| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Hyperlipoproteinemia Type II | D006938 | 22 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Hyperlipoproteinemias | D006951 | 15 associated lipids |
| Hyperlipoproteinemia Type III | D006952 | 4 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Influenza, Human | D007251 | 11 associated lipids |
| Keloid | D007627 | 12 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
(e,e,e,e)-squalene
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
Cross Reference
Introduction
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (e,e,e,e)-squalene?
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
PubChem Associated disorders and diseases
What pathways are associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (e,e,e,e)-squalene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with (e,e,e,e)-squalene?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with (e,e,e,e)-squalene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Furubayashi M et al. | Directed evolution of squalene synthase for dehydrosqualene biosynthesis. | 2014 | FEBS Lett. | pmid:25093296 |
| Treanor JJ | Expanding the options for confronting pandemic influenza. | 2014 | JAMA | pmid:25291574 |
| Mulligan MJ et al. | Serological responses to an avian influenza A/H7N9 vaccine mixed at the point-of-use with MF59 adjuvant: a randomized clinical trial. | 2014 | JAMA | pmid:25291577 |
| Belshe RB et al. | Immunogenicity of avian influenza A/Anhui/01/2005(H5N1) vaccine with MF59 adjuvant: a randomized clinical trial. | 2014 | JAMA | pmid:25291578 |
| Panini SR et al. | Sterol-independent regulation of 3-hydroxy-3-methylglutaryl-CoA reductase by mevalonate in Chinese hamster ovary cells. Magnitude and specificity. | 1989 | J. Biol. Chem. | pmid:2567731 |
| Viola F et al. | Inhibitors of cholesterol biosynthesis as potential hypocholesterolemic drugs. | 1989 Jul-Aug | Ital. J. Biochem. | pmid:2583986 |
| Bortz JT et al. | The origin of alkanes found in human skin surface lipids. | 1989 | J. Invest. Dermatol. | pmid:2584738 |
| Strandberg TE et al. | Effects of cholestyramine and squalene feeding on hepatic and serum plant sterols in the rat. | 1989 | Lipids | pmid:2586228 |
| Asari F et al. | Turbinaric acid, a cytotoxic secosqualene carboxylic acid from the brown alga Turbinaria ornata. | 1989 Sep-Oct | J. Nat. Prod. | pmid:2607351 |
| Chang TY et al. | Isolation and partial characterization of a cholesterol-requiring mutant of Chinese hamster ovary cells. | 1977 | Proc. Natl. Acad. Sci. U.S.A. | pmid:265577 |
| Morita T et al. | Inhibitory effect of a new mycotic agent, piritetrate on ergosterol biosynthesis in pathogenic fungi. | 1989 | J. Med. Vet. Mycol. | pmid:2666631 |
| Cattel L et al. | Drug design based on biosynthetic studies: synthesis, biological activity, and kinetics of new inhibitors of 2,3-oxidosqualene cyclase and squalene epoxidase. | 1989 Mar-May | Steroids | pmid:2678608 |
| Balliano G et al. | Inhibitors of ergosterol biosynthesis as potential antifungal drugs. | 1989 Jul-Aug | Ital. J. Biochem. | pmid:2684906 |
| McNamara DJ et al. | Measurement of daily cholesterol synthesis rates in man by assay of the fractional conversion of mevalonic acid to cholesterol. | 1977 | Proc. Natl. Acad. Sci. U.S.A. | pmid:268653 |
| Kamimura H et al. | [Studies on distribution, excretion and subacute toxicity of squalane in dogs]. | 1989 | Fukuoka Igaku Zasshi | pmid:2744688 |
| Dennis KJ and Shibamoto T | Production of malonaldehyde from squalene, a major skin surface lipid, during UV-irradiation. | 1989 | Photochem. Photobiol. | pmid:2756005 |
| Viola F et al. | In vitro metabolism of azasqualene derivatives and their effects on aminopyrine N-demethylase activity in rat liver microsomes. | 1989 | Biochem. Pharmacol. | pmid:2757649 |
| Sen SE and Prestwich GD | Squalene analogues containing isopropylidene mimics as potential inhibitors of pig liver squalene epoxidase and oxidosqualene cyclase. | 1989 | J. Med. Chem. | pmid:2769687 |
| Gylling H et al. | Effects of acipimox and cholestyramine on serum lipoproteins, non-cholesterol sterols and cholesterol absorption and elimination. | 1989 | Eur. J. Clin. Pharmacol. | pmid:2792164 |
| Anderson DG | Gorgosterol biosynthesis: localization of squalene formation in the zooxanthellar component of various gorgonians. | 1985 | Comp. Biochem. Physiol., B | pmid:2861942 |
| Popják G et al. | Effects of 2,3-iminosqualene on cultured cells. | 1987 | Proc. R. Soc. Lond., B, Biol. Sci. | pmid:2894034 |
| Strandberg TE et al. | Variations of hepatic cholesterol precursors during altered flows of endogenous and exogenous squalene in the rat. | 1989 | Biochim. Biophys. Acta | pmid:2917138 |
| Harry GJ et al. | Tellurium-induced neuropathy: metabolic alterations associated with demyelination and remyelination in rat sciatic nerve. | 1989 | J. Neurochem. | pmid:2918316 |
| Saint-Leger D et al. | A possible role for squalene in the pathogenesis of acne. I. In vitro study of squalene oxidation. | 1986 | Br. J. Dermatol. | pmid:2941049 |
| Saint-Leger D et al. | A possible role for squalene in the pathogenesis of acne. II. In vivo study of squalene oxides in skin surface and intra-comedonal lipids of acne patients. | 1986 | Br. J. Dermatol. | pmid:2941050 |
| Cohen LH et al. | Regulation of squalene synthetase activity in rat liver: elevation by cholestyramine, but no diurnal variation. | 1986 | Biochem. Biophys. Res. Commun. | pmid:2943275 |
| Kohashi O et al. | Preparation of arthritogenic hydrosoluble peptidoglycans from both arthritogenic and non-arthritogenic bacterial cell walls. | 1977 | Infect. Immun. | pmid:302240 |
| Masihi KN et al. | Biomedical applications of chromatographic fraction containing trehalose dimycolate in squalane emulsion. | 1988 | J. Chromatogr. | pmid:3042798 |
| Nazzaro-Porro M et al. | Lipoxygenase activity of Pityrosporum in vitro and in vivo. | 1986 | J. Invest. Dermatol. | pmid:3088129 |
| Kamimura H and Yoshimura H | [Stimulation of fecal excretion of the etiological compounds of yusho in rats]. | 1987 | Fukuoka Igaku Zasshi | pmid:3117660 |
| Raederstorff D and Rohmer M | Polyterpenoids as cholesterol and tetrahymanol surrogates in the ciliate Tetrahymena pyriformis. | 1988 | Biochim. Biophys. Acta | pmid:3130105 |
| Schmidt JB et al. | Sebum suppression by benzoylperoxide. | 1985 | Dermatologica | pmid:3158557 |
| Koivisto PV and Miettinen TA | Increased amounts of cholesterol precursors in lipoproteins after ileal exclusion. | 1988 | Lipids | pmid:3200122 |
| Koivisto PV and Miettinen TA | Evaluation of bile acid malabsorption by plasma cholesterol precursor sterols in familial hypercholesterolaemia patients with and without ileal exclusion. | 1988 | Scand. J. Clin. Lab. Invest. | pmid:3217753 |
| Gollub EG et al. | Yeast mutants deficient in heme biosynthesis and a heme mutant additionally blocked in cyclization of 2,3-oxidosqualene. | 1977 | J. Biol. Chem. | pmid:323256 |
| Sasiak K and Rilling HC | Purification to homogeneity and some properties of squalene synthetase. | 1988 | Arch. Biochem. Biophys. | pmid:3277535 |
| Balliano G et al. | Inhibition of sterol biosynthesis in Saccharomyces cerevisiae by N,N-diethylazasqualene and derivatives. | 1988 | Biochim. Biophys. Acta | pmid:3278744 |
| Field RB and Holmlund CE | Isolation of 2,3;22,23-dioxidosqualene and 24,25-oxidolanosterol from yeast. | 1977 | Arch. Biochem. Biophys. | pmid:327938 |
| Buttke TM et al. | Regulation of squalene epoxidase activity by membrane fatty acid composition in yeast. | 1988 | Lipids | pmid:3280941 |
| Popják G | "As I remember it" research on biosynthesis of fatty acids, triglycerides, squalene, and cholesterol. | 1977 | J Am Oil Chem Soc | pmid:328555 |
| Nishino T et al. | Synthesis of dehydrosqualene in microsomal fraction of Saccharomyces cerevisiae. | 1978 | Biochem. Biophys. Res. Commun. | pmid:32886 |
| Richter E | Stimulation of faecal excretion of hexachlorobenzene: a review. | 1986 | IARC Sci. Publ. | pmid:3298039 |
| Lorenz RT and Parks LW | Regulation of ergosterol biosynthesis and sterol uptake in a sterol-auxotrophic yeast. | 1987 | J. Bacteriol. | pmid:3301810 |
| van der Cammen TJ et al. | Prevention of pressure sores. A comparison of new and old pressure sore treatments. | 1987 | Br J Clin Pract | pmid:3332839 |
| Stein RA and Mead JF | Small hydrocarbons formed by the peroxidation of squalene. | 1988 | Chem. Phys. Lipids | pmid:3342456 |
| Färkkilä MA et al. | Raised plasma cholesterol precursors in patients with gut resections. | 1988 | Gut | pmid:3345929 |
| Keller RK and Simonet WS | Near normal levels of isoprenoid lipids in severe mevalonic aciduria. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3365255 |
| Nishimura S | [Fasting serum squalene in patients with gallstones and hyperlipidemia]. | 1988 | Nihon Shokakibyo Gakkai Zasshi | pmid:3385962 |
| Marco de la Calle C and Gibbons GF | Hepatic and intestinal formation of polar sterols in vivo in animals fed on a cholesterol-supplemented diet. | 1988 | Biochem. J. | pmid:3415662 |
| Imaeda K et al. | [Effect of sex-hormone on composition of rat skin surface lipid]. | 1987 | Nippon Yakurigaku Zasshi | pmid:3428773 |
| Appelkvist EL | In vitro labeling of peroxisomal cholesterol with radioactive precursors. | 1987 | Biosci. Rep. | pmid:3449127 |
| Byars NE and Allison AC | Adjuvant formulation for use in vaccines to elicit both cell-mediated and humoral immunity. | 1987 | Vaccine | pmid:3499713 |
| Cattel L et al. | The squalene-2,3-epoxide cyclase as a model for the development of new drugs. | 1986 | Lipids | pmid:3515096 |
| Barrett-Bee KJ et al. | The mode of antifungal action of tolnaftate. | 1986 | J. Med. Vet. Mycol. | pmid:3522841 |
| Ryder NS et al. | Inhibition of fungal and mammalian sterol biosynthesis by 2-aza-2,3-dihydrosqualene. | 1986 | FEBS Lett. | pmid:3525224 |
| Wojciechowski ZA | [Protein activators of the biosynthesis and metabolism of cholesterol]. | 1986 | Postepy Biochem. | pmid:3550764 |
| Aguilera JA et al. | Posthatching evolution of in vivo mevalonate metabolism in chick liver. | 1987 | Biochem. Int. | pmid:3579966 |
| Hori S et al. | [Studies on the therapeutic effect of squalane on symptoms of PCDFs poisoning in monkeys]. | 1987 | Fukuoka Igaku Zasshi | pmid:3666656 |
| Hayakawa K and Matsuo I | Effects of PUVA therapy on skin surface lipids: skin surface lipid peroxidation in psoriasis vulgaris and its biological significance. | 1986 | Tokai J. Exp. Clin. Med. | pmid:3672560 |
| Björkhem I et al. | Correlation between serum levels of some cholesterol precursors and activity of HMG-CoA reductase in human liver. | 1987 | J. Lipid Res. | pmid:3681138 |
| Burki E et al. | Endogenous sterol synthesis is not required for regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by low density lipoprotein. | 1987 | J. Lipid Res. | pmid:3681144 |
| Fujita H et al. | Chlorpromazine-sensitized photooxidation of squalene. | 1986 | Arch. Dermatol. Res. | pmid:3729541 |
| Hrelia S et al. | Effect of ethanol intake on human erythrocyte membrane fluidity and lipid composition. | 1986 | Biochem. Int. | pmid:3729966 |
| Matsuo I et al. | Lipid peroxidative potency of photosensitized thiazide diuretics. | 1986 | J. Invest. Dermatol. | pmid:3772156 |
| Ikekawa T et al. | [Studies on antitumor activity of squalene and its related compounds]. | 1986 | Yakugaku Zasshi | pmid:3772729 |
| Limberti A et al. | [Squalene-cholesterol ratio in the amniotic fluid and gestational age: changes in the threshold in relation to the preparation of the sample]. | 1986 | Quad Sclavo Diagn | pmid:3786665 |
| Gerst N et al. | Inhibition of cholesterol biosynthesis in 3T3 fibroblasts by 2-aza-2,3-dihydrosqualene, a rationally designed 2,3-oxidosqualene cyclase inhibitor. | 1986 | Biochem. Pharmacol. | pmid:3790151 |
| Kuswik-Rabiega G and Rilling HC | Squalene synthetase. Solubilization and partial purification of squalene synthetase, copurification of presqualene pyrophosphate and squalene synthetase activities. | 1987 | J. Biol. Chem. | pmid:3805037 |
| Miettinen TA et al. | Enhanced cholesterol elimination and synthesis related to low-density lipoprotein metabolism. | 1987 | Am. Heart J. | pmid:3812207 |
| Masihi KN et al. | Modulation of natural killer cytotoxicity by muramyl dipeptide and trehalose dimycolate incorporated in squalane droplets. | 1987 | Cancer Immunol. Immunother. | pmid:3815418 |
| Kashimoto T et al. | [Studies on therapeutic effect of 13-cis retinoic acid and squalene on symptoms of PCDFs poisoning in monkeys]. | 1985 | Fukuoka Igaku Zasshi | pmid:3862639 |
| Nishino T and Katsuki H | Formation of 12-cis-dehydrosqualene catalyzed by squalene synthetase. | 1985 | Meth. Enzymol. | pmid:3894880 |
| Pinto WJ et al. | Inhibition of sterol biosynthesis by ergosterol and cholesterol in Saccharomyces cerevisiae. | 1985 | Biochim. Biophys. Acta | pmid:3896318 |
| Morita T and Nozawa Y | Effects of antifungal agents on ergosterol biosynthesis in Candida albicans and Trichophyton mentagrophytes: differential inhibitory sites of naphthiomate and miconazole. | 1985 | J. Invest. Dermatol. | pmid:3902987 |
| Harrison DM | The biosynthesis of triterpenoids and steroids. | 1985 | Nat Prod Rep | pmid:3913885 |
| Johnson RC and Shah SN | Metabolism of intracerebrally injected mevalonate in brain of suckling and young adult rats. | 1985 | Neurochem. Res. | pmid:3925358 |
| Yamaguchi T et al. | Potentiation by squalene of antitumor effect of 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-nitros ourea in a murine tumor system. | 1985 | Jpn. J. Cancer Res. | pmid:3935620 |
| Garrett IR et al. | Ambivalent properties of gold drugs in adjuvant induced polyarthritis in rats. | 1985 | J. Rheumatol. | pmid:3937896 |
| Chen JK et al. | Biochemical characterization of the cholesterol-dependent growth of the NS-1 mouse myeloma cell line. | 1986 | Exp. Cell Res. | pmid:3943557 |
| Pentchev PG et al. | The cholesterol storage disorder of the mutant BALB/c mouse. A primary genetic lesion closely linked to defective esterification of exogenously derived cholesterol and its relationship to human type C Niemann-Pick disease. | 1986 | J. Biol. Chem. | pmid:3949747 |
| Vuoristo M and Miettinen TA | Enhanced synthesis of cholesterol and its precursors in jejunal mucosa in coeliac disease. | 1986 | Gut | pmid:3957109 |
| Williams ML and Elias PM | Heterogeneity in autosomal recessive ichthyosis. Clinical and biochemical differentiation of lamellar ichthyosis and nonbullous congenital ichthyosiform erythroderma. | 1985 | Arch Dermatol | pmid:3977371 |
| Jeng I et al. | Effect of a hypocholesterolemic agent on cholesteryl ester metabolism in glioblastoma cells. | 1985 | Biochem. Pharmacol. | pmid:3994747 |
| Yamada Y et al. | Oxidation of acyclic terpenoids by Corynebacterium sp. | 1985 | Appl. Environ. Microbiol. | pmid:4004225 |
| Duriatti A et al. | In vitro inhibition of animal and higher plants 2,3-oxidosqualene-sterol cyclases by 2-aza-2,3-dihydrosqualene and derivatives, and by other ammonium-containing molecules. | 1985 | Biochem. Pharmacol. | pmid:4015713 |
| McNamara DJ et al. | Role of the kidneys in the metabolism of plasma mevalonate. Studies in humans and in rhesus monkeys. | 1985 | J. Clin. Invest. | pmid:4019781 |
| Khullar N et al. | Immunomodulation of experimental malaria by MDP. | 1985 | Indian J Malariol | pmid:4029457 |
| Chin J and Bloch K | Stimulation by unsaturated fatty acid of squalene uptake in rat liver microsomes. | 1985 | J. Lipid Res. | pmid:4031660 |
| Ryder NS | Specific inhibition of fungal sterol biosynthesis by SF 86-327, a new allylamine antimycotic agent. | 1985 | Antimicrob. Agents Chemother. | pmid:4039119 |
| Ono T et al. | Involvement of NADPH-cytochrome c reductase in the rat liver squalene epoxidase system. | 1977 | Biochim. Biophys. Acta | pmid:403952 |
| Gower DB et al. | Axillary 5 alpha-androst-16-en-3-one in men and women: relationships with olfactory acuity to odorous 16-androstenes. | 1985 | Experientia | pmid:4043321 |
| Yamanishi Y et al. | Sterol and bile acid metabolism after short-term prednisolone treatment in patients with chronic active hepatitis. | 1985 | Gastroenterol. Jpn. | pmid:4043657 |
| Yoshimura H et al. | [Stimulating effect of squalene on fecal excretion of a high toxic 2,3,4,7,8-pentachlorodibenzofuran (PenCDF) in rats]. | 1985 | Fukuoka Igaku Zasshi | pmid:4043918 |
| Goad LJ et al. | Effect of the allylamine antifungal drug SF 86-327 on the growth and sterol synthesis of Leishmania mexicana mexicana promastigotes. | 1985 | Biochem. Pharmacol. | pmid:4052119 |
| Nosaka Y et al. | Biliary squalene levels in hepatobiliary disease. | 1985 | Gastroenterol. Jpn. | pmid:4054510 |
| Rilling HC | The mechanism of the condensation reactions of cholesterol biosynthesis. Fourth Morton lecture. | 1985 | Biochem. Soc. Trans. | pmid:4092833 |
| Van TAMELEN EE and Freed JH | Biochemical conversion of partially cyclized squalene 2,3-oxide types to the lanosterol system. Views on the normal enzymic cyclization process. | 1970 | J. Am. Chem. Soc. | pmid:4098774 |
| Mallory FB and Conner RL | Dehydrogenation and dealkylation of various sterols by Tetrahymena pyriformis. | 1971 | Lipids | pmid:4102490 |
| Singh EJ et al. | Hydrocarbons in human cervical mucus and the effect of oral contraception. | 1972 | J Reprod Med | pmid:4113025 |
| Voogt PA and Van der Horst DJ | Investigations of the capacity of synthesizing 3 -sterols in mollusca. 8. The biosynthesis of 3 -sterols in the pulmonates "Succinea putris" and "Arianta arbustorum". | 1972 | Arch. Int. Physiol. Biochim. | pmid:4114875 |