(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Shan H et al. | Enzymatic cyclization of dioxidosqualene to heterocyclic triterpenes. | 2005 | J. Am. Chem. Soc. | pmid:16366544 |
Zhang Y et al. | [Chemical constituents from the mangrove plant Ceriops tagal]. | 2005 | Yao Xue Xue Bao | pmid:16408813 |
Tanaka H et al. | Enzymatic formation of indole-containing unnatural cyclic polyprenoids by bacterial squalene:hopene cyclase. | 2005 | Org. Lett. | pmid:16354088 |
Wadman M | Race is on for flu vaccine. | 2005 | Nature | pmid:16267526 |
Krüger RH et al. | New phenylenediamine antiozonants for commodities based on natural and synthetic rubber. | 2005 | Food Addit Contam | pmid:16227180 |
Lodeiro S et al. | Enzyme redesign: two mutations cooperate to convert cycloartenol synthase into an accurate lanosterol synthase. | 2005 | J. Am. Chem. Soc. | pmid:16218577 |
Whitehouse MW | Prostanoids as friends, not foes: further evidence from the interference by cycloxygenase-inhibitory drugs when inducing tolerance to experimental arthritigens in rats. | 2005 | Inflammopharmacology | pmid:16259716 |
Henryk T et al. | [The effect of alcoxyglycerols, squalene and n-3 fatty acid on some innate immunity parameters in healthy people]. | 2005 | Pol. Merkur. Lekarski | pmid:15997638 |
Blagović B et al. | Lipid analysis of the plasma membrane and mitochondria of brewer's yeast. | 2005 | Folia Microbiol. (Praha) | pmid:15954530 |
Giner JL et al. | Detection of 1,2-hydride shifts in the formation of euph-7-ene by the squalene-tetrahymanol cyclase of Tetrahymena pyriformis. | 2005 | Chem. Commun. (Camb.) | pmid:15959594 |
Kim TW et al. | Airway gene transfer using cationic emulsion as a mucosal gene carrier. | 2005 | J Gene Med | pmid:15929068 |
Lavoie JM and Stevanovic T | Variation of chemical composition of the lipophilic extracts from yellow birch (Betula alleghaniensis) foliage. | 2005 | J. Agric. Food Chem. | pmid:15941310 |
Xiong Q et al. | Structure and reactivity of the dammarenyl cation: configurational transmission in triterpene synthesis. | 2005 | J. Org. Chem. | pmid:15989315 |
Archer NE et al. | Changes in the lipid composition of latent fingerprint residue with time after deposition on a surface. | 2005 | Forensic Sci. Int. | pmid:16182971 |
Influenza vaccine with squalene adjuvant: new preparation. No better than available products. | 2004 | Prescrire Int | pmid:15599987 | |
Lee HK et al. | Photoaffinity labeling identifies the substrate-binding site of mammalian squalene epoxidase. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15013417 |
Williams DK et al. | Analysis of latent fingerprint deposits by infrared microspectroscopy. | 2004 | Appl Spectrosc | pmid:15035712 |
Kalogeropoulos N and Andrikopoulos NK | Squalene in oils and fats from domestic and commercial fryings of potatoes. | 2004 | Int J Food Sci Nutr | pmid:14985184 |
Tanaka H et al. | 1-methylidenesqualene and 25-methylidenesqualene as active-site probes for bacterial squalene:hopene cyclase. | 2004 | Org. Lett. | pmid:14986979 |
Cravotto G et al. | Umbelliferone aminoalkyl derivatives, a new class of squalene-hopene cyclase inhibitors. | 2004 | Eur J Med Chem | pmid:15501540 |
Thoma R et al. | Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase. | 2004 | Nature | pmid:15525992 |
Puig-Barberà J et al. | Effectiveness of the MF59-adjuvanted influenza vaccine in preventing emergency admissions for pneumonia in the elderly over 64 years of age. | 2004 | Vaccine | pmid:15530669 |
Achitouv E et al. | C31-C34 methylated squalenes from a Bolivian strain of Botryococcus braunii. | 2004 | Phytochemistry | pmid:15541746 |
Ruf A et al. | The monotopic membrane protein human oxidosqualene cyclase is active as monomer. | 2004 | Biochem. Biophys. Res. Commun. | pmid:14766201 |
Suzuki M et al. | Loss of function of 3-hydroxy-3-methylglutaryl coenzyme A reductase 1 (HMG1) in Arabidopsis leads to dwarfing, early senescence and male sterility, and reduced sterol levels. | 2004 | Plant J. | pmid:14871314 |
O'Hagan DT et al. | Cationic microparticles are a potent delivery system for a HCV DNA vaccine. | 2004 | Vaccine | pmid:15542189 |
Stephenson I et al. | Detection of anti-H5 responses in human sera by HI using horse erythrocytes following MF59-adjuvanted influenza A/Duck/Singapore/97 vaccine. | 2004 | Virus Res. | pmid:15163495 |
Hu JJ et al. | [Antibody production and its neutralization of Abeta42's cytoxicity in BALB/c mice induced by Abeta42 and its subunit vaccines]. | 2004 | Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi | pmid:15191720 |
Holm BC et al. | Adjuvant oil induces waves of arthritogenic lymph node cells prior to arthritis onset. | 2004 | Clin. Exp. Immunol. | pmid:15196244 |
Fukasawa LO et al. | Adjuvant can improve protection induced by OMV vaccine against Neisseria meningitidis serogroups B/C in neonatal mice. | 2004 | FEMS Immunol. Med. Microbiol. | pmid:15196569 |
Tsai HF et al. | Candida glabrata erg1 mutant with increased sensitivity to azoles and to low oxygen tension. | 2004 | Antimicrob. Agents Chemother. | pmid:15215098 |
Maguire LS et al. | Fatty acid profile, tocopherol, squalene and phytosterol content of walnuts, almonds, peanuts, hazelnuts and the macadamia nut. | 2004 | Int J Food Sci Nutr | pmid:15223592 |
Abe I et al. | Mechanism and stereochemistry of enzymatic cyclization of 24,30-Bisnor-2,3-oxidosqualene by recombinant beta-amyrin synthase. | 2004 | J. Am. Chem. Soc. | pmid:15174853 |
Hess BA and Smentek L | Concerted nature of AB ring formation in the enzymatic cyclization of squalene to hopenes. | 2004 | Org. Lett. | pmid:15151397 |
Ketomaki A et al. | Effects of plant stanol and sterol esters on serum phytosterols in a family with familial hypercholesterolemia including a homozygous subject. | 2004 | J. Lab. Clin. Med. | pmid:15085084 |
Shenoy SD et al. | Induction of CYP3A by 2,3-oxidosqualene:lanosterol cyclase inhibitors is mediated by an endogenous squalene metabolite in primary cultured rat hepatocytes. | 2004 | Mol. Pharmacol. | pmid:15102959 |
Sato T et al. | Site-directed mutagenesis experiments on the putative deprotonation site of squalene-hopene cyclase from Alicyclobacillus acidocaldarius. | 2004 | Biosci. Biotechnol. Biochem. | pmid:15056909 |
Shin DH et al. | Amaranth squalene reduces serum and liver lipid levels in rats fed a cholesterol diet. | 2004 | Br. J. Biomed. Sci. | pmid:15058737 |
Ketomäki A et al. | Removal of intravenous Intralipid in patients with familial hypercholesterolemia during inhibition of cholesterol absorption and synthesis. | 2004 | Clin. Chim. Acta | pmid:15149875 |
Fazio GC et al. | Genome mining to identify new plant triterpenoids. | 2004 | J. Am. Chem. Soc. | pmid:15125655 |
Hoshino T et al. | Squalene-hopene cyclase: final deprotonation reaction, conformational analysis for the cyclization of (3R,S)-2,3-oxidosqualene and further evidence for the requirement of an isopropylidene moiety both for initiation of the polycyclization cascade and for the formation of the 5-membered E-ring. | 2004 | Org. Biomol. Chem. | pmid:15136801 |
Matyas GR et al. | Detection of antibodies to squalene: III. Naturally occurring antibodies to squalene in humans and mice. | 2004 | J. Immunol. Methods | pmid:15087221 |
Poralla K | Profound insights into squalene cyclization. | 2004 | Chem. Biol. | pmid:15112988 |
Reinert DJ et al. | Conversion of squalene to the pentacarbocyclic hopene. | 2004 | Chem. Biol. | pmid:15113001 |
Okada S et al. | Characterization of botryococcene synthase enzyme activity, a squalene synthase-like activity from the green microalga Botryococcus braunii, Race B. | 2004 | Arch. Biochem. Biophys. | pmid:14725863 |
Auwärter V et al. | Squalene in hair--a natural reference substance for the improved interpretation of fatty acid ethyl ester concentrations with respect to alcohol misuse. | 2004 | Forensic Sci. Int. | pmid:15451087 |
Ekanayake-Mudiyanselage S et al. | Oral supplementation with all-Rac- and RRR-alpha-tocopherol increases vitamin E levels in human sebum after a latency period of 14-21 days. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15753144 |
Vajdy M et al. | Mucosal and systemic anti-HIV responses in rhesus macaques following combinations of intranasal and parenteral immunizations. | 2004 | AIDS Res. Hum. Retroviruses | pmid:15588349 |
Hoshino T et al. | Deletion of the Gly600 residue of Alicyclobacillus acidocaldarius squalene cyclase alters the substrate specificity into that of the eukaryotic-type cyclase specific to (3S)-2,3-oxidosqualene. | 2004 | Angew. Chem. Int. Ed. Engl. | pmid:15593147 |
Scolastici C et al. | Squalene does not exhibit a chemopreventive activity and increases plasma cholesterol in a Wistar rat hepatocarcinogenesis model. | 2004 | Nutr Cancer | pmid:15572303 |