| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hyperlipoproteinemias | D006951 | 15 associated lipids |
| Demyelinating Diseases | D003711 | 15 associated lipids |
| Rosacea | D012393 | 13 associated lipids |
| Dermatitis, Occupational | D009783 | 12 associated lipids |
| Keloid | D007627 | 12 associated lipids |
| Otitis Media | D010033 | 12 associated lipids |
| Influenza, Human | D007251 | 11 associated lipids |
| Hepatitis | D006505 | 11 associated lipids |
| Pregnancy Complications, Infectious | D011251 | 11 associated lipids |
| Scalp Dermatoses | D012536 | 11 associated lipids |
(e,e,e,e)-squalene
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
Cross Reference
Introduction
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (e,e,e,e)-squalene?
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
PubChem Associated disorders and diseases
What pathways are associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (e,e,e,e)-squalene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with (e,e,e,e)-squalene?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with (e,e,e,e)-squalene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Rasch MR et al. | Chains, sheets, and droplets: assemblies of hydrophobic gold nanocrystals with saturated phosphatidylcholine lipid and squalene. | 2012 | Langmuir | pmid:23033891 |
| Della Cioppa G et al. | Superior immunogenicity of seasonal influenza vaccines containing full dose of MF59 (®) adjuvant: results from a dose-finding clinical trial in older adults. | 2012 | Hum Vaccin Immunother | pmid:22426371 |
| Ikematsu H et al. | Evaluation of immune response following one dose of an AS03A-adjuvanted H1N1 2009 pandemic influenza vaccine in Japanese adults 65 years of age or older. | 2012 | Hum Vaccin Immunother | pmid:22854661 |
| Vesikari T et al. | Homologous and heterologous antibody responses to a one-year booster dose of an MF59(®) adjuvanted A/H5N1 pre-pandemic influenza vaccine in pediatric subjects. | 2012 | Hum Vaccin Immunother | pmid:22777094 |
| Bencharitiwong R et al. | In vitro assessment of the allergenicity of novel MF59-adjuvanted pandemic H1N1 influenza vaccine produced in dog kidney cells. | 2012 | Hum Vaccin Immunother | pmid:22777093 |
| Faenzi E et al. | One dose of an MF59-adjuvanted pandemic A/H1N1 vaccine recruits pre-existing immune memory and induces the rapid rise of neutralizing antibodies. | 2012 | Vaccine | pmid:22521851 |
| Nakazawa A et al. | Optimization of culture conditions of the thraustochytrid Aurantiochytrium sp. strain 18W-13a for squalene production. | 2012 | Bioresour. Technol. | pmid:22023965 |
| Niehaus TD et al. | Functional identification of triterpene methyltransferases from Botryococcus braunii race B. | 2012 | J. Biol. Chem. | pmid:22241476 |
| Iorio AM et al. | Influenza viruses and cross-reactivity in healthy adults: humoral and cellular immunity induced by seasonal 2007/2008 influenza vaccination against vaccine antigens and 2009 A(H1N1) pandemic influenza virus. | 2012 | Vaccine | pmid:22245606 |
| Ambrose CS and Belshe RB | Influenza vaccine in young children. | 2012 | N. Engl. J. Med. | pmid:22276839 |
| Heikkinen T and Heinonen S | Influenza vaccine in young children. | 2012 | N. Engl. J. Med. | pmid:22276840 |
| Gasparini R et al. | Aflunov(®): a prepandemic influenza vaccine. | 2012 | Expert Rev Vaccines | pmid:22309663 |
| Spanova M et al. | Influence of squalene on lipid particle/droplet and membrane organization in the yeast Saccharomyces cerevisiae. | 2012 | Biochim. Biophys. Acta | pmid:22342273 |
| Palma P et al. | Safety and immunogenicity of a monovalent MF59®-adjuvanted A/H1N1 vaccine in HIV-infected children and young adults. | 2012 | Biologicals | pmid:22261282 |
| Heikkinen T et al. | Safety of MF59-adjuvanted A/H1N1 influenza vaccine in pregnancy: a comparative cohort study. | 2012 | Am. J. Obstet. Gynecol. | pmid:22939717 |
| Mannino S et al. | Effectiveness of adjuvanted influenza vaccination in elderly subjects in northern Italy. | 2012 | Am. J. Epidemiol. | pmid:22940713 |
| Klucker MF et al. | AF03, an alternative squalene emulsion-based vaccine adjuvant prepared by a phase inversion temperature method. | 2012 | J Pharm Sci | pmid:22941944 |
| Vishnubhatla S et al. | Contact lenses and the rate of evaporation measured in vitro; the influence of wear, squalene and wax. | 2012 | Cont Lens Anterior Eye | pmid:22906863 |
| Hoshino T et al. | Lanosterol biosynthesis: the critical role of the methyl-29 group of 2,3-oxidosqualene for the correct folding of this substrate and for the construction of the five-membered D ring. | 2012 | Chemistry | pmid:22933236 |
| Wilson KR et al. | The statistical evolution of multiple generations of oxidation products in the photochemical aging of chemically reduced organic aerosol. | 2012 | Phys Chem Chem Phys | pmid:22158973 |
| Xue Z et al. | Divergent evolution of oxidosqualene cyclases in plants. | 2012 | New Phytol. | pmid:22150097 |
| Oral E et al. | A new mechanism of oxidation in ultrahigh molecular weight polyethylene caused by squalene absorption. | 2012 | J. Biomed. Mater. Res. Part B Appl. Biomater. | pmid:22190411 |
| Sancho A et al. | More on influenza vaccine in young children. | 2012 | N. Engl. J. Med. | pmid:22738111 |
| Yang P et al. | Two concise enantioselective total syntheses of (-)-glabrescol implicate alternative biosynthetic pathways starting from squalene. | 2012 | Org. Lett. | pmid:22817611 |
| RamÃrez-Torres A et al. | Proteomics and gene expression analyses of squalene-supplemented mice identify microsomal thioredoxin domain-containing protein 5 changes associated with hepatic steatosis. | 2012 | J Proteomics | pmid:22796066 |
| Surls J et al. | Increased membrane cholesterol in lymphocytes diverts T-cells toward an inflammatory response. | 2012 | PLoS ONE | pmid:22723880 |
| Sémiramoth N et al. | Self-assembled squalenoylated penicillin bioconjugates: an original approach for the treatment of intracellular infections. | 2012 | ACS Nano | pmid:22482704 |
| Langley JM et al. | Safety and immunogenicity of 2010-2011 H1N12009-containing trivalent inactivated influenza vaccine in children 12-59 months of age previously given AS03-adjuvanted H1N12009 pandemic vaccine: a PHAC/CIHR Influenza Research Network (PCIRN) study. | 2012 | Vaccine | pmid:22469860 |
| Fukase H et al. | Assessment of the immunogenicity and safety of varying doses of an MF59®-adjuvanted cell culture-derived A/H1N1 pandemic influenza vaccine in Japanese paediatric, adult and elderly subjects. | 2012 | Vaccine | pmid:22472791 |
| Suthiwong J et al. | A new phenolic compound from the stem of Hymenocardia wallichii. | 2012 | J Asian Nat Prod Res | pmid:22423644 |
| Zhang XH et al. | Chemical composition of volatile oils from the pericarps of Indian sandalwood (Santalum album) by different extraction methods. | 2012 | Nat Prod Commun | pmid:22428257 |
| Guzmán Herrador BR et al. | Usefulness of health registries when estimating vaccine effectiveness during the influenza A(H1N1)pdm09 pandemic in Norway. | 2012 | BMC Infect. Dis. | pmid:22429643 |
| Hatz C et al. | A randomized clinical trial to identify the optimal antigen and MF59(®) adjuvant dose of a monovalent A/H1N1 pandemic influenza vaccine in healthy adult and elderly subjects. | 2012 | Vaccine | pmid:22446638 |
| Lai RP et al. | Mixed adjuvant formulations reveal a new combination that elicit antibody response comparable to Freund's adjuvants. | 2012 | PLoS ONE | pmid:22509385 |
| Marinaro M et al. | A caprine herpesvirus 1 vaccine adjuvanted with MF59â„¢ protects against vaginal infection and interferes with the establishment of latency in goats. | 2012 | PLoS ONE | pmid:22511971 |
| Calmy A et al. | Strong serological responses and HIV RNA increase following AS03-adjuvanted pandemic immunization in HIV-infected patients. | 2012 | HIV Med. | pmid:22093373 |
| Dell'Era L et al. | Immunogenicity, safety and tolerability of MF59-adjuvanted seasonal influenza vaccine in children with juvenile idiopathic arthritis. | 2012 | Vaccine | pmid:22138210 |
| Allain V et al. | Self-assembled nucleolipids: from supramolecular structure to soft nucleic acid and drug delivery devices. | 2012 | Nucleic Acids Res. | pmid:22075995 |
| Cosco D et al. | Self-assembled squalenoyl-cytarabine nanostructures as a potent nanomedicine for treatment of leukemic diseases. | 2012 | Int J Nanomedicine | pmid:22679366 |
| O'Hagan DT et al. | The mechanism of action of MF59 - an innately attractive adjuvant formulation. | 2012 | Vaccine | pmid:22682289 |
| Lokvam J and Fine PV | An oxidized squalene derivative from Protium subserratum Engl. (Engl.) growing in Peru. | 2012 | Molecules | pmid:22706374 |
| Yu S et al. | Novel Th1-biased adjuvant, SPO1, enhances mucosal and systemic immunogenicity of vaccines administered intranasally in mice. | 2012 | Vaccine | pmid:22709954 |
| Granados-Principal S et al. | Squalene ameliorates atherosclerotic lesions through the reduction of CD36 scavenger receptor expression in macrophages. | 2012 | Mol Nutr Food Res | pmid:22648620 |
| Song JY et al. | Comparison of the long-term immunogenicity of two pandemic influenza A/H1N1 2009 vaccines, the MF59-adjuvanted and unadjuvanted vaccines, in adults. | 2012 | Clin. Vaccine Immunol. | pmid:22379067 |
| Caproni E et al. | MF59 and Pam3CSK4 boost adaptive responses to influenza subunit vaccine through an IFN type I-independent mechanism of action. | 2012 | J. Immunol. | pmid:22351935 |
| Kim SK and Karadeniz F | Biological importance and applications of squalene and squalane. | 2012 | Adv. Food Nutr. Res. | pmid:22361190 |
| Dey AK et al. | Use of a polyanionic carbomer, Carbopol971P, in combination with MF59, improves antibody responses to HIV-1 envelope glycoprotein. | 2012 | Vaccine | pmid:22366638 |
| Garçon N et al. | Development and evaluation of AS03, an Adjuvant System containing α-tocopherol and squalene in an oil-in-water emulsion. | 2012 | Expert Rev Vaccines | pmid:22380826 |
| RamÃrez-Torres A et al. | Proteomics and gene expression analyses of mitochondria from squalene-treated apoE-deficient mice identify short-chain specific acyl-CoA dehydrogenase changes associated with fatty liver amelioration. | 2012 | J Proteomics | pmid:22402057 |
| Tronchoni J et al. | Lipid composition of wine strains of Saccharomyces kudriavzevii and Saccharomyces cerevisiae grown at low temperature. | 2012 | Int. J. Food Microbiol. | pmid:22405355 |
| Desmaële D et al. | Squalenoylation: a generic platform for nanoparticular drug delivery. | 2012 | J Control Release | pmid:21840355 |
| Naziri E et al. | Recovery of squalene from wine lees using ultrasound assisted extraction-a feasibility study. | 2012 | J. Agric. Food Chem. | pmid:22888984 |
| Peric M et al. | Electron paramagnetic resonance line shifts and line shape changes due to heisenberg spin exchange and dipole-dipole interactions of nitroxide free radicals in liquids 8. Further experimental and theoretical efforts to separate the effects of the two interactions. | 2012 | J Phys Chem A | pmid:22288424 |
| Liu Y et al. | [Researches on influence of squalene synthase gene polymorphism on catalytic efficiency of its encode enzyme in Glycyrrhiza uralensis]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:23627178 |
| Czajka H et al. | A phase II, randomised clinical trial to demonstrate the non-inferiority of low-dose MF59-adjuvanted pre-pandemic A/H5N1 influenza vaccine in adult and elderly subjects. | 2012 | J Prev Med Hyg | pmid:23362618 |
| Takami T et al. | A genetic and pharmacological analysis of isoprenoid pathway by LC-MS/MS in fission yeast. | 2012 | PLoS ONE | pmid:23145048 |
| Langley JM et al. | A randomized, controlled non-inferiority trial comparing A(H1N1)pmd09 vaccine antigen, with and without AS03 adjuvant system, co-administered or sequentially administered with an inactivated trivalent seasonal influenza vaccine. | 2012 | BMC Infect. Dis. | pmid:23110320 |
| Bihari I et al. | Assessment of antigen-specific and cross-reactive antibody responses to an MF59-adjuvanted A/H5N1 prepandemic influenza vaccine in adult and elderly subjects. | 2012 | Clin. Vaccine Immunol. | pmid:23081815 |
| Tetsutani K and Ishii KJ | Adjuvants in influenza vaccines. | 2012 | Vaccine | pmid:23084848 |
| Liu YT et al. | Protein engineering of Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase into parkeol synthase. | 2012 | Org. Lett. | pmid:23043506 |
| Ta MT et al. | Accumulation of squalene is associated with the clustering of lipid droplets. | 2012 | FEBS J. | pmid:23013491 |
| Nielsen AB et al. | Immune response after one or two doses of pandemic influenza A (H1N1) monovalent, AS03-adjuvanted vaccine in HIV infected adults. | 2012 | Vaccine | pmid:23036498 |
| Binks BP et al. | How membrane permeation is affected by donor delivery solvent. | 2012 | Phys Chem Chem Phys | pmid:23073464 |
| Yockel S and Schatz GC | Dynamic QM/MM: a hybrid approach to simulating gas-liquid interactions. | 2012 | Top Curr Chem | pmid:21506003 |
| Van Damme P et al. | Long-term persistence of humoral and cellular immune responses induced by an AS03A-adjuvanted H1N1 2009 influenza vaccine: an open-label, randomized study in adults aged 18-60 years and older. | 2013 | Hum Vaccin Immunother | pmid:23571166 |
| Guan X et al. | Immunotherapeutic efficiency of a tetravalent Aβ1-15 vaccine in APP/PS1 transgenic mice as mouse model for Alzheimer's disease. | 2013 | Hum Vaccin Immunother | pmid:23732905 |
| Goff PH et al. | Adjuvants and immunization strategies to induce influenza virus hemagglutinin stalk antibodies. | 2013 | PLoS ONE | pmid:24223176 |
| Candela S et al. | An early (3-6 weeks) active surveillance study to assess the safety of pandemic influenza vaccine Focetria in a province of Emilia-Romagna region, Italy - part one. | 2013 | Vaccine | pmid:22766247 |
| Dosio F et al. | Ruthenium polypyridyl squalene derivative: a novel self-assembling lipophilic probe for cellular imaging. | 2013 | Int J Pharm | pmid:22824513 |
| Ventura R et al. | Technology transfer of an oil-in-water vaccine-adjuvant for strengthening pandemic influenza preparedness in Indonesia. | 2013 | Vaccine | pmid:22884665 |
| Moro ML et al. | A population based cohort study to assess the safety of pandemic influenza vaccine Focetria in Emilia-Romagna region, Italy - part two. | 2013 | Vaccine | pmid:22885015 |
| Ruiz-Aragón J et al. | [Assessment of the MF59-adjuvanted pandemic influenza A/H1N1 vaccine. Systematic review of literature]. | 2013 | An Pediatr (Barc) | pmid:23490433 |
| Yüzbaşıoğlu D et al. | Genotoxicity assessment of vaccine adjuvant squalene. | 2013 | Food Chem. Toxicol. | pmid:23454296 |
| Malmierca MG et al. | Relevance of trichothecenes in fungal physiology: disruption of tri5 in Trichoderma arundinaceum. | 2013 | Fungal Genet. Biol. | pmid:23454546 |
| RodrÃguez-López J et al. | Epoxide-opening cascades triggered by a Nicholas reaction: total synthesis of teurilene. | 2013 | Angew. Chem. Int. Ed. Engl. | pmid:23436322 |
| Skowronski DM et al. | Re: "effectiveness of adjuvanted influenza vaccination in elderly subjects in northern Italy". | 2013 | Am. J. Epidemiol. | pmid:23436898 |
| Kalogeropoulos N et al. | Nutritional evaluation and health promoting activities of nuts and seeds cultivated in Greece. | 2013 | Int J Food Sci Nutr | pmid:23641668 |
| Tascon M et al. | Determinations of gas-liquid partition coefficients using capillary chromatographic columns. Alkanols in squalane. | 2013 | J Chromatogr A | pmid:23659974 |
| Ito R et al. | Purification, kinetics, inhibitors and CD for recombinant β-amyrin synthase from Euphorbia tirucalli L and functional analysis of the DCTA motif, which is highly conserved among oxidosqualene cyclases. | 2013 | FEBS J. | pmid:23294602 |
| Zotos A et al. | Effect of baking of sardine (Sardina pilchardus) and frying of anchovy (Engraulis encrasicholus) in olive and sunflower oil on their quality. | 2013 | Food Sci Technol Int | pmid:23239760 |
| O'Hagan DT et al. | The history of MF59(®) adjuvant: a phoenix that arose from the ashes. | 2013 | Expert Rev Vaccines | pmid:23256736 |
| Kostyuk VA et al. | Modulation of human keratinocyte responses to solar UV by plant polyphenols as a basis for chemoprevention of non-melanoma skin cancers. | 2013 | Curr. Med. Chem. | pmid:23210792 |
| Caron J et al. | Improving the antitumor activity of squalenoyl-paclitaxel conjugate nanoassemblies by manipulating the linker between paclitaxel and squalene. | 2013 | Adv Healthc Mater | pmid:23213041 |
| Rubinstein F et al. | Influenza A/H1N1 MF59 adjuvanted vaccine in pregnant women and adverse perinatal outcomes: multicentre study. | 2013 | BMJ | pmid:23381200 |
| Puleston R et al. | Multi-centre observational study of transplacental transmission of influenza antibodies following vaccination with AS03(A)-adjuvanted H1N1 2009 vaccine. | 2013 | PLoS ONE | pmid:23372640 |
| Kabuto H et al. | Effects of squalene/squalane on dopamine levels, antioxidant enzyme activity, and fatty acid composition in the striatum of Parkinson's disease mouse model. | 2013 | J Oleo Sci | pmid:23357814 |
| Lin YS et al. | A real-time impedance-sensing chip for the detection of emulsion phase separation. | 2013 | Electrophoresis | pmid:23765861 |
| Mann JF et al. | Pulmonary delivery of DNA vaccine constructs using deacylated PEI elicits immune responses and protects against viral challenge infection. | 2013 | J Control Release | pmid:23774102 |
| Puig-Barberà J et al. | MF59-adjuvanted and virosomal influenza vaccines for preventing influenza hospitalization in older people: comparative effectiveness using the Valencia health care information system. | 2013 | Vaccine | pmid:23731629 |
| Vriet C et al. | From squalene to brassinolide: the steroid metabolic and signaling pathways across the plant kingdom. | 2013 | Mol Plant | pmid:23761349 |
| Gilmore SF et al. | Role of squalene in the organization of monolayers derived from lipid extracts of Halobacterium salinarum. | 2013 | Langmuir | pmid:23713788 |
| Okajima M et al. | Preparation and physicochemical properties of surfactant-free emulsions using electrolytic-reduction ion water containing lithium magnesium sodium silicate. | 2013 | Drug Discov Ther | pmid:23715508 |
| Hong WK et al. | Characterization of a squalene synthase from the thraustochytrid microalga Aurantiochytrium sp. KRS101. | 2013 | J. Microbiol. Biotechnol. | pmid:23676912 |
| Yoshimura T et al. | Solution properties and emulsification properties of amino acid-based gemini surfactants derived from cysteine. | 2013 | J Oleo Sci | pmid:23985487 |
| Fu D et al. | ATR-IR study of ozone initiated heterogeneous oxidation of squalene in an indoor environment. | 2013 | Environ. Sci. Technol. | pmid:23957297 |
| Van Buynder PG et al. | The comparative effectiveness of adjuvanted and unadjuvanted trivalent inactivated influenza vaccine (TIV) in the elderly. | 2013 | Vaccine | pmid:23933368 |
| Vinay TN et al. | Inactivated vaccine against viral hemorrhagic septicemia (VHS) emulsified with squalene and aluminum hydroxide adjuvant provides long term protection in olive flounder (Paralichthys olivaceus). | 2013 | Vaccine | pmid:23896420 |
| Ito R et al. | Effect of cation-π interactions and steric bulk on the catalytic action of oxidosqualene cyclase: a case study of Phe728 of β-amyrin synthase from Euphorbia tirucalli L. | 2013 | Chemistry | pmid:24203491 |
| Rigane G et al. | Effect of storage on refined olive oil composition: stabilization by addition of chlorophyll pigments and squalene. | 2013 | J Oleo Sci | pmid:24292349 |
| Esche R et al. | Online LC-GC-based analysis of minor lipids in various tree nuts and peanuts. | 2013 | J. Agric. Food Chem. | pmid:24251555 |