(e,e,e,e)-squalene

(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.

Cross Reference

Introduction

To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (e,e,e,e)-squalene?

(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene

MeSH term MeSH ID Detail
Cholestasis D002779 23 associated lipids
Lymphoma, B-Cell D016393 24 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Brain Diseases D001927 27 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Micronuclei, Chromosome-Defective D048629 33 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Acne Vulgaris D000152 35 associated lipids
Per page 10 20 50 100 | Total 84

PubChem Associated disorders and diseases

What pathways are associated with (e,e,e,e)-squalene

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with (e,e,e,e)-squalene?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (e,e,e,e)-squalene?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with (e,e,e,e)-squalene

Download all related citations
Per page 10 20 50 100 | Total 1766
Authors Title Published Journal PubMed Link
Miettinen TA and Gylling H Cholesterol synthesis and absorption in coronary patients with lipid triad and isolated high LDL cholesterol in a 4S subgroup. 2003 Atherosclerosis pmid:12801618
Rontani JF et al. Production of a polyunsaturated isoprenoid wax ester during aerobic metabolism of squalene by Marinobacter squalenivorans sp. nov. 2003 Appl. Environ. Microbiol. pmid:12839795
Zhang L et al. Proopiomelanocortin peptides and sebogenesis. 2003 Ann. N. Y. Acad. Sci. pmid:12851311
Satoh M et al. Induction of lupus autoantibodies by adjuvants. 2003 J. Autoimmun. pmid:12892730
Podda A and Del Giudice G MF59-adjuvanted vaccines: increased immunogenicity with an optimal safety profile. 2003 Expert Rev Vaccines pmid:12899571
Iorio AM et al. Antibody responses and HIV-1 viral load in HIV-1-seropositive subjects immunised with either the MF59-adjuvanted influenza vaccine or a conventional non-adjuvanted subunit vaccine during highly active antiretroviral therapy. 2003 Vaccine pmid:12922092
Catalán CA et al. A linear sesterterpene, two squalene derivatives and two peptide derivatives from Croton hieronymi. 2003 Phytochemistry pmid:12943786
DALE J Dehydrogenation of squalene with N-bromosuccinimide. 1952 Arch. Biochem. Biophys. pmid:13008464
Pye RJ et al. Skin surface lipid composition in rosacea. 1976 Br. J. Dermatol. pmid:130159
Cooper MF et al. Sebaceous lipogenesis in human skin. Variability with age and with severity of acne. 1976 Br. J. Dermatol. pmid:130160
NICOLAIDES N and ROTHMAN S Studies on the chemical composition of human hair fat. I. The squalene-cholesterol relationship in children and adults. 1952 J. Invest. Dermatol. pmid:13023010
LANGDON RG and BLOCH K The biosynthesis of squalene. 1953 J. Biol. Chem. pmid:13034767
LANGDON RG and BLOCH K The utilization of squalene in the biosynthesis of cholesterol. 1953 J. Biol. Chem. pmid:13034768
WHEATLEY VR Studies of sebum. IV. The estimation of squalene in sebum and sebum-like materials. 1953 Biochem. J. pmid:13115346
POPJAK G Biosynthesis of squalene and cholesterol in vitro from acetate-1-C14. 1954 Arch. Biochem. Biophys. pmid:13125576
Bogan BW et al. Alkanindiges illinoisensis gen. nov., sp. nov., an obligately hydrocarbonoclastic, aerobic squalane-degrading bacterium isolated from oilfield soils. 2003 Int. J. Syst. Evol. Microbiol. pmid:13130023
SCHWENK E et al. Studies on the biosynthesis of cholesterol. VI. Companions of cholesterol-C14 in liver perfusions, including squalene-C14 as possible precursors in its biosynthesis. 1954 Arch. Biochem. Biophys. pmid:13139684
EIDINOFF ML et al. The biosynthesis of squalene from acetate in man. 1954 J. Clin. Invest. pmid:13143078
SQUALENE, a precursor of cholesterol. 1954 Nutr. Rev. pmid:13166142
CORNFORTH JW and POPJAK G Studies on the biosynthesis of cholesterol. 3. Distribution of 14C in squalene biosynthesized from [Me-14C]acetate. 1954 Biochem. J. pmid:13208629
Van Sickle WA et al. Inhibition of cholesterol synthesis by cyclopropylamine derivatives of squalene in human hepatoblastoma cells in culture. 1992 Lipids pmid:1326069
RABINOWITZ JL et al. Branched chain acids in the biosynthesis of squalene and cholesterol. 1955 Fed. Proc. pmid:13262139
DICKHART W The squalene contents of various oils. 1955 Am J Pharm Sci Support Public Health pmid:13275573
SQUALENE and cholesterol synthesis in the human skin. 1956 Nutr. Rev. pmid:13309889
Murakoshi M et al. Inhibition by squalene of the tumor-promoting activity of 12-O-tetradecanoylphorbol-13-acetate in mouse-skin carcinogenesis. 1992 Int. J. Cancer pmid:1334056
DITURI F et al. Terpenoid intermediates in the biosynthesis of cholesterol. 1956 J. Biol. Chem. pmid:13345809
VILLALBA GOMEZ GM [Squalene index]. 1956 May-Aug Rev Sanid Asist Soc pmid:13379961
Fujita H and Matsuo I Type I lipid photo-oxidation by the nonsteroidal anti-inflammatory drug suprofen: a possible key to its photosensitivity. 1992-1993 Oct Photodermatol Photoimmunol Photomed pmid:1342189
BOUGHTON B et al. Studies of sebum. VIII. Observations on the squalene and cholesterol content and the possible functions of squalene in human sebum. 1957 Biochem. J. pmid:13426103
HELLER JH et al. Squalene content of various shark livers. 1957 Nature pmid:13430738
TCHEN TT and BLOCH K On the conversion of squalene to lanosterol in vitro. 1957 J. Biol. Chem. pmid:13438881
TCHEN TT and BLOCH K On the mechanism of enzymatic cyclization of squalene. 1957 J. Biol. Chem. pmid:13438882
SOBEL H et al. Determinations of squalene in sebum from the forehead of patients with skin cancer. 1957 J. Invest. Dermatol. pmid:13491890
DITURI F et al. Precursors of squalene and cholesterol. 1957 J. Biol. Chem. pmid:13502345
CORNFORTH JW et al. Studies on the biosynthesis of cholesterol. 5. Biosynthesis of squalene from DL-3-hydroxy-3-methyl [2-14C] pentano-5-lactone. 1958 Biochem. J. pmid:13535596
WOLFF RE and GODEFROY N [Transformation of synthetic squalene (11, 1414C) to cholesterol in rats]. 1958 C. R. Hebd. Seances Acad. Sci. pmid:13537384
WOLFF RE and PICHAT L [Synthesis of 11,14-C14-squalene]. 1958 C. R. Hebd. Seances Acad. Sci. pmid:13537435
EIDINOFF ML et al. Cholesterol biosynthesis: studies related to the metabolic role of squalene. 1958 J. Clin. Invest. pmid:13539207
Gloor M [The significance of physiological and biochemical deviations from the norm on the skin surface for infectious skin diseases (proceedings)]. 1976 Z. Hautkr. pmid:13544
POPJAK G et al. Studies on the biosynthesis of cholesterol. 6. Coenzyme requirements of liver enzymes for synthesis of squalene and of sterol from DL-3-hydroxy-3-methyl-[2-14C] pentano-5-lactone. 1958 Biochem. J. pmid:13546172
LOUD AV and BUCHER NL The turnover of squalene in relation to the biosynthesis of cholesterol. 1958 J. Biol. Chem. pmid:13563436
MARKLEY K and GURIN S Decarboxylation of mevalonic acid and conversion to squalene; enzyme fractionation and cofactors. 1959 Biochim. Biophys. Acta pmid:13628647
RILLING HC and BLOCH K On the mechanism of squaiene biogenesis from mevalonic acid. 1959 J. Biol. Chem. pmid:13654391
Kushwaha SC and Kates M Lipid composition of Neurospora crassa. 1976 Lipids pmid:136584
ANDERSON DG et al. The conversion of farnesyl pyrophosphate to squalene by soluble extracts of microsomes. 1960 Biochem. Biophys. Res. Commun. pmid:13683185
GAYLOR JL Anaerobic conversion of acetate to squalene by rat skin. 1961 Proc. Soc. Exp. Biol. Med. pmid:13704081
GOODMAN DS Studies on the conversion of squalene to sterol with rat liver enzymes. 1961 J. Biol. Chem. pmid:13707027
GOSSELIN L and PODBER-WAGNER E [New observations on the particles interfering in the biosynthesis of squalene from mevalonic acid]. 1961 Arch. Int. Physiol. Biochim. pmid:13707370
Cooper MF et al. Sebaceous lipogenesis and androgen metabolism in acne. 1976 Biochem. Soc. Trans. pmid:137154
PATTERSON JF Biosynthesis of squalene by rat preputial gland. 1960 Proc. Soc. Exp. Biol. Med. pmid:13733368
POPJAK G et al. Mechanism of squalene biosynthesis from mevalonate and farnesyl pyrophosphate. 1961 Biochem. Biophys. Res. Commun. pmid:13737103
POPJAK G et al. Studies on the biosynthesis of cholesterol. XV. Mechanism of squalene biosynthesis from farnesyl pyrophosphate and from mevalonate. 1961 J. Biol. Chem. pmid:13737104
RENZINI G [Detection of sterols and squalene in B. coli aerogenes]. 1960 Nov-Dec Nuovi Ann Ig Microbiol pmid:13740904
SEDEE PD Intermediary metabolism in aseptically reared blowfly larvae, Calliphora erythrocephala (Meig.). I. Buosynthesis of squalene and cholesterol. 1961 Arch. Int. Physiol. Biochim. pmid:13749584
MELCHIORRI-SANTOLINI U and RENZINI G [Detection of sterols and squalene in sporigenic bacteria]. 1960 Nov-Dec Nuovi Ann Ig Microbiol pmid:13769177
WOOTTON JM and WRIGHT LD Biosynthesis of squalene by the annelid Lumbricus terrestris. 1960 Nature pmid:13786660
WITTING LA and PORTER JW Intermediates in the conversion of mevalonic acid to squalene by a rat liver enzyme system. 1959 J. Biol. Chem. pmid:13845505
KROENING F [On the induction of leukemia in C57B1 mice following painting of the dorsal part of the skin with short-chain fatty acids, fatty acid esters and with squalene]. 1959 Acta Unio Int Contra Cancrum pmid:13848508
GOODMAN DS and POPJAK G Studies on the biosynthesis of cholesterol. XII. Synthesis of allyl pyrophosphates from mevalonate and their conversion into squalene with liver enzymes. 1960 J. Lipid Res. pmid:13851061
NICHOLAS HJ and THOMAS BE Intracerebral incorporation of [2-14C]mevalonic acid into adult rat brain squalene and cholesterol. 1959 Biochim. Biophys. Acta pmid:13854106
ALAM SQ et al. Detection and estimation of squalene in leaves. 1962 Nature pmid:13860005
CHILDS CR and BLOCH K Further observations on the biosynthesis of squalene. 1962 J. Biol. Chem. pmid:13878983
GOSSELIN L et al. Particulate enzyme system for the synthesis of squalene from 2-(14C)-mevalonic acid. 1962 Nature pmid:13900654
GOSSELIN L Utilization of (2-14C) mevalonic acid by rat liver cell fraction: evidence for an attachment of a squalene precursor to a cellular component insoluble at acid pH. 1962 Arch. Int. Physiol. Biochim. pmid:13900655
HOLMES WL and STACK E Gas chromatography of squalene, sterols and bile acid methyl esters. 1962 Biochim. Biophys. Acta pmid:13908533
GAYLOR JL Biosynthesis of skin sterols. III. Conversion of squalene to sterols by rat skin. 1963 J. Biol. Chem. pmid:13946923
GAYLOR JL Biosynthesis of skin sterols. V. Effect of arsenite inhibition and the accumulation of labeled lanosta-7, 24-dien-3 beta-ol in rat skin. 1963 Arch. Biochem. Biophys. pmid:13946925
JACHYMCZYK W [Biosynthesis of triterpenoid compounds]. 1963 Postepy Biochem. pmid:13957182
BEELER DA et al. The biosynthesis of squalene from mevalonic acid-2-C-14 and farnesyl pyrophosphate-4,8,12-C-14 by carrot and tomato enzymes. 1963 Arch. Biochem. Biophys. pmid:13970235
SAMUELSSON B and GOODMAN DS Stereochemistry of the hydrogen transfer to squalene during its biosynthesis from farnesyl pyrophosphate. 1963 Biochem. Biophys. Res. Commun. pmid:13976173
PROSTENIK M and MUNK-WEINERT M The isolation of squalene from human brain. 1963 Biochim. Biophys. Acta pmid:13986372
BURGESS TL and WILSON JD Studies on hormonal regulation of squalene synthesis in preputial gland and skin of the rat. 1963 Proc. Soc. Exp. Biol. Med. pmid:14016990
CALTABIANO S and SPREMOLLA G [Histological and humoral aspects of experimental atherosclerosis induced by squalene in rabbits treated with triparanol]. 1963 Arch Sci Med (Torino) pmid:14017944
CAPSTACK E et al. The biosynthesis of squalene in germinating seeds of Pisum sativum. 1962 Biochemistry pmid:14018475
CARAVACA J et al. Inhibition of squalene and cholesterol biosynthesis by hepatocatalase (Caperase). 1963 Biochem. Biophys. Res. Commun. pmid:14018515
CORNFORTH JW et al. Stereospecific insertion of hydrogen atom into squalene from reduced nicotinamide-adenine dinucleotides. 1963 Biochem. Biophys. Res. Commun. pmid:14023096
GRIESEMER RD and THOMAS RW LIPOGENESIS IN HUMAN SKIN. II. THE EFFECT OF PHYSICAL AND CHEMICAL FACTORS ON IN VITRO LIPOGENESIS FROM ACETATE. 1963 J. Invest. Dermatol. pmid:14059599
LIBERTI A et al. ISOTOPIC EFFECTS IN GAS-LIQUID CHROMATOGRAPHY. I. GAS CHROMATOGRAPHIC BEHAVIOUR OF BENZENE AND PERDEUTEROBENZENE. 1963 J. Chromatogr. pmid:14066512
GRIESEMER RD and THOMAS RW LIPOGENESIS IN HUMAN SKIN. III. VARIATION WITH BODY SITE. 1963 J. Invest. Dermatol. pmid:14066602
LUPIEN PJ et al. EFFECT OF AN ANTIBIOTIC ON LIPID FRACTIONS IN PLASMS AND EGG YOLK OF LAYING HENS. 1963 Can J Biochem Physiol pmid:14083981
SAMUELSSON B and GOODMAN DS STEREOCHEMISTRY AT THE CENTER OF SQUALENE DURING ITS BIOSYNTHESIS FROM FARNESYL PYROPHOSPHATE AND SUBSEQUENT CONVERSION TO CHOLESTEROL. 1964 J. Biol. Chem. pmid:14114881
ALEXANDER GJ and ALEXANDER RB INHIBITION OF CHOLESTEROL SYNTHESIS IN VIVO BY A CONVULSANT, METRAZOL. 1964 Proc. Soc. Exp. Biol. Med. pmid:14117448
BROOKS SC and GODEFROI VC QUANITITATIVE COLLECTION OF MICRO AMOUNTS OF STEROIDS FROM GAS-LIQUID CHROMATOGRAPHY. 1964 Anal. Biochem. pmid:14134426
Tait RM Development of a radiometric spot-wash assay for squalene synthase. 1992 Anal. Biochem. pmid:1416027
HORLICK L and AVIGAN J STEROLS OF SKIN IN THE NORMAL AND TRIPARANOL-TREATED RAT. 1963 J. Lipid Res. pmid:14168146
TSAI SC et al. TESTICULAR STEROLS. 1. INCORPORATION OF MEVALONATE AND ACETATE INTO STEROLS BY TESTICULAR TISSUE FROM RATS. 1964 Arch. Biochem. Biophys. pmid:14186739
GOODMAN DS SQUALENE IN HUMAN AND RAT BLOOD PLASMA. 1964 J. Clin. Invest. pmid:14192529
SALOKANGAS RA et al. TERPENE METABOLISM IN THE RAT TESTIS. I. THE CONVERSION OF ISOPENTENYL PYROPHOSPHATE TO SQUALENE AND STEROLS. 1964 Biochemistry pmid:14211625
MCCARTHY MJ et al. COMPOSITION OF MOLECULAR DISTILLATES OF BUTTER OIL: ISOLATION AND IDENTIFICATION OF COMPONENTS OTHER THAN GLYCERIDES. 1964 J. Lipid Res. pmid:14221107
LUCY JA and DINGLE JT FAT-SOLUBLE VITAMINS AND BIOLOGICAL MEMBRANES. 1964 Nature pmid:14222261
KARLSON P [NOBEL PRIZE FOR MEDICINE AND PHYSIOLOGY IN 1964]. 1965 Dtsch. Med. Wochenschr. pmid:14238764
VAN DEN OORD A THE ABSENCE OF CHOLESTEROL SYNTHESIS IN THE CRAB, CANCER PAGURUS L. 1964 Comp. Biochem. Physiol. pmid:14246359
DILLER ER and HARVEY OA INTERRELATIONSHIP OF STEROL AND FATTY ACID BIOSYNTHESIS IN RAT LIVER SLICES AS RELATED TO DIETARY LIPID. 1964 Biochemistry pmid:14269326
SHORB MS et al. EFFECT OF TRIPARANOL ON SYNTHESIS OF SQUALENE AND TETRAHYMANOL BY TETRAHYMENA PYRIFORMIS. 1965 Proc. Soc. Exp. Biol. Med. pmid:14277681
NUSBAUM-CASSUTO E and VILLOUTREIX J [DEMONSTRATION OF LYCOPERSENE IN HIGHER PLANTS]. 1965 C. R. Hebd. Seances Acad. Sci. pmid:14287016
HELLIG HR and SAVARD K BIOSYNTHESIS OF PROGESTERONE, STEROLS, AND SQUALENE FROM ACETATE-1-14-C AND MEVALONATE-2-14-C BY THE BOVINE CORPUS LUTEUM IN VITRO. 1965 J. Biol. Chem. pmid:14299614
NICHOLAS HJ and BOMBAUGH KJ CONSTITUENTS OF THE HYDROCARBON FRACTION OF BEEF BRAINS. 1965 Biochim. Biophys. Acta pmid:14320231
CAPSTACKE JR et al. SQUALENE IN PISUM SATIVUM. ITS CYCLIZATION TO BETA-AMYRIN AND LABELING PATTERN. 1965 J. Biol. Chem. pmid:14321361
CORNFORTH JW et al. THE MIGRATION AND ELIMINATION OF HYDROGEN DURING BIOSYNTHESIS OF CHOLESTEROL FROM SQUALENE. 1965 J. Am. Chem. Soc. pmid:14329430
DIPLOCK AT et al. VITAMIN A AND ISOPRENOID SYNTHESIS IN THE RAT. 1965 Biochem. J. pmid:14333548