(e,e,e,e)-squalene

(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.

Cross Reference

Introduction

To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (e,e,e,e)-squalene?

(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene

MeSH term MeSH ID Detail
Leukemia P388 D007941 43 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Leukemia, Hairy Cell D007943 5 associated lipids
Lipodystrophy D008060 4 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Lung Neoplasms D008175 171 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Nervous System Diseases D009422 37 associated lipids
Neuroblastoma D009447 66 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Dermatitis, Occupational D009783 12 associated lipids
Occupational Diseases D009784 42 associated lipids
Ossification, Heterotopic D009999 2 associated lipids
Otitis Media D010033 12 associated lipids
Pain D010146 64 associated lipids
Parkinson Disease D010300 53 associated lipids
Parvoviridae Infections D010322 4 associated lipids
Periodontitis D010518 22 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
Per page 10 20 50 100 | Total 84

PubChem Associated disorders and diseases

What pathways are associated with (e,e,e,e)-squalene

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with (e,e,e,e)-squalene?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (e,e,e,e)-squalene?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with (e,e,e,e)-squalene

Download all related citations
Per page 10 20 50 100 | Total 1766
Authors Title Published Journal PubMed Link
Fontana A et al. Evidence for the biosynthesis of squalene via the methylerythritol phosphate pathway in a Streptomyces sp. obtained from a marine sediment. 2001 J. Org. Chem. pmid:11529755
Someya K et al. The antioxidant effect of palm fruit carotene on skin lipid peroxidation in guinea pigs as estimated by chemiluminescence-HPLC method. 1994 J. Nutr. Sci. Vitaminol. pmid:7844638
Singh DK and Porter TD Inhibition of sterol 4alpha-methyl oxidase is the principal mechanism by which garlic decreases cholesterol synthesis. 2006 J. Nutr. pmid:16484558
HIGH EG and DAY HG Effects of different amounts of lutein, squalene, phytol and related substances on the utilization of carotene and vitamin A for storage and growth in the rat. 1951 J. Nutr. pmid:14851042
Matschiner JT et al. Effect of indigestible oils on vitamin K deficiency in the rat. 1967 J. Nutr. pmid:6021812
Matschiner JT et al. Mechanism of the effect of retinoic acid and squalene on vitamin K deficiency in the rat. 1967 J. Nutr. pmid:6021953
Shao MJ and Lei KY Conversion of [2-14C] mevalonate into cholesterol, lanosterol and squalene in copper-deficient rats. 1980 J. Nutr. pmid:7373433
Michikawa M and Yanagisawa K Apolipoprotein E4 induces neuronal cell death under conditions of suppressed de novo cholesterol synthesis. 1998 J. Neurosci. Res. pmid:9778150
Schulz JG et al. HMG-CoA reductase inhibition causes neurite loss by interfering with geranylgeranylpyrophosphate synthesis. 2004 J. Neurochem. pmid:15030386
Jones JP et al. Rate of sterol formation by rat brain glia and neurons in vitro and in vivo. 1975 J. Neurochem. pmid:1110355
Wagner-Recio M et al. Tellurium blocks cholesterol synthesis by inhibiting squalene metabolism: preferential vulnerability to this metabolic block leads to peripheral nervous system demyelination. 1991 J. Neurochem. pmid:1940905
Harry GJ et al. Tellurium-induced neuropathy: metabolic alterations associated with demyelination and remyelination in rat sciatic nerve. 1989 J. Neurochem. pmid:2918316
Dennick RG et al. Sterol content and squaline-2(3)-epoxide-lanosterol cyclase activity in human foetal brain during early and mid-gestation. 1974 J. Neurochem. pmid:4854410
Ramsey RB et al. The biosynthesis of cholesterol and other sterols by brain tissue. Distribution in subcellular fractions as a function of time after intracerebral injection into developing brain of (2- 14 C)mevalonic. 1972 J. Neurochem. pmid:5009889
Ramsey RB et al. Squalene-like isoprenoid hydrocarbons in bovine brain. 1971 J. Neurochem. pmid:5129357
Ramsey RB et al. The biosynthesis of cholesterol and other sterols by brain tissue. Distribution in subcellular fractions as a function of time after intracerebral injection of [2-14C]-mevalonic acid. 1971 J. Neurochem. pmid:5092868
Michikawa M and Yanagisawa K Inhibition of cholesterol production but not of nonsterol isoprenoid products induces neuronal cell death. 1999 J. Neurochem. pmid:10349836
Dennick RG and Dean PD Squalene-2(3)-epoxide-lanosterol cyclase in developing rat brain. 1974 J. Neurochem. pmid:4277662
Shamberger RJ Inhibitory effect of vitamin A on carcinogenesis. 1971 J. Natl. Cancer Inst. pmid:5157584
Harro CD et al. Safety and immunogenicity trial in adult volunteers of a human papillomavirus 16 L1 virus-like particle vaccine. 2001 J. Natl. Cancer Inst. pmid:11181775
Asari F et al. Turbinaric acid, a cytotoxic secosqualene carboxylic acid from the brown alga Turbinaria ornata. 1989 Sep-Oct J. Nat. Prod. pmid:2607351
Tran TV et al. NF-κB inhibitors from Eurycoma longifolia. 2014 J. Nat. Prod. pmid:24467387
Noro JC et al. Tetrahdroxysqualene from Rhus taitensis shows antimycobacterial activity against Mycobacterium tuberculosis. 2008 J. Nat. Prod. pmid:18710283
Abe I et al. Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase. 2001 J. Nat. Prod. pmid:11520216
Gaber BP and Goodsell DS The art of molecular graphics. Escape from flatland. 2000 J. Mol. Graph. Model. pmid:10935209
Tornabene TG Non-aerated cultivation of Halobacterium cutirubrum and its effect on cellular squalenes. 1978 J. Mol. Evol. pmid:691076
Tornabene TG et al. Phytanyl-glycerol ethers and squalenes in the archaebacterium Methanobacterium thermoautotrophicum. 1978 J. Mol. Evol. pmid:691077
Tornabene TG et al. Squalenes, phytanes and other isoprenoids as major neutral lipids of methanogenic and thermoacidophilic "archaebacteria". 1979 J. Mol. Evol. pmid:458874
Peri A and Serio M Neuroprotective effects of the Alzheimer's disease-related gene seladin-1. 2008 J. Mol. Endocrinol. pmid:18768664
Hong WK et al. Characterization of a squalene synthase from the thraustochytrid microalga Aurantiochytrium sp. KRS101. 2013 J. Microbiol. Biotechnol. pmid:23676912
Song JY et al. Long-term and cross-reactive immunogenicity of inactivated trivalent influenza vaccine in the elderly: MF59-adjuvanted vaccine versus unadjuvanted vaccine. 2013 J. Med. Virol. pmid:23852684
Morita T et al. Inhibitory effect of a new mycotic agent, piritetrate on ergosterol biosynthesis in pathogenic fungi. 1989 J. Med. Vet. Mycol. pmid:2666631
Barrett-Bee KJ et al. The mode of antifungal action of tolnaftate. 1986 J. Med. Vet. Mycol. pmid:3522841
Yoder JA et al. Squalene: a naturally abundant mammalian skin secretion and long distance tick-attractant (Acari: Ixodidae). 1999 J. Med. Entomol. pmid:10467784
Raouane M et al. Synthesis, characterization, and in vivo delivery of siRNA-squalene nanoparticles targeting fusion oncogene in papillary thyroid carcinoma. 2011 J. Med. Chem. pmid:21561161
Sen SE et al. Inhibition of vertebrate squalene epoxidase by extended and truncated analogues of trisnorsqualene alcohol. 1990 J. Med. Chem. pmid:2342064
Sen SE and Prestwich GD Squalene analogues containing isopropylidene mimics as potential inhibitors of pig liver squalene epoxidase and oxidosqualene cyclase. 1989 J. Med. Chem. pmid:2769687
Ceruti M et al. 29-Methylidene-2,3-oxidosqualene derivatives as stereospecific mechanism-based inhibitors of liver and yeast oxidosqualene cyclase. 1998 J. Med. Chem. pmid:9484504
Stach D et al. Synthesis and inhibition studies of sulfur-substituted squalene oxide analogues as mechanism-based inhibitors of 2,3-oxidosqualene-lanosterol cyclase. 1997 J. Med. Chem. pmid:9003518
Chan C et al. The squalestatins: decarboxy and 4-deoxy analogues as potent squalene synthase inhibitors. 1996 J. Med. Chem. pmid:8568810
Barth MM et al. Structural and stereoelectronic requirements for the inhibition of mammalian 2,3-oxidosqualene cyclase by substituted isoquinoline derivatives. 1996 J. Med. Chem. pmid:8691425
Prashad M Amidinium cation as a mimic of allylic carbocation: synthesis and squalene synthetase inhibitory activity of an amidinium analog of a carbocation intermediate. 1993 J. Med. Chem. pmid:8496942
Ceruti M et al. 2,3-Epoxy-10-aza-10,11-dihydrosqualene, a high-energy intermediate analogue inhibitor of 2,3-oxidosqualene cyclase. 1992 J. Med. Chem. pmid:1501233
Witiak DT et al. Inhibition of cholesterolgenesis in vitro by chlorophenoxyacetic acids. Effect of alpha-methyl groups. 1969 J. Med. Chem. pmid:5793168
MCCARTHY MJ et al. COMPOSITION OF MOLECULAR DISTILLATES OF BUTTER OIL: ISOLATION AND IDENTIFICATION OF COMPONENTS OTHER THAN GLYCERIDES. 1964 J. Lipid Res. pmid:14221107
Liu GC et al. Measurement of squalene in human tissues and plasma: validation and application. 1976 J. Lipid Res. pmid:1255019
Eisele B et al. Effects of a novel 2,3-oxidosqualene cyclase inhibitor on cholesterol biosynthesis and lipid metabolism in vivo. 1997 J. Lipid Res. pmid:9101437
Gylling H et al. Insulin sensitivity regulates cholesterol metabolism to a greater extent than obesity: lessons from the METSIM Study. 2010 J. Lipid Res. pmid:20436182
Raskin P and Siperstein MD Mevalonate metabolism by renal tissue in vitro. 1974 J. Lipid Res. pmid:4811213
Shechter I et al. A deficiency of mixed function oxidase activities in the cholesterol biosynthetic pathway of human granulocytes. 1980 J. Lipid Res. pmid:7381322