| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Hyperlipoproteinemia Type II | D006938 | 22 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Hyperlipoproteinemias | D006951 | 15 associated lipids |
| Hyperlipoproteinemia Type III | D006952 | 4 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Influenza, Human | D007251 | 11 associated lipids |
| Keloid | D007627 | 12 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
(e,e,e,e)-squalene
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
Cross Reference
Introduction
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (e,e,e,e)-squalene?
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
PubChem Associated disorders and diseases
What pathways are associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (e,e,e,e)-squalene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with (e,e,e,e)-squalene?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with (e,e,e,e)-squalene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| VROMAN HE and BAKER GL | LIMITS OF DETECTION OF SOME LIPIDS IN THIN-LAYER CHROMATOGRAPHY. | 1965 | J. Chromatogr. | pmid:14334204 |
| GOSSELIN L and DUVIVIER J | [BIOSYNTHESIS OF FARNESOL PYROPHOSPHATE AND SQUALENE FROM 2-C14-MEVALONIC ACID BY CELL FRACTIONS OF ADRENAL HOMOGENATE]. | 1965 | Bull. Soc. Chim. Biol. | pmid:14337120 |
| GOODWIN TW and WILLIAMS RJ | A MECHANISM FOR THE CYCLIZATION OF AN ACYCLIC PRECURSOR TO FORM BETA-CAROTENE. | 1965 | Biochem. J. | pmid:14342248 |
| Puhvel SM and Sakamoto M | An in vivo evaluation of the inflammatory effect of purified comedonal components in human skin. | 1977 | J. Invest. Dermatol. | pmid:143497 |
| NICOLAIDES N and ROTHMAN S | The site of sterol and squalene synthesis in the human skin. | 1955 | J. Invest. Dermatol. | pmid:14354270 |
| BOUGHTON B et al. | Some observations of the nature, origin and possible function of the squalene and other hydrocarbons of human sebum. | 1955 | J. Invest. Dermatol. | pmid:14354278 |
| MACKENNA RM et al. | Squalene and other hydrocarbons in human sebum. | 1955 | J. Physiol. (Lond.) | pmid:14354699 |
| Allison AC and Byars NE | Syntex adjuvant formulation. | 1992 | Res. Immunol. | pmid:1439132 |
| SCHOEN H and FAHSOLD W | [Studies on the problem of resorption of squalene]. | 1960 | Klin. Wochenschr. | pmid:14443328 |
| Boutaud O et al. | Preferential cyclization of 2,3(S):22(S),23-dioxidosqualene by mammalian 2,3-oxidosqualene-lanosterol cyclase. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1445330 |
| POPJAK G et al. | Studies on the biosynthesis of cholesterol. XVI. Chemical synthesis of 1-H2-3-2-C-14- and 1-D2-2-C-14-trans-trans-farnesyl pyrophosphate and their utilization in squalene biosynthesis. | 1962 | J. Biol. Chem. | pmid:14487886 |
| POPJAK G et al. | Sterospecificity of hydrogen transfer from reduced triphosphopyridine nucleotide to squalene during its synthesis from farnesyl pyrophosphate. | 1962 | Biochem. Biophys. Res. Commun. | pmid:14487887 |
| ROTHBLAT GH et al. | A quantitative colorimetric assay for squalene. | 1962 | Anal. Biochem. | pmid:14494417 |
| Veen M et al. | Combined overexpression of genes of the ergosterol biosynthetic pathway leads to accumulation of sterols in Saccharomyces cerevisiae. | 2003 | FEMS Yeast Res. | pmid:14554200 |
| Rajamani R and Gao J | Balancing kinetic and thermodynamic control: the mechanism of carbocation cyclization by squalene cyclase. | 2003 | J. Am. Chem. Soc. | pmid:14558824 |
| Saint-Léger D | [Normal and pathologic sebaceous function. Research in a shallow milieu?]. | 2003 | Pathol. Biol. | pmid:14567194 |
| Das B et al. | In vitro cytoprotective activity of squalene on a bone marrow versus neuroblastoma model of cisplatin-induced toxicity. implications in cancer chemotherapy. | 2003 | Eur. J. Cancer | pmid:14602142 |
| Mateos R et al. | Antioxidant effect of phenolic compounds, alpha-tocopherol, and other minor components in virgin olive oil. | 2003 | J. Agric. Food Chem. | pmid:14611189 |
| Miettinen TA and Gylling H | Synthesis and absorption markers of cholesterol in serum and lipoproteins during a large dose of statin treatment. | 2003 | Eur. J. Clin. Invest. | pmid:14636301 |
| He HP et al. | Supercritical carbon dioxide extraction of oil and squalene from amaranthus grain. | 2003 | J. Agric. Food Chem. | pmid:14690374 |
| Miettinen TA et al. | Low synthesis and high absorption of cholesterol characterize type 1 diabetes. | 2004 | Diabetes Care | pmid:14693966 |
| Passi S et al. | The combined use of oral and topical lipophilic antioxidants increases their levels both in sebum and stratum corneum. | 2003 | Biofactors | pmid:14695946 |
| Sherman DR et al. | Components of sterol biosynthesis assembled on the oxygen-avid hemoglobin of Ascaris. | 1992 | Science | pmid:1470914 |
| Mills OH et al. | Enhancement of comedogenic substances by ultraviolet radiation. | 1978 | Br. J. Dermatol. | pmid:147099 |
| Kuroda Y et al. | Distinctive patterns of autoimmune response induced by different types of mineral oil. | 2004 | Toxicol. Sci. | pmid:14718649 |
| Okada S et al. | Characterization of botryococcene synthase enzyme activity, a squalene synthase-like activity from the green microalga Botryococcus braunii, Race B. | 2004 | Arch. Biochem. Biophys. | pmid:14725863 |
| Marshall BC and Adler SP | Avidity maturation following immunization with two human cytomegalovirus (CMV) vaccines: a live attenuated vaccine (Towne) and a recombinant glycoprotein vaccine (gB/MF59). | 2003 | Viral Immunol. | pmid:14733736 |
| Worsham DN et al. | Evidence for cholesterol scavenging by Pneumocystis and potential modifications of host-synthesized sterols by the P. carinii SAM:SMT. | 2003 | J. Eukaryot. Microbiol. | pmid:14736216 |
| Bakalar B et al. | Changes in cholesterol and its precursors during the first days after major trauma. | 2003 | Wien. Klin. Wochenschr. | pmid:14743581 |
| Xu R et al. | On the origins of triterpenoid skeletal diversity. | 2004 | Phytochemistry | pmid:14751299 |
| Hayashi N et al. | Effect of sunlight exposure and aging on skin surface lipids and urate. | 2003 | Exp. Dermatol. | pmid:14756518 |
| Kawaki H | The interaction of monosubstituted benzenes with the stationary liquid in gas liquid chromatography. | 2004 | Chem. Pharm. Bull. | pmid:14758007 |
| Ruf A et al. | The monotopic membrane protein human oxidosqualene cyclase is active as monomer. | 2004 | Biochem. Biophys. Res. Commun. | pmid:14766201 |
| HADORN H and JUNGKUNZ R | [Further studies on squalene. 4]. | 1950 | Mitt Lebensmittelunters Hyg | pmid:14806249 |
| FLESCH P | Hair loss from squalene. | 1951 | Proc. Soc. Exp. Biol. Med. | pmid:14844354 |
| HIGH EG and DAY HG | Effects of different amounts of lutein, squalene, phytol and related substances on the utilization of carotene and vitamin A for storage and growth in the rat. | 1951 | J. Nutr. | pmid:14851042 |
| Suzuki M et al. | Loss of function of 3-hydroxy-3-methylglutaryl coenzyme A reductase 1 (HMG1) in Arabidopsis leads to dwarfing, early senescence and male sterility, and reduced sterol levels. | 2004 | Plant J. | pmid:14871314 |
| Kalogeropoulos N and Andrikopoulos NK | Squalene in oils and fats from domestic and commercial fryings of potatoes. | 2004 | Int J Food Sci Nutr | pmid:14985184 |
| Tanaka H et al. | 1-methylidenesqualene and 25-methylidenesqualene as active-site probes for bacterial squalene:hopene cyclase. | 2004 | Org. Lett. | pmid:14986979 |
| Nikkilä K et al. | Liver transplantation modifies serum cholestanol, cholesterol precursor and plant sterol levels. | 1992 | Clin. Chim. Acta | pmid:1499139 |
| Silva CJ and Djerassi C | Biosynthetic studies of marine lipids 36. The origin of common sterol side chains in eleven sponges using [3-3H]-squalene. | 1992 Jan-Feb | Comp. Biochem. Physiol., B | pmid:1499273 |
| Ceruti M et al. | 2,3-Epoxy-10-aza-10,11-dihydrosqualene, a high-energy intermediate analogue inhibitor of 2,3-oxidosqualene cyclase. | 1992 | J. Med. Chem. | pmid:1501233 |
| Lee HK et al. | Photoaffinity labeling identifies the substrate-binding site of mammalian squalene epoxidase. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15013417 |
| Abe I et al. | Enzymatic cyclization of 22,23-dihydro-2,3-oxidosqualene into euph-7-en-3beta-ol and bacchar-12-en-3beta-ol by recombinant beta-amyrin synthase. | 2004 | J. Am. Chem. Soc. | pmid:15025461 |
| Schulz JG et al. | HMG-CoA reductase inhibition causes neurite loss by interfering with geranylgeranylpyrophosphate synthesis. | 2004 | J. Neurochem. | pmid:15030386 |
| Williams DK et al. | Analysis of latent fingerprint deposits by infrared microspectroscopy. | 2004 | Appl Spectrosc | pmid:15035712 |
| Uchino T et al. | Potent protecting effects of Catuaba (Anemopaegma mirandum) extracts against hydroperoxide-induced cytotoxicity. | 2004 | Toxicol In Vitro | pmid:15046771 |
| Sato T et al. | Site-directed mutagenesis experiments on the putative deprotonation site of squalene-hopene cyclase from Alicyclobacillus acidocaldarius. | 2004 | Biosci. Biotechnol. Biochem. | pmid:15056909 |
| Shin DH et al. | Amaranth squalene reduces serum and liver lipid levels in rats fed a cholesterol diet. | 2004 | Br. J. Biomed. Sci. | pmid:15058737 |
| Lewis DJ et al. | Rapid and frequent induction of protective immunity exceeding UK recommendations for healthcare settings by MF59-adjuvated hepatitis B vaccine. | 2003 | Commun Dis Public Health | pmid:15067859 |
| Ketomaki A et al. | Effects of plant stanol and sterol esters on serum phytosterols in a family with familial hypercholesterolemia including a homozygous subject. | 2004 | J. Lab. Clin. Med. | pmid:15085084 |
| Matyas GR et al. | Detection of antibodies to squalene: III. Naturally occurring antibodies to squalene in humans and mice. | 2004 | J. Immunol. Methods | pmid:15087221 |
| Shenoy SD et al. | Induction of CYP3A by 2,3-oxidosqualene:lanosterol cyclase inhibitors is mediated by an endogenous squalene metabolite in primary cultured rat hepatocytes. | 2004 | Mol. Pharmacol. | pmid:15102959 |
| Cenedella RJ et al. | Cholesterylene, a newly recognized tissue lipid, found at high levels in the cornea. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1510688 |
| Taton M et al. | Inhibition of 2,3-oxidosqualene cyclases. | 1992 | Biochemistry | pmid:1510977 |
| Poralla K | Profound insights into squalene cyclization. | 2004 | Chem. Biol. | pmid:15112988 |
| Reinert DJ et al. | Conversion of squalene to the pentacarbocyclic hopene. | 2004 | Chem. Biol. | pmid:15113001 |
| Fazio GC et al. | Genome mining to identify new plant triterpenoids. | 2004 | J. Am. Chem. Soc. | pmid:15125655 |
| Hoshino T et al. | Squalene-hopene cyclase: final deprotonation reaction, conformational analysis for the cyclization of (3R,S)-2,3-oxidosqualene and further evidence for the requirement of an isopropylidene moiety both for initiation of the polycyclization cascade and for the formation of the 5-membered E-ring. | 2004 | Org. Biomol. Chem. | pmid:15136801 |
| Ketomäki A et al. | Removal of intravenous Intralipid in patients with familial hypercholesterolemia during inhibition of cholesterol absorption and synthesis. | 2004 | Clin. Chim. Acta | pmid:15149875 |
| Hess BA and Smentek L | Concerted nature of AB ring formation in the enzymatic cyclization of squalene to hopenes. | 2004 | Org. Lett. | pmid:15151397 |
| Stephenson I et al. | Detection of anti-H5 responses in human sera by HI using horse erythrocytes following MF59-adjuvanted influenza A/Duck/Singapore/97 vaccine. | 2004 | Virus Res. | pmid:15163495 |
| Abe I et al. | Mechanism and stereochemistry of enzymatic cyclization of 24,30-Bisnor-2,3-oxidosqualene by recombinant beta-amyrin synthase. | 2004 | J. Am. Chem. Soc. | pmid:15174853 |
| Hu JJ et al. | [Antibody production and its neutralization of Abeta42's cytoxicity in BALB/c mice induced by Abeta42 and its subunit vaccines]. | 2004 | Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi | pmid:15191720 |
| Kuroda Y et al. | Autoimmunity induced by adjuvant hydrocarbon oil components of vaccine. | 2004 | Biomed. Pharmacother. | pmid:15194169 |
| Holm BC et al. | Adjuvant oil induces waves of arthritogenic lymph node cells prior to arthritis onset. | 2004 | Clin. Exp. Immunol. | pmid:15196244 |
| Fukasawa LO et al. | Adjuvant can improve protection induced by OMV vaccine against Neisseria meningitidis serogroups B/C in neonatal mice. | 2004 | FEMS Immunol. Med. Microbiol. | pmid:15196569 |
| Abe I et al. | Inhibitors of squalene biosynthesis and metabolism. | 1994 | Nat Prod Rep | pmid:15200015 |
| Abe I et al. | Affinity labeling of vertebrate oxidosqualene cyclases with a tritiated suicide substrate. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1520315 |
| Tsai HF et al. | Candida glabrata erg1 mutant with increased sensitivity to azoles and to low oxygen tension. | 2004 | Antimicrob. Agents Chemother. | pmid:15215098 |
| Maguire LS et al. | Fatty acid profile, tocopherol, squalene and phytosterol content of walnuts, almonds, peanuts, hazelnuts and the macadamia nut. | 2004 | Int J Food Sci Nutr | pmid:15223592 |
| Sabeena Farvin KH et al. | Effect of squalene on tissue defense system in isoproterenol-induced myocardial infarction in rats. | 2004 | Pharmacol. Res. | pmid:15225664 |
| Pragst F et al. | Wipe-test and patch-test for alcohol misuse based on the concentration ratio of fatty acid ethyl esters and squalene CFAEE/CSQ in skin surface lipids. | 2004 | Forensic Sci. Int. | pmid:15240027 |
| Nakano S et al. | Squalene-hopene cyclase: insight into the role of the methyl group on the squalene backbone upon the polycyclization cascade. Enzymatic cyclization products of squalene analogs lacking a 26-methyl group and possessing a methyl group at C7 or C11. | 2004 | Org. Biomol. Chem. | pmid:15254628 |
| Kamimura H et al. | Enhanced elimination of theophylline, phenobarbital and strychnine from the bodies of rats and mice by squalane treatment. | 1992 | J. Pharmacobio-dyn. | pmid:1527697 |
| Ruf BR et al. | Open, randomized study to compare the immunogenicity and reactogenicity of an influenza split vaccine with an MF59-adjuvanted subunit vaccine and a virosome-based subunit vaccine in elderly. | 2004 | Infection | pmid:15293073 |
| Süli J et al. | Experimental squalene adjuvant. I. Preparation and testing of its effectiveness. | 2004 | Vaccine | pmid:15308373 |
| BenÃsek Z et al. | Experimental squalene adjuvant. II. Harmlessness and local reactogenity. | 2004 | Vaccine | pmid:15308374 |
| Schulz S et al. | Mechanisms of cell growth inhibition and cell cycle arrest in human colonic adenocarcinoma cells by dehydroepiandrosterone: role of isoprenoid biosynthesis. | 1992 | Cancer Res. | pmid:1531325 |
| Hronská L et al. | Low concentrations of the non-ionic detergent Nonidet P-40 interfere with sterol biogenesis and viability of the yeast Saccharomyces cerevisiae. | 2004 | FEMS Microbiol. Lett. | pmid:15336428 |
| SOBEL H | Squalene in sebum and sebum-like materials. | 1949 | J. Invest. Dermatol. | pmid:15398762 |
| Auwärter V et al. | Squalene in hair--a natural reference substance for the improved interpretation of fatty acid ethyl ester concentrations with respect to alcohol misuse. | 2004 | Forensic Sci. Int. | pmid:15451087 |
| Cravotto G et al. | Umbelliferone aminoalkyl derivatives, a new class of squalene-hopene cyclase inhibitors. | 2004 | Eur J Med Chem | pmid:15501540 |
| Thoma R et al. | Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase. | 2004 | Nature | pmid:15525992 |
| Puig-Barberà J et al. | Effectiveness of the MF59-adjuvanted influenza vaccine in preventing emergency admissions for pneumonia in the elderly over 64 years of age. | 2004 | Vaccine | pmid:15530669 |
| Achitouv E et al. | C31-C34 methylated squalenes from a Bolivian strain of Botryococcus braunii. | 2004 | Phytochemistry | pmid:15541746 |
| O'Hagan DT et al. | Cationic microparticles are a potent delivery system for a HCV DNA vaccine. | 2004 | Vaccine | pmid:15542189 |
| Scolastici C et al. | Squalene does not exhibit a chemopreventive activity and increases plasma cholesterol in a Wistar rat hepatocarcinogenesis model. | 2004 | Nutr Cancer | pmid:15572303 |
| Sun S et al. | The combination effects of phenolic compounds and fluconazole on the formation of ergosterol in Candida albicans determined by high-performance liquid chromatography/tandem mass spectrometry. | 2005 | Anal. Biochem. | pmid:15582556 |
| Vajdy M et al. | Mucosal and systemic anti-HIV responses in rhesus macaques following combinations of intranasal and parenteral immunizations. | 2004 | AIDS Res. Hum. Retroviruses | pmid:15588349 |
| Hoshino T et al. | Deletion of the Gly600 residue of Alicyclobacillus acidocaldarius squalene cyclase alters the substrate specificity into that of the eukaryotic-type cyclase specific to (3S)-2,3-oxidosqualene. | 2004 | Angew. Chem. Int. Ed. Engl. | pmid:15593147 |
| Influenza vaccine with squalene adjuvant: new preparation. No better than available products. | 2004 | Prescrire Int | pmid:15599987 | |
| Ekanayake-Mudiyanselage S et al. | Vitamin E delivery to human skin by a rinse-off product: penetration of alpha-tocopherol versus wash-out effects of skin surface lipids. | 2005 Jan-Feb | Skin Pharmacol Physiol | pmid:15608499 |
| Zadák Z et al. | [The role of cholesterol and intermediary metabolites of its synthesis in intensive care and parenteral nutrition]. | 2000 | Vnitr Lek | pmid:15637893 |
| Hung CF et al. | Physicochemical characterization and gene transfection efficiency of lipid emulsions with various co-emulsifiers. | 2005 | Int J Pharm | pmid:15652212 |
| Nikkilä K et al. | Serum and hepatic cholestanol, squalene and noncholesterol sterols in man: a study on liver transplantation. | 1992 | Hepatology | pmid:1568728 |
| Ekanayake-Mudiyanselage S et al. | Oral supplementation with all-Rac- and RRR-alpha-tocopherol increases vitamin E levels in human sebum after a latency period of 14-21 days. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15753144 |
| Aguilera Y et al. | The protective role of squalene in alcohol damage in the chick embryo retina. | 2005 | Exp. Eye Res. | pmid:15781281 |
| Lee KH et al. | Squalene aspiration pneumonia in children: radiographic and CT findings as the first clue to diagnosis. | 2005 | Pediatr Radiol | pmid:15806404 |
| Kim TW et al. | Airway gene transfer using cationic emulsion as a mucosal gene carrier. | 2005 | J Gene Med | pmid:15929068 |