(e,e,e,e)-squalene
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
Cross Reference
Introduction
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (e,e,e,e)-squalene?
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
PubChem Associated disorders and diseases
What pathways are associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (e,e,e,e)-squalene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with (e,e,e,e)-squalene?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with (e,e,e,e)-squalene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| HORLICK L and AVIGAN J | STEROLS OF SKIN IN THE NORMAL AND TRIPARANOL-TREATED RAT. | 1963 | J. Lipid Res. | pmid:14168146 |
| LUPIEN PJ et al. | EFFECT OF AN ANTIBIOTIC ON LIPID FRACTIONS IN PLASMS AND EGG YOLK OF LAYING HENS. | 1963 | Can J Biochem Physiol | pmid:14083981 |
| JACHYMCZYK W | [Biosynthesis of triterpenoid compounds]. | 1963 | Postepy Biochem. | pmid:13957182 |
| BEELER DA et al. | The biosynthesis of squalene from mevalonic acid-2-C-14 and farnesyl pyrophosphate-4,8,12-C-14 by carrot and tomato enzymes. | 1963 | Arch. Biochem. Biophys. | pmid:13970235 |
| SAMUELSSON B and GOODMAN DS | Stereochemistry of the hydrogen transfer to squalene during its biosynthesis from farnesyl pyrophosphate. | 1963 | Biochem. Biophys. Res. Commun. | pmid:13976173 |
| CAPSTACK E et al. | The biosynthesis of squalene in germinating seeds of Pisum sativum. | 1962 | Biochemistry | pmid:14018475 |
| ALAM SQ et al. | Detection and estimation of squalene in leaves. | 1962 | Nature | pmid:13860005 |
| GOSSELIN L et al. | Particulate enzyme system for the synthesis of squalene from 2-(14C)-mevalonic acid. | 1962 | Nature | pmid:13900654 |
| GOSSELIN L | Utilization of (2-14C) mevalonic acid by rat liver cell fraction: evidence for an attachment of a squalene precursor to a cellular component insoluble at acid pH. | 1962 | Arch. Int. Physiol. Biochim. | pmid:13900655 |
| CHILDS CR and BLOCH K | Further observations on the biosynthesis of squalene. | 1962 | J. Biol. Chem. | pmid:13878983 |
| HOLMES WL and STACK E | Gas chromatography of squalene, sterols and bile acid methyl esters. | 1962 | Biochim. Biophys. Acta | pmid:13908533 |
| POPJAK G et al. | Studies on the biosynthesis of cholesterol. XVI. Chemical synthesis of 1-H2-3-2-C-14- and 1-D2-2-C-14-trans-trans-farnesyl pyrophosphate and their utilization in squalene biosynthesis. | 1962 | J. Biol. Chem. | pmid:14487886 |
| POPJAK G et al. | Sterospecificity of hydrogen transfer from reduced triphosphopyridine nucleotide to squalene during its synthesis from farnesyl pyrophosphate. | 1962 | Biochem. Biophys. Res. Commun. | pmid:14487887 |
| ROTHBLAT GH et al. | A quantitative colorimetric assay for squalene. | 1962 | Anal. Biochem. | pmid:14494417 |
| GAYLOR JL | Anaerobic conversion of acetate to squalene by rat skin. | 1961 | Proc. Soc. Exp. Biol. Med. | pmid:13704081 |
| GOODMAN DS | Studies on the conversion of squalene to sterol with rat liver enzymes. | 1961 | J. Biol. Chem. | pmid:13707027 |
| GOSSELIN L and PODBER-WAGNER E | [New observations on the particles interfering in the biosynthesis of squalene from mevalonic acid]. | 1961 | Arch. Int. Physiol. Biochim. | pmid:13707370 |
| SEDEE PD | Intermediary metabolism in aseptically reared blowfly larvae, Calliphora erythrocephala (Meig.). I. Buosynthesis of squalene and cholesterol. | 1961 | Arch. Int. Physiol. Biochim. | pmid:13749584 |
| POPJAK G et al. | Mechanism of squalene biosynthesis from mevalonate and farnesyl pyrophosphate. | 1961 | Biochem. Biophys. Res. Commun. | pmid:13737103 |
| POPJAK G et al. | Studies on the biosynthesis of cholesterol. XV. Mechanism of squalene biosynthesis from farnesyl pyrophosphate and from mevalonate. | 1961 | J. Biol. Chem. | pmid:13737104 |
| MELCHIORRI-SANTOLINI U and RENZINI G | [Detection of sterols and squalene in sporigenic bacteria]. | 1960 Nov-Dec | Nuovi Ann Ig Microbiol | pmid:13769177 |
| RENZINI G | [Detection of sterols and squalene in B. coli aerogenes]. | 1960 Nov-Dec | Nuovi Ann Ig Microbiol | pmid:13740904 |
| WOOTTON JM and WRIGHT LD | Biosynthesis of squalene by the annelid Lumbricus terrestris. | 1960 | Nature | pmid:13786660 |
| GOODMAN DS and POPJAK G | Studies on the biosynthesis of cholesterol. XII. Synthesis of allyl pyrophosphates from mevalonate and their conversion into squalene with liver enzymes. | 1960 | J. Lipid Res. | pmid:13851061 |
| PATTERSON JF | Biosynthesis of squalene by rat preputial gland. | 1960 | Proc. Soc. Exp. Biol. Med. | pmid:13733368 |
| ANDERSON DG et al. | The conversion of farnesyl pyrophosphate to squalene by soluble extracts of microsomes. | 1960 | Biochem. Biophys. Res. Commun. | pmid:13683185 |
| SCHOEN H and FAHSOLD W | [Studies on the problem of resorption of squalene]. | 1960 | Klin. Wochenschr. | pmid:14443328 |
| WITTING LA and PORTER JW | Intermediates in the conversion of mevalonic acid to squalene by a rat liver enzyme system. | 1959 | J. Biol. Chem. | pmid:13845505 |
| KROENING F | [On the induction of leukemia in C57B1 mice following painting of the dorsal part of the skin with short-chain fatty acids, fatty acid esters and with squalene]. | 1959 | Acta Unio Int Contra Cancrum | pmid:13848508 |
| NICHOLAS HJ and THOMAS BE | Intracerebral incorporation of [2-14C]mevalonic acid into adult rat brain squalene and cholesterol. | 1959 | Biochim. Biophys. Acta | pmid:13854106 |
| MARKLEY K and GURIN S | Decarboxylation of mevalonic acid and conversion to squalene; enzyme fractionation and cofactors. | 1959 | Biochim. Biophys. Acta | pmid:13628647 |
| RILLING HC and BLOCH K | On the mechanism of squaiene biogenesis from mevalonic acid. | 1959 | J. Biol. Chem. | pmid:13654391 |
| CORNFORTH JW et al. | Studies on the biosynthesis of cholesterol. 5. Biosynthesis of squalene from DL-3-hydroxy-3-methyl [2-14C] pentano-5-lactone. | 1958 | Biochem. J. | pmid:13535596 |
| WOLFF RE and GODEFROY N | [Transformation of synthetic squalene (11, 1414C) to cholesterol in rats]. | 1958 | C. R. Hebd. Seances Acad. Sci. | pmid:13537384 |
| WOLFF RE and PICHAT L | [Synthesis of 11,14-C14-squalene]. | 1958 | C. R. Hebd. Seances Acad. Sci. | pmid:13537435 |
| EIDINOFF ML et al. | Cholesterol biosynthesis: studies related to the metabolic role of squalene. | 1958 | J. Clin. Invest. | pmid:13539207 |
| POPJAK G et al. | Studies on the biosynthesis of cholesterol. 6. Coenzyme requirements of liver enzymes for synthesis of squalene and of sterol from DL-3-hydroxy-3-methyl-[2-14C] pentano-5-lactone. | 1958 | Biochem. J. | pmid:13546172 |
| LOUD AV and BUCHER NL | The turnover of squalene in relation to the biosynthesis of cholesterol. | 1958 | J. Biol. Chem. | pmid:13563436 |
| BOUGHTON B et al. | Studies of sebum. VIII. Observations on the squalene and cholesterol content and the possible functions of squalene in human sebum. | 1957 | Biochem. J. | pmid:13426103 |
| HELLER JH et al. | Squalene content of various shark livers. | 1957 | Nature | pmid:13430738 |
| TCHEN TT and BLOCH K | On the conversion of squalene to lanosterol in vitro. | 1957 | J. Biol. Chem. | pmid:13438881 |
| TCHEN TT and BLOCH K | On the mechanism of enzymatic cyclization of squalene. | 1957 | J. Biol. Chem. | pmid:13438882 |
| SOBEL H et al. | Determinations of squalene in sebum from the forehead of patients with skin cancer. | 1957 | J. Invest. Dermatol. | pmid:13491890 |
| DITURI F et al. | Precursors of squalene and cholesterol. | 1957 | J. Biol. Chem. | pmid:13502345 |
| VILLALBA GOMEZ GM | [Squalene index]. | 1956 May-Aug | Rev Sanid Asist Soc | pmid:13379961 |
| SQUALENE and cholesterol synthesis in the human skin. | 1956 | Nutr. Rev. | pmid:13309889 | |
| DITURI F et al. | Terpenoid intermediates in the biosynthesis of cholesterol. | 1956 | J. Biol. Chem. | pmid:13345809 |
| NICOLAIDES N and ROTHMAN S | The site of sterol and squalene synthesis in the human skin. | 1955 | J. Invest. Dermatol. | pmid:14354270 |
| BOUGHTON B et al. | Some observations of the nature, origin and possible function of the squalene and other hydrocarbons of human sebum. | 1955 | J. Invest. Dermatol. | pmid:14354278 |
| MACKENNA RM et al. | Squalene and other hydrocarbons in human sebum. | 1955 | J. Physiol. (Lond.) | pmid:14354699 |
| DICKHART W | The squalene contents of various oils. | 1955 | Am J Pharm Sci Support Public Health | pmid:13275573 |
| RABINOWITZ JL et al. | Branched chain acids in the biosynthesis of squalene and cholesterol. | 1955 | Fed. Proc. | pmid:13262139 |
| CORNFORTH JW and POPJAK G | Studies on the biosynthesis of cholesterol. 3. Distribution of 14C in squalene biosynthesized from [Me-14C]acetate. | 1954 | Biochem. J. | pmid:13208629 |
| SQUALENE, a precursor of cholesterol. | 1954 | Nutr. Rev. | pmid:13166142 | |
| EIDINOFF ML et al. | The biosynthesis of squalene from acetate in man. | 1954 | J. Clin. Invest. | pmid:13143078 |
| POPJAK G | Biosynthesis of squalene and cholesterol in vitro from acetate-1-C14. | 1954 | Arch. Biochem. Biophys. | pmid:13125576 |
| SCHWENK E et al. | Studies on the biosynthesis of cholesterol. VI. Companions of cholesterol-C14 in liver perfusions, including squalene-C14 as possible precursors in its biosynthesis. | 1954 | Arch. Biochem. Biophys. | pmid:13139684 |
| WHEATLEY VR | Studies of sebum. IV. The estimation of squalene in sebum and sebum-like materials. | 1953 | Biochem. J. | pmid:13115346 |
| LANGDON RG and BLOCH K | The biosynthesis of squalene. | 1953 | J. Biol. Chem. | pmid:13034767 |
| LANGDON RG and BLOCH K | The utilization of squalene in the biosynthesis of cholesterol. | 1953 | J. Biol. Chem. | pmid:13034768 |
| NICOLAIDES N and ROTHMAN S | Studies on the chemical composition of human hair fat. I. The squalene-cholesterol relationship in children and adults. | 1952 | J. Invest. Dermatol. | pmid:13023010 |
| DALE J | Dehydrogenation of squalene with N-bromosuccinimide. | 1952 | Arch. Biochem. Biophys. | pmid:13008464 |
| FLESCH P | Hair loss from squalene. | 1951 | Proc. Soc. Exp. Biol. Med. | pmid:14844354 |
| HIGH EG and DAY HG | Effects of different amounts of lutein, squalene, phytol and related substances on the utilization of carotene and vitamin A for storage and growth in the rat. | 1951 | J. Nutr. | pmid:14851042 |
| HADORN H and JUNGKUNZ R | [Further studies on squalene. 4]. | 1950 | Mitt Lebensmittelunters Hyg | pmid:14806249 |
| SOBEL H | Squalene in sebum and sebum-like materials. | 1949 | J. Invest. Dermatol. | pmid:15398762 |