(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Dugan RE and Porter JW | Hog liver squalene synthetase: the partial purification of the particulate enzyme and kinetic analysis of the reaction. | 1972 | Arch. Biochem. Biophys. | pmid:4403691 |
Okada S et al. | Molecular characterization of squalene synthase from the green microalga Botryococcus braunii, race B. | 2000 | Arch. Biochem. Biophys. | pmid:10620354 |
Trocha PJ and Sprinson DB | Location and regulation of early enzymes of sterol biosynthesis in yeast. | 1976 | Arch. Biochem. Biophys. | pmid:7207 |
Lopez D et al. | Compensatory responses to inhibition of hepatic squalene synthase. | 1998 | Arch. Biochem. Biophys. | pmid:9514656 |
Sasiak K and Rilling HC | Purification to homogeneity and some properties of squalene synthetase. | 1988 | Arch. Biochem. Biophys. | pmid:3277535 |
SCHWENK E et al. | Studies on the biosynthesis of cholesterol. VI. Companions of cholesterol-C14 in liver perfusions, including squalene-C14 as possible precursors in its biosynthesis. | 1954 | Arch. Biochem. Biophys. | pmid:13139684 |
Fujita H et al. | Chlorpromazine-sensitized photooxidation of squalene. | 1986 | Arch. Dermatol. Res. | pmid:3729541 |
Fujie T et al. | Culture of cells derived from the human sebaceous gland under serum-free conditions without a biological feeder layer or specific matrices. | 1996 | Arch. Dermatol. Res. | pmid:8931874 |
Yamamoto A et al. | Impaired water barrier function in acne vulgaris. | 1995 | Arch. Dermatol. Res. | pmid:7763094 |
Gosselin L | [Utilization of farnesyl pyrophosphate by rat liver microsomes in the absence of nicotinamide adenine dinucleotides]. | 1964 | Arch. Int. Physiol. Biochim. | pmid:4157959 |