(e,e,e,e)-squalene

(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.

Cross Reference

Introduction

To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (e,e,e,e)-squalene?

(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene

MeSH term MeSH ID Detail
Dermatitis, Occupational D009783 12 associated lipids
Rosacea D012393 13 associated lipids
Hyperlipoproteinemias D006951 15 associated lipids
Demyelinating Diseases D003711 15 associated lipids
Celiac Disease D002446 16 associated lipids
Cholelithiasis D002769 16 associated lipids
Xanthomatosis D014973 17 associated lipids
Olfaction Disorders D000857 17 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Periodontitis D010518 22 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with (e,e,e,e)-squalene

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with (e,e,e,e)-squalene?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (e,e,e,e)-squalene?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with (e,e,e,e)-squalene

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Authors Title Published Journal PubMed Link
Friedlander EJ et al. Supernatant protein factor facilitates intermembrane transfer of squalene. 1980 J. Biol. Chem. pmid:7410347
Shechter I et al. A deficiency of mixed function oxidase activities in the cholesterol biosynthetic pathway of human granulocytes. 1980 J. Lipid Res. pmid:7381322
Shao MJ and Lei KY Conversion of [2-14C] mevalonate into cholesterol, lanosterol and squalene in copper-deficient rats. 1980 J. Nutr. pmid:7373433
Caras IW et al. Interactions of supernatant protein factor with components of the microsomal squalene epoxidase system. Binding of supernatant protein factor to anionic phospholipids. 1980 J. Biol. Chem. pmid:7364757
Falcone DJ et al. Enhancement of cholesterol and cholesteryl ester accumulation in re-endothelialized aorta. 1980 Am. J. Pathol. pmid:7361865
Bell FP Effect of di-2-ethylhexyl phthalate in the female rat: inhibition of hepatic and adrenal sterologenesis in vitro. 1980 Bull Environ Contam Toxicol pmid:7357111
Strandberg TE et al. Squalene and sterol synthesis in isolated small-intestinal cells of the rat. 1981 Scand. J. Gastroenterol. pmid:7323711
Miettinen TA and Tilvis RS Cholesterol synthesis and storage in adipose tissue. 1981 Int J Obes pmid:7319685
Miettinen TA and Tilvis R Comparison of different components in the fractional conversion of mevalonate to cholesterol with cholesterol synthesis and serum methyl sterols. 1981 Scand. J. Clin. Lab. Invest. pmid:7313530
Mironova VN and Chaialo PP [Cholesterol biosynthesis in the blood of rabbits with experimental atherosclerosis]. 1978 Biull Eksp Biol Med pmid:728610
Downing DT et al. Estimation of sebum production rates in man by measurement of the squalene content of skin biopsies. 1981 J. Invest. Dermatol. pmid:7276619
McGinley KJ et al. Regional variations in density of cutaneous propionibacteria: correlation of Propionibacterium acnes populations with sebaceous secretion. 1980 J. Clin. Microbiol. pmid:7276142
Ivashkevich SP et al. [Effects of sterols having different chemical structure and squalene on osmotic resistance of erythrocytes]. 1981 Biokhimiia pmid:7272362
Tornabene TG Formation of hydrocarbons by bacteria and algae. 1981 Basic Life Sci. pmid:7271715
Carelli C et al. Persistent enhancement of cell-mediated and antibody immune responses after administration of muramyl dipeptide derivatives with antigen in metabolizable oil. 1981 Infect. Immun. pmid:7263069
Wysocki SJ et al. Lipids in forehead vernix from newborn infants. 1981 Biol. Neonate pmid:7260215
Kojima Y et al. Protein-facilitated intermembrane transfer of squalene. Demonstration by density gradient centrifugation. 1981 J. Biol. Chem. pmid:7251595
Ito M et al. Killing of tumor cells in vitro by macrophages from mice given injections of squalene-treated cell wall skeleton of Nocardia rubra. 1981 Cancer Res. pmid:7248952
Hunter MI et al. The effect of temperature on the growth and lipid composition of the extremely halophilic coccus, Sarcina marina. 1981 Antonie Van Leeuwenhoek pmid:7247392
Anisimov MM et al. [Effect of triterpene glycosides on the biosynthesis of sterols and fatty acids by the yeast Saccharomyces carlsbergensis]. 1978 Jul-Aug Prikl. Biokhim. Mikrobiol. pmid:724665