| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cholestasis | D002779 | 23 associated lipids |
| Arthritis, Experimental | D001169 | 24 associated lipids |
| Lymphoma, B-Cell | D016393 | 24 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Brain Diseases | D001927 | 27 associated lipids |
| Vitamin E Deficiency | D014811 | 29 associated lipids |
| Micronuclei, Chromosome-Defective | D048629 | 33 associated lipids |
| Peripheral Nervous System Diseases | D010523 | 33 associated lipids |
| Thyroid Neoplasms | D013964 | 33 associated lipids |
| Acne Vulgaris | D000152 | 35 associated lipids |
(e,e,e,e)-squalene
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
Cross Reference
Introduction
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (e,e,e,e)-squalene?
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
PubChem Associated disorders and diseases
What pathways are associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (e,e,e,e)-squalene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with (e,e,e,e)-squalene?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with (e,e,e,e)-squalene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Berglund J et al. | Safety, immunogenicity, and antibody persistence following an investigational Streptococcus pneumoniae and Haemophilus influenzae triple-protein vaccine in a phase 1 randomized controlled study in healthy adults. | 2014 | Clin. Vaccine Immunol. | pmid:24173029 |
| Song YC et al. | A novel emulsion-type adjuvant containing CpG oligodeoxynucleotides enhances CD8+ T-cell-mediated anti-tumor immunity. | 2014 | J Control Release | pmid:24177312 |
| Chen WL et al. | Disintegration and cancer immunotherapy efficacy of a squalane-in-water delivery system emulsified by bioresorbable poly(ethylene glycol)-block-polylactide. | 2014 | Biomaterials | pmid:24268203 |
| Hoschler K et al. | Administration of AS03B-adjuvanted A(H1N1)pdm09 vaccine in children aged <3 years enhances antibody response to H3 and B viruses following a single dose of trivalent vaccine one year later. | 2014 | Clin. Infect. Dis. | pmid:24149079 |
| Hoshino T et al. | β-Amyrin biosynthesis: the critical role of steric volume at C-19 of 2,3-oxidosqualene for its correct folding to generate the pentacyclic scaffold. | 2014 | Org. Lett. | pmid:24960408 |
| Ali HM et al. | Effects of silencing the RET/PTC1 oncogene in papillary thyroid carcinoma by siRNA-squalene nanoparticles with and without fusogenic companion GALA-cholesterol. | 2014 | Thyroid | pmid:23885719 |
| Treanor JJ | Expanding the options for confronting pandemic influenza. | 2014 | JAMA | pmid:25291574 |
| Belshe RB et al. | Immunogenicity of avian influenza A/Anhui/01/2005(H5N1) vaccine with MF59 adjuvant: a randomized clinical trial. | 2014 | JAMA | pmid:25291578 |
| Mulligan MJ et al. | Serological responses to an avian influenza A/H7N9 vaccine mixed at the point-of-use with MF59 adjuvant: a randomized clinical trial. | 2014 | JAMA | pmid:25291577 |
| Koval'ova VA et al. | [Effects of natural antioxidants on the content of lipids, proteins and carbohydrates in rat's gastric mucosal cells under experimental ulceration]. | 2014 | Fiziol Zh | pmid:25007524 |
| Liu CI et al. | Structural insights into the catalytic mechanism of human squalene synthase. | 2014 | Acta Crystallogr. D Biol. Crystallogr. | pmid:24531458 |
| Maksimenko A et al. | A unique squalenoylated and nonpegylated doxorubicin nanomedicine with systemic long-circulating properties and anticancer activity. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24385587 |
| Milanetti F et al. | Safety and immunogenicity of co-administered MF59-adjuvanted 2009 pandemic and plain 2009-10 seasonal influenza vaccines in rheumatoid arthritis patients on biologicals. | 2014 | Clin. Exp. Immunol. | pmid:24666311 |
| Bentinger M et al. | Effects of various squalene epoxides on coenzyme Q and cholesterol synthesis. | 2014 | Biochim. Biophys. Acta | pmid:24747199 |
| Gillard P et al. | Long-term booster schedules with AS03A-adjuvanted heterologous H5N1 vaccines induces rapid and broad immune responses in Asian adults. | 2014 | BMC Infect. Dis. | pmid:24628789 |
| Tran TV et al. | NF-κB inhibitors from Eurycoma longifolia. | 2014 | J. Nat. Prod. | pmid:24467387 |
| Vinay TN et al. | Toxicity and dose determination of quillaja saponin, aluminum hydroxide and squalene in olive flounder (Paralichthys olivaceus). | 2014 | Vet. Immunol. Immunopathol. | pmid:23570990 |
| Maksimenko A et al. | Therapeutic modalities of squalenoyl nanocomposites in colon cancer: an ongoing search for improved efficacy. | 2014 | ACS Nano | pmid:24555414 |
| Chmielewska AM et al. | Combined adenovirus vector and hepatitis C virus envelope protein prime-boost regimen elicits T cell and neutralizing antibody immune responses. | 2014 | J. Virol. | pmid:24599994 |
| Furubayashi M et al. | Directed evolution of squalene synthase for dehydrosqualene biosynthesis. | 2014 | FEBS Lett. | pmid:25093296 |
| Brown AJ et al. | Cholesterol precursors: more than mere markers of biosynthesis. | 2014 | Curr. Opin. Lipidol. | pmid:24378747 |
| Poder A et al. | An observer-blind, randomized, multi-center trial assessing long-term safety and immunogenicity of AS03-adjuvanted or unadjuvanted H1N1/2009 influenza vaccines in children 10-17 years of age. | 2014 | Vaccine | pmid:24252703 |
| Wołosik K et al. | The importance and perspective of plant-based squalene in cosmetology. | 2013 Jan-Feb | J Cosmet Sci | pmid:23449131 |
| Nguyen HT et al. | Molecular characterization of Glycine max squalene synthase genes in seed phytosterol biosynthesis. | 2013 | Plant Physiol. Biochem. | pmid:24036394 |
| Borchman D et al. | Confirmation of the presence of squalene in human eyelid lipid by heteronuclear single quantum correlation spectroscopy. | 2013 | Lipids | pmid:24081494 |
| Rajaram K et al. | Comparative bioactive studies between wild plant and callus culture of Tephrosia tinctoria pers. | 2013 | Appl. Biochem. Biotechnol. | pmid:24026411 |
| Villa M et al. | Safety of MF59-adjuvanted influenza vaccination in the elderly: results of a comparative study of MF59-adjuvanted vaccine versus nonadjuvanted influenza vaccine in northern Italy. | 2013 | Am. J. Epidemiol. | pmid:23863759 |
| Robinson ES et al. | Organic aerosol mixing observed by single-particle mass spectrometry. | 2013 | J Phys Chem A | pmid:24131283 |
| Rouleau I et al. | Increased risk of anaphylaxis following administration of 2009 AS03-adjuvanted monovalent pandemic A/H1N1 (H1N1pdm09) vaccine. | 2013 | Vaccine | pmid:24144473 |
| Lepeltier E et al. | Self-assembly of squalene-based nucleolipids: relating the chemical structure of the bioconjugates to the architecture of the nanoparticles. | 2013 | Langmuir | pmid:24219056 |
| Vono M et al. | The adjuvant MF59 induces ATP release from muscle that potentiates response to vaccination. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24324152 |
| Pannkuk EL et al. | Sebaceous lipid profiling of bat integumentary tissues: quantitative analysis of free Fatty acids, monoacylglycerides, squalene, and sterols. | 2013 | Chem. Biodivers. | pmid:24327437 |
| Tegenge MA and Mitkus RJ | A physiologically-based pharmacokinetic (PBPK) model of squalene-containing adjuvant in human vaccines. | 2013 | J Pharmacokinet Pharmacodyn | pmid:23912214 |
| Hosogaya N et al. | The heme-binding protein Dap1 links iron homeostasis to azole resistance via the P450 protein Erg11 in Candida glabrata. | 2013 | FEMS Yeast Res. | pmid:23496820 |
| Rappuoli R | Vaccine adjuvants: the future is bright. Interview by Jenaid Rees. | 2013 | Expert Rev Vaccines | pmid:23829664 |
| Trung Bui D et al. | Polymer prodrug nanoparticles based on naturally occurring isoprenoid for anticancer therapy. | 2013 | Biomacromolecules | pmid:23829862 |
| Bruun Laursen A | [Catastrophic consequences of Pandemrix swine flu vaccine containing squalene]. | 2013 | Ugeskr. Laeg. | pmid:23833781 |
| Mølbak K | [Squalene unlikely sinner]. | 2013 | Ugeskr. Laeg. | pmid:23833782 |
| Gefenaite G et al. | Effectiveness of A(H1N1)pdm09 influenza vaccine in adults recommended for annual influenza vaccination. | 2013 | PLoS ONE | pmid:23840413 |
| Fox CB and Haensler J | An update on safety and immunogenicity of vaccines containing emulsion-based adjuvants. | 2013 | Expert Rev Vaccines | pmid:23885820 |
| Sisco E et al. | Evaluation of C60 secondary ion mass spectrometry for the chemical analysis and imaging of fingerprints. | 2013 | Forensic Sci. Int. | pmid:23890648 |
| King KL et al. | Inelastic scattering of OH radicals from organic liquids: isolating the thermal desorption channel. | 2013 | Phys Chem Chem Phys | pmid:23807737 |
| Chandramouli S et al. | Generation of a parvovirus B19 vaccine candidate. | 2013 | Vaccine | pmid:23827313 |
| Song JY et al. | Long-term and cross-reactive immunogenicity of inactivated trivalent influenza vaccine in the elderly: MF59-adjuvanted vaccine versus unadjuvanted vaccine. | 2013 | J. Med. Virol. | pmid:23852684 |
| Son J et al. | Immunogenicity of low-dose MF59-adjuvanted 2009 influenza A/H1N1 vaccine in dialysis patients. | 2013 | Clin. Exp. Nephrol. | pmid:22990301 |
| Durier C et al. | Long-term immunogenicity of two doses of 2009 A/H1N1v vaccine with and without AS03(A) adjuvant in HIV-1-infected adults. | 2013 | AIDS | pmid:23018437 |
| Lin YK et al. | Squalene-containing nanostructured lipid carriers promote percutaneous absorption and hair follicle targeting of diphencyprone for treating alopecia areata. | 2013 | Pharm. Res. | pmid:23070602 |
| Lopez P et al. | Combined administration of MF59-adjuvanted A/H5N1 prepandemic and seasonal influenza vaccines: long-term antibody persistence and robust booster responses 1 year after a one-dose priming schedule. | 2013 | Clin. Vaccine Immunol. | pmid:23536690 |
| Mazein A et al. | A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway. | 2013 | Biochem. Pharmacol. | pmid:23583456 |
| Ueda D et al. | Cyclization of squalene from both termini: identification of an onoceroid synthase and enzymatic synthesis of ambrein. | 2013 | J. Am. Chem. Soc. | pmid:24274794 |