(e,e,e,e)-squalene

(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.

Cross Reference

Introduction

To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (e,e,e,e)-squalene?

(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene

MeSH term MeSH ID Detail
Hypercholesterolemia D006937 91 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Hyperlipidemias D006949 73 associated lipids
Hyperlipoproteinemias D006951 15 associated lipids
Hyperlipoproteinemia Type III D006952 4 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Inflammation D007249 119 associated lipids
Influenza, Human D007251 11 associated lipids
Keloid D007627 12 associated lipids
Leukemia D007938 74 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with (e,e,e,e)-squalene

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with (e,e,e,e)-squalene?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (e,e,e,e)-squalene?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (e,e,e,e)-squalene?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with (e,e,e,e)-squalene

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Per page 10 20 50 100 | Total 1766
Authors Title Published Journal PubMed Link
O'Hagan DT et al. The history of MF59(®) adjuvant: a phoenix that arose from the ashes. 2013 Expert Rev Vaccines pmid:23256736
Naziri E and Tsimidou MZ Formulated squalene for food related applications. 2013 Recent Pat Food Nutr Agric pmid:23270393
Ito R et al. Purification, kinetics, inhibitors and CD for recombinant β-amyrin synthase from Euphorbia tirucalli L and functional analysis of the DCTA motif, which is highly conserved among oxidosqualene cyclases. 2013 FEBS J. pmid:23294602
Kabuto H et al. Effects of squalene/squalane on dopamine levels, antioxidant enzyme activity, and fatty acid composition in the striatum of Parkinson's disease mouse model. 2013 J Oleo Sci pmid:23357814
Czajka H et al. A phase II, randomised clinical trial to demonstrate the non-inferiority of low-dose MF59-adjuvanted pre-pandemic A/H5N1 influenza vaccine in adult and elderly subjects. 2012 J Prev Med Hyg pmid:23362618
Puleston R et al. Multi-centre observational study of transplacental transmission of influenza antibodies following vaccination with AS03(A)-adjuvanted H1N1 2009 vaccine. 2013 PLoS ONE pmid:23372640
Rubinstein F et al. Influenza A/H1N1 MF59 adjuvanted vaccine in pregnant women and adverse perinatal outcomes: multicentre study. 2013 BMJ pmid:23381200
Naughton C et al. Transcription forms and remodels supercoiling domains unfolding large-scale chromatin structures. 2013 Nat. Struct. Mol. Biol. pmid:23416946
Sen SE et al. Inhibition of vertebrate squalene epoxidase by extended and truncated analogues of trisnorsqualene alcohol. 1990 J. Med. Chem. pmid:2342064
Rodríguez-López J et al. Epoxide-opening cascades triggered by a Nicholas reaction: total synthesis of teurilene. 2013 Angew. Chem. Int. Ed. Engl. pmid:23436322
Skowronski DM et al. Re: "effectiveness of adjuvanted influenza vaccination in elderly subjects in northern Italy". 2013 Am. J. Epidemiol. pmid:23436898
Ono T and Bloch K Solubilization and partial characterization of rat liver squalene epoxidase. 1975 J. Biol. Chem. pmid:234459
Wołosik K et al. The importance and perspective of plant-based squalene in cosmetology. 2013 Jan-Feb J Cosmet Sci pmid:23449131
Yüzbaşıoğlu D et al. Genotoxicity assessment of vaccine adjuvant squalene. 2013 Food Chem. Toxicol. pmid:23454296
Malmierca MG et al. Relevance of trichothecenes in fungal physiology: disruption of tri5 in Trichoderma arundinaceum. 2013 Fungal Genet. Biol. pmid:23454546
Ruiz-Aragón J et al. [Assessment of the MF59-adjuvanted pandemic influenza A/H1N1 vaccine. Systematic review of literature]. 2013 An Pediatr (Barc) pmid:23490433
Hosogaya N et al. The heme-binding protein Dap1 links iron homeostasis to azole resistance via the P450 protein Erg11 in Candida glabrata. 2013 FEMS Yeast Res. pmid:23496820
McElhaney JE et al. AS03-adjuvanted versus non-adjuvanted inactivated trivalent influenza vaccine against seasonal influenza in elderly people: a phase 3 randomised trial. 2013 Lancet Infect Dis pmid:23518156
Ledgerwood JE AS03-adjuvanted influenza vaccine in elderly people. 2013 Lancet Infect Dis pmid:23518157
Lopez P et al. Combined administration of MF59-adjuvanted A/H5N1 prepandemic and seasonal influenza vaccines: long-term antibody persistence and robust booster responses 1 year after a one-dose priming schedule. 2013 Clin. Vaccine Immunol. pmid:23536690
Vera-Lastra O et al. Autoimmune/inflammatory syndrome induced by adjuvants (Shoenfeld's syndrome): clinical and immunological spectrum. 2013 Expert Rev Clin Immunol pmid:23557271
Ačimovič J and Rozman D Steroidal triterpenes of cholesterol synthesis. 2013 Molecules pmid:23558541
Hillaireau H et al. Anti-HIV efficacy and biodistribution of nucleoside reverse transcriptase inhibitors delivered as squalenoylated prodrug nanoassemblies. 2013 Biomaterials pmid:23562054
Vinay TN et al. Toxicity and dose determination of quillaja saponin, aluminum hydroxide and squalene in olive flounder (Paralichthys olivaceus). 2014 Vet. Immunol. Immunopathol. pmid:23570990
Van Damme P et al. Long-term persistence of humoral and cellular immune responses induced by an AS03A-adjuvanted H1N1 2009 influenza vaccine: an open-label, randomized study in adults aged 18-60 years and older. 2013 Hum Vaccin Immunother pmid:23571166
Mazein A et al. A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway. 2013 Biochem. Pharmacol. pmid:23583456
Lange S et al. Aminopropylindenes derived from Grundmann's ketone as a novel chemotype of oxidosqualene cyclase inhibitors. 2013 Eur J Med Chem pmid:23583910
Ruehl CR et al. The influence of molecular structure and aerosol phase on the heterogeneous oxidation of normal and branched alkanes by OH. 2013 J Phys Chem A pmid:23611149
Liu Y et al. [Researches on influence of squalene synthase gene polymorphism on catalytic efficiency of its encode enzyme in Glycyrrhiza uralensis]. 2012 Zhongguo Zhong Yao Za Zhi pmid:23627178
Bischoff AL et al. Altered response to A(H1N1)pnd09 vaccination in pregnant women: a single blinded randomized controlled trial. 2013 PLoS ONE pmid:23637733
Kalogeropoulos N et al. Nutritional evaluation and health promoting activities of nuts and seeds cultivated in Greece. 2013 Int J Food Sci Nutr pmid:23641668
Wijnans L et al. Effectiveness of MF59â„¢ adjuvanted influenza A(H1N1)pdm09 vaccine in risk groups in the Netherlands. 2013 PLoS ONE pmid:23646191
Tascon M et al. Determinations of gas-liquid partition coefficients using capillary chromatographic columns. Alkanols in squalane. 2013 J Chromatogr A pmid:23659974
Hong WK et al. Characterization of a squalene synthase from the thraustochytrid microalga Aurantiochytrium sp. KRS101. 2013 J. Microbiol. Biotechnol. pmid:23676912
Calabro S et al. The adjuvant effect of MF59 is due to the oil-in-water emulsion formulation, none of the individual components induce a comparable adjuvant effect. 2013 Vaccine pmid:23684834
Gavaldà J et al. Immunogenicity of pandemic influenza A H1N1/2009 adjuvanted vaccine in pediatric solid organ transplant recipients. 2013 Pediatr Transplant pmid:23692602
Gilmore SF et al. Role of squalene in the organization of monolayers derived from lipid extracts of Halobacterium salinarum. 2013 Langmuir pmid:23713788
Palamarchuk VI [Characteristics of the radiation-induced changes in the content of sterols and squalene in the lymphoid system tissues and erythrocyte membranes of rats]. 1990 May-Jun Radiobiologiia pmid:2371389
Okajima M et al. Preparation and physicochemical properties of surfactant-free emulsions using electrolytic-reduction ion water containing lithium magnesium sodium silicate. 2013 Drug Discov Ther pmid:23715508
Morimoto Y et al. Biomimetic epoxide-opening cascades of oxasqualenoids triggered by hydrolysis of the terminal epoxide. 2013 Org. Lett. pmid:23721415
Puig-Barberà J et al. MF59-adjuvanted and virosomal influenza vaccines for preventing influenza hospitalization in older people: comparative effectiveness using the Valencia health care information system. 2013 Vaccine pmid:23731629
Guan X et al. Immunotherapeutic efficiency of a tetravalent Aβ1-15 vaccine in APP/PS1 transgenic mice as mouse model for Alzheimer's disease. 2013 Hum Vaccin Immunother pmid:23732905
Segura-Velázquez R et al. Influenza vaccine: development of a novel intranasal and subcutaneous recombinant adjuvant. 2013 Vaccine pmid:23746458
Vriet C et al. From squalene to brassinolide: the steroid metabolic and signaling pathways across the plant kingdom. 2013 Mol Plant pmid:23761349
Lin YS et al. A real-time impedance-sensing chip for the detection of emulsion phase separation. 2013 Electrophoresis pmid:23765861
Mann JF et al. Pulmonary delivery of DNA vaccine constructs using deacylated PEI elicits immune responses and protects against viral challenge infection. 2013 J Control Release pmid:23774102
Keller RK and Fliesler SJ Incorporation of squalene into rod outer segments. 1990 J. Biol. Chem. pmid:2380183
King KL et al. Inelastic scattering of OH radicals from organic liquids: isolating the thermal desorption channel. 2013 Phys Chem Chem Phys pmid:23807737
Chandramouli S et al. Generation of a parvovirus B19 vaccine candidate. 2013 Vaccine pmid:23827313
Rappuoli R Vaccine adjuvants: the future is bright. Interview by Jenaid Rees. 2013 Expert Rev Vaccines pmid:23829664
Trung Bui D et al. Polymer prodrug nanoparticles based on naturally occurring isoprenoid for anticancer therapy. 2013 Biomacromolecules pmid:23829862
Bruun Laursen A [Catastrophic consequences of Pandemrix swine flu vaccine containing squalene]. 2013 Ugeskr. Laeg. pmid:23833781
Mølbak K [Squalene unlikely sinner]. 2013 Ugeskr. Laeg. pmid:23833782
Gefenaite G et al. Effectiveness of A(H1N1)pdm09 influenza vaccine in adults recommended for annual influenza vaccination. 2013 PLoS ONE pmid:23840413
Song JY et al. Long-term and cross-reactive immunogenicity of inactivated trivalent influenza vaccine in the elderly: MF59-adjuvanted vaccine versus unadjuvanted vaccine. 2013 J. Med. Virol. pmid:23852684
Yang WH et al. Long-term immunogenicity of an AS03-adjuvanted influenza A(H1N1)pdm09 vaccine in young and elderly adults: an observer-blind, randomized trial. 2013 Vaccine pmid:23856331
Villa M et al. Safety of MF59-adjuvanted influenza vaccination in the elderly: results of a comparative study of MF59-adjuvanted vaccine versus nonadjuvanted influenza vaccine in northern Italy. 2013 Am. J. Epidemiol. pmid:23863759
Ali HM et al. Effects of silencing the RET/PTC1 oncogene in papillary thyroid carcinoma by siRNA-squalene nanoparticles with and without fusogenic companion GALA-cholesterol. 2014 Thyroid pmid:23885719
Fox CB and Haensler J An update on safety and immunogenicity of vaccines containing emulsion-based adjuvants. 2013 Expert Rev Vaccines pmid:23885820
Sisco E et al. Evaluation of C60 secondary ion mass spectrometry for the chemical analysis and imaging of fingerprints. 2013 Forensic Sci. Int. pmid:23890648
Vinay TN et al. Inactivated vaccine against viral hemorrhagic septicemia (VHS) emulsified with squalene and aluminum hydroxide adjuvant provides long term protection in olive flounder (Paralichthys olivaceus). 2013 Vaccine pmid:23896420
Tegenge MA and Mitkus RJ A physiologically-based pharmacokinetic (PBPK) model of squalene-containing adjuvant in human vaccines. 2013 J Pharmacokinet Pharmacodyn pmid:23912214
Van Buynder PG et al. The comparative effectiveness of adjuvanted and unadjuvanted trivalent inactivated influenza vaccine (TIV) in the elderly. 2013 Vaccine pmid:23933368
Fu D et al. ATR-IR study of ozone initiated heterogeneous oxidation of squalene in an indoor environment. 2013 Environ. Sci. Technol. pmid:23957297
Yoshimura T et al. Solution properties and emulsification properties of amino acid-based gemini surfactants derived from cysteine. 2013 J Oleo Sci pmid:23985487
Rajaram K et al. Comparative bioactive studies between wild plant and callus culture of Tephrosia tinctoria pers. 2013 Appl. Biochem. Biotechnol. pmid:24026411
Nguyen HT et al. Molecular characterization of Glycine max squalene synthase genes in seed phytosterol biosynthesis. 2013 Plant Physiol. Biochem. pmid:24036394
Florin-Christensen M et al. Inhibition of Trypanosoma cruzi growth and sterol biosynthesis by lovastatin. 1990 Biochem. Biophys. Res. Commun. pmid:2407242
Borchman D et al. Confirmation of the presence of squalene in human eyelid lipid by heteronuclear single quantum correlation spectroscopy. 2013 Lipids pmid:24081494
Nakagawa M et al. Potentiation by squalene of the cytotoxicity of anticancer agents against cultured mammalian cells and murine tumor. 1985 Jpn. J. Cancer Res. pmid:2408954
Robinson ES et al. Organic aerosol mixing observed by single-particle mass spectrometry. 2013 J Phys Chem A pmid:24131283
Rouleau I et al. Increased risk of anaphylaxis following administration of 2009 AS03-adjuvanted monovalent pandemic A/H1N1 (H1N1pdm09) vaccine. 2013 Vaccine pmid:24144473
Hoschler K et al. Administration of AS03B-adjuvanted A(H1N1)pdm09 vaccine in children aged <3 years enhances antibody response to H3 and B viruses following a single dose of trivalent vaccine one year later. 2014 Clin. Infect. Dis. pmid:24149079
Berglund J et al. Safety, immunogenicity, and antibody persistence following an investigational Streptococcus pneumoniae and Haemophilus influenzae triple-protein vaccine in a phase 1 randomized controlled study in healthy adults. 2014 Clin. Vaccine Immunol. pmid:24173029
Song YC et al. A novel emulsion-type adjuvant containing CpG oligodeoxynucleotides enhances CD8+ T-cell-mediated anti-tumor immunity. 2014 J Control Release pmid:24177312
Ito R et al. Effect of cation-π interactions and steric bulk on the catalytic action of oxidosqualene cyclase: a case study of Phe728 of β-amyrin synthase from Euphorbia tirucalli L. 2013 Chemistry pmid:24203491
Lepeltier E et al. Self-assembly of squalene-based nucleolipids: relating the chemical structure of the bioconjugates to the architecture of the nanoparticles. 2013 Langmuir pmid:24219056
Goff PH et al. Adjuvants and immunization strategies to induce influenza virus hemagglutinin stalk antibodies. 2013 PLoS ONE pmid:24223176
Esche R et al. Online LC-GC-based analysis of minor lipids in various tree nuts and peanuts. 2013 J. Agric. Food Chem. pmid:24251555
Poder A et al. An observer-blind, randomized, multi-center trial assessing long-term safety and immunogenicity of AS03-adjuvanted or unadjuvanted H1N1/2009 influenza vaccines in children 10-17 years of age. 2014 Vaccine pmid:24252703
Chen WL et al. Disintegration and cancer immunotherapy efficacy of a squalane-in-water delivery system emulsified by bioresorbable poly(ethylene glycol)-block-polylactide. 2014 Biomaterials pmid:24268203
Ueda D et al. Cyclization of squalene from both termini: identification of an onoceroid synthase and enzymatic synthesis of ambrein. 2013 J. Am. Chem. Soc. pmid:24274794
Rigane G et al. Effect of storage on refined olive oil composition: stabilization by addition of chlorophyll pigments and squalene. 2013 J Oleo Sci pmid:24292349
Vono M et al. The adjuvant MF59 induces ATP release from muscle that potentiates response to vaccination. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:24324152
Pannkuk EL et al. Sebaceous lipid profiling of bat integumentary tissues: quantitative analysis of free Fatty acids, monoacylglycerides, squalene, and sterols. 2013 Chem. Biodivers. pmid:24327437
Brown AJ et al. Cholesterol precursors: more than mere markers of biosynthesis. 2014 Curr. Opin. Lipidol. pmid:24378747
Maksimenko A et al. A unique squalenoylated and nonpegylated doxorubicin nanomedicine with systemic long-circulating properties and anticancer activity. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:24385587
Tran TV et al. NF-κB inhibitors from Eurycoma longifolia. 2014 J. Nat. Prod. pmid:24467387
Liu CI et al. Structural insights into the catalytic mechanism of human squalene synthase. 2014 Acta Crystallogr. D Biol. Crystallogr. pmid:24531458
Maksimenko A et al. Therapeutic modalities of squalenoyl nanocomposites in colon cancer: an ongoing search for improved efficacy. 2014 ACS Nano pmid:24555414
Chmielewska AM et al. Combined adenovirus vector and hepatitis C virus envelope protein prime-boost regimen elicits T cell and neutralizing antibody immune responses. 2014 J. Virol. pmid:24599994
Aguilera JA et al. Age-related changes in the mevalonate metabolism in vivo in chick kidneys. 1988 Arch. Int. Physiol. Biochim. pmid:2460056
Gillard P et al. Long-term booster schedules with AS03A-adjuvanted heterologous H5N1 vaccines induces rapid and broad immune responses in Asian adults. 2014 BMC Infect. Dis. pmid:24628789
Milanetti F et al. Safety and immunogenicity of co-administered MF59-adjuvanted 2009 pandemic and plain 2009-10 seasonal influenza vaccines in rheumatoid arthritis patients on biologicals. 2014 Clin. Exp. Immunol. pmid:24666311
Bentinger M et al. Effects of various squalene epoxides on coenzyme Q and cholesterol synthesis. 2014 Biochim. Biophys. Acta pmid:24747199
Heinemann SH and Sigworth FJ Estimation of Na+ dwell time in the gramicidin A channel. Na+ ions as blockers of H+ currents. 1989 Biochim. Biophys. Acta pmid:2480817
Hoshino T et al. β-Amyrin biosynthesis: the critical role of steric volume at C-19 of 2,3-oxidosqualene for its correct folding to generate the pentacyclic scaffold. 2014 Org. Lett. pmid:24960408
Koval'ova VA et al. [Effects of natural antioxidants on the content of lipids, proteins and carbohydrates in rat's gastric mucosal cells under experimental ulceration]. 2014 Fiziol Zh pmid:25007524
Kohno T and Ohnishi Y [Histopathology of meibomian gland abnormalities in experimental PenCB intoxicated beagle treated with squalane]. 1989 Fukuoka Igaku Zasshi pmid:2501191
Hashiguchi I et al. [Histological study on the gingiva in PenCB poisoned beagle dogs]. 1989 Fukuoka Igaku Zasshi pmid:2501192