| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hyperlipoproteinemias | D006951 | 15 associated lipids |
| Demyelinating Diseases | D003711 | 15 associated lipids |
| Rosacea | D012393 | 13 associated lipids |
| Dermatitis, Occupational | D009783 | 12 associated lipids |
| Otitis Media | D010033 | 12 associated lipids |
| Keloid | D007627 | 12 associated lipids |
| Influenza, Human | D007251 | 11 associated lipids |
| Hepatitis | D006505 | 11 associated lipids |
| Pregnancy Complications, Infectious | D011251 | 11 associated lipids |
| Scalp Dermatoses | D012536 | 11 associated lipids |
(e,e,e,e)-squalene
(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.
Cross Reference
Introduction
To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (e,e,e,e)-squalene?
(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene
PubChem Associated disorders and diseases
What pathways are associated with (e,e,e,e)-squalene
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (e,e,e,e)-squalene?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with (e,e,e,e)-squalene?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with (e,e,e,e)-squalene?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with (e,e,e,e)-squalene
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
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| Hwang SM et al. | Comparison of the adverse events associated with MF59-adjuvanted and non-adjuvanted H1N1 vaccines in healthy young male Korean soldiers. | 2012 | Jpn. J. Infect. Dis. | pmid:22627298 |
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| Rickman LS et al. | Use of adjuvant containing mycobacterial cell-wall skeleton, monophosphoryl lipid A, and squalane in malaria circumsporozoite protein vaccine. | 1991 | Lancet | pmid:1673211 |
| Nicholson KG et al. | Safety and antigenicity of non-adjuvanted and MF59-adjuvanted influenza A/Duck/Singapore/97 (H5N3) vaccine: a randomised trial of two potential vaccines against H5N1 influenza. | 2001 | Lancet | pmid:11425416 |
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| Scallen TJ et al. | Sterol carrier protein hypothesis: requirement for three substrate-specific soluble proteins in liver cholesterol biosynthesis. | 1975 | Life Sci. | pmid:165341 |
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| Egwim PO and Kummerow FA | In vitro hepatic cholesterogenesis in rats fed corn oil and fat-free diets. | 1973 | Life Sci. II | pmid:4708203 |
| Yeo HC and Shibamoto T | Formation of formaldehyde and malonaldehyde by photooxidation of squalene. | 1992 | Lipids | pmid:1608304 |
| Koivisto PV and Miettinen TA | Increased amounts of cholesterol precursors in lipoproteins after ileal exclusion. | 1988 | Lipids | pmid:3200122 |
| Mallory FB and Conner RL | Dehydrogenation and dealkylation of various sterols by Tetrahymena pyriformis. | 1971 | Lipids | pmid:4102490 |
| Kushwaha SC and Kates M | Lipid composition of Neurospora crassa. | 1976 | Lipids | pmid:136584 |
| Bell FP | Inhibition of hepatic sterol and squalene biosynthesis in rats fed di-i-ethylhexyl phthalate. | 1976 | Lipids | pmid:994746 |
| Johnson RC and Shah SN | Binding of squalene, lanosterol, desmosterol, and cholesterol to proteins in brain and liver 105,000 g supernatant fractions: evidence for specific binding sites. | 1976 | Lipids | pmid:994754 |
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| Tilvis RS and Miettinen TA | Dietary squalene increases tissue sterols and fecal bile acids in the rat. | 1983 | Lipids | pmid:6835033 |
| Tilvis RS and Miettinen TA | Absorption and metabolic fate of dietary 3H-squalene in the rat. | 1983 | Lipids | pmid:6855483 |
| Porcellati G et al. | Inhibition of cholesterol synthesis by beta-benzal butyric acid and derivatives. | 1969 | Lipids | pmid:5785689 |
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| Ceruti M et al. | Vinyl sulfide derivatives of truncated oxidosqualene as selective inhibitors of oxidosqualene and squalene-hopene cyclases. | 2001 | Lipids | pmid:11485168 |
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| Matthan NR et al. | Deuterium uptake and plasma cholesterol precursor levels correspond as methods for measurement of endogenous cholesterol synthesis in hypercholesterolemic women. | 2000 | Lipids | pmid:11026626 |
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| Borchman D et al. | Confirmation of the presence of squalene in human eyelid lipid by heteronuclear single quantum correlation spectroscopy. | 2013 | Lipids | pmid:24081494 |