(e,e,e,e)-squalene

(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.

Cross Reference

Introduction

To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (e,e,e,e)-squalene?

(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene

MeSH term MeSH ID Detail
Otitis Media D010033 12 associated lipids
Rosacea D012393 13 associated lipids
Hyperlipoproteinemias D006951 15 associated lipids
Demyelinating Diseases D003711 15 associated lipids
Cholelithiasis D002769 16 associated lipids
Celiac Disease D002446 16 associated lipids
Olfaction Disorders D000857 17 associated lipids
Xanthomatosis D014973 17 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Periodontitis D010518 22 associated lipids
Per page 10 20 50 100 | Total 84

PubChem Associated disorders and diseases

What pathways are associated with (e,e,e,e)-squalene

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with (e,e,e,e)-squalene?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (e,e,e,e)-squalene?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with (e,e,e,e)-squalene

Download all related citations
Per page 10 20 50 100 | Total 1766
Authors Title Published Journal PubMed Link
Pimm MV et al. Suppression of an ascitic rat hepatoma with cord factor and Nocardia cell wall skeleton in squalene emulsions. 1980 Eur J Cancer pmid:7227439
Sirtori CR et al. Reduced triglyceridemia and increased high density lipoprotein cholesterol levels after treatment with acipimox, a new inhibitor of lipolysis. 1981 Feb-Mar Atherosclerosis pmid:7225165
Brassell SC et al. Specific acyclic isoprenoids as biological markers of methanogenic bacteria in marine sediments. 1981 Nature pmid:7219553
Lindholm JS and Downing DT Occurrence of squalene in skin surface lipids of the otter, the beaver and the kinkajou. 1980 Lipids pmid:7219074
Yarkoni E et al. Immunotherapy of experimental cancer with a mixture of synthetic muramyl dipeptide and trehalose dimycolate. 1981 Infect. Immun. pmid:7216489
Trocha PJ and Sprinson DB Location and regulation of early enzymes of sterol biosynthesis in yeast. 1976 Arch. Biochem. Biophys. pmid:7207
Miettinen TA Diurnal variation of cholesterol precursors squalene and methyl sterols in human plasma lipoproteins. 1982 J. Lipid Res. pmid:7200504
Albers-Jackson B et al. Incorporation of 14C acetate into the sterols of rabbit lens in organ culture. 1982-1983 Curr. Eye Res. pmid:7184713
Bird S and Gower DB Axillary 5 alpha-androst-16-en-3-one, cholesterol and squalene in men; preliminary evidence for 5 alpha-androst-16-en-3-one being a product of bacterial action. 1982 J. Steroid Biochem. pmid:7176644
PokrovskiÄ­ AA et al. [Method of isolating, identifying and quantitatively determining alkanes, cycloalkanes, monocyclic arenes and squalene in animal organs and tissues]. 1978 Sep-Oct Vopr Pitan pmid:716335
Bell FP and Hubert EV Stimulation of hepatic squalene and triglyceride synthesis by dimethylsulfoxide, in vitro. 1982 Lipids pmid:7162368
Morin RJ and Srikantaiah MV Inhibition of rat liver sterol formation by isoprenoid and conjugated ene compounds. 1982 Pharmacol Res Commun pmid:7156175
Olugbade TA et al. Chemical constituents of Cnestis ferruginea DC. I. Petroleum ether fraction. 1982 J Ethnopharmacol pmid:7154704
Maugh TH Completing the puzzle of steroid synthesis, a mystery in the biological synthesis of steroids is solved, providing a new approach to chemical synthesis of the compounds. 1982 Science pmid:7146911
Morozova RP et al. [Separation of lipid extract from animal blood and tissues and isolation of squalene and sterols from it]. 1982 Jul-Aug Ukr. Biokhim. Zh. pmid:7135500
Emmons GT et al. Effects of 20,25-diazacholesterol on cholesterol synthesis in cultured chick muscle cells: a radiogas chromatographic and mass spectrometric study of the post-squalene sector. 1982 Biomed. Mass Spectrom. pmid:7126761
Tilvis RS and Miettinen TA Fate of intravenously administered squalene in the rat. 1982 Biochim. Biophys. Acta pmid:7126611
Dillard CJ et al. Lipid peroxidation during chronic inflammation induced in rats by Freund's adjuvant: effect of vitamin E as measured by expired pentane. 1982 Res. Commun. Chem. Pathol. Pharmacol. pmid:7122999
Saudek CD et al. Plasma squalene: lipoprotein distribution and kinetic analysis. 1978 J. Lipid Res. pmid:712242
Morin RJ et al. Effect of age and cholestyramine feeding on rat liver 3-hydroxy-3-methyl glutaryl CoA reductase, sterol carrier protein 1 and sterol carrier protein 2 activities. 1982 Lipids pmid:7121212
Tilvis R et al. Metabolism of squalene in human fat cells. Demonstration of a two-pool system. 1982 J. Biol. Chem. pmid:7107606
Tiffany JM Individual variations in human meibomian lipid composition. 1978 Exp. Eye Res. pmid:710541
Torinuki W et al. Effect of beta-carotene on ultraweak chemiluminescence of UVB-irradiated squalene. 1982 Tohoku J. Exp. Med. pmid:7101278
Richter E and Schäfer SG The effect of squalane on the absorption of dietary cholesterol by the rat. 1982 Res Exp Med (Berl) pmid:7100640
Richter E and Schäfer SG Effect of squalane on hexachlorobenzene (HCB) concentrations in tissues of mice. 1982 J Environ Sci Health B pmid:7096897
Messeri G et al. Amniotic fluid squalene and gestational age. 1982 Clin. Chem. pmid:7094305
Richter E et al. Effects of dietary paraffin, squalane and sucrose polyester on residue disposition and elimination of hexachlorobenzene in rats. 1982 Chem. Biol. Interact. pmid:7083398
Tilvis RS et al. Lipid composition of bile and gallbladder mucosa in patients with acalculous cholesterolosis. 1982 Gastroenterology pmid:7060883
Pratt HP Preimplantation mouse embryos synthesize membrane sterols. 1982 Dev. Biol. pmid:7054002
Bach D and Miller IR Glyceryl monooleate black lipid membranes obtained from squalene solutions. 1980 Biophys. J. pmid:7053057
Takatsuji H et al. Formation of dehydrosqualene catalyzed by squalene synthetase in Saccharomyces cerevisiae. 1982 J. Biochem. pmid:7042703
Masuda A et al. Potentiation of antifungal effect of amphotericin B by squalene, an intermediate for sterol biosynthesis. 1982 J. Antibiot. pmid:7042672
Schroepfer GJ Sterol biosynthesis. 1981 Annu. Rev. Biochem. pmid:7023367
Yarkoni E and Rapp HJ Influence of type of oil and surfactant concentration on the efficacy of emulsified Mycobacterium bovis BCG cell walls to induce tumor regression in guinea pigs. 1980 Infect. Immun. pmid:6995325
White SH Formation of "solvent-free" black lipid bilayer membranes from glyceryl monooleate dispersed in squalene. 1978 Biophys. J. pmid:698340
Torinuki W et al. [Emission spectral analysis of ultraweak chemiluminescence from linolenic acid and squalene peroxides (author's transl)]. 1982 Nihon Hifuka Gakkai Zasshi pmid:6978954
Yoshino K and Matsuo I [Squalene peroxide formation by UVA irradiation with or without 8-MOP (author's transl)]. 1981 Nihon Hifuka Gakkai Zasshi pmid:6971356
Jenkins DT et al. Amniotic fluid squalene: a useful test in prolonged pregnancy. 1982 Aust N Z J Obstet Gynaecol pmid:6959611
Moroyama T [Sterol metabolism of cultured skin tissue of chick embryo and the effect of anticholesterolemic drugs and chemical carcinogens on it (author's transl)]. 1981 Hiroshima Daigaku Shigaku Zasshi pmid:6953141
Tornabene TG et al. Phytanyl-glycerol ethers and squalenes in the archaebacterium Methanobacterium thermoautotrophicum. 1978 J. Mol. Evol. pmid:691077
Tornabene TG Non-aerated cultivation of Halobacterium cutirubrum and its effect on cellular squalenes. 1978 J. Mol. Evol. pmid:691076
Lapointe JY and Laprade R Kinetics of carrier-mediated ion transport in two new types of solvent-free lipid bilayers. 1982 Biophys. J. pmid:6896832
Tilvis R and Miettinen TA Squalene, methyl sterol, and cholesterol levels in human organs. Postmortem analysis of their distributions. 1980 Arch. Pathol. Lab. Med. pmid:6892520
Kudchodkar BJ et al. Mechanisms of hypolipidemic action of nicotinic acid. 1978 Clin. Pharmacol. Ther. pmid:688728
Palamarchuk VI et al. [Content of squalene and sterols in tissues of the hemopoietic system in normal rats and in experimental leukemia]. 1983 May-Jun Vopr. Med. Khim. pmid:6880121
Hérodin F and Dormont D [Comparative kinetics of spleen cell-mediated antibody-dependent cytotoxic activity in mice treated with BCG or Mycobacterium smegmatis]. 1983 Mar-Apr Ann. Immunol. (Paris) pmid:6870194
Ohkuma T et al. Intensification of host's immunity by squalene in sarcoma 180 bearing ICR mice. 1983 J. Pharmacobio-dyn. pmid:6864440
Tanio Y et al. Regression of line-10 hepatocarcinoma with synthetic quinonyl muramyl dipeptide in strain-2 guinea pigs. 1983 Gan pmid:6862142
Tilvis RS and Miettinen TA Absorption and metabolic fate of dietary 3H-squalene in the rat. 1983 Lipids pmid:6855483
Fuks-Holmberg D and Bloch K Intermembrane transfer of squalene promoted by supernatant protein factor. 1983 J. Lipid Res. pmid:6854149