| MeSH term | MeSH ID | Detail |
|---|---|---|
| Keloid | D007627 | 12 associated lipids |
| Rosacea | D012393 | 13 associated lipids |
| Demyelinating Diseases | D003711 | 15 associated lipids |
| Hyperlipoproteinemias | D006951 | 15 associated lipids |
| Cholelithiasis | D002769 | 16 associated lipids |
| Celiac Disease | D002446 | 16 associated lipids |
| Olfaction Disorders | D000857 | 17 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Periodontitis | D010518 | 22 associated lipids |
| Hyperlipoproteinemia Type II | D006938 | 22 associated lipids |
(e,e,e,e)-squalene
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
Cross Reference
Introduction
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (e,e,e,e)-squalene?
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
PubChem Associated disorders and diseases
What pathways are associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (e,e,e,e)-squalene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with (e,e,e,e)-squalene?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with (e,e,e,e)-squalene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| WOOTTON JM and WRIGHT LD | Biosynthesis of squalene by the annelid Lumbricus terrestris. | 1960 | Nature | pmid:13786660 |
| GOODMAN DS and POPJAK G | Studies on the biosynthesis of cholesterol. XII. Synthesis of allyl pyrophosphates from mevalonate and their conversion into squalene with liver enzymes. | 1960 | J. Lipid Res. | pmid:13851061 |
| PATTERSON JF | Biosynthesis of squalene by rat preputial gland. | 1960 | Proc. Soc. Exp. Biol. Med. | pmid:13733368 |
| ANDERSON DG et al. | The conversion of farnesyl pyrophosphate to squalene by soluble extracts of microsomes. | 1960 | Biochem. Biophys. Res. Commun. | pmid:13683185 |
| MELCHIORRI-SANTOLINI U and RENZINI G | [Detection of sterols and squalene in sporigenic bacteria]. | 1960 Nov-Dec | Nuovi Ann Ig Microbiol | pmid:13769177 |
| RENZINI G | [Detection of sterols and squalene in B. coli aerogenes]. | 1960 Nov-Dec | Nuovi Ann Ig Microbiol | pmid:13740904 |
| GAYLOR JL | Anaerobic conversion of acetate to squalene by rat skin. | 1961 | Proc. Soc. Exp. Biol. Med. | pmid:13704081 |
| GOODMAN DS | Studies on the conversion of squalene to sterol with rat liver enzymes. | 1961 | J. Biol. Chem. | pmid:13707027 |
| GOSSELIN L and PODBER-WAGNER E | [New observations on the particles interfering in the biosynthesis of squalene from mevalonic acid]. | 1961 | Arch. Int. Physiol. Biochim. | pmid:13707370 |
| SEDEE PD | Intermediary metabolism in aseptically reared blowfly larvae, Calliphora erythrocephala (Meig.). I. Buosynthesis of squalene and cholesterol. | 1961 | Arch. Int. Physiol. Biochim. | pmid:13749584 |
| POPJAK G et al. | Mechanism of squalene biosynthesis from mevalonate and farnesyl pyrophosphate. | 1961 | Biochem. Biophys. Res. Commun. | pmid:13737103 |
| POPJAK G et al. | Studies on the biosynthesis of cholesterol. XV. Mechanism of squalene biosynthesis from farnesyl pyrophosphate and from mevalonate. | 1961 | J. Biol. Chem. | pmid:13737104 |
| CAPSTACK E et al. | The biosynthesis of squalene in germinating seeds of Pisum sativum. | 1962 | Biochemistry | pmid:14018475 |
| ALAM SQ et al. | Detection and estimation of squalene in leaves. | 1962 | Nature | pmid:13860005 |
| GOSSELIN L et al. | Particulate enzyme system for the synthesis of squalene from 2-(14C)-mevalonic acid. | 1962 | Nature | pmid:13900654 |
| GOSSELIN L | Utilization of (2-14C) mevalonic acid by rat liver cell fraction: evidence for an attachment of a squalene precursor to a cellular component insoluble at acid pH. | 1962 | Arch. Int. Physiol. Biochim. | pmid:13900655 |
| CHILDS CR and BLOCH K | Further observations on the biosynthesis of squalene. | 1962 | J. Biol. Chem. | pmid:13878983 |
| POPJAK G et al. | Studies on the biosynthesis of cholesterol. XVI. Chemical synthesis of 1-H2-3-2-C-14- and 1-D2-2-C-14-trans-trans-farnesyl pyrophosphate and their utilization in squalene biosynthesis. | 1962 | J. Biol. Chem. | pmid:14487886 |
| POPJAK G et al. | Sterospecificity of hydrogen transfer from reduced triphosphopyridine nucleotide to squalene during its synthesis from farnesyl pyrophosphate. | 1962 | Biochem. Biophys. Res. Commun. | pmid:14487887 |
| ROTHBLAT GH et al. | A quantitative colorimetric assay for squalene. | 1962 | Anal. Biochem. | pmid:14494417 |