(e,e,e,e)-squalene
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
Cross Reference
Introduction
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (e,e,e,e)-squalene?
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
PubChem Associated disorders and diseases
What pathways are associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (e,e,e,e)-squalene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with (e,e,e,e)-squalene?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with (e,e,e,e)-squalene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Werthemann L and Johnson WS | Application of the chloro ketal Claisen reaction to the total synthesis of squalene. | 1970 | Proc. Natl. Acad. Sci. U.S.A. | pmid:5274470 |
| Werthemann L and Johnson WS | Application of the chloro ketal claisen reaction to the total synthesis of squalene. Experimental details. | 1970 | Proc. Natl. Acad. Sci. U.S.A. | pmid:5275377 |
| Morton RA | Natural substances formed biologically from mevalonic acid. Chairman's opening remarks. | 1970 | Biochem. Soc. Symp. | pmid:4944436 |
| Van TAMELEN EE and Freed JH | Biochemical conversion of partially cyclized squalene 2,3-oxide types to the lanosterol system. Views on the normal enzymic cyclization process. | 1970 | J. Am. Chem. Soc. | pmid:4098774 |
| Popják G | Conversion of mevalonic acid into prenyl hydrocarbons as exemplified by the synthesis of squalene. | 1970 | Biochem. Soc. Symp. | pmid:4332649 |
| Brooks CJ et al. | Lipids of human atheroma. VI. Hydrocarbons of the atheromatous plaque. | 1970 | Lipids | pmid:5488810 |
| Jayme M et al. | The nature of the hydrogen migrations in the cyclization of squalene oxide to lanosterol. | 1970 | J. Am. Chem. Soc. | pmid:5435274 |
| van Tamelen EE et al. | Minimal substrate structural requirements for lanosterol-squalene 2,3-oxide cyclase action. 10'-norsqualene 2,3-oxide. | 1970 | J. Am. Chem. Soc. | pmid:5435278 |
| Phytochemistry: terpenoids for progress. | 1970 | Nature | pmid:5437511 | |
| Yamamoto S and Bloch K | Studies on squalene epoxidase of rat liver. | 1970 | J. Biol. Chem. | pmid:5438357 |
| Gallin JI et al. | Increased serum levels of seualene in patients with acute influenza. | 1970 | N. Engl. J. Med. | pmid:5442630 |
| Zander JM et al. | Tetrahymanol biosynthesis. Studies in vitro on squalene cyclization. | 1970 | J. Biol. Chem. | pmid:5442819 |
| Rahman R et al. | Removal of the 4,4-dimethyl carbons in the enzymic conversion of lanosterol to cholesterol. Initial loss of the 4-alpha-methyl group. | 1970 | J. Biol. Chem. | pmid:5445804 |
| Corey EJ and Yamamoto H | Correlation of a protosterol from 20,21-dehydro-2,3-oxidosqualene and 2,3-oxidosqualene-sterol cyclase with dihydrolanosterol. | 1970 | Tetrahedron Lett. | pmid:5447652 |
| Kligman AM et al. | Comedogenicity of human sebum. | 1970 | Arch Dermatol | pmid:4247928 |
| Godinez MH et al. | The biosynthesis of isoprenoid lipids including ubiquinone in muscle from normal and genetically dystrophic mice. | 1970 | Arch. Biochem. Biophys. | pmid:5460184 |
| Caspi E and Mulheirn LJ | Mechanism of squalene cyclization. Biosynthesis of fusidic acid from (4R)-[2-14C,43H]mevalonic acid. | 1970 | J. Am. Chem. Soc. | pmid:5460747 |
| Villee CA | Shark oil and medicine. | 1970 | N. Engl. J. Med. | pmid:5462581 |
| Stefanovich V and Kajiyama G | Squalene and cholestanol in normal rabbit aorta. | 1970 May-Jun | Atherosclerosis | pmid:5433085 |
| Habczyńska D et al. | [The effect of squalene and cholesterol on the histological picture of the periodontium in white rats]. | 1970 Oct-Nov | Czas Stomatol | pmid:5274119 |
| Scallen TJ et al. | Studies on the enzymatic synthesis of cholesterol: use of a liver acetone powder. | 1971 | Lipids | pmid:4396848 |
| Fiser RH et al. | Effects of acute infection on cholesterogenesis in the rhesus monkey. | 1971 | Proc. Soc. Exp. Biol. Med. | pmid:4399094 |
| Edmond J et al. | Presqualene alcohol. Further evidence on the structure of a C 30 precursor of squalene. | 1971 | J. Biol. Chem. | pmid:4399596 |
| Anding C et al. | Sterol biosynthesis in Euglena gracilis Z. Sterol precursors in light-grown and dark-grown Euglena gracilis Z. | 1971 | Eur. J. Biochem. | pmid:5003307 |
| Dean PD | The cyclases of triterpene and sterol biosynthesis. | 1971 | Steroidologia | pmid:5004310 |
| Shamberger RJ | Inhibitory effect of vitamin A on carcinogenesis. | 1971 | J. Natl. Cancer Inst. | pmid:5157584 |
| Bird CW et al. | Steroids and squalene in Methylococcus capsulatus grown on methane. | 1971 | Nature | pmid:4929985 |
| van Leusden HA et al. | Squalene and lanosterol synthesis in the foeto-placental unit at midgestation. | 1971 | Acta Endocrinol. | pmid:5108099 |
| Ramsey RB et al. | Squalene-like isoprenoid hydrocarbons in bovine brain. | 1971 | J. Neurochem. | pmid:5129357 |
| Taylor RF and Ikawa M | Gas chromatography of carotenoids. | 1971 | Anal. Biochem. | pmid:5130948 |
| Boguslawski W and Zelewski L | Inhibition of cholesterol biosynthesis by the respiratory chain inhibitors in human placenta and in rat liver. | 1971 | Biochem. Pharmacol. | pmid:5132889 |
| Wells JW | Steroids in the pineal gland of the domestic fowl (Gallus domesticus): cholesterol and its biosynthesis. | 1971 | Comp. Biochem. Physiol., B | pmid:5133342 |
| van Tamelen EE et al. | Formation of A-B cis- and trans-19-norlanosterols by enzymic cyclization of 6'-norsqualene 2,3-oxide. | 1971 | J. Am. Chem. Soc. | pmid:5135874 |
| Chida N and Okamura T | Increased cholesterol-biosynthesis in familial hypercholesterolemia. | 1971 | Tohoku J. Exp. Med. | pmid:5140375 |
| Ramsey RB et al. | The biosynthesis of cholesterol and other sterols by brain tissue. Distribution in subcellular fractions as a function of time after intracerebral injection of [2-14C]-mevalonic acid. | 1971 | J. Neurochem. | pmid:5092868 |
| Mallory FB and Conner RL | Dehydrogenation and dealkylation of various sterols by Tetrahymena pyriformis. | 1971 | Lipids | pmid:4102490 |
| Tamelen EE and Schwartz MA | Mechanism of presqualene pyrophosphate-squalene biosynthesis. | 1971 | J. Am. Chem. Soc. | pmid:4323745 |
| Rilling HC et al. | Studies on the mechanism of squalene biosynthesis. Presqualene pyrophosphate, stereochemistry and a mechanism for its conversion to squalene. | 1971 | J. Am. Chem. Soc. | pmid:4323746 |
| Mulheirn LJ and Caspi E | Mechanism of squalene cyclization. The biosynthesis of fusidic acid. | 1971 | J. Biol. Chem. | pmid:5553407 |
| Cotterill JA et al. | A semiquantitative method for the biochemical analysis of sebum. | 1971 | Br. J. Dermatol. | pmid:5557832 |
| Cunliffe WJ et al. | Variations in skin surface lipid composition with different sampling techniques. I. | 1971 | Br. J. Dermatol. | pmid:5557833 |
| Ramsey RB et al. | The biosynthesis of cholesterol and other sterols by brain tissue. II. A comparison of in vitro and in vivo methods. | 1971 | Lipids | pmid:5559874 |
| Peter G et al. | [Gas-chromatography studies on sebaceous gland lipids. II. Composition of sebaceous gland lipids in various age groups]. | 1971 | Arch Dermatol Forsch | pmid:5560856 |
| Peter G and Peter R | [Studies on the composition of palmar skin surface fat in relation to age and its biochemical bases]. | 1971 | Arch Dermatol Forsch | pmid:5571755 |
| Ramsey RB et al. | The biosynthesis of cholesterol and other sterols by brain tissue. I. Subcellular biosynthesis in vitro. | 1971 | Lipids | pmid:5574907 |
| Daly MM | Biosynthesis of squalene and sterols by rat aorta. | 1971 | J. Lipid Res. | pmid:5579265 |
| Altman LJ et al. | Synthesis and conversion of presqualene alcohol to squalene. | 1971 | J. Am. Chem. Soc. | pmid:5550251 |
| Coates RM and Robinson WH | Stereoselective total synthesis of (plus or minus)-presqualene alcohol. | 1971 | J. Am. Chem. Soc. | pmid:5550252 |
| Jones JP et al. | Lipid biosynthesis in neuron-enriched and glial-enriched fractions of rat brain: sterol formation. | 1971 | Life Sci. II | pmid:5569686 |
| Malhotra HC and Nes WR | The mechanism of introduction of alkyl groups at C-24 of sterols. IV. Inhibition by triparanol. | 1971 | J. Biol. Chem. | pmid:5570429 |