| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dermatitis, Occupational | D009783 | 12 associated lipids |
| Rosacea | D012393 | 13 associated lipids |
| Demyelinating Diseases | D003711 | 15 associated lipids |
| Hyperlipoproteinemias | D006951 | 15 associated lipids |
| Celiac Disease | D002446 | 16 associated lipids |
| Cholelithiasis | D002769 | 16 associated lipids |
| Olfaction Disorders | D000857 | 17 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Hyperlipoproteinemia Type II | D006938 | 22 associated lipids |
| Periodontitis | D010518 | 22 associated lipids |
(e,e,e,e)-squalene
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
Cross Reference
Introduction
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (e,e,e,e)-squalene?
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
PubChem Associated disorders and diseases
What pathways are associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (e,e,e,e)-squalene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with (e,e,e,e)-squalene?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with (e,e,e,e)-squalene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kelly GS | Squalene and its potential clinical uses. | 1999 | Altern Med Rev | pmid:9988781 |
| Hilgers LA et al. | Sulfolipo-cyclodextrin in squalane-in-water as a novel and safe vaccine adjuvant. | 1999 | Vaccine | pmid:9987157 |
| Minutello M et al. | Safety and immunogenicity of an inactivated subunit influenza virus vaccine combined with MF59 adjuvant emulsion in elderly subjects, immunized for three consecutive influenza seasons. | 1999 | Vaccine | pmid:9987141 |
| Novoselova EG and KolomiÄtseva IK | [Early radiation impairments of the metabolism of cholesterol, squalene and ubiquinone in rat liver]. | 1976 Jul-Aug | Radiobiologiia | pmid:996254 |
| Johnson RC and Shah SN | Binding of squalene, lanosterol, desmosterol, and cholesterol to proteins in brain and liver 105,000 g supernatant fractions: evidence for specific binding sites. | 1976 | Lipids | pmid:994754 |
| Bell FP | Inhibition of hepatic sterol and squalene biosynthesis in rats fed di-i-ethylhexyl phthalate. | 1976 | Lipids | pmid:994746 |
| Fernández JJ et al. | Evaluation of the cytotoxic activity of polyethers isolated from Laurencia. | 1998 | Bioorg. Med. Chem. | pmid:9925286 |
| Fisher JE et al. | Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9874784 |
| Goldberg I and Shechter I | Occurrence of squalene in methanol-grown bacteria. | 1978 | J. Bacteriol. | pmid:98521 |
| Smiałek M et al. | Experimental squalene encephaloneuropathy in the rat. | 1997 | Folia Neuropathol | pmid:9833408 |
| Cattel L and Ceruti M | Inhibitors of 2,3-oxidosqualene cyclase as tools for studying the mechanism and function of the enzyme. | 1998 | Crit. Rev. Biochem. Mol. Biol. | pmid:9827705 |
| Singh M et al. | A comparison of biodegradable microparticles and MF59 as systemic adjuvants for recombinant gD from HSV-2. | 1998 | Vaccine | pmid:9795387 |
| Schedin S et al. | Alterations in the biosynthesis of cholesterol, dolichol and dolichyl-P in the genetic cholesterol homeostasis disorder, Niemann-Pick type C disease. | 1998 | Biochim. Biophys. Acta | pmid:9795206 |
| Saenz MT et al. | Cytostatic activity of some compounds from the unsaponifiable fraction obtained from virgin olive oil. | 1998 | Farmaco | pmid:9786644 |
| Michikawa M and Yanagisawa K | Apolipoprotein E4 induces neuronal cell death under conditions of suppressed de novo cholesterol synthesis. | 1998 | J. Neurosci. Res. | pmid:9778150 |
| Bibikova MV and Bondareva NS | [Drugs of microbial origin for treatment of atherosclerosis]. | 1998 | Antibiot. Khimioter. | pmid:9777104 |
| Joshi MK et al. | Importance of specific native lipids in controlling the photocycle of bacteriorhodopsin. | 1998 | Biochemistry | pmid:9772173 |
| Kushiro T et al. | Beta-amyrin synthase--cloning of oxidosqualene cyclase that catalyzes the formation of the most popular triterpene among higher plants. | 1998 | Eur. J. Biochem. | pmid:9746369 |
| Weldon MK et al. | Surface enhanced Raman spectroscopic monitor of P. acnes lipid hydrolysis in vitro. | 1998 | J. Lipid Res. | pmid:9741703 |
| Grabowski GA et al. | Evidence for carrier proteins in bile acid synthesis. The effect of squalene and sterol carrier protein and albumin on the activity of 12alpha-hydroxylase. | 1976 | Biochim. Biophys. Acta | pmid:974090 |