(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Cen-Pacheco F et al. | Cytotoxic oxasqualenoids from the red alga Laurencia viridis. | 2011 | Eur J Med Chem | pmid:21616566 |
Raouane M et al. | Synthesis, characterization, and in vivo delivery of siRNA-squalene nanoparticles targeting fusion oncogene in papillary thyroid carcinoma. | 2011 | J. Med. Chem. | pmid:21561161 |
Nowosielski M and Hoffmann M | Do the substituent effects affect conformational freedom of squalene in hopene biosynthesis? | 2011 | J Mol Model | pmid:21562825 |
Hernández-GarcÃa I et al. | [Adverse events after administration of A/H1N1 vaccine to patients]. | 2011 | Med Clin (Barc) | pmid:20199781 |
Fox CB et al. | Effects of emulsifier concentration, composition, and order of addition in squalene-phosphatidylcholine oil-in-water emulsions. | 2011 | Pharm Dev Technol | pmid:20550484 |
Celia C et al. | Gemcitabine-loaded innovative nanocarriers vs GEMZAR: biodistribution, pharmacokinetic features and in vivo antitumor activity. | 2011 | Expert Opin Drug Deliv | pmid:22077480 |
Tsai TF | MF59 adjuvanted seasonal and pandemic influenza vaccines. | 2011 | Yakugaku Zasshi | pmid:22129867 |
Puig-Barberà J et al. | MF59™-adjuvanted seasonal influenza vaccine in young children. | 2011 | Expert Rev Vaccines | pmid:22043952 |
Viganò A et al. | Long-term immunogenicity after one and two doses of a monovalent MF59-adjuvanted A/H1N1 Influenza virus vaccine coadministered with the seasonal 2009-2010 nonadjuvanted Influenza virus vaccine in HIV-infected children, adolescents, and young adults in a randomized controlled trial. | 2011 | Clin. Vaccine Immunol. | pmid:21795458 |
Huijskens E et al. | Immunogenicity, boostability, and sustainability of the immune response after vaccination against Influenza A virus (H1N1) 2009 in a healthy population. | 2011 | Clin. Vaccine Immunol. | pmid:21795459 |
Pollard AJ and Hill AV | Antibody repertoire: embracing diversity. | 2011 | Sci Transl Med | pmid:21795586 |
Okike IO et al. | The immunogenicity of a novel A (H1N1) vaccine in HIV-infected children. | 2011 | Vaccine | pmid:21742005 |
Packwood DM and Phillips LF | A stochastic, local mode study of neon-liquid surface collision dynamics. | 2011 | Phys Chem Chem Phys | pmid:21042647 |
Andrews N et al. | Age-specific effectiveness of an oil-in-water adjuvanted pandemic (H1N1) 2009 vaccine against confirmed infection in high risk groups in England. | 2011 | J. Infect. Dis. | pmid:21148494 |
Kajaste-Rudnitski A et al. | Induction of protective antibody response by MF59-adjuvanted 2009 pandemic A/H1N1v influenza vaccine in HIV-1-infected individuals. | 2011 | AIDS | pmid:21150561 |
Launay O et al. | Safety and immunogenicity of a monovalent 2009 influenza A/H1N1v vaccine adjuvanted with AS03A or unadjuvanted in HIV-infected adults: a randomized, controlled trial. | 2011 | J. Infect. Dis. | pmid:21628666 |
Piccialli V et al. | Isolation of a bis-iodurated tetra-THF as a trace product from the oxidation of squalene with RuOâ‚„ and its double ring expansion to a novel bis-THF-bis-THP compound. | 2011 | Molecules | pmid:21709619 |
Iannazzo S | Pharmacoeconomic evaluation of the MF59--adjuvanted influenza vaccine in the elderly population in Italy. | 2011 | J Prev Med Hyg | pmid:21710816 |
Seubert A et al. | Adjuvanticity of the oil-in-water emulsion MF59 is independent of Nlrp3 inflammasome but requires the adaptor protein MyD88. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21690334 |
AÄimoviÄ J et al. | Circadian rhythm of cholesterol synthesis in mouse liver: a statistical analysis of the post-squalene metabolites in wild-type and Crem-knock-out mice. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21531203 |
Siedenburg G and Jendrossek D | Squalene-hopene cyclases. | 2011 | Appl. Environ. Microbiol. | pmid:21531832 |
Tsai TF et al. | Explorations of clinical trials and pharmacovigilance databases of MF59®-adjuvanted influenza vaccines for associated cases of narcolepsy. | 2011 | Scand. J. Infect. Dis. | pmid:21534891 |
Esposito S et al. | Influenza A/H1N1 MF59-adjuvanted vaccine in preterm and term children aged 6 to 23 months. | 2011 | Pediatrics | pmid:21464195 |
Esposito S et al. | An open-label, randomized clinical trial assessing immunogenicity, safety and tolerability of pandemic influenza A/H1N1 MF59-adjuvanted vaccine administered sequentially or simultaneously with seasonal virosomal-adjuvanted influenza vaccine to paediatric kidney transplant recipients. | 2011 | Nephrol. Dial. Transplant. | pmid:20974645 |
Montana M et al. | Safety review: squalene and thimerosal in vaccines. | 2010 Nov-Dec | Therapie | pmid:21176760 |
Voyron S et al. | Antifungal activity of bis-azasqualenes, inhibitors of oxidosqualene cyclase. | 2010 | Mycoses | pmid:19549106 |
van Himbergen TM et al. | Familial combined hyperlipidemia is associated with alterations in the cholesterol synthesis pathway. | 2010 | Arterioscler. Thromb. Vasc. Biol. | pmid:19834104 |
Keitel W et al. | Dose ranging of adjuvant and antigen in a cell culture H5N1 influenza vaccine: safety and immunogenicity of a phase 1/2 clinical trial. | 2010 | Vaccine | pmid:19835829 |
Brunner R et al. | The ABC of clinical and experimental adjuvants--a brief overview. | 2010 | Immunol. Lett. | pmid:19895847 |
Eroglu E and Melis A | Extracellular terpenoid hydrocarbon extraction and quantitation from the green microalgae Botryococcus braunii var. Showa. | 2010 | Bioresour. Technol. | pmid:20005092 |
Kalvodova L | Squalene-based oil-in-water emulsion adjuvants perturb metabolism of neutral lipids and enhance lipid droplet formation. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20018176 |
Kimura M et al. | Protostadienol synthase from Aspergillus fumigatus: functional conversion into lanosterol synthase. | 2010 | Biochem. Biophys. Res. Commun. | pmid:19951700 |
Mantzouridou F and Tsimidou MZ | Observations on squalene accumulation in Saccharomyces cerevisiae due to the manipulation of HMG2 and ERG6. | 2010 | FEMS Yeast Res. | pmid:20550581 |
Van Damme P et al. | Evaluation of non-inferiority of intradermal versus adjuvanted seasonal influenza vaccine using two serological techniques: a randomised comparative study. | 2010 | BMC Infect. Dis. | pmid:20504306 |
Waddington CS et al. | Safety and immunogenicity of AS03B adjuvanted split virion versus non-adjuvanted whole virion H1N1 influenza vaccine in UK children aged 6 months-12 years: open label, randomised, parallel group, multicentre study. | 2010 | BMJ | pmid:20508026 |
Beck F et al. | Queries about vaccines containing squalene. | 2010 | Immunol. Cell Biol. | pmid:20157330 |
Gerpe A et al. | Naftifine-analogues as anti-Trypanosoma cruzi agents. | 2010 | Eur J Med Chem | pmid:20163894 |
Warleta F et al. | Squalene protects against oxidative DNA damage in MCF10A human mammary epithelial cells but not in MCF7 and MDA-MB-231 human breast cancer cells. | 2010 | Food Chem. Toxicol. | pmid:20138105 |
Sugihara N et al. | Novel fractionation method for squalene and phytosterols contained in the deodorization distillate of rice bran oil. | 2010 | J Oleo Sci | pmid:20103978 |
Chen CC et al. | Effects of lipophilic emulsifiers on the oral administration of lovastatin from nanostructured lipid carriers: physicochemical characterization and pharmacokinetics. | 2010 | Eur J Pharm Biopharm | pmid:20060469 |
Spanova M et al. | Effect of lipid particle biogenesis on the subcellular distribution of squalene in the yeast Saccharomyces cerevisiae. | 2010 | J. Biol. Chem. | pmid:20032462 |
Tsai T et al. | Exposure to MF59-adjuvanted influenza vaccines during pregnancy--a retrospective analysis. | 2010 | Vaccine | pmid:19969117 |
Pietrella D et al. | A beta-glucan-conjugate vaccine and anti-beta-glucan antibodies are effective against murine vaginal candidiasis as assessed by a novel in vivo imaging technique. | 2010 | Vaccine | pmid:20038431 |
Gasparini R et al. | Impact of prior or concomitant seasonal influenza vaccination on MF59-adjuvanted H1N1v vaccine (Focetria) in adult and elderly subjects. | 2010 | Int. J. Clin. Pract. | pmid:20039974 |
Narayan BH et al. | Modulation of doxorubicin-induced genotoxicity by squalene in Balb/c mice. | 2010 | Food Funct | pmid:21776469 |
Bildstein L et al. | Transmembrane diffusion of gemcitabine by a nanoparticulate squalenoyl prodrug: an original drug delivery pathway. | 2010 | J Control Release | pmid:20691740 |
Weiss TL et al. | Raman spectroscopy analysis of botryococcene hydrocarbons from the green microalga Botryococcus braunii. | 2010 | J. Biol. Chem. | pmid:20705610 |
Nakagawa K et al. | gamma-Tocotrienol reduces squalene hydroperoxide-induced inflammatory responses in HaCaT keratinocytes. | 2010 | Lipids | pmid:20714817 |
Black S et al. | Safety of MF59-adjuvanted versus non-adjuvanted influenza vaccines in children and adolescents: an integrated analysis. | 2010 | Vaccine | pmid:20813217 |
Beran J et al. | A phase III, randomized, open-label study to assess the tolerability and immunogenicity of an H5N1 influenza vaccine administered to healthy adults with a 1-, 2-, 3-, or 6-week interval between first and second doses. | 2010 | Clin Ther | pmid:21316535 |