(e,e,e,e)-squalene
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
Cross Reference
Introduction
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (e,e,e,e)-squalene?
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
PubChem Associated disorders and diseases
What pathways are associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (e,e,e,e)-squalene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with (e,e,e,e)-squalene?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with (e,e,e,e)-squalene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Malathi P and Ganguly J | Studies on metabolism of vitamin A. 8. Effect of ascorbate on isoprenoid metabolism in vitamin A-deficient rats. | 1964 | Biochem. J. | pmid:5837438 |
| Smith AG and Goad LJ | Sterol biosynthesis by the sea urchin Echinus esculentus. | 1974 | Biochem. J. | pmid:4441383 |
| DIPLOCK AT et al. | VITAMIN A AND ISOPRENOID SYNTHESIS IN THE RAT. | 1965 | Biochem. J. | pmid:14333548 |
| GOODWIN TW and WILLIAMS RJ | A MECHANISM FOR THE CYCLIZATION OF AN ACYCLIC PRECURSOR TO FORM BETA-CAROTENE. | 1965 | Biochem. J. | pmid:14342248 |
| Smith AG and Goad LJ | Sterol biosynthesis in the echinoderm Asterias rubens. | 1975 | Biochem. J. | pmid:1147897 |
| Etemadi AH et al. | Assay of the possible organization of particle-bound enzymes with squalene synthetase and squalene oxidocyclase systems. | 1969 | Biochem. J. | pmid:4388240 |
| Stone KJ and Hemming FW | The incorporation of [2-14C, 4R-3H1] mevalonate and [2-14C, 4S-3H1] mevalonate into squalene, ubiquinone and ergosterol of Aspergillus fumigatus Fresenius. | 1965 | Biochem. J. | pmid:4284430 |
| Walton MJ and Pennock JF | Some studies on the biosynthesis of ubiguinone, isoprenoid alcohols, squalene and sterols by marine invertebrates. | 1972 | Biochem. J. | pmid:4403925 |
| Green TR and Baisted DJ | Development of the activities of enzymes of the isoprenoid pathway during early stages of pea-seed germination. | 1972 | Biochem. J. | pmid:4348263 |
| Marco de la Calle C and Gibbons GF | Hepatic and intestinal formation of polar sterols in vivo in animals fed on a cholesterol-supplemented diet. | 1988 | Biochem. J. | pmid:3415662 |
| Smith AG and Goad LJ | Sterol biosynthesis in the starfish Asterias rubens and Henricia sanguinolenta. | 1971 | Biochem. J. | pmid:5126917 |
| Bloxham DP and Akhtar M | Studies on the control of cholesterol biosynthesis: the adenosine 3':5'-cyclic monophosphate-dependent accumulation of a steroid carboxylic acid. | 1971 | Biochem. J. | pmid:4331371 |
| Willett JD and Downey WL | Sterol biosynthesis in the free-living nematode Panagrellus redivivus. | 1974 | Biochem. J. | pmid:4822732 |
| Green TR and Baisted DJ | Development of the squalene-synthesizing system during early stages of pea seed germination. | 1971 | Biochem. J. | pmid:4335540 |
| Ginger ML et al. | Elucidation of carbon sources used for the biosynthesis of fatty acids and sterols in the trypanosomatid Leishmania mexicana. | 1999 | Biochem. J. | pmid:10455027 |
| CORNFORTH JW and POPJAK G | Studies on the biosynthesis of cholesterol. 3. Distribution of 14C in squalene biosynthesized from [Me-14C]acetate. | 1954 | Biochem. J. | pmid:13208629 |
| WHEATLEY VR | Studies of sebum. IV. The estimation of squalene in sebum and sebum-like materials. | 1953 | Biochem. J. | pmid:13115346 |
| Sargent JR et al. | Metabolism of mevalonic acid in the liver of the dogfish Scyliorhinus caniculus. | 1970 | Biochem. J. | pmid:5420034 |
| Stone KJ and Hemming FW | The stereochemistry of hexahydroprenol, ubiquinone and ergosterol biosynthesis in the mycelium of Aspergillus fumigatus Fresenius. | 1967 | Biochem. J. | pmid:4292001 |
| Rees HH et al. | Studies in phytosterol biosynthesis. Mechanism of biosynthesis of cycloartenol. | 1968 | Biochem. J. | pmid:4297048 |
| Akhtar M et al. | The incorporation of a hydrogen atom at C-15 of cholesterol biosynthesized from squalene. | 1969 | Biochem. J. | pmid:5343788 |
| Rees HH et al. | The biosynthesis of beta-amyrin. Mechanism of squalene cyclization. | 1968 | Biochem. J. | pmid:5639923 |
| Akhtar M et al. | The role of a cholesta-8,14-dien-3-beta-ol system in cholesterol biosynthesis. | 1969 | Biochem. J. | pmid:5783476 |
| CORNFORTH JW et al. | Studies on the biosynthesis of cholesterol. 5. Biosynthesis of squalene from DL-3-hydroxy-3-methyl [2-14C] pentano-5-lactone. | 1958 | Biochem. J. | pmid:13535596 |
| Goodwin TW and Williams RJ | A mechanism for the biosynthesis of alpha-carotene. | 1965 | Biochem. J. | pmid:5881648 |
| POPJAK G et al. | Studies on the biosynthesis of cholesterol. 6. Coenzyme requirements of liver enzymes for synthesis of squalene and of sterol from DL-3-hydroxy-3-methyl-[2-14C] pentano-5-lactone. | 1958 | Biochem. J. | pmid:13546172 |
| BOUGHTON B et al. | Studies of sebum. VIII. Observations on the squalene and cholesterol content and the possible functions of squalene in human sebum. | 1957 | Biochem. J. | pmid:13426103 |
| Walton TJ et al. | Biosynthesis of xanthophylls in higher plants: stereochemistry of hydroxylation at C-3. | 1969 | Biochem. J. | pmid:5801311 |
| Yamamoto S and Bloch K | On the enzymes catalysing the transformation of squalene to lanosterol. | 1969 | Biochem. J. | pmid:5807185 |
| Higgins MJ and Kekwick RG | The role of malonyl-coenzyme A in isoprenoid biosynthesis. | 1969 | Biochem. J. | pmid:5807201 |
| Scharf SS and Simpson KL | Attempts to detect lycopersene formation in yeast. | 1968 | Biochem. J. | pmid:5753091 |
| Caspi E et al. | The biosynthesis of tetrahymanol in vitro. | 1968 | Biochem. J. | pmid:5696872 |
| Threlfall DR et al. | Biosynthesis of phytoquinones. Incorporation of L-[Me-14C,3H]methionine into terpenoid quinones and chromanols in maize shoots. | 1968 | Biochem. J. | pmid:5721452 |
| Cenedella RJ | Concentration-dependent effects of AY-9944 and U18666A on sterol synthesis in brain. Variable sensitivities of metabolic steps. | 1980 | Biochem. Pharmacol. | pmid:6159896 |
| Viola F et al. | In vitro metabolism of azasqualene derivatives and their effects on aminopyrine N-demethylase activity in rat liver microsomes. | 1989 | Biochem. Pharmacol. | pmid:2757649 |
| Gerst N et al. | Inhibition of cholesterol biosynthesis in 3T3 fibroblasts by 2-aza-2,3-dihydrosqualene, a rationally designed 2,3-oxidosqualene cyclase inhibitor. | 1986 | Biochem. Pharmacol. | pmid:3790151 |
| Dollis D and Schuber F | Effects of a 2,3-oxidosqualene-lanosterol cyclase inhibitor 2,3:22,23-dioxidosqualene and 24,25-epoxycholesterol on the regulation of cholesterol biosynthesis in human hepatoma cell line HepG2. | 1994 | Biochem. Pharmacol. | pmid:8043030 |
| Jeng I et al. | Effect of a hypocholesterolemic agent on cholesteryl ester metabolism in glioblastoma cells. | 1985 | Biochem. Pharmacol. | pmid:3994747 |
| Duriatti A et al. | In vitro inhibition of animal and higher plants 2,3-oxidosqualene-sterol cyclases by 2-aza-2,3-dihydrosqualene and derivatives, and by other ammonium-containing molecules. | 1985 | Biochem. Pharmacol. | pmid:4015713 |
| Boguslawski W and Zelewski L | Inhibition of cholesterol biosynthesis by the respiratory chain inhibitors in human placenta and in rat liver. | 1971 | Biochem. Pharmacol. | pmid:5132889 |
| Goad LJ et al. | Effect of the allylamine antifungal drug SF 86-327 on the growth and sterol synthesis of Leishmania mexicana mexicana promastigotes. | 1985 | Biochem. Pharmacol. | pmid:4052119 |
| Porcellati G and Giorgini D | The effect of alpha-methyl gamma-phenyl butyric acid on sterol biosynthesis in vitro. | 1969 | Biochem. Pharmacol. | pmid:5772592 |
| Mazein A et al. | A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway. | 2013 | Biochem. Pharmacol. | pmid:23583456 |
| Viola F et al. | Inhibition of 2,3-oxidosqualene cyclase and sterol biosynthesis by 10- and 19-azasqualene derivatives. | 1995 | Biochem. Pharmacol. | pmid:7575639 |
| Yamamoto S and Bloch K | Enzymatic studies on the oxidative cyclizations of squalene. | 1970 | Biochem. Soc. Symp. | pmid:4400141 |
| Morton RA | Natural substances formed biologically from mevalonic acid. Chairman's opening remarks. | 1970 | Biochem. Soc. Symp. | pmid:4944436 |
| Popják G | Conversion of mevalonic acid into prenyl hydrocarbons as exemplified by the synthesis of squalene. | 1970 | Biochem. Soc. Symp. | pmid:4332649 |
| Rahier A et al. | Inhibition of 2,3-oxidosqualene: beta-amyrin-cyclase, S-adenosyl-L-methionine: cycloartenol C-24-methyltransferase and cycloeucalenol: obtusifoliol isomerase by rationally designed molecules containing a tertiary amine function. | 1983 | Biochem. Soc. Trans. | pmid:6642064 |
| Rilling HC | The mechanism of the condensation reactions of cholesterol biosynthesis. Fourth Morton lecture. | 1985 | Biochem. Soc. Trans. | pmid:4092833 |
| Cooper MF et al. | Sebaceous lipogenesis and androgen metabolism in acne. | 1976 | Biochem. Soc. Trans. | pmid:137154 |