(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Shan H et al. | Enzymatic cyclization of dioxidosqualene to heterocyclic triterpenes. | 2005 | J. Am. Chem. Soc. | pmid:16366544 |
Zhang Y et al. | [Chemical constituents from the mangrove plant Ceriops tagal]. | 2005 | Yao Xue Xue Bao | pmid:16408813 |
Tanaka H et al. | Enzymatic formation of indole-containing unnatural cyclic polyprenoids by bacterial squalene:hopene cyclase. | 2005 | Org. Lett. | pmid:16354088 |
Lau HL et al. | Simultaneous quantification of free fatty acids, free sterols, squalene, and acylglycerol molecular species in palm oil by high-temperature gas chromatography--flame ionization detection. | 2005 | Lipids | pmid:16094863 |
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Choo YM et al. | Application of supercritical fluid chromatography in the quantitative analysis of minor components (carotenes, vitamin E, sterols, and squalene) from palm oil. | 2005 | Lipids | pmid:16028723 |
Hung CF et al. | Physicochemical characterization and gene transfection efficiency of lipid emulsions with various co-emulsifiers. | 2005 | Int J Pharm | pmid:15652212 |
Henryk T et al. | [The effect of alcoxyglycerols, squalene and n-3 fatty acid on some innate immunity parameters in healthy people]. | 2005 | Pol. Merkur. Lekarski | pmid:15997638 |
Blagović B et al. | Lipid analysis of the plasma membrane and mitochondria of brewer's yeast. | 2005 | Folia Microbiol. (Praha) | pmid:15954530 |
Giner JL et al. | Detection of 1,2-hydride shifts in the formation of euph-7-ene by the squalene-tetrahymanol cyclase of Tetrahymena pyriformis. | 2005 | Chem. Commun. (Camb.) | pmid:15959594 |
Kim TW et al. | Airway gene transfer using cationic emulsion as a mucosal gene carrier. | 2005 | J Gene Med | pmid:15929068 |
Lavoie JM and Stevanovic T | Variation of chemical composition of the lipophilic extracts from yellow birch (Betula alleghaniensis) foliage. | 2005 | J. Agric. Food Chem. | pmid:15941310 |
Sun S et al. | The combination effects of phenolic compounds and fluconazole on the formation of ergosterol in Candida albicans determined by high-performance liquid chromatography/tandem mass spectrometry. | 2005 | Anal. Biochem. | pmid:15582556 |
Williams DK et al. | Analysis of latent fingerprint deposits by infrared microspectroscopy. | 2004 | Appl Spectrosc | pmid:15035712 |
Kalogeropoulos N and Andrikopoulos NK | Squalene in oils and fats from domestic and commercial fryings of potatoes. | 2004 | Int J Food Sci Nutr | pmid:14985184 |
Tanaka H et al. | 1-methylidenesqualene and 25-methylidenesqualene as active-site probes for bacterial squalene:hopene cyclase. | 2004 | Org. Lett. | pmid:14986979 |
Abe I et al. | Enzymatic cyclization of 22,23-dihydro-2,3-oxidosqualene into euph-7-en-3beta-ol and bacchar-12-en-3beta-ol by recombinant beta-amyrin synthase. | 2004 | J. Am. Chem. Soc. | pmid:15025461 |
Schulz JG et al. | HMG-CoA reductase inhibition causes neurite loss by interfering with geranylgeranylpyrophosphate synthesis. | 2004 | J. Neurochem. | pmid:15030386 |
Uchino T et al. | Potent protecting effects of Catuaba (Anemopaegma mirandum) extracts against hydroperoxide-induced cytotoxicity. | 2004 | Toxicol In Vitro | pmid:15046771 |
Cravotto G et al. | Umbelliferone aminoalkyl derivatives, a new class of squalene-hopene cyclase inhibitors. | 2004 | Eur J Med Chem | pmid:15501540 |
Thoma R et al. | Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase. | 2004 | Nature | pmid:15525992 |
Puig-Barberà J et al. | Effectiveness of the MF59-adjuvanted influenza vaccine in preventing emergency admissions for pneumonia in the elderly over 64 years of age. | 2004 | Vaccine | pmid:15530669 |
Achitouv E et al. | C31-C34 methylated squalenes from a Bolivian strain of Botryococcus braunii. | 2004 | Phytochemistry | pmid:15541746 |
Ruf A et al. | The monotopic membrane protein human oxidosqualene cyclase is active as monomer. | 2004 | Biochem. Biophys. Res. Commun. | pmid:14766201 |
Hronská L et al. | Low concentrations of the non-ionic detergent Nonidet P-40 interfere with sterol biogenesis and viability of the yeast Saccharomyces cerevisiae. | 2004 | FEMS Microbiol. Lett. | pmid:15336428 |
Ruf BR et al. | Open, randomized study to compare the immunogenicity and reactogenicity of an influenza split vaccine with an MF59-adjuvanted subunit vaccine and a virosome-based subunit vaccine in elderly. | 2004 | Infection | pmid:15293073 |
Süli J et al. | Experimental squalene adjuvant. I. Preparation and testing of its effectiveness. | 2004 | Vaccine | pmid:15308373 |
BenÃsek Z et al. | Experimental squalene adjuvant. II. Harmlessness and local reactogenity. | 2004 | Vaccine | pmid:15308374 |
Nakano S et al. | Squalene-hopene cyclase: insight into the role of the methyl group on the squalene backbone upon the polycyclization cascade. Enzymatic cyclization products of squalene analogs lacking a 26-methyl group and possessing a methyl group at C7 or C11. | 2004 | Org. Biomol. Chem. | pmid:15254628 |
Pragst F et al. | Wipe-test and patch-test for alcohol misuse based on the concentration ratio of fatty acid ethyl esters and squalene CFAEE/CSQ in skin surface lipids. | 2004 | Forensic Sci. Int. | pmid:15240027 |
Sabeena Farvin KH et al. | Effect of squalene on tissue defense system in isoproterenol-induced myocardial infarction in rats. | 2004 | Pharmacol. Res. | pmid:15225664 |
Kuroda Y et al. | Autoimmunity induced by adjuvant hydrocarbon oil components of vaccine. | 2004 | Biomed. Pharmacother. | pmid:15194169 |
Holm BC et al. | Adjuvant oil induces waves of arthritogenic lymph node cells prior to arthritis onset. | 2004 | Clin. Exp. Immunol. | pmid:15196244 |
Fukasawa LO et al. | Adjuvant can improve protection induced by OMV vaccine against Neisseria meningitidis serogroups B/C in neonatal mice. | 2004 | FEMS Immunol. Med. Microbiol. | pmid:15196569 |
Tsai HF et al. | Candida glabrata erg1 mutant with increased sensitivity to azoles and to low oxygen tension. | 2004 | Antimicrob. Agents Chemother. | pmid:15215098 |
Maguire LS et al. | Fatty acid profile, tocopherol, squalene and phytosterol content of walnuts, almonds, peanuts, hazelnuts and the macadamia nut. | 2004 | Int J Food Sci Nutr | pmid:15223592 |
Abe I et al. | Mechanism and stereochemistry of enzymatic cyclization of 24,30-Bisnor-2,3-oxidosqualene by recombinant beta-amyrin synthase. | 2004 | J. Am. Chem. Soc. | pmid:15174853 |
Hess BA and Smentek L | Concerted nature of AB ring formation in the enzymatic cyclization of squalene to hopenes. | 2004 | Org. Lett. | pmid:15151397 |
Ketomaki A et al. | Effects of plant stanol and sterol esters on serum phytosterols in a family with familial hypercholesterolemia including a homozygous subject. | 2004 | J. Lab. Clin. Med. | pmid:15085084 |
Okada S et al. | Characterization of botryococcene synthase enzyme activity, a squalene synthase-like activity from the green microalga Botryococcus braunii, Race B. | 2004 | Arch. Biochem. Biophys. | pmid:14725863 |
Xu R et al. | On the origins of triterpenoid skeletal diversity. | 2004 | Phytochemistry | pmid:14751299 |
Kawaki H | The interaction of monosubstituted benzenes with the stationary liquid in gas liquid chromatography. | 2004 | Chem. Pharm. Bull. | pmid:14758007 |
Miettinen TA et al. | Low synthesis and high absorption of cholesterol characterize type 1 diabetes. | 2004 | Diabetes Care | pmid:14693966 |
Kuroda Y et al. | Distinctive patterns of autoimmune response induced by different types of mineral oil. | 2004 | Toxicol. Sci. | pmid:14718649 |
Auwärter V et al. | Squalene in hair--a natural reference substance for the improved interpretation of fatty acid ethyl ester concentrations with respect to alcohol misuse. | 2004 | Forensic Sci. Int. | pmid:15451087 |
Ekanayake-Mudiyanselage S et al. | Oral supplementation with all-Rac- and RRR-alpha-tocopherol increases vitamin E levels in human sebum after a latency period of 14-21 days. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15753144 |
Vajdy M et al. | Mucosal and systemic anti-HIV responses in rhesus macaques following combinations of intranasal and parenteral immunizations. | 2004 | AIDS Res. Hum. Retroviruses | pmid:15588349 |
Hoshino T et al. | Deletion of the Gly600 residue of Alicyclobacillus acidocaldarius squalene cyclase alters the substrate specificity into that of the eukaryotic-type cyclase specific to (3S)-2,3-oxidosqualene. | 2004 | Angew. Chem. Int. Ed. Engl. | pmid:15593147 |
Scolastici C et al. | Squalene does not exhibit a chemopreventive activity and increases plasma cholesterol in a Wistar rat hepatocarcinogenesis model. | 2004 | Nutr Cancer | pmid:15572303 |