(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Sofer SS and Rilling HC | Mechanism of squalene biosynthesis: evidence against the involvement of free nerolidyl pyrophosphate. | 1969 | J. Lipid Res. | pmid:4305712 |
Etemadi AH et al. | Assay of the possible organization of particle-bound enzymes with squalene synthetase and squalene oxidocyclase systems. | 1969 | Biochem. J. | pmid:4388240 |
Hayaishi O and Nozaki M | Nature and mechanisms of oxygenases. | 1969 | Science | pmid:4304952 |
Akhtar M et al. | The incorporation of a hydrogen atom at C-15 of cholesterol biosynthesized from squalene. | 1969 | Biochem. J. | pmid:5343788 |
Gershbein LL and Singh EJ | Hydrocarbons of dogfish and cod livers and herring oil. | 1969 | J Am Oil Chem Soc | pmid:5345048 |
Downing DT et al. | Variability in the chemical composition of human skin surface lipids. | 1969 | J. Invest. Dermatol. | pmid:5347411 |
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Lewis RW | Distribution of dietary squalene in a wandering Albatross, diomedea exultans. | 1969 | Nature | pmid:5358352 |
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Boyd GS and Onajobi FD | Control of cholesterol biosynthesis by a plasma apo-lipoprotein. | 1969 | Nature | pmid:5789314 |
Saxena SC and Zandee DI | Biosynthesis of fatty acids and cholesterol in a fresh-water carp, "Scardinius erythrophthalmus" from sodium acetate-1-14C. | 1969 | Arch. Int. Physiol. Biochim. | pmid:4188405 |
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Frayha GJ | A study of the synthesis and absorption of cholesterol in hydatid cysts (Echinococcus granulosus). | 1968 | Comp. Biochem. Physiol. | pmid:5710286 |
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Dempsey ME | Inhibition of lipid biosynthesis. | 1968 | Ann. N. Y. Acad. Sci. | pmid:4385358 |
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Clayton RB et al. | The role of substrate structure in the initiation of enzymic cyclization of squalene 2,3-oxide. Studies with 2,3-cis-1'-norsqual ene 2,3-oxide and 2,3-trans-1'-norsqualene 2,3-oxide. | 1968 | J. Am. Chem. Soc. | pmid:5638313 |
Rees HH et al. | The biosynthesis of beta-amyrin. Mechanism of squalene cyclization. | 1968 | Biochem. J. | pmid:5639923 |
Rees HH et al. | Cyclization of 2,3-oxidosqualene to cycloartenol in a cell-free system from higher plants. | 1968 | Tetrahedron Lett. | pmid:5640097 |
Aaronson S and Fulco L | Effect of hypocholesteremic compounds on bacterial multiplication. | 1968 | J. Gen. Microbiol. | pmid:5640227 |
Chesterton CJ | Distribution of cholesterol precursors and other lipids among rat liver intracellular structures. | 1968 | J. Biol. Chem. | pmid:5646164 |
St Clair RW et al. | Synthesis of squalene and sterols by isolated segments of human and pigeon arteries. | 1968 | Exp. Mol. Pathol. | pmid:5647248 |
Scallen TJ et al. | Enzymatic conversion of squalene to cholesterol by an acetone powder of rat liver microsomes. | 1968 | Biochem. Biophys. Res. Commun. | pmid:5653642 |
Dada OA et al. | Biosynthesis of phytoquinones. Stereospecific biosynthesis of the polyprenyl side chains of terpenoid quinones and chromanols in maize shoots. | 1968 | Eur. J. Biochem. | pmid:5653765 |
Wepierre J et al. | Percutaneous absorption and removal by the body fluids of 14C ethyl alcohol, 3H perhydrosqualene and 14C p-cymene. | 1968 | Eur. J. Pharmacol. | pmid:5654669 |
Gianelly AA and Terner C | Inhibition of cholesterol biosynthesis by dehydroepiandrosterone in lactating mammary gland. | 1968 | Endocrinology | pmid:4177463 |
Locke DC | Chromatographic study of solutions of hydrocarbons in acetonitrile. | 1968 | J. Chromatogr. | pmid:5656425 |
Voogt PA | Investigations of the capacity of synthesizing 3 beta-sterols in Mollusca. 3. The biosynthesis of 3 beta-sterols in some archeogastropods. | 1968 | Arch. Int. Physiol. Biochim. | pmid:4178041 |
Bighi C et al. | Interpretation of gas chromatographic data. Hydrocarbons and aromatic compounds on Carbowax 400. | 1968 | J. Chromatogr. | pmid:5658564 |
Giddings JC et al. | High pressure gas chromatography of nonvolatile species. Compressed gas is used to cause migration of intractable solutes. | 1968 | Science | pmid:5675186 |
De Souza NJ and Nes WR | Sterols: isolation from a blue-green alga. | 1968 | Science | pmid:5677529 |
White HB et al. | The occurrence of squalene in kipid of fowlpox virus. | 1968 | J. Biol. Chem. | pmid:5684008 |
Scharf SS and Simpson KL | Attempts to detect lycopersene formation in yeast. | 1968 | Biochem. J. | pmid:5753091 |
Merdinger E et al. | Composition of lipids in extracts of Pullularia pullulans. | 1968 | Can. J. Microbiol. | pmid:5693067 |
Caspi E et al. | The biosynthesis of tetrahymanol in vitro. | 1968 | Biochem. J. | pmid:5696872 |
Ackman RG et al. | Unusual occurrence of squalene in a fish, the eulachon Thaleichthys pacificus. | 1968 | Nature | pmid:5701840 |
Conner RL et al. | Cholesterol inhibition of pentacyclic triterpenoid biosynthesis in Tetrahymena pyriformis. | 1968 | J. Protozool. | pmid:5703082 |
Suzuki R | Specific requirements of bile salts for absorption of cholesterol from the intestine. | 1968 | Keio J Med | pmid:5715537 |
Mukherjee S and Bhose A | Studies on estrogen regulation of cholesterol biosynthesis in rat liver microsomes. | 1968 | Biochim. Biophys. Acta | pmid:5721032 |
Threlfall DR et al. | Biosynthesis of phytoquinones. Incorporation of L-[Me-14C,3H]methionine into terpenoid quinones and chromanols in maize shoots. | 1968 | Biochem. J. | pmid:5721452 |
Autrum H et al. | [Squalene in the glandular secretion of mammals]. | 1968 | Naturwissenschaften | pmid:5726004 |