(e,e,e,e)-squalene

(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.

Cross Reference

Introduction

To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (e,e,e,e)-squalene?

(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene

MeSH term MeSH ID Detail
Dermatitis, Occupational D009783 12 associated lipids
Rosacea D012393 13 associated lipids
Demyelinating Diseases D003711 15 associated lipids
Hyperlipoproteinemias D006951 15 associated lipids
Celiac Disease D002446 16 associated lipids
Cholelithiasis D002769 16 associated lipids
Olfaction Disorders D000857 17 associated lipids
Xanthomatosis D014973 17 associated lipids
Periodontitis D010518 22 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with (e,e,e,e)-squalene

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with (e,e,e,e)-squalene?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (e,e,e,e)-squalene?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with (e,e,e,e)-squalene

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Authors Title Published Journal PubMed Link
Radisky ES and Poulter CD Squalene synthase: steady-state, pre-steady-state, and isotope-trapping studies. 2000 Biochemistry pmid:10677224
Sporn MB and Suh N Chemoprevention of cancer. 2000 Carcinogenesis pmid:10688873
O'Hagan DT et al. Microparticles in MF59, a potent adjuvant combination for a recombinant protein vaccine against HIV-1. 2000 Vaccine pmid:10699327
Moebius FF et al. Genetic defects in postsqualene cholesterol biosynthesis. 2000 Trends Endocrinol. Metab. pmid:10707051
Drulak MW et al. Vaccination of seropositive subjects with CHIRON CMV gB subunit vaccine combined with MF59 adjuvant for production of CMV immune globulin. 2000 Viral Immunol. pmid:10733168
Rajaratnam RA et al. Independent association of serum squalene and noncholesterol sterols with coronary artery disease in postmenopausal women. 2000 J. Am. Coll. Cardiol. pmid:10758959
Relas H et al. Effect of stanol ester on postabsorptive squalene and retinyl palmitate. 2000 Metab. Clin. Exp. pmid:10778871
Viola F et al. Rationally designed inhibitors as tools for comparing the mechanism of squalene-hopene cyclase with oxidosqualene cyclase. 2000 Lipids pmid:10783007
Alving CR and Grabenstein JD Re: Antibodies to squalene in Gulf War Syndrome. 2000 Exp. Mol. Pathol. pmid:10816387
Rhodes CJ et al. "Spin-labelling" with the second hydrogen radioisotope: radicals formed from squalene by muonium addition. 2000 Free Radic. Res. pmid:10826923