(e,e,e,e)-squalene

(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.

Cross Reference

Introduction

To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (e,e,e,e)-squalene?

(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene

MeSH term MeSH ID Detail
Dermatitis, Occupational D009783 12 associated lipids
Rosacea D012393 13 associated lipids
Hyperlipoproteinemias D006951 15 associated lipids
Demyelinating Diseases D003711 15 associated lipids
Cholelithiasis D002769 16 associated lipids
Celiac Disease D002446 16 associated lipids
Olfaction Disorders D000857 17 associated lipids
Xanthomatosis D014973 17 associated lipids
Periodontitis D010518 22 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with (e,e,e,e)-squalene

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with (e,e,e,e)-squalene?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (e,e,e,e)-squalene?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with (e,e,e,e)-squalene

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Authors Title Published Journal PubMed Link
Cornforth JW et al. Studies on the biosynthesis of cholesterol. XVII. The asymmetric synthesis of a symmetrical molecule. 1966 Proc. R. Soc. Lond., B, Biol. Sci. pmid:4379289
Cornforth JW et al. Studies on the biosynthesis of cholesterol XIX. Steric course of hydrogen eliminations and of C-C bond formations in squalene biosynthesis. 1966 Proc. R. Soc. Lond., B, Biol. Sci. pmid:4379291
Blondin GA et al. The biosynthesis of squalene and sterols in fish. 1966 Comp. Biochem. Physiol. pmid:4380202
Paoletti P et al. Lipid biosynthesis from labelled precursors in an experimental brain tumor-bearing mouse. 1966 Neurochirurgia (Stuttg) pmid:5966653
Williams RJ et al. A possible mechanism for the biosynthesis of eschscholtzxanthin. 1966 Biochim. Biophys. Acta pmid:5966716
Cory EJ et al. 2,3-oxidosqualene, an intermediate in the biological synthesis of sterols from squalene. 1966 J. Am. Chem. Soc. pmid:5918046
Corey EJ and Russey WE Metabolic fate of 10,11-dihydrosqualene in sterol-producing rat liver homogenate. 1966 J. Am. Chem. Soc. pmid:5918047
Van Tamelen EE et al. Enzymic conversion of squalene 2,3-oxide to lanosterol and cholesterol. 1966 J. Am. Chem. Soc. pmid:5918048
Cmelik SH and Webster GD Squalene in vernix caseosa from African neonates. 1966 Cent Afr J Med pmid:5919884
Hsia SL et al. Lipid metabolism in human skin. I. Lipogenesis from acetate-1-14C. 1966 J. Invest. Dermatol. pmid:5924299