(e,e,e,e)-squalene

(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.

Cross Reference

Introduction

To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (e,e,e,e)-squalene?

(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene

MeSH term MeSH ID Detail
Cholestasis D002779 23 associated lipids
Lymphoma, B-Cell D016393 24 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Brain Diseases D001927 27 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
Micronuclei, Chromosome-Defective D048629 33 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Acne Vulgaris D000152 35 associated lipids
Nervous System Diseases D009422 37 associated lipids
Arthritis D001168 41 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Occupational Diseases D009784 42 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Leukemia P388 D007941 43 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Psoriasis D011565 47 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with (e,e,e,e)-squalene

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with (e,e,e,e)-squalene?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (e,e,e,e)-squalene?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with (e,e,e,e)-squalene

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Per page 10 20 50 100 | Total 1766
Authors Title Published Journal PubMed Link
Yamamoto S and Bloch K Enzymatic studies on the oxidative cyclizations of squalene. 1970 Biochem. Soc. Symp. pmid:4400141
Werthemann L and Johnson WS Application of the chloro ketal Claisen reaction to the total synthesis of squalene. 1970 Proc. Natl. Acad. Sci. U.S.A. pmid:5274470
Werthemann L and Johnson WS Application of the chloro ketal claisen reaction to the total synthesis of squalene. Experimental details. 1970 Proc. Natl. Acad. Sci. U.S.A. pmid:5275377
Morton RA Natural substances formed biologically from mevalonic acid. Chairman's opening remarks. 1970 Biochem. Soc. Symp. pmid:4944436
Van TAMELEN EE and Freed JH Biochemical conversion of partially cyclized squalene 2,3-oxide types to the lanosterol system. Views on the normal enzymic cyclization process. 1970 J. Am. Chem. Soc. pmid:4098774
Epstein WW and Rilling HC Studies on the mechanism of squalene biosynthesis. The structure of presqualene pyrophosphate. 1970 J. Biol. Chem. pmid:4318477
Rilling HC Biosynthesis of presqualene pyrophosphate by liver microsomes. 1970 J. Lipid Res. pmid:4322765
Robinson DR and West CA Biosynthesis of cyclic diterpenes in extracts from seedlings of Ricinus communis L. I. Identification of diterpene hydrocarbons formed from mevalonate. 1970 Biochemistry pmid:5411208
Ramasastry P et al. Chemical composition of human skin surface lipids from birth to puberty. 1970 J. Invest. Dermatol. pmid:5414607
Sloviter HA et al. Biosynthesis of cholesterol in rabbit reticulocytes and its exchange with plasma. 1970 J. Lipid Res. pmid:5418482
Sargent JR et al. Metabolism of mevalonic acid in the liver of the dogfish Scyliorhinus caniculus. 1970 Biochem. J. pmid:5420034
Miettinen TA et al. Serum squalene and methyl sterols. 1970 N. Engl. J. Med. pmid:5470273
Peter G et al. [Gas chromatographic examinations of sebaceous gland lipids. I. Total lipid determination]. 1970 Arch Klin Exp Dermatol pmid:5477881
el-Ibrashy MT and Mansour MH Hormonal action of certain biologically active compounds in Agrotis ypsilon larvae. 1970 Experientia pmid:5483755
Pochi PE et al. Sebaceous gland response in man to prolonged total caloric deprivation. 1970 J. Invest. Dermatol. pmid:5483834
Brooks CJ et al. Lipids of human atheroma. VI. Hydrocarbons of the atheromatous plaque. 1970 Lipids pmid:5488810
Jayme M et al. The nature of the hydrogen migrations in the cyclization of squalene oxide to lanosterol. 1970 J. Am. Chem. Soc. pmid:5435274
van Tamelen EE et al. Minimal substrate structural requirements for lanosterol-squalene 2,3-oxide cyclase action. 10'-norsqualene 2,3-oxide. 1970 J. Am. Chem. Soc. pmid:5435278
Phytochemistry: terpenoids for progress. 1970 Nature pmid:5437511
Yamamoto S and Bloch K Studies on squalene epoxidase of rat liver. 1970 J. Biol. Chem. pmid:5438357
Gallin JI et al. Increased serum levels of seualene in patients with acute influenza. 1970 N. Engl. J. Med. pmid:5442630
Zander JM et al. Tetrahymanol biosynthesis. Studies in vitro on squalene cyclization. 1970 J. Biol. Chem. pmid:5442819
Rahman R et al. Removal of the 4,4-dimethyl carbons in the enzymic conversion of lanosterol to cholesterol. Initial loss of the 4-alpha-methyl group. 1970 J. Biol. Chem. pmid:5445804
Corey EJ and Yamamoto H Correlation of a protosterol from 20,21-dehydro-2,3-oxidosqualene and 2,3-oxidosqualene-sterol cyclase with dihydrolanosterol. 1970 Tetrahedron Lett. pmid:5447652
Kligman AM et al. Comedogenicity of human sebum. 1970 Arch Dermatol pmid:4247928
Godinez MH et al. The biosynthesis of isoprenoid lipids including ubiquinone in muscle from normal and genetically dystrophic mice. 1970 Arch. Biochem. Biophys. pmid:5460184
Caspi E and Mulheirn LJ Mechanism of squalene cyclization. Biosynthesis of fusidic acid from (4R)-[2-14C,43H]mevalonic acid. 1970 J. Am. Chem. Soc. pmid:5460747
Villee CA Shark oil and medicine. 1970 N. Engl. J. Med. pmid:5462581
St Clair RW et al. Influence of atherosclerosis on the composition, synthesis, and esterification of lipids in aortas of squirrel monkeys (Saimiri sciureus). 1969 Sep-Oct J Atheroscler Res pmid:4986077
Kelley MT et al. Biosynthesis of squalene and cholesterol by cell-free extracts of adult rat brain. 1969 J. Lipid Res. pmid:4305711
Sofer SS and Rilling HC Mechanism of squalene biosynthesis: evidence against the involvement of free nerolidyl pyrophosphate. 1969 J. Lipid Res. pmid:4305712
Etemadi AH et al. Assay of the possible organization of particle-bound enzymes with squalene synthetase and squalene oxidocyclase systems. 1969 Biochem. J. pmid:4388240
Popják G et al. Biosynthesis and structure of a new intermediate between farnesyl pyrophosphate and squalene. 1969 J. Biol. Chem. pmid:4388617
Fabre-Joneau M et al. [The nature and distribution of hydrocarbons in the yeast Candida utilis]. 1969 C.R. Hebd. Seances Acad. Sci., Ser. D, Sci. Nat. pmid:4980247
Frayha GJ and Fairbairn D Lipid metabolism in helminth parasites--VI. Synthesis of 2-cis,6-trans farnesol by Hymenolepis diminuta (Cestoda). 1969 Comp. Biochem. Physiol. pmid:4306773
Suzue G and Porter JW Enzymatic synthesis of lycopene from [4-14C]isopentenyl pyrophosphate. 1969 Biochim. Biophys. Acta pmid:4308120
Hayaishi O and Nozaki M Nature and mechanisms of oxygenases. 1969 Science pmid:4304952
Akhtar M et al. The incorporation of a hydrogen atom at C-15 of cholesterol biosynthesized from squalene. 1969 Biochem. J. pmid:5343788
Gershbein LL and Singh EJ Hydrocarbons of dogfish and cod livers and herring oil. 1969 J Am Oil Chem Soc pmid:5345048
Downing DT et al. Variability in the chemical composition of human skin surface lipids. 1969 J. Invest. Dermatol. pmid:5347411
Partin JC and Schubert WK Small intestinal mucosa in cholesterol ester storage disease. A light and electron microscope study. 1969 Gastroenterology pmid:5348089
Ramm PJ and Caspi E The stereochemistry of tritium at carbon atoms 1, 7, and 15 in cholesterol derived from (3R,2R)-(2-3H)-mevalonic acid. 1969 J. Biol. Chem. pmid:5350956
Lewis RW Distribution of dietary squalene in a wandering Albatross, diomedea exultans. 1969 Nature pmid:5358352
Eneroth P et al. Steroids in newborns and infants. Identification of 24,25-dihydro-delta-9(ll)-lanosterol and 4 alpha, 14 alpha-dimethyl substituted sterols among the esterified and free sterols in human meconium. 1969 Eur. J. Biochem. pmid:5368336
Schlösser E et al. Sterols in species of Pythium. 1969 Arch Mikrobiol pmid:5384630
Yamamoto S et al. Some properties of the microsomal 2,3-oxidosqualene sterol cyclase. 1969 Proc. Natl. Acad. Sci. U.S.A. pmid:5257956
Porcellati G and Giorgini D The effect of alpha-methyl gamma-phenyl butyric acid on sterol biosynthesis in vitro. 1969 Biochem. Pharmacol. pmid:5772592
Goad LJ and Goodwin TW Studies in phytosterol biosynthesis: observations on the biosynthesis of fucosterol in the marine brown alga Fucus spiralis. 1969 Eur. J. Biochem. pmid:5780485
Eppenberger U et al. [Anerobic cyclization of squalen-2,3-epoxide to cycloartenol in Nicotiana tabacum L. tissue cultures]. 1969 Eur. J. Biochem. pmid:5781271
Ikekawa N et al. Determination of morphine in urine by gas chromatography. 1969 Anal. Biochem. pmid:5781407
Akhtar M et al. The role of a cholesta-8,14-dien-3-beta-ol system in cholesterol biosynthesis. 1969 Biochem. J. pmid:5783476
Tornabene TG et al. Occurrence of squalene, di- and tetrahydrosqualenes, and vitamin MK8 in an extremely halophilic bacterium, Halobacterium cutirubrun. 1969 J. Lipid Res. pmid:5785002
Porcellati G et al. Inhibition of cholesterol synthesis by beta-benzal butyric acid and derivatives. 1969 Lipids pmid:5785689
Boyd GS and Onajobi FD Control of cholesterol biosynthesis by a plasma apo-lipoprotein. 1969 Nature pmid:5789314
Saxena SC and Zandee DI Biosynthesis of fatty acids and cholesterol in a fresh-water carp, "Scardinius erythrophthalmus" from sodium acetate-1-14C. 1969 Arch. Int. Physiol. Biochim. pmid:4188405
Theiner M and Friedman L Characterization of rat tissues by gas-liquid chromatography with the electron capture detector. 1969 Proc. Soc. Exp. Biol. Med. pmid:4183040
Witiak DT et al. Inhibition of cholesterolgenesis in vitro by chlorophenoxyacetic acids. Effect of alpha-methyl groups. 1969 J. Med. Chem. pmid:5793168
Rees HH et al. 2,3-oxidosqualene cycloartenol cyclase from Ochromonas malhamensis. 1969 Biochim. Biophys. Acta pmid:5797101
Walton TJ et al. Biosynthesis of xanthophylls in higher plants: stereochemistry of hydroxylation at C-3. 1969 Biochem. J. pmid:5801311
Miettinen TA Serum squalene and methyl sterols as indicators of cholesterol synthesis in vivo. 1969 Life Sci. pmid:5801489
Foti L et al. Biosynthesis of cholesterol from long-chain fatty acids in cell-free systems from rat liver. 1969 Life Sci. pmid:5804653
Yamamoto S and Bloch K On the enzymes catalysing the transformation of squalene to lanosterol. 1969 Biochem. J. pmid:5807185
Higgins MJ and Kekwick RG The role of malonyl-coenzyme A in isoprenoid biosynthesis. 1969 Biochem. J. pmid:5807201
Frayha GJ A study of the synthesis and absorption of cholesterol in hydatid cysts (Echinococcus granulosus). 1968 Comp. Biochem. Physiol. pmid:5710286
Suzue G et al. Presence of squalene in Staphylococcus. 1968 Arch. Biochem. Biophys. pmid:5650319
Dempsey ME Inhibition of lipid biosynthesis. 1968 Ann. N. Y. Acad. Sci. pmid:4385358
Scallen TJ et al. Enzymatic conversion of squalene to cholesterol by an acetone powder of rat liver microsomes. 1968 J. Biol. Chem. pmid:4386511
Lofland HB et al. Atherosclerosis in Cebus monkeys. II. Arterial metabolism. 1968 Exp. Mol. Pathol. pmid:4969998
Cornforth JW Olefin alkylation in biosynthesis. 1968 Angew. Chem. Int. Ed. Engl. pmid:4976264
Sih CJ and Whitlock HW Biochemistry of steroids. 1968 Annu. Rev. Biochem. pmid:4875723
Rees HH et al. Studies in phytosterol biosynthesis. Mechanism of biosynthesis of cycloartenol. 1968 Biochem. J. pmid:4297048
Jollow D et al. The biogenesis of mitochondria. 3. The lipid composition of aerobically and anaerobically grown Saccharomyces cerevisiae as related to the membrane systems of the cells. 1968 J. Cell Biol. pmid:4297785
Shafai T and Lewin LM Effects of myo-inositol deficiency upon the lipid composition of the yeast, Saccharomyces carlsbergensis. 1968 Biochim. Biophys. Acta pmid:4298231
McLaren L et al. Dense-gas chromatography of nonvolatile substances of high molecular weight. 1968 Science pmid:5634909
Chorbanian AV Sterol synthesis in the human arterial intima. 1968 J. Clin. Invest. pmid:5637146
Clayton RB et al. The role of substrate structure in the initiation of enzymic cyclization of squalene 2,3-oxide. Studies with 2,3-cis-1'-norsqual ene 2,3-oxide and 2,3-trans-1'-norsqualene 2,3-oxide. 1968 J. Am. Chem. Soc. pmid:5638313
Rees HH et al. The biosynthesis of beta-amyrin. Mechanism of squalene cyclization. 1968 Biochem. J. pmid:5639923
Rees HH et al. Cyclization of 2,3-oxidosqualene to cycloartenol in a cell-free system from higher plants. 1968 Tetrahedron Lett. pmid:5640097
Aaronson S and Fulco L Effect of hypocholesteremic compounds on bacterial multiplication. 1968 J. Gen. Microbiol. pmid:5640227
Chesterton CJ Distribution of cholesterol precursors and other lipids among rat liver intracellular structures. 1968 J. Biol. Chem. pmid:5646164
St Clair RW et al. Synthesis of squalene and sterols by isolated segments of human and pigeon arteries. 1968 Exp. Mol. Pathol. pmid:5647248
Scallen TJ et al. Enzymatic conversion of squalene to cholesterol by an acetone powder of rat liver microsomes. 1968 Biochem. Biophys. Res. Commun. pmid:5653642
Dada OA et al. Biosynthesis of phytoquinones. Stereospecific biosynthesis of the polyprenyl side chains of terpenoid quinones and chromanols in maize shoots. 1968 Eur. J. Biochem. pmid:5653765
Wepierre J et al. Percutaneous absorption and removal by the body fluids of 14C ethyl alcohol, 3H perhydrosqualene and 14C p-cymene. 1968 Eur. J. Pharmacol. pmid:5654669
Gianelly AA and Terner C Inhibition of cholesterol biosynthesis by dehydroepiandrosterone in lactating mammary gland. 1968 Endocrinology pmid:4177463
Locke DC Chromatographic study of solutions of hydrocarbons in acetonitrile. 1968 J. Chromatogr. pmid:5656425
Voogt PA Investigations of the capacity of synthesizing 3 beta-sterols in Mollusca. 3. The biosynthesis of 3 beta-sterols in some archeogastropods. 1968 Arch. Int. Physiol. Biochim. pmid:4178041
Bighi C et al. Interpretation of gas chromatographic data. Hydrocarbons and aromatic compounds on Carbowax 400. 1968 J. Chromatogr. pmid:5658564
Giddings JC et al. High pressure gas chromatography of nonvolatile species. Compressed gas is used to cause migration of intractable solutes. 1968 Science pmid:5675186
De Souza NJ and Nes WR Sterols: isolation from a blue-green alga. 1968 Science pmid:5677529
White HB et al. The occurrence of squalene in kipid of fowlpox virus. 1968 J. Biol. Chem. pmid:5684008
Scharf SS and Simpson KL Attempts to detect lycopersene formation in yeast. 1968 Biochem. J. pmid:5753091
Merdinger E et al. Composition of lipids in extracts of Pullularia pullulans. 1968 Can. J. Microbiol. pmid:5693067
Caspi E et al. The biosynthesis of tetrahymanol in vitro. 1968 Biochem. J. pmid:5696872
Ackman RG et al. Unusual occurrence of squalene in a fish, the eulachon Thaleichthys pacificus. 1968 Nature pmid:5701840
Conner RL et al. Cholesterol inhibition of pentacyclic triterpenoid biosynthesis in Tetrahymena pyriformis. 1968 J. Protozool. pmid:5703082
Suzuki R Specific requirements of bile salts for absorption of cholesterol from the intestine. 1968 Keio J Med pmid:5715537
Mukherjee S and Bhose A Studies on estrogen regulation of cholesterol biosynthesis in rat liver microsomes. 1968 Biochim. Biophys. Acta pmid:5721032
Threlfall DR et al. Biosynthesis of phytoquinones. Incorporation of L-[Me-14C,3H]methionine into terpenoid quinones and chromanols in maize shoots. 1968 Biochem. J. pmid:5721452
Autrum H et al. [Squalene in the glandular secretion of mammals]. 1968 Naturwissenschaften pmid:5726004