(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Hronská L et al. | Low concentrations of the non-ionic detergent Nonidet P-40 interfere with sterol biogenesis and viability of the yeast Saccharomyces cerevisiae. | 2004 | FEMS Microbiol. Lett. | pmid:15336428 |
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Scolastici C et al. | Squalene does not exhibit a chemopreventive activity and increases plasma cholesterol in a Wistar rat hepatocarcinogenesis model. | 2004 | Nutr Cancer | pmid:15572303 |
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Nikkilä K et al. | Serum and hepatic cholestanol, squalene and noncholesterol sterols in man: a study on liver transplantation. | 1992 | Hepatology | pmid:1568728 |
Ekanayake-Mudiyanselage S et al. | Oral supplementation with all-Rac- and RRR-alpha-tocopherol increases vitamin E levels in human sebum after a latency period of 14-21 days. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15753144 |
Aguilera Y et al. | The protective role of squalene in alcohol damage in the chick embryo retina. | 2005 | Exp. Eye Res. | pmid:15781281 |
Lee KH et al. | Squalene aspiration pneumonia in children: radiographic and CT findings as the first clue to diagnosis. | 2005 | Pediatr Radiol | pmid:15806404 |
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