(e,e,e,e)-squalene
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
Cross Reference
Introduction
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (e,e,e,e)-squalene?
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
PubChem Associated disorders and diseases
What pathways are associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (e,e,e,e)-squalene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with (e,e,e,e)-squalene?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with (e,e,e,e)-squalene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bowden PE et al. | Effects of 5alpha-reduced androgens on preputial-gland size and lipogenic activity. | 1976 | Biochem. Soc. Trans. | pmid:1001770 |
| Cooper MF et al. | Effects of testosterone and alpha-melanocyte-stimulating hormone on preputial-gland (sebaceous) activity. | 1976 | Biochem. Soc. Trans. | pmid:1001771 |
| SALOKANGAS RA et al. | TERPENE METABOLISM IN THE RAT TESTIS. I. THE CONVERSION OF ISOPENTENYL PYROPHOSPHATE TO SQUALENE AND STEROLS. | 1964 | Biochemistry | pmid:14211625 |
| DILLER ER and HARVEY OA | INTERRELATIONSHIP OF STEROL AND FATTY ACID BIOSYNTHESIS IN RAT LIVER SLICES AS RELATED TO DIETARY LIPID. | 1964 | Biochemistry | pmid:14269326 |
| CAPSTACK E et al. | The biosynthesis of squalene in germinating seeds of Pisum sativum. | 1962 | Biochemistry | pmid:14018475 |
| Lanyi JK et al. | Lipid interactions in membranes of extremely halophilic bacteria. II. Modification of the bilayer structure by squalene. | 1974 | Biochemistry | pmid:4373043 |
| Zheng YF et al. | Inhibition kinetics and affinity labeling of bacterial squalene:hopene cyclase by thia-substituted analogues of 2, 3-oxidosqualene. | 1998 | Biochemistry | pmid:9558334 |
| Basáñez G et al. | Effect of single chain lipids on phospholipase C-promoted vesicle fusion. A test for the stalk hypothesis of membrane fusion. | 1998 | Biochemistry | pmid:9521711 |
| Radisky ES and Poulter CD | Squalene synthase: steady-state, pre-steady-state, and isotope-trapping studies. | 2000 | Biochemistry | pmid:10677224 |
| Joshi MK et al. | Importance of specific native lipids in controlling the photocycle of bacteriorhodopsin. | 1998 | Biochemistry | pmid:9772173 |
| Robinson DR and West CA | Biosynthesis of cyclic diterpenes in extracts from seedlings of Ricinus communis L. I. Identification of diterpene hydrocarbons formed from mevalonate. | 1970 | Biochemistry | pmid:5411208 |
| Dalidowicz JE and McDonald HJ | Site of the in vitro inhibition of cholesterol biosynthesis by tolbutamide and phenethylbiguanide. | 1965 | Biochemistry | pmid:4284598 |
| Zelewski L and Villee CA | The biosynthesis of squalene, lanosterol, and cholesterol by minced human placenta. | 1966 | Biochemistry | pmid:5963423 |
| Taton M et al. | Inhibition of 2,3-oxidosqualene cyclases. | 1992 | Biochemistry | pmid:1510977 |
| Hellig HR and Savard K | Sterol biosynthesis in the bovine corpus luteum in vitro. | 1966 | Biochemistry | pmid:6006805 |
| Dembitsky VM and Srebnik M | Variability of hydrocarbon and fatty acid components in cultures of the filamentous cyanobacterium Scytonema sp. isolated from microbial community "black cover" of limestone walls in Jerusalem. | 2002 | Biochemistry Mosc. | pmid:12495426 |
| Chen JS et al. | Osmometric and microscopic studies on bilayers of polar lipids from the extreme halophile, Halobacterium cutirubrum. | 1974 | Biochim. Biophys. Acta | pmid:4407051 |
| NICHOLAS HJ and BOMBAUGH KJ | CONSTITUENTS OF THE HYDROCARBON FRACTION OF BEEF BRAINS. | 1965 | Biochim. Biophys. Acta | pmid:14320231 |
| Mak KM and Trier JS | Radioautographic and chemical evidence for (5- 3 H)mevalonate incorporation into cholesterol by rat villous absorptive cells. | 1972 | Biochim. Biophys. Acta | pmid:4642214 |
| Heinemann SH and Sigworth FJ | Estimation of Na+ dwell time in the gramicidin A channel. Na+ ions as blockers of H+ currents. | 1989 | Biochim. Biophys. Acta | pmid:2480817 |
| Cain CE et al. | Hydrocarbons from human meninges and meningiomas. | 1967 | Biochim. Biophys. Acta | pmid:6078120 |
| Bojesen E et al. | Sterol biosynthesis in vitro of rat renal inner medulla. | 1973 | Biochim. Biophys. Acta | pmid:4713153 |
| Tabacik C et al. | Oxidosqualene cyclization in human placenta. An easy step of sterol biosynthesis. | 1975 | Biochim. Biophys. Acta | pmid:1236745 |
| NICHOLAS HJ and THOMAS BE | Intracerebral incorporation of [2-14C]mevalonic acid into adult rat brain squalene and cholesterol. | 1959 | Biochim. Biophys. Acta | pmid:13854106 |
| Astruc M et al. | Squalene epoxidase and oxidosqualene lanosterol-cyclase activities in cholesterogenic and non-cholesterogenic tissues. | 1977 | Biochim. Biophys. Acta | pmid:857899 |
| Strandberg TE et al. | Variations of hepatic cholesterol precursors during altered flows of endogenous and exogenous squalene in the rat. | 1989 | Biochim. Biophys. Acta | pmid:2917138 |
| Raederstorff D and Rohmer M | Polyterpenoids as cholesterol and tetrahymanol surrogates in the ciliate Tetrahymena pyriformis. | 1988 | Biochim. Biophys. Acta | pmid:3130105 |
| Matyas GR et al. | Lipid binding properties of 4E10, 2F5, and WR304 monoclonal antibodies that neutralize HIV-1. | 2009 | Biochim. Biophys. Acta | pmid:19100711 |
| Tansey TR and Shechter I | Structure and regulation of mammalian squalene synthase. | 2000 | Biochim. Biophys. Acta | pmid:11111077 |
| Taramino S et al. | Interactions of oxidosqualene cyclase (Erg7p) with 3-keto reductase (Erg27p) and other enzymes of sterol biosynthesis in yeast. | 2010 | Biochim. Biophys. Acta | pmid:19879375 |
| Balliano G et al. | Inhibition of sterol biosynthesis in Saccharomyces cerevisiae by N,N-diethylazasqualene and derivatives. | 1988 | Biochim. Biophys. Acta | pmid:3278744 |
| Schedin S et al. | Alterations in the biosynthesis of cholesterol, dolichol and dolichyl-P in the genetic cholesterol homeostasis disorder, Niemann-Pick type C disease. | 1998 | Biochim. Biophys. Acta | pmid:9795206 |
| Kramer JK et al. | Structure ditermination of the squalene, dihydrosqualene and tetrahydrosqualene in Halobacterium cutirubrum. | 1972 | Biochim. Biophys. Acta | pmid:5037322 |
| Pinto WJ et al. | Inhibition of sterol biosynthesis by ergosterol and cholesterol in Saccharomyces cerevisiae. | 1985 | Biochim. Biophys. Acta | pmid:3896318 |
| Kushwaha SC et al. | Isolation and identification of dehydrosqualene and C 40 -carotenoid pigments in Halobacterium cutirubrum. | 1972 | Biochim. Biophys. Acta | pmid:5038263 |
| Avigan J et al. | In vitro biosynthesis of lipids, proteins and deoxyribonucleic acid in aortic tissue and in culture aortic cells. | 1972 | Biochim. Biophys. Acta | pmid:5041430 |
| Perzl M et al. | Cloning of conserved genes from Zymomonas mobilis and Bradyrhizobium japonicum that function in the biosynthesis of hopanoid lipids. | 1998 | Biochim. Biophys. Acta | pmid:9714766 |
| Lohner K et al. | Squalene promotes the formation of non-bilayer structures in phospholipid model membranes. | 1993 | Biochim. Biophys. Acta | pmid:8399307 |
| HOLMES WL and STACK E | Gas chromatography of squalene, sterols and bile acid methyl esters. | 1962 | Biochim. Biophys. Acta | pmid:13908533 |
| MARKLEY K and GURIN S | Decarboxylation of mevalonic acid and conversion to squalene; enzyme fractionation and cofactors. | 1959 | Biochim. Biophys. Acta | pmid:13628647 |
| Suzue G and Porter JW | Enzymatic synthesis of lycopene from [4-14C]isopentenyl pyrophosphate. | 1969 | Biochim. Biophys. Acta | pmid:4308120 |
| Horie M et al. | An inhibitor of squalene epoxidase, NB-598, suppresses the secretion of cholesterol and triacylglycerol and simultaneously reduces apolipoprotein B in HepG2 cells. | 1993 | Biochim. Biophys. Acta | pmid:8504141 |
| Tilvis RS and Miettinen TA | Fate of intravenously administered squalene in the rat. | 1982 | Biochim. Biophys. Acta | pmid:7126611 |
| Bertolino A et al. | Polyisoprenoid amphiphilic compounds as inhibitors of squalene synthesis and other microsomal enzymes. | 1978 | Biochim. Biophys. Acta | pmid:210830 |
| Rao KS and Olson RE | The effect of excessive vitamin A upon the metabolism of isoprenoid compounds in rat liver. | 1967 | Biochim. Biophys. Acta | pmid:6049507 |
| Williams RJ et al. | A possible mechanism for the biosynthesis of eschscholtzxanthin. | 1966 | Biochim. Biophys. Acta | pmid:5966716 |
| Ono T et al. | Involvement of NADPH-cytochrome c reductase in the rat liver squalene epoxidase system. | 1977 | Biochim. Biophys. Acta | pmid:403952 |
| Brooks CJ et al. | Squalene, 26-hydroxycholesterol and 7-ketocholesterol in human atheromatous plaques. | 1966 | Biochim. Biophys. Acta | pmid:5973204 |
| Rees HH et al. | 2,3-oxidosqualene cycloartenol cyclase from Ochromonas malhamensis. | 1969 | Biochim. Biophys. Acta | pmid:5797101 |
| Mukherjee S and Bhose A | Studies on estrogen regulation of cholesterol biosynthesis in rat liver microsomes. | 1968 | Biochim. Biophys. Acta | pmid:5721032 |