(e,e,e,e)-squalene

(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.

Cross Reference

Introduction

To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (e,e,e,e)-squalene?

(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene

MeSH term MeSH ID Detail
Photosensitivity Disorders D010787 8 associated lipids
Pneumonia, Lipid D011017 2 associated lipids
Precancerous Conditions D011230 48 associated lipids
Pregnancy Complications, Infectious D011251 11 associated lipids
Psoriasis D011565 47 associated lipids
Rosacea D012393 13 associated lipids
Scalp Dermatoses D012536 11 associated lipids
Stomach Ulcer D013276 75 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Tinea Versicolor D014010 5 associated lipids
Viremia D014766 4 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Xanthomatosis D014973 17 associated lipids
Weight Gain D015430 101 associated lipids
Simian Acquired Immunodeficiency Syndrome D016097 4 associated lipids
Lymphoma, B-Cell D016393 24 associated lipids
Keratitis, Herpetic D016849 5 associated lipids
Coronavirus Infections D018352 4 associated lipids
Parasitemia D018512 5 associated lipids
Persian Gulf Syndrome D018923 1 associated lipids
Per page 10 20 50 100 | Total 84

PubChem Associated disorders and diseases

What pathways are associated with (e,e,e,e)-squalene

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with (e,e,e,e)-squalene?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (e,e,e,e)-squalene?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with (e,e,e,e)-squalene

Download all related citations
Per page 10 20 50 100 | Total 1766
Authors Title Published Journal PubMed Link
Morimoto Y et al. Asymmetric total synthesis of highly symmetric squalene-derived cytotoxic polyethers. 2002 Chirality pmid:12112332
Hoshino T and Ohashi S Importance of the methyl group at C10 of squalene for hopene biosynthesis and novel carbocyclic skeletons with 6/5 + 5/5 + (6) ring system(s). 2002 Org. Lett. pmid:12123374
Asa PB et al. Antibodies to squalene in recipients of anthrax vaccine. 2002 Exp. Mol. Pathol. pmid:12127050
Asano KG et al. Chemical composition of fingerprints for gender determination. 2002 J. Forensic Sci. pmid:12136987
Pérez-Camino MC et al. Determination of esters of fatty acids with low molecular weight alcohols in olive oils. 2002 J. Agric. Food Chem. pmid:12137504
Jarstfer MB et al. Recombinant squalene synthase. Synthesis of non-head-to-tail isoprenoids in the absence of NADPH. 2002 J. Am. Chem. Soc. pmid:12137536
Blagg BS et al. Recombinant squalene synthase. A mechanism for the rearrangement of presqualene diphosphate to squalene. 2002 J. Am. Chem. Soc. pmid:12137537
Matyas GR et al. Induction and detection of antibodies to squalene. II. Optimization of the assay for murine antibodies. 2002 J. Immunol. Methods pmid:12165433
Connolly JD and Hill RA Triterpenoids. 2002 Nat Prod Rep pmid:12195814
Hess BA Concomitant C-ring Expansion and D-ring formation in lanosterol biosynthesis from squalene without violation of Markovnikov's rule. 2002 J. Am. Chem. Soc. pmid:12197724
Rontani JF et al. Aerobic and anaerobic metabolism of squalene by a denitrifying bacterium isolated from marine sediment. 2002 Arch. Microbiol. pmid:12209261
Skeiky YA et al. Protective efficacy of a tandemly linked, multi-subunit recombinant leishmanial vaccine (Leish-111f) formulated in MPL adjuvant. 2002 Vaccine pmid:12213399
Yoo YC et al. Inhibitory effect of BCG cell-wall skeletons (BCG-CWS) emulsified in squalane on tumor growth and metastasis in mice. 2002 Arch. Pharm. Res. pmid:12214866
Wentzinger LF et al. Inhibition of squalene synthase and squalene epoxidase in tobacco cells triggers an up-regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase. 2002 Plant Physiol. pmid:12226513
Gylling H and Miettinen TA Inheritance of cholesterol metabolism of probands with high or low cholesterol absorption. 2002 J. Lipid Res. pmid:12235179
Rastrelli L et al. Rate of degradation of alpha-tocopherol, squalene, phenolics, and polyunsaturated fatty acids in olive oil during different storage conditions. 2002 J. Agric. Food Chem. pmid:12236680
Bernier UR et al. Chemical analysis of human skin emanations: comparison of volatiles from humans that differ in attraction of Aedes aegypti (Diptera: Culicidae). 2002 J. Am. Mosq. Control Assoc. pmid:12322940
Ley JP et al. 3,4-Dihydroxymandelic acid, a noradrenalin metabolite with powerful antioxidative potential. 2002 J. Agric. Food Chem. pmid:12358456
Quang DN et al. Concentriols B, C and D, three squalene-type triterpenoids from the ascomycete Daldinia concentrica. 2002 Phytochemistry pmid:12359521
Tabacik C et al. Oxidosqualene cyclization in human placenta. An easy step of sterol biosynthesis. 1975 Biochim. Biophys. Acta pmid:1236745
Zhang Z et al. Effect of squalene and shark liver oil on serum cholesterol level in hamsters. 2002 Int J Food Sci Nutr pmid:12396466
Hauss T et al. Squalane is in the midplane of the lipid bilayer: implications for its function as a proton permeability barrier. 2002 Biochim. Biophys. Acta pmid:12460672
Ostlund RE et al. Effects of trace components of dietary fat on cholesterol metabolism: phytosterols, oxysterols, and squalene. 2002 Nutr. Rev. pmid:12462517
Clouse SD Brassinosteroids. Plant counterparts to animal steroid hormones? 2002 Vitam. Horm. pmid:12481548
Dembitsky VM and Srebnik M Variability of hydrocarbon and fatty acid components in cultures of the filamentous cyanobacterium Scytonema sp. isolated from microbial community "black cover" of limestone walls in Jerusalem. 2002 Biochemistry Mosc. pmid:12495426
Strauss JS et al. Skin lipids and acne. 1975 Annu. Rev. Med. pmid:125065
Lee KT et al. Structure of three new terpenoids, spiciformisins a and b, and monocyclosqualene, isolated from the herbs of Ligularia fischeri var. spiciformis and cytotoxicity. 2002 Arch. Pharm. Res. pmid:12510832
Flores-Sánchez IJ et al. Biosynthesis of sterols and triterpenes in cell suspension cultures of Uncaria tomentosa. 2002 Plant Cell Physiol. pmid:12514247
Wiss O Influence of a lipogenic diet on the cholesterol synthesis in rats in vivo. 1976 Biochem. Biophys. Res. Commun. pmid:1252232
Wiss O Influence of fasting and cholesterol feeding on the cholesterol synthesis in rats in vivo. 1976 Biochem. Biophys. Res. Commun. pmid:1252233
Hess BA Formation of the C ring in the lanosterol biosynthesis from squalene. 2003 Org. Lett. pmid:12529131
Kushwaha SC and Kates M Nonpolar lipids of a halotolerant species of Staphylococcus epidermidis. 1976 Can. J. Biochem. pmid:1252986
Khallouki F et al. Consumption of argan oil (Morocco) with its unique profile of fatty acids, tocopherols, squalene, sterols and phenolic compounds should confer valuable cancer chemopreventive effects. 2003 Eur. J. Cancer Prev. pmid:12548113
Liu GC et al. Measurement of squalene in human tissues and plasma: validation and application. 1976 J. Lipid Res. pmid:1255019
Miettinen TA et al. Serum noncholesterol sterols during inhibition of cholesterol synthesis by statins. 2003 J. Lab. Clin. Med. pmid:12577049
Ballou WR et al. Safety and immunogenicity of a recombinant parvovirus B19 vaccine formulated with MF59C.1. 2003 J. Infect. Dis. pmid:12599085
Ketomäki A et al. Squalene and noncholesterol sterols in serum and lipoproteins of children with and without familial hypercholesterolemia. 2003 Pediatr. Res. pmid:12612218
Righetti M et al. The in vitro metabolism of mevalonate by sterol and non-sterol pathways. 1976 J. Biol. Chem. pmid:1262340
Stephenson I et al. Boosting immunity to influenza H5N1 with MF59-adjuvanted H5N3 A/Duck/Singapore/97 vaccine in a primed human population. 2003 Vaccine pmid:12639491
Souto ML et al. The inhibitory effects of squalene-derived triterpenes on protein phosphatase PP2A. 2003 Bioorg. Med. Chem. Lett. pmid:12657259
Luan Z et al. Statins inhibit secretion of metalloproteinases-1, -2, -3, and -9 from vascular smooth muscle cells and macrophages. 2003 Arterioscler. Thromb. Vasc. Biol. pmid:12663370
Schulz-Gasch T and Stahl M Mechanistic insights into oxidosqualene cyclizations through homology modeling. 2003 J Comput Chem pmid:12666166
Banzhoff A et al. A new MF59-adjuvanted influenza vaccine enhances the immune response in the elderly with chronic diseases: results from an immunogenicity meta-analysis. 2003 May-Jun Gerontology pmid:12679609
Hendler RW et al. Purple membrane lipid control of bacteriorhodopsin conformational flexibility and photocycle activity. 2003 Eur. J. Biochem. pmid:12709050
Ahrens EH Sterol balance in hyperlipidemic patients after dietary exchange of carbohydrate for fat. 1976 J. Lipid Res. pmid:1270936
Lu HT et al. Preparative separation and purification of squalene from the microalga Thraustochytrium ATCC 26185 by high-speed counter-current chromatography. 2003 J Chromatogr A pmid:12779217
Chiba K et al. Characteristics of skin wrinkling and dermal changes induced by repeated application of squalene monohydroperoxide to hairless mouse skin. 2003 Jul-Aug Skin Pharmacol. Appl. Skin Physiol. pmid:12784064
Rocco F et al. Conjugated methyl sulfide and phenyl sulfide derivatives of oxidosqualene as inhibitors of oxidosqualene and squalene-hopene cyclases. 2003 Lipids pmid:12784859
Ekanayake Mudiyanselage S et al. Ultraviolet a induces generation of squalene monohydroperoxide isomers in human sebum and skin surface lipids in vitro and in vivo. 2003 J. Invest. Dermatol. pmid:12787115
Madani KA Effects of trace components of dietary fat on cholesterol metabolism: phytosterols, oxysterols, and squalene. 2003 Nutr. Rev. pmid:12795450