(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Naughton C et al. | Transcription forms and remodels supercoiling domains unfolding large-scale chromatin structures. | 2013 | Nat. Struct. Mol. Biol. | pmid:23416946 |
Naziri E and Tsimidou MZ | Formulated squalene for food related applications. | 2013 | Recent Pat Food Nutr Agric | pmid:23270393 |
Morimoto Y et al. | Biomimetic epoxide-opening cascades of oxasqualenoids triggered by hydrolysis of the terminal epoxide. | 2013 | Org. Lett. | pmid:23721415 |
Van Damme P et al. | Long-term persistence of humoral and cellular immune responses induced by an AS03A-adjuvanted H1N1 2009 influenza vaccine: an open-label, randomized study in adults aged 18-60 years and older. | 2013 | Hum Vaccin Immunother | pmid:23571166 |
Guan X et al. | Immunotherapeutic efficiency of a tetravalent Aβ1-15 vaccine in APP/PS1 transgenic mice as mouse model for Alzheimer's disease. | 2013 | Hum Vaccin Immunother | pmid:23732905 |
Goff PH et al. | Adjuvants and immunization strategies to induce influenza virus hemagglutinin stalk antibodies. | 2013 | PLoS ONE | pmid:24223176 |
Lepeltier E et al. | Self-assembly of squalene-based nucleolipids: relating the chemical structure of the bioconjugates to the architecture of the nanoparticles. | 2013 | Langmuir | pmid:24219056 |
Candela S et al. | An early (3-6 weeks) active surveillance study to assess the safety of pandemic influenza vaccine Focetria in a province of Emilia-Romagna region, Italy - part one. | 2013 | Vaccine | pmid:22766247 |
Dosio F et al. | Ruthenium polypyridyl squalene derivative: a novel self-assembling lipophilic probe for cellular imaging. | 2013 | Int J Pharm | pmid:22824513 |
Ventura R et al. | Technology transfer of an oil-in-water vaccine-adjuvant for strengthening pandemic influenza preparedness in Indonesia. | 2013 | Vaccine | pmid:22884665 |
Moro ML et al. | A population based cohort study to assess the safety of pandemic influenza vaccine Focetria in Emilia-Romagna region, Italy - part two. | 2013 | Vaccine | pmid:22885015 |
Ruiz-Aragón J et al. | [Assessment of the MF59-adjuvanted pandemic influenza A/H1N1 vaccine. Systematic review of literature]. | 2013 | An Pediatr (Barc) | pmid:23490433 |
Yüzbaşıoğlu D et al. | Genotoxicity assessment of vaccine adjuvant squalene. | 2013 | Food Chem. Toxicol. | pmid:23454296 |
Malmierca MG et al. | Relevance of trichothecenes in fungal physiology: disruption of tri5 in Trichoderma arundinaceum. | 2013 | Fungal Genet. Biol. | pmid:23454546 |
RodrÃguez-López J et al. | Epoxide-opening cascades triggered by a Nicholas reaction: total synthesis of teurilene. | 2013 | Angew. Chem. Int. Ed. Engl. | pmid:23436322 |
Skowronski DM et al. | Re: "effectiveness of adjuvanted influenza vaccination in elderly subjects in northern Italy". | 2013 | Am. J. Epidemiol. | pmid:23436898 |
Hosogaya N et al. | The heme-binding protein Dap1 links iron homeostasis to azole resistance via the P450 protein Erg11 in Candida glabrata. | 2013 | FEMS Yeast Res. | pmid:23496820 |
Wijnans L et al. | Effectiveness of MF59â„¢ adjuvanted influenza A(H1N1)pdm09 vaccine in risk groups in the Netherlands. | 2013 | PLoS ONE | pmid:23646191 |
Gavaldà J et al. | Immunogenicity of pandemic influenza A H1N1/2009 adjuvanted vaccine in pediatric solid organ transplant recipients. | 2013 | Pediatr Transplant | pmid:23692602 |
Calabro S et al. | The adjuvant effect of MF59 is due to the oil-in-water emulsion formulation, none of the individual components induce a comparable adjuvant effect. | 2013 | Vaccine | pmid:23684834 |
Bischoff AL et al. | Altered response to A(H1N1)pnd09 vaccination in pregnant women: a single blinded randomized controlled trial. | 2013 | PLoS ONE | pmid:23637733 |
Kalogeropoulos N et al. | Nutritional evaluation and health promoting activities of nuts and seeds cultivated in Greece. | 2013 | Int J Food Sci Nutr | pmid:23641668 |
Tascon M et al. | Determinations of gas-liquid partition coefficients using capillary chromatographic columns. Alkanols in squalane. | 2013 | J Chromatogr A | pmid:23659974 |
Ito R et al. | Purification, kinetics, inhibitors and CD for recombinant β-amyrin synthase from Euphorbia tirucalli L and functional analysis of the DCTA motif, which is highly conserved among oxidosqualene cyclases. | 2013 | FEBS J. | pmid:23294602 |
Zotos A et al. | Effect of baking of sardine (Sardina pilchardus) and frying of anchovy (Engraulis encrasicholus) in olive and sunflower oil on their quality. | 2013 | Food Sci Technol Int | pmid:23239760 |
O'Hagan DT et al. | The history of MF59(®) adjuvant: a phoenix that arose from the ashes. | 2013 | Expert Rev Vaccines | pmid:23256736 |
Kostyuk VA et al. | Modulation of human keratinocyte responses to solar UV by plant polyphenols as a basis for chemoprevention of non-melanoma skin cancers. | 2013 | Curr. Med. Chem. | pmid:23210792 |
Caron J et al. | Improving the antitumor activity of squalenoyl-paclitaxel conjugate nanoassemblies by manipulating the linker between paclitaxel and squalene. | 2013 | Adv Healthc Mater | pmid:23213041 |
Rubinstein F et al. | Influenza A/H1N1 MF59 adjuvanted vaccine in pregnant women and adverse perinatal outcomes: multicentre study. | 2013 | BMJ | pmid:23381200 |
Puleston R et al. | Multi-centre observational study of transplacental transmission of influenza antibodies following vaccination with AS03(A)-adjuvanted H1N1 2009 vaccine. | 2013 | PLoS ONE | pmid:23372640 |
Kabuto H et al. | Effects of squalene/squalane on dopamine levels, antioxidant enzyme activity, and fatty acid composition in the striatum of Parkinson's disease mouse model. | 2013 | J Oleo Sci | pmid:23357814 |
Son J et al. | Immunogenicity of low-dose MF59-adjuvanted 2009 influenza A/H1N1 vaccine in dialysis patients. | 2013 | Clin. Exp. Nephrol. | pmid:22990301 |
Vera-Lastra O et al. | Autoimmune/inflammatory syndrome induced by adjuvants (Shoenfeld's syndrome): clinical and immunological spectrum. | 2013 | Expert Rev Clin Immunol | pmid:23557271 |
AÄimoviÄ J and Rozman D | Steroidal triterpenes of cholesterol synthesis. | 2013 | Molecules | pmid:23558541 |
Segura-Velázquez R et al. | Influenza vaccine: development of a novel intranasal and subcutaneous recombinant adjuvant. | 2013 | Vaccine | pmid:23746458 |
Lin YS et al. | A real-time impedance-sensing chip for the detection of emulsion phase separation. | 2013 | Electrophoresis | pmid:23765861 |
Mann JF et al. | Pulmonary delivery of DNA vaccine constructs using deacylated PEI elicits immune responses and protects against viral challenge infection. | 2013 | J Control Release | pmid:23774102 |
Puig-Barberà J et al. | MF59-adjuvanted and virosomal influenza vaccines for preventing influenza hospitalization in older people: comparative effectiveness using the Valencia health care information system. | 2013 | Vaccine | pmid:23731629 |
Vriet C et al. | From squalene to brassinolide: the steroid metabolic and signaling pathways across the plant kingdom. | 2013 | Mol Plant | pmid:23761349 |
Gilmore SF et al. | Role of squalene in the organization of monolayers derived from lipid extracts of Halobacterium salinarum. | 2013 | Langmuir | pmid:23713788 |
Okajima M et al. | Preparation and physicochemical properties of surfactant-free emulsions using electrolytic-reduction ion water containing lithium magnesium sodium silicate. | 2013 | Drug Discov Ther | pmid:23715508 |
Hong WK et al. | Characterization of a squalene synthase from the thraustochytrid microalga Aurantiochytrium sp. KRS101. | 2013 | J. Microbiol. Biotechnol. | pmid:23676912 |
Yoshimura T et al. | Solution properties and emulsification properties of amino acid-based gemini surfactants derived from cysteine. | 2013 | J Oleo Sci | pmid:23985487 |
Fu D et al. | ATR-IR study of ozone initiated heterogeneous oxidation of squalene in an indoor environment. | 2013 | Environ. Sci. Technol. | pmid:23957297 |
Van Buynder PG et al. | The comparative effectiveness of adjuvanted and unadjuvanted trivalent inactivated influenza vaccine (TIV) in the elderly. | 2013 | Vaccine | pmid:23933368 |
Vinay TN et al. | Inactivated vaccine against viral hemorrhagic septicemia (VHS) emulsified with squalene and aluminum hydroxide adjuvant provides long term protection in olive flounder (Paralichthys olivaceus). | 2013 | Vaccine | pmid:23896420 |
Ito R et al. | Effect of cation-π interactions and steric bulk on the catalytic action of oxidosqualene cyclase: a case study of Phe728 of β-amyrin synthase from Euphorbia tirucalli L. | 2013 | Chemistry | pmid:24203491 |
Rigane G et al. | Effect of storage on refined olive oil composition: stabilization by addition of chlorophyll pigments and squalene. | 2013 | J Oleo Sci | pmid:24292349 |
Esche R et al. | Online LC-GC-based analysis of minor lipids in various tree nuts and peanuts. | 2013 | J. Agric. Food Chem. | pmid:24251555 |
Ueda D et al. | Cyclization of squalene from both termini: identification of an onoceroid synthase and enzymatic synthesis of ambrein. | 2013 | J. Am. Chem. Soc. | pmid:24274794 |