(e,e,e,e)-squalene
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
Cross Reference
Introduction
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (e,e,e,e)-squalene?
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
PubChem Associated disorders and diseases
What pathways are associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (e,e,e,e)-squalene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with (e,e,e,e)-squalene?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with (e,e,e,e)-squalene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Cuzzopoli M et al. | Effect of nephrectomy and cholesterol feeding on the metabolism of intravenously administered DL-mevalonate in the rat. | 1972 | Metab. Clin. Exp. | pmid:4641957 |
| Mak KM and Trier JS | Radioautographic and chemical evidence for (5- 3 H)mevalonate incorporation into cholesterol by rat villous absorptive cells. | 1972 | Biochim. Biophys. Acta | pmid:4642214 |
| Dennick RG | The intracellular organisation of cholesterol biosynthesis. A review. | 1972 | Steroids Lipids Res | pmid:4572325 |
| Salen G and Polito A | Biosynthesis of 5 -cholestan-3 -ol in cerebrotendinous xanthomatosis. | 1972 | J. Clin. Invest. | pmid:4550120 |
| Green TR and Baisted DJ | Development of the activities of enzymes of the isoprenoid pathway during early stages of pea-seed germination. | 1972 | Biochem. J. | pmid:4348263 |
| Mullakhanbhai MF and Francis GW | Bacterial lipids. 1. Lipid constituents of a moderately halophilic bacterium. | 1972 | Acta Chem Scand | pmid:5049648 |
| Coates RM and Robinson WH | Solvolysis of trans-2,2-dimethyl-3-(2'-methylpropenyl)cyclobutyl tosylate. Model reactions relevant to squalene biosynthesis. | 1972 | J. Am. Chem. Soc. | pmid:5053868 |
| Ainsworth L and Nitchuk WM | Cholesterol biosynthesis by sheep foetal liver and placenta in vitro. | 1972 | J. Endocrinol. | pmid:5062219 |
| Goodfellow RD and Liu GC | Squalene metabolism in the larva of the fly, Sarcophaga bullata. | 1972 | J. Insect Physiol. | pmid:5009197 |
| Ramsey RB et al. | The biosynthesis of cholesterol and other sterols by brain tissue. Distribution in subcellular fractions as a function of time after intracerebral injection into developing brain of (2- 14 C)mevalonic. | 1972 | J. Neurochem. | pmid:5009889 |
| Downing DT et al. | Changes in skin surface lipid composition induced by severe caloric restriction in man. | 1972 | Am. J. Clin. Nutr. | pmid:5010536 |
| Asakawa A et al. | The effect of nicotinamide on the cholesterol biosynthesis by cell-free rat brain extract. | 1972 | J Nihon Univ Sch Dent | pmid:4269195 |
| Singh EJ et al. | Hydrocarbons in human cervical mucus and the effect of oral contraception. | 1972 | J Reprod Med | pmid:4113025 |
| Voogt PA and Van der Horst DJ | Investigations of the capacity of synthesizing 3 -sterols in mollusca. 8. The biosynthesis of 3 -sterols in the pulmonates "Succinea putris" and "Arianta arbustorum". | 1972 | Arch. Int. Physiol. Biochim. | pmid:4114875 |
| Sipe JD and Holmlund CE | A comparison of the effects of some hypocholesteremic compounds on squalene metabolism in Tetrahymena pyriformis and rat liver. | 1972 | Biochim. Biophys. Acta | pmid:4116026 |
| Ramsey RB et al. | Distribution of alkanes in normal and atherosclerotic rabbit aortas. | 1972 May-Jun | Atherosclerosis | pmid:5051654 |
| Ritter MC and Dempsey ME | Squalene and sterol carrier protein: structural properties, lipid-binding, and function in cholesterol biosynthesis. | 1973 | Proc. Natl. Acad. Sci. U.S.A. | pmid:4509660 |
| Terakado M et al. | Effects of arsenite on incorporation of mevalonate-2-14C into squalene-14C in rabbit dental pulp. | 1973 | J Nihon Univ Sch Dent | pmid:4517364 |
| Anding C et al. | [Comparative cyclization of 2,3 epoxide of methylene-22-dihydro-22-squalene in cell-free systems extracted from animal and higher plant tissues]. | 1973 | C.R. Hebd. Seances Acad. Sci., Ser. D, Sci. Nat. | pmid:4632903 |
| Ruzicka L | In the borderland between bioorganic chemistry and biochemistry. | 1973 | Annu. Rev. Biochem. | pmid:4600996 |
| Bose AK and Hungund BL | The role of glycine in the biosynthesis of steroids. | 1973 | Experientia | pmid:4582087 |
| David MH and Kirsop BH | A correlation between oxygen requirements and the products of sterol synthesis in strains of Saccharomyces cerevisiae. | 1973 | J. Gen. Microbiol. | pmid:4584066 |
| Clark RP and Shirley SG | Identification of skin in airborne particulate matter. | 1973 | Nature | pmid:4585846 |
| Johnson RC and Shah SN | Evidence for the participation of two soluble noncatalytic proteins in hepatic microsomal cholesterol synthesis. | 1973 | Biochem. Biophys. Res. Commun. | pmid:4741538 |
| Egwim PO and Kummerow FA | In vitro hepatic cholesterogenesis in rats fed corn oil and fat-free diets. | 1973 | Life Sci. II | pmid:4708203 |
| Bojesen E et al. | Sterol biosynthesis in vitro of rat renal inner medulla. | 1973 | Biochim. Biophys. Acta | pmid:4713153 |
| Shah SN | Regulation of hepatic cholesterol synthesis from mevalonate in suckling and weaned rats. | 1973 | Lipids | pmid:4713377 |
| Phleger CF et al. | Pressure effect on squalene-2,3-oxide cyclization in fish. | 1973 | Comp. Biochem. Physiol., B | pmid:4719990 |
| van Leusden HA et al. | Lack of squalene and lanosterol synthesis by the perfused human placenta at term. | 1973 | J. Steroid Biochem. | pmid:4747979 |
| Farrington JW et al. | Intercalibration of analyses of recently biosynthesized hydrocarbons and petroleum hydrocarbons in marine lipids. | 1973 | Bull Environ Contam Toxicol | pmid:4753263 |
| Murakami S | Isolation and analysis of squalene alcohols from rat preputial glands. | 1973 | Kobe J Med Sci | pmid:4764042 |
| Hellstrom KH et al. | Studies of the in vivo metabolism of mevalonic acid in the normal rat. | 1973 | J. Clin. Invest. | pmid:4703220 |
| Qureshi AA et al. | Squalene synthetase. II. Purification and properties of bakers' yeast enzyme. | 1973 | J. Biol. Chem. | pmid:4348552 |
| Beytia E et al. | Squalene synthetase. 3. Mechanism of the reaction. | 1973 | J. Biol. Chem. | pmid:4348553 |
| Slakey LL et al. | Occurrence of the enzymes effecting the conversion of acetyl CoA to squalene in homogenates of hog aorta. | 1973 | J. Lipid Res. | pmid:4351784 |
| Morris PW and Gorski J | Control of steroidogenesis in pre-ovulatory cells. Luteinizing hormone stimulation of (14C)-acetate incorporation into sterols. | 1973 | J. Biol. Chem. | pmid:4355508 |
| Derksen A and Cohen P | Extensive incorporation of (2-14C) mevalonic acid into cholesterol precursors by human platelets in vitro. | 1973 | J. Biol. Chem. | pmid:4355579 |
| Inomata N | [Symposium I: aging and the activity of the sebaceous glands]. | 1973 | Nihon Hifuka Gakkai Zasshi | pmid:4546667 |
| Faulkner DJ and Petersen MR | Application of the claisen rearrangement to the synthesis of trans trisubstituted olefinic bonds. Synthesis of squalene and insect juvenile hormone. | 1973 | J. Am. Chem. Soc. | pmid:4687674 |
| Caspi E et al. | Mechanism of squalene cyclization: the chiral origin of the C-7 and C-15 hydrogen atoms of fusidic acid. | 1973 | J. Steroid Biochem. | pmid:4795867 |
| Ebersole RC et al. | Mechanism of oxidative cyclization of squalene. Evidence for cyclization of squalene from either end of the squalene molecule in the in vivo biosynthesis of fusidic acid by Fusidium coccineum. | 1973 | J. Am. Chem. Soc. | pmid:4796972 |
| Tabacik C et al. | The squalene epoxidase-cyclase activity of human term placenta. | 1973 | FEBS Lett. | pmid:4747843 |
| Bhavani BR and Short RV | Formation of steroids by the pregnant mare. 3. Metabolism of 14C-squalene and 3H-dehydroisoandrosterone injected into the fetal circulation. | 1973 | Endocrinology | pmid:4267110 |
| Williams M et al. | The effect of local temperature changes on sebum excretion rate and forehead surface lipid composition. | 1973 | Br. J. Dermatol. | pmid:4270005 |
| Gloor M et al. | [Composition of skin surface lipids in persons with seborrhoea sicca and seborrhoea oleosa (author's transl)]. | 1973 | Arch Dermatol Forsch | pmid:4270568 |
| Cunliffe WJ et al. | Tetracycline and acne vulgaris: a clinical and laboratory investigation. | 1973 | Br Med J | pmid:4271323 |
| Cotterill JA et al. | Variation in skin surface lipid composition and sebum excretion rate with time. | 1973 | Acta Derm. Venereol. | pmid:4127454 |
| Voogt PA | Investigations of the capacity of synthesizing 3 beta-sterols in mollusca. X. Biosynthesis and composition of 3 beta-sterols in Cephalopoda. | 1973 | Arch. Int. Physiol. Biochim. | pmid:4127479 |
| Qureshi AA et al. | Biosynthesis of prelycopersene pyrophosphate and lycopersene by squalene synthetase. | 1973 | J. Biol. Chem. | pmid:4144543 |
| Kawaguchi A et al. | Subcellular distribution of sesterterpene- and sterol-biosynthesizing activities in Cochliobolus heterostrophus. | 1973 | Biochim. Biophys. Acta | pmid:4120185 |