(e,e,e,e)-squalene

(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.

Cross Reference

Introduction

To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (e,e,e,e)-squalene?

(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene

MeSH term MeSH ID Detail
Leukemia P388 D007941 43 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Leukemia, Hairy Cell D007943 5 associated lipids
Lipodystrophy D008060 4 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Lung Neoplasms D008175 171 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Nervous System Diseases D009422 37 associated lipids
Neuroblastoma D009447 66 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Dermatitis, Occupational D009783 12 associated lipids
Occupational Diseases D009784 42 associated lipids
Ossification, Heterotopic D009999 2 associated lipids
Otitis Media D010033 12 associated lipids
Pain D010146 64 associated lipids
Parkinson Disease D010300 53 associated lipids
Parvoviridae Infections D010322 4 associated lipids
Periodontitis D010518 22 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with (e,e,e,e)-squalene

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with (e,e,e,e)-squalene?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (e,e,e,e)-squalene?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with (e,e,e,e)-squalene

Download all related citations
Per page 10 20 50 100 | Total 1766
Authors Title Published Journal PubMed Link
Scolastici C et al. Squalene does not exhibit a chemopreventive activity and increases plasma cholesterol in a Wistar rat hepatocarcinogenesis model. 2004 Nutr Cancer pmid:15572303
MELCHIORRI-SANTOLINI U and RENZINI G [Detection of sterols and squalene in sporigenic bacteria]. 1960 Nov-Dec Nuovi Ann Ig Microbiol pmid:13769177
RENZINI G [Detection of sterols and squalene in B. coli aerogenes]. 1960 Nov-Dec Nuovi Ann Ig Microbiol pmid:13740904
Allain V et al. Self-assembled nucleolipids: from supramolecular structure to soft nucleic acid and drug delivery devices. 2012 Nucleic Acids Res. pmid:22075995
Imaeda K et al. [Effect of sex-hormone on composition of rat skin surface lipid]. 1987 Nippon Yakurigaku Zasshi pmid:3428773
Shimizu Y et al. [Innovation of vaccine adjuvants]. 2008 Nippon Rinsho pmid:18939490
Uotani J [The changes of sterol in lenses]. 1984 Nippon Ganka Gakkai Zasshi pmid:6711397
Nishimura S [Fasting serum squalene in patients with gallstones and hyperlipidemia]. 1988 Nihon Shokakibyo Gakkai Zasshi pmid:3385962
Yoshino K and Matsuo I [Squalene peroxide formation by UVA irradiation with or without 8-MOP (author's transl)]. 1981 Nihon Hifuka Gakkai Zasshi pmid:6971356
Torinuki W et al. [Emission spectral analysis of ultraweak chemiluminescence from linolenic acid and squalene peroxides (author's transl)]. 1982 Nihon Hifuka Gakkai Zasshi pmid:6978954
Inomata N [Symposium I: aging and the activity of the sebaceous glands]. 1973 Nihon Hifuka Gakkai Zasshi pmid:4546667
Xue Z et al. Divergent evolution of oxidosqualene cyclases in plants. 2012 New Phytol. pmid:22150097
Inagaki YS et al. Investigation of the potential for triterpene synthesis in rice through genome mining and metabolic engineering. 2011 New Phytol. pmid:21501172
Petrik MS et al. Aluminum adjuvant linked to Gulf War illness induces motor neuron death in mice. 2007 Neuromolecular Med. pmid:17114826
Paoletti P et al. Lipid biosynthesis from labelled precursors in an experimental brain tumor-bearing mouse. 1966 Neurochirurgia (Stuttg) pmid:5966653
Johnson RC and Shah SN Metabolism of intracerebrally injected mevalonate in brain of suckling and young adult rats. 1985 Neurochem. Res. pmid:3925358
Esposito S et al. An open-label, randomized clinical trial assessing immunogenicity, safety and tolerability of pandemic influenza A/H1N1 MF59-adjuvanted vaccine administered sequentially or simultaneously with seasonal virosomal-adjuvanted influenza vaccine to paediatric kidney transplant recipients. 2011 Nephrol. Dial. Transplant. pmid:20974645
Das B et al. Squalene selectively protects mouse bone marrow progenitors against cisplatin and carboplatin-induced cytotoxicity in vivo without protecting tumor growth. 2008 Neoplasia pmid:18813359
Autrum H et al. [Squalene in the glandular secretion of mammals]. 1968 Naturwissenschaften pmid:5726004
Wadman M Race is on for flu vaccine. 2005 Nature pmid:16267526
Thoma R et al. Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase. 2004 Nature pmid:15525992
Clark RP and Shirley SG Identification of skin in airborne particulate matter. 1973 Nature pmid:4585846
LUCY JA and DINGLE JT FAT-SOLUBLE VITAMINS AND BIOLOGICAL MEMBRANES. 1964 Nature pmid:14222261
WOOTTON JM and WRIGHT LD Biosynthesis of squalene by the annelid Lumbricus terrestris. 1960 Nature pmid:13786660
ALAM SQ et al. Detection and estimation of squalene in leaves. 1962 Nature pmid:13860005
Bird CW et al. Steroids and squalene in Methylococcus capsulatus grown on methane. 1971 Nature pmid:4929985
GOSSELIN L et al. Particulate enzyme system for the synthesis of squalene from 2-(14C)-mevalonic acid. 1962 Nature pmid:13900654
Phytochemistry: terpenoids for progress. 1970 Nature pmid:5437511
Lewis RW Distribution of dietary squalene in a wandering Albatross, diomedea exultans. 1969 Nature pmid:5358352
Boyd GS and Onajobi FD Control of cholesterol biosynthesis by a plasma apo-lipoprotein. 1969 Nature pmid:5789314
Brassell SC et al. Specific acyclic isoprenoids as biological markers of methanogenic bacteria in marine sediments. 1981 Nature pmid:7219553
HELLER JH et al. Squalene content of various shark livers. 1957 Nature pmid:13430738
Ackman RG et al. Unusual occurrence of squalene in a fish, the eulachon Thaleichthys pacificus. 1968 Nature pmid:5701840
Naughton C et al. Transcription forms and remodels supercoiling domains unfolding large-scale chromatin structures. 2013 Nat. Struct. Mol. Biol. pmid:23416946
Ali NA et al. Essential oil composition of leaves of Stachys yemenensis obtained by supercritical COâ‚‚. 2010 Nat. Prod. Res. pmid:21104527
Harrison DM The biosynthesis of triterpenoids and steroids. 1985 Nat Prod Rep pmid:3913885
Abe I et al. Inhibitors of squalene biosynthesis and metabolism. 1994 Nat Prod Rep pmid:15200015
Connolly JD and Hill RA Triterpenoids. 2002 Nat Prod Rep pmid:12195814
Zhang XH et al. Chemical composition of volatile oils from the pericarps of Indian sandalwood (Santalum album) by different extraction methods. 2012 Nat Prod Commun pmid:22428257
Pili B et al. Liposomal squalenoyl-gemcitabine: formulation, characterization and anticancer activity evaluation. 2010 Nanoscale pmid:20820745
Réjiba S et al. Squalenoyl gemcitabine nanomedicine overcomes the low efficacy of gemcitabine therapy in pancreatic cancer. 2011 Nanomedicine pmid:21419876
Couvreur P et al. Squalenoyl nanomedicines as potential therapeutics. 2006 Nano Lett. pmid:17090088
Finotti E et al. Synergistic effects of alpha-tocopherol, beta-sitosterol and squalene on antioxidant activity assayed by crocin bleaching method. 2000 Nahrung pmid:11075383
Stephenson I et al. Antigenically distinct MF59-adjuvanted vaccine to boost immunity to H5N1. 2008 N. Engl. J. Med. pmid:18843132
Pass RF et al. Vaccine prevention of maternal cytomegalovirus infection. 2009 N. Engl. J. Med. pmid:19297572
Vesikari T et al. Oil-in-water emulsion adjuvant with influenza vaccine in young children. 2011 N. Engl. J. Med. pmid:21995388
Ambrose CS and Belshe RB Influenza vaccine in young children. 2012 N. Engl. J. Med. pmid:22276839
Heikkinen T and Heinonen S Influenza vaccine in young children. 2012 N. Engl. J. Med. pmid:22276840
Miettinen TA et al. Serum squalene and methyl sterols. 1970 N. Engl. J. Med. pmid:5470273
Gallin JI et al. Increased serum levels of seualene in patients with acute influenza. 1970 N. Engl. J. Med. pmid:5442630