(e,e,e,e)-squalene
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
Cross Reference
Introduction
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (e,e,e,e)-squalene?
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
PubChem Associated disorders and diseases
What pathways are associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (e,e,e,e)-squalene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with (e,e,e,e)-squalene?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with (e,e,e,e)-squalene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tikekar RV et al. | Processing stability of squalene in amaranth and antioxidant potential of amaranth extract. | 2008 | J. Agric. Food Chem. | pmid:18950184 |
| Lin Y et al. | Induction of broad CD4+ and CD8+ T-cell responses and cross-neutralizing antibodies against hepatitis C virus by vaccination with Th1-adjuvanted polypeptides followed by defective alphaviral particles expressing envelope glycoproteins gpE1 and gpE2 and nonstructural proteins 3, 4, and 5. | 2008 | J. Virol. | pmid:18508900 |
| Reddy LH et al. | Squalenoylation favorably modifies the in vivo pharmacokinetics and biodistribution of gemcitabine in mice. | 2008 | Drug Metab. Dispos. | pmid:18474674 |
| Heinemann L et al. | Effective induction of type 1 helper IgG2a and cytotoxic T-cell responses in mice following immunization with human papillomavirus type 16 E2 in MF59. | 2008 | Viral Immunol. | pmid:18476769 |
| Winne JM et al. | Nonenzymic polycyclization of analogues of oxidosqualene with a preformed C-ring. | 2008 | Org. Biomol. Chem. | pmid:18480904 |
| Arias JL et al. | Magnetoresponsive squalenoyl gemcitabine composite nanoparticles for cancer active targeting. | 2008 | Langmuir | pmid:18540685 |
| Sotiroudis TG and Kyrtopoulos SA | Anticarcinogenic compounds of olive oil and related biomarkers. | 2008 | Eur J Nutr | pmid:18458836 |
| Helske S et al. | Accumulation of cholesterol precursors and plant sterols in human stenotic aortic valves. | 2008 | J. Lipid Res. | pmid:18398220 |
| Tan MA et al. | Antitubercular triterpenes and phytosterols from Pandanus tectorius Soland. var. laevis. | 2008 | J Nat Med | pmid:18404330 |
| Kwon SM et al. | In vivo time-dependent gene expression of cationic lipid-based emulsion as a stable and biocompatible non-viral gene carrier. | 2008 | J Control Release | pmid:18384902 |
| Kanaji N et al. | Positron emission tomography-positive squalene-induced lipoid pneumonia confirmed by gas chromatography-mass spectrometry of bronchoalveolar lavage fluid. | 2008 | Am. J. Med. Sci. | pmid:18414072 |
| Simonen PP et al. | The distribution of squalene and non-cholesterol sterols in lipoproteins in type 2 diabetes. | 2007 | Atherosclerosis | pmid:16963050 |
| Galli U et al. | Design, synthesis, and biological evaluation of new (2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-ol ethers as inhibitors of human and Trypanosoma cruzi oxidosqualene cyclase. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17027267 |
| Hazotte A et al. | High-temperature micro liquid chromatography for lipid molecular species analysis with evaporative light scattering detection. | 2007 | J Chromatogr A | pmid:17161844 |
| Petrik MS et al. | Aluminum adjuvant linked to Gulf War illness induces motor neuron death in mice. | 2007 | Neuromolecular Med. | pmid:17114826 |
| Morimoto Y et al. | Total synthesis and determination of the absolute configuration of (+)-intricatetraol. | 2007 | Angew. Chem. Int. Ed. Engl. | pmid:17191285 |
| Klesius PH et al. | The macrophage chemotactic activity of Streptococcus agalactiae and Streptococcus iniae extracellular products (ECP). | 2007 | Fish Shellfish Immunol. | pmid:17212985 |
| Puig-Barberà J et al. | Effectiveness of MF59-adjuvanted subunit influenza vaccine in preventing hospitalisations for cardiovascular disease, cerebrovascular disease and pneumonia in the elderly. | 2007 | Vaccine | pmid:17889411 |
| Puig Barberà J and González Vidal D | MF59-adjuvanted subunit influenza vaccine: an improved interpandemic influenza vaccine for vulnerable populations. | 2007 | Expert Rev Vaccines | pmid:17931147 |
| O'Hagan DT | MF59 is a safe and potent vaccine adjuvant that enhances protection against influenza virus infection. | 2007 | Expert Rev Vaccines | pmid:17931151 |
| Arnoldi A et al. | Synthesis and antifungal activity of a series of N-substituted [2-(2,4-dichlorophenyl)-3-(1,2,4-triazol-1-yl)]propylamines. | 2007 | J. Agric. Food Chem. | pmid:17896810 |
| Guillon C et al. | Formulation of HIV-1 Tat and p24 antigens by PLA nanoparticles or MF59 impacts the breadth, but not the magnitude, of serum and faecal antibody responses in rabbits. | 2007 | Vaccine | pmid:17904700 |
| Hazotte A et al. | Comparison of universal detectors for high-temperature micro liquid chromatography. | 2007 | J Chromatogr A | pmid:17905258 |
| O'Hagan DT et al. | MF59 is a safe and potent vaccine adjuvant for flu vaccines in humans: what did we learn during its development? | 2007 | Clin. Pharmacol. Ther. | pmid:17971820 |
| Villagra A et al. | Histone deacetylase 3 down-regulates cholesterol synthesis through repression of lanosterol synthase gene expression. | 2007 | J. Biol. Chem. | pmid:17925399 |
| Barrero AF et al. | Mild TiIII- and Mn/ZrIV-catalytic reductive coupling of allylic halides: efficient synthesis of symmetric terpenes. | 2007 | J. Org. Chem. | pmid:17375959 |
| Baldo V et al. | MF59-adjuvanted influenza vaccine confers superior immunogenicity in adult subjects (18-60 years of age) with chronic diseases who are at risk of post-influenza complications. | 2007 | Vaccine | pmid:17383057 |
| Buddhan S et al. | Protective effect of dietary squalene supplementation on mitochondrial function in liver of aged rats. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17574827 |
| Ryan E et al. | Phytosterol, squalene, tocopherol content and fatty acid profile of selected seeds, grains, and legumes. | 2007 | Plant Foods Hum Nutr | pmid:17594521 |
| Gylling H et al. | Cholesterol synthesis prevails over absorption in metabolic syndrome. | 2007 | Transl Res | pmid:17543849 |
| Shrestha LK et al. | Effect of water on foaming properties of diglycerol fatty acid ester-oil systems. | 2007 | Langmuir | pmid:17523681 |
| Lamb DC et al. | Lanosterol biosynthesis in the prokaryote Methylococcus capsulatus: insight into the evolution of sterol biosynthesis. | 2007 | Mol. Biol. Evol. | pmid:17567593 |
| Güldür T et al. | Excretion rate and composition of skin surface lipids on the foreheads of adult males with type IV hyperlipoproteinemia. | 2007 | J Basic Clin Physiol Pharmacol | pmid:17569244 |
| Giera M et al. | Fast and easy in vitro screening assay for cholesterol biosynthesis inhibitors in the post-squalene pathway. | 2007 | Steroids | pmid:17583759 |
| Jagadish B et al. | Squalene-derived flexible linkers for bioactive peptides. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17448660 |
| Ren Y et al. | Three-dimensional topographic index applied to the prediction of acyclic C5-C8 alkenes Kováts retention indices on polydimethylsiloxane and squalane columns. | 2007 | J Chromatogr A | pmid:17466321 |
| Mountfort KA et al. | Identification of oxidation products of squalene in solution and in latent fingerprints by ESI-MS and LC/APCI-MS. | 2007 | Anal. Chem. | pmid:17343365 |
| Hoshino T et al. | Production of epoxydammaranes by the enzymatic reactions of (3R)- and (3S)-2,3-squalene diols and those of 2,3:22,23-dioxidosqualenes with recombinant squalene cyclase and the mechanistic insight into the polycyclization reactions. | 2007 | Org. Biomol. Chem. | pmid:17315066 |
| Kasai H et al. | Rubritalea squalenifaciens sp. nov., a squalene-producing marine bacterium belonging to subdivision 1 of the phylum 'Verrucomicrobia'. | 2007 | Int. J. Syst. Evol. Microbiol. | pmid:17625207 |
| Pearson A et al. | Novel hopanoid cyclases from the environment. | 2007 | Environ. Microbiol. | pmid:17686016 |
| de Bruijn I et al. | Antibody induction by virosomal, MF59-adjuvanted, or conventional influenza vaccines in the elderly. | 2007 | Vaccine | pmid:18063446 |
| Waterman E and Lockwood B | Active components and clinical applications of olive oil. | 2007 | Altern Med Rev | pmid:18069902 |
| Reddy LH et al. | A new nanomedicine of gemcitabine displays enhanced anticancer activity in sensitive and resistant leukemia types. | 2007 | J Control Release | pmid:17878060 |
| Nakagawa K et al. | Ion-trap tandem mass spectrometric analysis of squalene monohydroperoxide isomers in sunlight-exposed human skin. | 2007 | J. Lipid Res. | pmid:17848584 |
| Khoury H et al. | Simultaneous determination of gemcitabine and gemcitabine-squalene by liquid chromatography-tandem mass spectrometry in human plasma. | 2007 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:17851141 |
| Castelli F et al. | Enhancement of gemcitabine affinity for biomembranes by conjugation with squalene: differential scanning calorimetry and Langmuir-Blodgett studies using biomembrane models. | 2007 | J Colloid Interface Sci | pmid:17765257 |
| Bråve A et al. | Candidate HIV-1 gp140DeltaV2, Gag and Tat vaccines protect against experimental HIV-1/MuLV challenge. | 2007 | Vaccine | pmid:17707956 |
| Wei A and Shibamoto T | Antioxidant activities of essential oil mixtures toward skin lipid squalene oxidized by UV irradiation. | 2007 | Cutan Ocul Toxicol | pmid:17687687 |
| Szostak WB and Szostak-Wegierek D | [Health properties of shark oil]. | 2006 | Prz. Lek. | pmid:17083160 |
| Morikubo N et al. | Cation-pi interaction in the polyolefin cyclization cascade uncovered by incorporating unnatural amino acids into the catalytic sites of squalene cyclase. | 2006 | J. Am. Chem. Soc. | pmid:17017798 |