl Pyrophosphate homologs. | 1972 | J. Am. Chem. Soc. | pmid:4332125 |
| Slakey LL et al. | The effects of fasting, refeeding, and time of day on the levels of enzymes effecting the conversion of -hydroxy- -methylglutaryl-coenzyme A to squalene. | 1972 | J. Biol. Chem. | pmid:4337504 |
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| Stone KJ and Strominger JL | Inhibition of sterol biosynthesis by bacitracin. | 1972 | Proc. Natl. Acad. Sci. U.S.A. | pmid:4338587 |
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| Singh EJ et al. | Hydrocarbons in human cervical mucus and the effect of oral contraception. | 1972 | J Reprod Med | pmid:4113025 |
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| Sipe JD and Holmlund CE | A comparison of the effects of some hypocholesteremic compounds on squalene metabolism in Tetrahymena pyriformis and rat liver. | 1972 | Biochim. Biophys. Acta | pmid:4116026 |