(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Fujita H and Matsuo I | In vitro phototoxic activities of new quinolone antibacterial agents: lipid peroxidative potentials. | 1994 | Photodermatol Photoimmunol Photomed | pmid:7880759 |
Someya K et al. | The antioxidant effect of palm fruit carotene on skin lipid peroxidation in guinea pigs as estimated by chemiluminescence-HPLC method. | 1994 | J. Nutr. Sci. Vitaminol. | pmid:7844638 |
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Fliesler SJ et al. | Isoprenoid lipid metabolism in the retina: dynamics of squalene and cholesterol incorporation and turnover in frog rod outer segment membranes. | 1995 | Exp. Eye Res. | pmid:7720806 |
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Morin RJ and Srikantaiah MV | In vitro conversion of squalene from squalene-phospholipid liposomes into sterols by rat liver microsomes and cytosol. | 1980 | J. Lipid Res. | pmid:7462811 |
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Nelson JA et al. | Biosynthesis of 24,25-epoxycholesterol from squalene 2,3;22,23-dioxide. | 1981 | J. Biol. Chem. | pmid:7451488 |
Srikantaiah MV et al. | Inhibition of rat hepatic sterol formation from squalene by plasma lipoproteins. | 1980 | Lipids | pmid:7432102 |
Matsumoto G and Hanya T | Presence of squalane in urban aquatic environments. | 1980 | J. Chromatogr. | pmid:7410506 |
Friedlander EJ et al. | Supernatant protein factor facilitates intermembrane transfer of squalene. | 1980 | J. Biol. Chem. | pmid:7410347 |
Shechter I et al. | A deficiency of mixed function oxidase activities in the cholesterol biosynthetic pathway of human granulocytes. | 1980 | J. Lipid Res. | pmid:7381322 |
Shao MJ and Lei KY | Conversion of [2-14C] mevalonate into cholesterol, lanosterol and squalene in copper-deficient rats. | 1980 | J. Nutr. | pmid:7373433 |
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Bell FP | Effect of di-2-ethylhexyl phthalate in the female rat: inhibition of hepatic and adrenal sterologenesis in vitro. | 1980 | Bull Environ Contam Toxicol | pmid:7357111 |
Strandberg TE et al. | Squalene and sterol synthesis in isolated small-intestinal cells of the rat. | 1981 | Scand. J. Gastroenterol. | pmid:7323711 |
Miettinen TA and Tilvis RS | Cholesterol synthesis and storage in adipose tissue. | 1981 | Int J Obes | pmid:7319685 |
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Mironova VN and Chaialo PP | [Cholesterol biosynthesis in the blood of rabbits with experimental atherosclerosis]. | 1978 | Biull Eksp Biol Med | pmid:728610 |
Downing DT et al. | Estimation of sebum production rates in man by measurement of the squalene content of skin biopsies. | 1981 | J. Invest. Dermatol. | pmid:7276619 |
McGinley KJ et al. | Regional variations in density of cutaneous propionibacteria: correlation of Propionibacterium acnes populations with sebaceous secretion. | 1980 | J. Clin. Microbiol. | pmid:7276142 |
Ivashkevich SP et al. | [Effects of sterols having different chemical structure and squalene on osmotic resistance of erythrocytes]. | 1981 | Biokhimiia | pmid:7272362 |
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Carelli C et al. | Persistent enhancement of cell-mediated and antibody immune responses after administration of muramyl dipeptide derivatives with antigen in metabolizable oil. | 1981 | Infect. Immun. | pmid:7263069 |
Wysocki SJ et al. | Lipids in forehead vernix from newborn infants. | 1981 | Biol. Neonate | pmid:7260215 |
Kojima Y et al. | Protein-facilitated intermembrane transfer of squalene. Demonstration by density gradient centrifugation. | 1981 | J. Biol. Chem. | pmid:7251595 |
Ito M et al. | Killing of tumor cells in vitro by macrophages from mice given injections of squalene-treated cell wall skeleton of Nocardia rubra. | 1981 | Cancer Res. | pmid:7248952 |
Hunter MI et al. | The effect of temperature on the growth and lipid composition of the extremely halophilic coccus, Sarcina marina. | 1981 | Antonie Van Leeuwenhoek | pmid:7247392 |
Anisimov MM et al. | [Effect of triterpene glycosides on the biosynthesis of sterols and fatty acids by the yeast Saccharomyces carlsbergensis]. | 1978 Jul-Aug | Prikl. Biokhim. Mikrobiol. | pmid:724665 |