(e,e,e,e)-squalene

(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.

Cross Reference

Introduction

To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (e,e,e,e)-squalene?

(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene

MeSH term MeSH ID Detail
Lipodystrophy D008060 4 associated lipids
Leukemia, Hairy Cell D007943 5 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Leukemia P388 D007941 43 associated lipids
Leukemia D007938 74 associated lipids
Keloid D007627 12 associated lipids
Influenza, Human D007251 11 associated lipids
Inflammation D007249 119 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Hyperlipoproteinemia Type III D006952 4 associated lipids
Hyperlipoproteinemias D006951 15 associated lipids
Hyperlipidemias D006949 73 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Hepatitis D006505 11 associated lipids
Hemolysis D006461 131 associated lipids
Gallbladder Diseases D005705 3 associated lipids
Fibrosarcoma D005354 8 associated lipids
Fatigue D005221 10 associated lipids
Fasciitis D005208 2 associated lipids
Per page 10 20 50 100 | Total 84

PubChem Associated disorders and diseases

What pathways are associated with (e,e,e,e)-squalene

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with (e,e,e,e)-squalene?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (e,e,e,e)-squalene?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with (e,e,e,e)-squalene

Download all related citations
Per page 10 20 50 100 | Total 1766
Authors Title Published Journal PubMed Link
Shabtay A et al. The potential of Pleurotus-treated olive mill solid waste as cattle feed. 2009 Bioresour. Technol. pmid:19683915
Eroglu E and Melis A Extracellular terpenoid hydrocarbon extraction and quantitation from the green microalgae Botryococcus braunii var. Showa. 2010 Bioresour. Technol. pmid:20005092
Hoshino T et al. New cyclization mechanism for squalene: a ring-expansion step for the five-membered C-ring intermediate in hopene biosynthesis. 1999 Biosci. Biotechnol. Biochem. pmid:10635573
Sato T et al. Overexpression of squalene-hopene cyclase by the pET vector in Escherichia coli and first identification of tryptophan and aspartic acid residues inside the QW motif as active sites. 1998 Biosci. Biotechnol. Biochem. pmid:9532806
Kaya K et al. Thraustochytrid Aurantiochytrium sp. 18W-13a accummulates high amounts of squalene. 2011 Biosci. Biotechnol. Biochem. pmid:22056449
Sato T et al. Site-directed mutagenesis experiments on the putative deprotonation site of squalene-hopene cyclase from Alicyclobacillus acidocaldarius. 2004 Biosci. Biotechnol. Biochem. pmid:15056909
Appelkvist EL In vitro labeling of peroxisomal cholesterol with radioactive precursors. 1987 Biosci. Rep. pmid:3449127
Ghimire GP et al. Squalene-hopene cyclase (Spterp25) from Streptomyces peucetius: sequence analysis, expression and functional characterization. 2009 Biotechnol. Lett. pmid:19116691
Mironova VN and Chaialo PP [Cholesterol biosynthesis in the blood of rabbits with experimental atherosclerosis]. 1978 Biull Eksp Biol Med pmid:728610
Yachnin S and Mannickarottu V Increased 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol biosynthesis in freshly isolated hairy cell leukemia cells. 1984 Blood pmid:6696995
Gillard P et al. Long-term booster schedules with AS03A-adjuvanted heterologous H5N1 vaccines induces rapid and broad immune responses in Asian adults. 2014 BMC Infect. Dis. pmid:24628789
Van Damme P et al. Evaluation of non-inferiority of intradermal versus adjuvanted seasonal influenza vaccine using two serological techniques: a randomised comparative study. 2010 BMC Infect. Dis. pmid:20504306
Guzmán Herrador BR et al. Usefulness of health registries when estimating vaccine effectiveness during the influenza A(H1N1)pdm09 pandemic in Norway. 2012 BMC Infect. Dis. pmid:22429643
Langley JM et al. A randomized, controlled non-inferiority trial comparing A(H1N1)pmd09 vaccine antigen, with and without AS03 adjuvant system, co-administered or sequentially administered with an inactivated trivalent seasonal influenza vaccine. 2012 BMC Infect. Dis. pmid:23110320
Waddington CS et al. Safety and immunogenicity of AS03B adjuvanted split virion versus non-adjuvanted whole virion H1N1 influenza vaccine in UK children aged 6 months-12 years: open label, randomised, parallel group, multicentre study. 2010 BMJ pmid:20508026
Rubinstein F et al. Influenza A/H1N1 MF59 adjuvanted vaccine in pregnant women and adverse perinatal outcomes: multicentre study. 2013 BMJ pmid:23381200
Paroli E [Effect of beta-carotene and of squalene on analgesia and respiratory depression caused by morphine]. 1964 Boll. Soc. Ital. Biol. Sper. pmid:5877121
van der Cammen TJ et al. Prevention of pressure sores. A comparison of new and old pressure sore treatments. 1987 Br J Clin Pract pmid:3332839
Wysocki SJ et al. Amniotic fluid squalene and fetal maturity. 1979 Br J Obstet Gynaecol pmid:508672
Editorial: Drugs for gastric ulceration. 1974 Br Med J pmid:4832233
Cunliffe WJ et al. Tetracycline and acne vulgaris: a clinical and laboratory investigation. 1973 Br Med J pmid:4271323
Cotterill JA et al. Further observations on the pathogenesis of acne. 1972 Br Med J pmid:4262616
Shin DH et al. Amaranth squalene reduces serum and liver lipid levels in rats fed a cholesterol diet. 2004 Br. J. Biomed. Sci. pmid:15058737
Dykes PJ et al. Analysis of the non-ionic detergent-soluble lipids of human stratum corneum. 1984 Br. J. Dermatol. pmid:6696844
Saint-Leger D et al. A possible role for squalene in the pathogenesis of acne. I. In vitro study of squalene oxidation. 1986 Br. J. Dermatol. pmid:2941049
Saint-Leger D et al. A possible role for squalene in the pathogenesis of acne. II. In vivo study of squalene oxides in skin surface and intra-comedonal lipids of acne patients. 1986 Br. J. Dermatol. pmid:2941050
Dogliotti M et al. Nutritional influences of pellagra on sebum composition. 1977 Br. J. Dermatol. pmid:889695
Cotterill JA et al. Age and sex variation in skin surface lipid composition and sebum excretion rate. 1972 Br. J. Dermatol. pmid:5077864
Williams M et al. The effect of local temperature changes on sebum excretion rate and forehead surface lipid composition. 1973 Br. J. Dermatol. pmid:4270005
Cotterill JA et al. Sebum excretion rate and biochemistry in patients with acne vulgaris treated by oral fenfluramine. 1971 Br. J. Dermatol. pmid:4255130
Cotterill JA et al. The effect of trimethoprim-sulphamethoxazole on sebum excretion rate and biochemistry in acne vulgaris. 1971 Br. J. Dermatol. pmid:4255131
Summerly R and Woodbury S The in vitro incorporation of 14 C-acetate into the isolated sebaceous glands and appendage-freed epidermis of human skin. A technique for the study of lipid synthesis in the isolated sebaceous gland. 1971 Br. J. Dermatol. pmid:4257140
Cuncliffe WJ et al. Skin surface lipids in acne. 1971 Br. J. Dermatol. pmid:4257142
Cotterill JA et al. Variations in skin surface lipid composition and sebum excretion rate with different sampling techniques. II. 1972 Br. J. Dermatol. pmid:4260102
Cotterill JA et al. A semiquantitative method for the biochemical analysis of sebum. 1971 Br. J. Dermatol. pmid:5557832
Cunliffe WJ et al. Variations in skin surface lipid composition with different sampling techniques. I. 1971 Br. J. Dermatol. pmid:5557833
Pye RJ et al. Skin surface lipid composition in rosacea. 1976 Br. J. Dermatol. pmid:130159
Cooper MF et al. Sebaceous lipogenesis in human skin. Variability with age and with severity of acne. 1976 Br. J. Dermatol. pmid:130160
Mills OH et al. Enhancement of comedogenic substances by ultraviolet radiation. 1978 Br. J. Dermatol. pmid:147099
Laitinen K et al. Plant stanol ester spreads as components of a balanced diet for pregnant and breast-feeding women: evaluation of clinical safety. 2009 Br. J. Nutr. pmid:19017423
Relas H et al. Acute effect of dietary stanyl ester dose on post-absorptive alpha-tocopherol, beta-carotene, retinol and retinyl palmitate concentrations. 2001 Br. J. Nutr. pmid:11242481
Toews AD et al. Tellurium causes dose-dependent coordinate down-regulation of myelin gene expression. 1997 Brain Res. Mol. Brain Res. pmid:9387870
Albro PW and Fishbein L Intestinal absorption of polychlorinated biphenyls in rats. 1972 Bull Environ Contam Toxicol pmid:4630020
Farrington JW et al. Intercalibration of analyses of recently biosynthesized hydrocarbons and petroleum hydrocarbons in marine lipids. 1973 Bull Environ Contam Toxicol pmid:4753263
Bell FP Effect of di-2-ethylhexyl phthalate in the female rat: inhibition of hepatic and adrenal sterologenesis in vitro. 1980 Bull Environ Contam Toxicol pmid:7357111
Couvreur P ["Squalenoylation": a new approach to the design of anticancer and antiviral nanomedicines]. 2009 Bull. Acad. Natl. Med. pmid:19883017
GOSSELIN L and DUVIVIER J [BIOSYNTHESIS OF FARNESOL PYROPHOSPHATE AND SQUALENE FROM 2-C14-MEVALONIC ACID BY CELL FRACTIONS OF ADRENAL HOMOGENATE]. 1965 Bull. Soc. Chim. Biol. pmid:14337120
Socaciu C et al. In vitro yeast (Saccharomyces cerevisiae) presqualene and squalene synthesis related to substrate and cofactor availability. 1995 C. R. Acad. Sci. III, Sci. Vie pmid:8521075
NUSBAUM-CASSUTO E and VILLOUTREIX J [DEMONSTRATION OF LYCOPERSENE IN HIGHER PLANTS]. 1965 C. R. Hebd. Seances Acad. Sci. pmid:14287016
WOLFF RE and GODEFROY N [Transformation of synthetic squalene (11, 1414C) to cholesterol in rats]. 1958 C. R. Hebd. Seances Acad. Sci. pmid:13537384