(e,e,e,e)-squalene
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
Cross Reference
Introduction
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (e,e,e,e)-squalene?
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
PubChem Associated disorders and diseases
What pathways are associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (e,e,e,e)-squalene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with (e,e,e,e)-squalene?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with (e,e,e,e)-squalene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Baudner BC et al. | MF59 emulsion is an effective delivery system for a synthetic TLR4 agonist (E6020). | 2009 | Pharm. Res. | pmid:19255727 |
| Alam MM et al. | Phase behavior, formation, and rheology of cubic phase and related gel emulsion in Tween 80/water/oil systems. | 2009 | J Oleo Sci | pmid:19491531 |
| Herchi W et al. | Characterization and quantification of the aliphatic hydrocarbon fraction during linseed development ( Linum usitatissimum L.). | 2009 | J. Agric. Food Chem. | pmid:19492811 |
| Cho S et al. | High-dose squalene ingestion increases type I procollagen and decreases ultraviolet-induced DNA damage in human skin in vivo but is associated with transient adverse effects. | 2009 | Clin. Exp. Dermatol. | pmid:19522983 |
| Petrick L and Dubowski Y | Heterogeneous oxidation of squalene film by ozone under various indoor conditions. | 2009 | Indoor Air | pmid:19500173 |
| Vesikari T et al. | MF59-adjuvanted influenza vaccine (FLUAD) in children: safety and immunogenicity following a second year seasonal vaccination. | 2009 | Vaccine | pmid:19840662 |
| Kim ES et al. | Squalene-induced exogenous lipoid pneumonia in an infant. | 2009 | Pediatr Int | pmid:19799746 |
| Tagliabue A and Rappuoli R | Vaccine adjuvants: the dream becomes real. | 2008 Sep-Oct | Hum Vaccin | pmid:18682690 |
| Reddy LH et al. | Squalenoyl nanomedicine of gemcitabine is more potent after oral administration in leukemia-bearing rats: study of mechanisms. | 2008 | Anticancer Drugs | pmid:18827565 |
| Stephenson I et al. | Antigenically distinct MF59-adjuvanted vaccine to boost immunity to H5N1. | 2008 | N. Engl. J. Med. | pmid:18843132 |
| Tikekar RV et al. | Processing stability of squalene in amaranth and antioxidant potential of amaranth extract. | 2008 | J. Agric. Food Chem. | pmid:18950184 |
| Zolot AM et al. | Quantum-state resolved reactive scattering at the gas-liquid interface: F+squalane (C30H62) dynamics via high-resolution infrared absorption of nascent HF(v,J). | 2008 | J Chem Phys | pmid:19026079 |
| Li RC et al. | [Study on the safety and immunogenicity of MF59-adjuvanted influenza subunit vaccine in Chinese elderly]. | 2008 | Zhonghua Liu Xing Bing Xue Za Zhi | pmid:19040034 |
| Wu TK et al. | Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase: a chemistry-biology interdisciplinary study of the protein's structure-function-reaction mechanism relationships. | 2008 | Chem Rec | pmid:18956480 |
| Shimizu Y et al. | [Innovation of vaccine adjuvants]. | 2008 | Nippon Rinsho | pmid:18939490 |
| Barra A et al. | Chemical characterization and DNA tracking of Sardinian botargo by Mugil cephalus from different geographical origins. | 2008 | J. Agric. Food Chem. | pmid:18942834 |
| Banzhoff A et al. | MF59-adjuvanted vaccines for seasonal and pandemic influenza prophylaxis. | 2008 | Influenza Other Respir Viruses | pmid:19453401 |
| Lin Y et al. | Induction of broad CD4+ and CD8+ T-cell responses and cross-neutralizing antibodies against hepatitis C virus by vaccination with Th1-adjuvanted polypeptides followed by defective alphaviral particles expressing envelope glycoproteins gpE1 and gpE2 and nonstructural proteins 3, 4, and 5. | 2008 | J. Virol. | pmid:18508900 |
| Reddy LH et al. | Squalenoylation favorably modifies the in vivo pharmacokinetics and biodistribution of gemcitabine in mice. | 2008 | Drug Metab. Dispos. | pmid:18474674 |
| Heinemann L et al. | Effective induction of type 1 helper IgG2a and cytotoxic T-cell responses in mice following immunization with human papillomavirus type 16 E2 in MF59. | 2008 | Viral Immunol. | pmid:18476769 |
| Winne JM et al. | Nonenzymic polycyclization of analogues of oxidosqualene with a preformed C-ring. | 2008 | Org. Biomol. Chem. | pmid:18480904 |
| Arias JL et al. | Magnetoresponsive squalenoyl gemcitabine composite nanoparticles for cancer active targeting. | 2008 | Langmuir | pmid:18540685 |
| Sotiroudis TG and Kyrtopoulos SA | Anticarcinogenic compounds of olive oil and related biomarkers. | 2008 | Eur J Nutr | pmid:18458836 |
| Tong R and McDonald FE | Mimicking biosynthesis: total synthesis of the triterpene natural product abudinol B from a squalene-like precursor. | 2008 | Angew. Chem. Int. Ed. Engl. | pmid:18459096 |
| Shahiwala A and Amiji MM | Enhanced mucosal and systemic immune response with squalane oil-containing multiple emulsions upon intranasal and oral administration in mice. | 2008 | J Drug Target | pmid:18446609 |
| Schultze V et al. | Safety of MF59 adjuvant. | 2008 | Vaccine | pmid:18462843 |
| Zhang JX et al. | Sex- and gonad-affecting scent compounds and 3 male pheromones in the rat. | 2008 | Chem. Senses | pmid:18515819 |
| Metzger P et al. | Braunicetals: acetals from condensation of macrocyclic aldehydes and terpene diols in Botryococcus braunii. | 2008 | Phytochemistry | pmid:18639308 |
| Catalán J et al. | The photophysics of all-trans polyenes from ttbP5, a nonphotolabile pentaene. | 2008 | J Chem Phys | pmid:18624481 |
| Mosca F et al. | Molecular and cellular signatures of human vaccine adjuvants. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18650390 |
| Peri A and Serio M | Neuroprotective effects of the Alzheimer's disease-related gene seladin-1. | 2008 | J. Mol. Endocrinol. | pmid:18768664 |
| Kürti L et al. | Conformational energetics of cationic backbone rearrangements in triterpenoid biosynthesis provide an insight into enzymatic control of product. | 2008 | J. Am. Chem. Soc. | pmid:18558677 |
| Abe I | [Engineering of squalene cyclizing enzymes]. | 2008 | Yakugaku Zasshi | pmid:18670176 |
| Noro JC et al. | Tetrahdroxysqualene from Rhus taitensis shows antimycobacterial activity against Mycobacterium tuberculosis. | 2008 | J. Nat. Prod. | pmid:18710283 |
| Tachi M and Iwamori M | Mass spectrometric characterization of cholesterol esters and wax esters in epidermis of fetal, adult and keloidal human skin. | 2008 | Exp. Dermatol. | pmid:17979971 |
| Das B et al. | Squalene selectively protects mouse bone marrow progenitors against cisplatin and carboplatin-induced cytotoxicity in vivo without protecting tumor growth. | 2008 | Neoplasia | pmid:18813359 |
| Huber VC and McCullers JA | Vaccines against pandemic influenza: what can be done before the next pandemic? | 2008 | Pediatr. Infect. Dis. J. | pmid:18820570 |
| Nováková Z et al. | Membrane proteins and squalene-hydrosqualene profile in methanoarchaeon Methanothermobacter thermautotrophicus resistant to N,N'-dicyclohexylcarbodiimide. | 2008 | Folia Microbiol. (Praha) | pmid:18661300 |
| Morimoto Y | The role of chemical synthesis in structure elucidation of oxasqualenoids. | 2008 | Org. Biomol. Chem. | pmid:18452003 |
| Radosević K et al. | Antibody and T-cell responses to a virosomal adjuvanted H9N2 avian influenza vaccine: impact of distinct additional adjuvants. | 2008 | Vaccine | pmid:18514980 |
| Gerpe A et al. | Heteroallyl-containing 5-nitrofuranes as new anti-Trypanosoma cruzi agents with a dual mechanism of action. | 2008 | Bioorg. Med. Chem. | pmid:17981471 |
| Durando P et al. | Safety and immunogenicity of two influenza virus subunit vaccines, with or without MF59 adjuvant, administered to human immunodeficiency virus type 1-seropositive and -seronegative adults. | 2008 | Clin. Vaccine Immunol. | pmid:18003811 |
| Pelle E et al. | Identification of histamine receptors and reduction of squalene levels by an antihistamine in sebocytes. | 2008 | J. Invest. Dermatol. | pmid:18007585 |
| Miettinen TA et al. | Synthesis and absorption of cholesterol in Finnish boys by serum non-cholesterol sterols: the cardiovascular risk in Young Finns Study. | 2008 | Atherosclerosis | pmid:18178213 |
| Wack A et al. | Combination adjuvants for the induction of potent, long-lasting antibody and T-cell responses to influenza vaccine in mice. | 2008 | Vaccine | pmid:18162266 |
| Zhang W et al. | Feeding with supplemental squalene enhances the productive performance in boars. | 2008 | Anim. Reprod. Sci. | pmid:18164149 |
| Couvreur P et al. | Discovery of new hexagonal supramolecular nanostructures formed by squalenoylation of an anticancer nucleoside analogue. | 2008 | Small | pmid:18247384 |
| Reddy LH et al. | Preclinical toxicology (subacute and acute) and efficacy of a new squalenoyl gemcitabine anticancer nanomedicine. | 2008 | J. Pharmacol. Exp. Ther. | pmid:18258784 |
| Bernstein DI et al. | Effects of adjuvants on the safety and immunogenicity of an avian influenza H5N1 vaccine in adults. | 2008 | J. Infect. Dis. | pmid:18260764 |
| Simonen P et al. | The validity of serum squalene and non-cholesterol sterols as surrogate markers of cholesterol synthesis and absorption in type 2 diabetes. | 2008 | Atherosclerosis | pmid:17875306 |
| Babiychuk E et al. | Allelic mutant series reveal distinct functions for Arabidopsis cycloartenol synthase 1 in cell viability and plastid biogenesis. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18287026 |
| Ansaldi F et al. | Cross-protection by MF59-adjuvanted influenza vaccine: neutralizing and haemagglutination-inhibiting antibody activity against A(H3N2) drifted influenza viruses. | 2008 | Vaccine | pmid:18294741 |
| Chang MH et al. | The isolation and characterization of Pseudozyma sp. JCC 207, a novel producer of squalene. | 2008 | Appl. Microbiol. Biotechnol. | pmid:18299826 |
| Fox CB et al. | Monitoring the effects of component structure and source on formulation stability and adjuvant activity of oil-in-water emulsions. | 2008 | Colloids Surf B Biointerfaces | pmid:18440205 |
| Lee S and Poulter CD | Cloning, solubilization, and characterization of squalene synthase from Thermosynechococcus elongatus BP-1. | 2008 | J. Bacteriol. | pmid:18375558 |
| Seubert A et al. | The adjuvants aluminum hydroxide and MF59 induce monocyte and granulocyte chemoattractants and enhance monocyte differentiation toward dendritic cells. | 2008 | J. Immunol. | pmid:18390722 |
| Yoon J et al. | Rubritalea sabuli sp. nov., a carotenoid- and squalene-producing member of the family Verrucomicrobiaceae, isolated from marine sediment. | 2008 | Int. J. Syst. Evol. Microbiol. | pmid:18398208 |
| Helske S et al. | Accumulation of cholesterol precursors and plant sterols in human stenotic aortic valves. | 2008 | J. Lipid Res. | pmid:18398220 |
| Tan MA et al. | Antitubercular triterpenes and phytosterols from Pandanus tectorius Soland. var. laevis. | 2008 | J Nat Med | pmid:18404330 |
| Kwon SM et al. | In vivo time-dependent gene expression of cationic lipid-based emulsion as a stable and biocompatible non-viral gene carrier. | 2008 | J Control Release | pmid:18384902 |
| Kanaji N et al. | Positron emission tomography-positive squalene-induced lipoid pneumonia confirmed by gas chromatography-mass spectrometry of bronchoalveolar lavage fluid. | 2008 | Am. J. Med. Sci. | pmid:18414072 |
| Simonen PP et al. | The distribution of squalene and non-cholesterol sterols in lipoproteins in type 2 diabetes. | 2007 | Atherosclerosis | pmid:16963050 |
| Galli U et al. | Design, synthesis, and biological evaluation of new (2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-ol ethers as inhibitors of human and Trypanosoma cruzi oxidosqualene cyclase. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17027267 |
| Hazotte A et al. | High-temperature micro liquid chromatography for lipid molecular species analysis with evaporative light scattering detection. | 2007 | J Chromatogr A | pmid:17161844 |
| Petrik MS et al. | Aluminum adjuvant linked to Gulf War illness induces motor neuron death in mice. | 2007 | Neuromolecular Med. | pmid:17114826 |
| Morimoto Y et al. | Total synthesis and determination of the absolute configuration of (+)-intricatetraol. | 2007 | Angew. Chem. Int. Ed. Engl. | pmid:17191285 |
| Klesius PH et al. | The macrophage chemotactic activity of Streptococcus agalactiae and Streptococcus iniae extracellular products (ECP). | 2007 | Fish Shellfish Immunol. | pmid:17212985 |
| Puig-Barberà J et al. | Effectiveness of MF59-adjuvanted subunit influenza vaccine in preventing hospitalisations for cardiovascular disease, cerebrovascular disease and pneumonia in the elderly. | 2007 | Vaccine | pmid:17889411 |
| Puig Barberà J and González Vidal D | MF59-adjuvanted subunit influenza vaccine: an improved interpandemic influenza vaccine for vulnerable populations. | 2007 | Expert Rev Vaccines | pmid:17931147 |
| O'Hagan DT | MF59 is a safe and potent vaccine adjuvant that enhances protection against influenza virus infection. | 2007 | Expert Rev Vaccines | pmid:17931151 |
| Arnoldi A et al. | Synthesis and antifungal activity of a series of N-substituted [2-(2,4-dichlorophenyl)-3-(1,2,4-triazol-1-yl)]propylamines. | 2007 | J. Agric. Food Chem. | pmid:17896810 |
| Guillon C et al. | Formulation of HIV-1 Tat and p24 antigens by PLA nanoparticles or MF59 impacts the breadth, but not the magnitude, of serum and faecal antibody responses in rabbits. | 2007 | Vaccine | pmid:17904700 |
| Hazotte A et al. | Comparison of universal detectors for high-temperature micro liquid chromatography. | 2007 | J Chromatogr A | pmid:17905258 |
| O'Hagan DT et al. | MF59 is a safe and potent vaccine adjuvant for flu vaccines in humans: what did we learn during its development? | 2007 | Clin. Pharmacol. Ther. | pmid:17971820 |
| Villagra A et al. | Histone deacetylase 3 down-regulates cholesterol synthesis through repression of lanosterol synthase gene expression. | 2007 | J. Biol. Chem. | pmid:17925399 |
| Barrero AF et al. | Mild TiIII- and Mn/ZrIV-catalytic reductive coupling of allylic halides: efficient synthesis of symmetric terpenes. | 2007 | J. Org. Chem. | pmid:17375959 |
| Baldo V et al. | MF59-adjuvanted influenza vaccine confers superior immunogenicity in adult subjects (18-60 years of age) with chronic diseases who are at risk of post-influenza complications. | 2007 | Vaccine | pmid:17383057 |
| Buddhan S et al. | Protective effect of dietary squalene supplementation on mitochondrial function in liver of aged rats. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17574827 |
| Ryan E et al. | Phytosterol, squalene, tocopherol content and fatty acid profile of selected seeds, grains, and legumes. | 2007 | Plant Foods Hum Nutr | pmid:17594521 |
| Gylling H et al. | Cholesterol synthesis prevails over absorption in metabolic syndrome. | 2007 | Transl Res | pmid:17543849 |
| Shrestha LK et al. | Effect of water on foaming properties of diglycerol fatty acid ester-oil systems. | 2007 | Langmuir | pmid:17523681 |
| Lamb DC et al. | Lanosterol biosynthesis in the prokaryote Methylococcus capsulatus: insight into the evolution of sterol biosynthesis. | 2007 | Mol. Biol. Evol. | pmid:17567593 |
| Güldür T et al. | Excretion rate and composition of skin surface lipids on the foreheads of adult males with type IV hyperlipoproteinemia. | 2007 | J Basic Clin Physiol Pharmacol | pmid:17569244 |
| Giera M et al. | Fast and easy in vitro screening assay for cholesterol biosynthesis inhibitors in the post-squalene pathway. | 2007 | Steroids | pmid:17583759 |
| Jagadish B et al. | Squalene-derived flexible linkers for bioactive peptides. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17448660 |
| Ren Y et al. | Three-dimensional topographic index applied to the prediction of acyclic C5-C8 alkenes Kováts retention indices on polydimethylsiloxane and squalane columns. | 2007 | J Chromatogr A | pmid:17466321 |
| Mountfort KA et al. | Identification of oxidation products of squalene in solution and in latent fingerprints by ESI-MS and LC/APCI-MS. | 2007 | Anal. Chem. | pmid:17343365 |
| Hoshino T et al. | Production of epoxydammaranes by the enzymatic reactions of (3R)- and (3S)-2,3-squalene diols and those of 2,3:22,23-dioxidosqualenes with recombinant squalene cyclase and the mechanistic insight into the polycyclization reactions. | 2007 | Org. Biomol. Chem. | pmid:17315066 |
| Kasai H et al. | Rubritalea squalenifaciens sp. nov., a squalene-producing marine bacterium belonging to subdivision 1 of the phylum 'Verrucomicrobia'. | 2007 | Int. J. Syst. Evol. Microbiol. | pmid:17625207 |
| Pearson A et al. | Novel hopanoid cyclases from the environment. | 2007 | Environ. Microbiol. | pmid:17686016 |
| de Bruijn I et al. | Antibody induction by virosomal, MF59-adjuvanted, or conventional influenza vaccines in the elderly. | 2007 | Vaccine | pmid:18063446 |
| Waterman E and Lockwood B | Active components and clinical applications of olive oil. | 2007 | Altern Med Rev | pmid:18069902 |
| Reddy LH et al. | A new nanomedicine of gemcitabine displays enhanced anticancer activity in sensitive and resistant leukemia types. | 2007 | J Control Release | pmid:17878060 |
| Nakagawa K et al. | Ion-trap tandem mass spectrometric analysis of squalene monohydroperoxide isomers in sunlight-exposed human skin. | 2007 | J. Lipid Res. | pmid:17848584 |
| Khoury H et al. | Simultaneous determination of gemcitabine and gemcitabine-squalene by liquid chromatography-tandem mass spectrometry in human plasma. | 2007 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:17851141 |
| Castelli F et al. | Enhancement of gemcitabine affinity for biomembranes by conjugation with squalene: differential scanning calorimetry and Langmuir-Blodgett studies using biomembrane models. | 2007 | J Colloid Interface Sci | pmid:17765257 |
| Bråve A et al. | Candidate HIV-1 gp140DeltaV2, Gag and Tat vaccines protect against experimental HIV-1/MuLV challenge. | 2007 | Vaccine | pmid:17707956 |
| Wei A and Shibamoto T | Antioxidant activities of essential oil mixtures toward skin lipid squalene oxidized by UV irradiation. | 2007 | Cutan Ocul Toxicol | pmid:17687687 |
| Del Giudice G et al. | An MF59-adjuvanted inactivated influenza vaccine containing A/Panama/1999 (H3N2) induced broader serological protection against heterovariant influenza virus strain A/Fujian/2002 than a subunit and a split influenza vaccine. | 2006 | Vaccine | pmid:16464520 |
| Gonor KV et al. | [The influence of a diet with including amaranth oil on antioxidant and immune status in patients with ischemic heart disease and hyperlipoproteidemia]. | 2006 | Vopr Pitan | pmid:17313043 |