(e,e,e,e)-squalene

(e,e,e,e)-squalene is a lipid of Fatty Acyls (FA) class. (e,e,e,e)-squalene is associated with abnormalities such as Hypercholesterolemia and Cataract. The involved functions are known as Process, metaplastic cell transformation, Protein Overexpression, Anabolism and Biosynthetic Pathways. (e,e,e,e)-squalene often locates in Membrane, Protoplasm, Plasma membrane, Tissue membrane and Back. The associated genes with (e,e,e,e)-squalene are Genome, IMPACT gene, GAPDH gene, GTF2I gene and Chromatin. The related lipids are Membrane Lipids, cycloartenol, Sterols, Fatty Acids and Nonesterified Fatty Acids.

Cross Reference

Introduction

To understand associated biological information of (e,e,e,e)-squalene, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (e,e,e,e)-squalene?

(e,e,e,e)-squalene is suspected in Hypercholesterolemia, Cataract and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,e,e,e)-squalene

MeSH term MeSH ID Detail
Hyperlipoproteinemias D006951 15 associated lipids
Demyelinating Diseases D003711 15 associated lipids
Rosacea D012393 13 associated lipids
Keloid D007627 12 associated lipids
Otitis Media D010033 12 associated lipids
Dermatitis, Occupational D009783 12 associated lipids
Pregnancy Complications, Infectious D011251 11 associated lipids
Scalp Dermatoses D012536 11 associated lipids
Influenza, Human D007251 11 associated lipids
Hepatitis D006505 11 associated lipids
Per page 10 20 50 100 | Total 84

PubChem Associated disorders and diseases

What pathways are associated with (e,e,e,e)-squalene

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with (e,e,e,e)-squalene?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with (e,e,e,e)-squalene?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (e,e,e,e)-squalene?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with (e,e,e,e)-squalene

Download all related citations
Per page 10 20 50 100 | Total 1766
Authors Title Published Journal PubMed Link
Kim ES et al. Squalene-induced exogenous lipoid pneumonia in an infant. 2009 Pediatr Int pmid:19799746
Lee KH et al. Squalene aspiration pneumonia in children: radiographic and CT findings as the first clue to diagnosis. 2005 Pediatr Radiol pmid:15806404
Gavaldà J et al. Immunogenicity of pandemic influenza A H1N1/2009 adjuvanted vaccine in pediatric solid organ transplant recipients. 2013 Pediatr Transplant pmid:23692602
Vesikari T et al. Enhanced immunogenicity of seasonal influenza vaccines in young children using MF59 adjuvant. 2009 Pediatr. Infect. Dis. J. pmid:19561422
Huber VC and McCullers JA Vaccines against pandemic influenza: what can be done before the next pandemic? 2008 Pediatr. Infect. Dis. J. pmid:18820570
Langley JM et al. Randomized, multicenter trial of a single dose of AS03-adjuvanted or unadjuvanted H1N1 2009 pandemic influenza vaccine in children 6 months to <9 years of age: safety and immunogenicity. 2012 Pediatr. Infect. Dis. J. pmid:22801094
Block SL et al. Dose-range study of MF59-adjuvanted versus nonadjuvanted monovalent A/H1N1 pandemic influenza vaccine in six- to less than thirty-six-month-old children. 2012 Pediatr. Infect. Dis. J. pmid:22481427
Mitchell DK et al. Immunogenicity of a recombinant human cytomegalovirus gB vaccine in seronegative toddlers. 2002 Pediatr. Infect. Dis. J. pmid:11840080
Nassim C et al. Identification of antigen and adjuvant doses resulting in optimal immunogenicity and antibody persistence up to 1 year after immunization with a pandemic A/H1N1 influenza vaccine in children 3 to < 9 years of age. 2012 Pediatr. Infect. Dis. J. pmid:22418661
Ketomäki A et al. Squalene and noncholesterol sterols in serum and lipoproteins of children with and without familial hypercholesterolemia. 2003 Pediatr. Res. pmid:12612218
Vesikari T et al. Immunogenicity and safety of MF59-adjuvanted H5N1 influenza vaccine from infancy to adolescence. 2010 Pediatrics pmid:20819892
Esposito S et al. Influenza A/H1N1 MF59-adjuvanted vaccine in preterm and term children aged 6 to 23 months. 2011 Pediatrics pmid:21464195
Adrangui M et al. [Water-surfactant-oil diagrams based on perhydrosqualene and triglycerides (Miglyol 812). Study of emulsion phases and stability]. 1979 Pharm Acta Helv pmid:515109
Ott G et al. MF59. Design and evaluation of a safe and potent adjuvant for human vaccines. 1995 Pharm Biotechnol pmid:7551221
Fox CB et al. Effects of emulsifier concentration, composition, and order of addition in squalene-phosphatidylcholine oil-in-water emulsions. 2011 Pharm Dev Technol pmid:20550484
Baudner BC et al. MF59 emulsion is an effective delivery system for a synthetic TLR4 agonist (E6020). 2009 Pharm. Res. pmid:19255727
Lin YK et al. Squalene-containing nanostructured lipid carriers promote percutaneous absorption and hair follicle targeting of diphencyprone for treating alopecia areata. 2013 Pharm. Res. pmid:23070602
Morin RJ and Srikantaiah MV Inhibition of rat liver sterol formation by isoprenoid and conjugated ene compounds. 1982 Pharmacol Res Commun pmid:7156175
Sabeena Farvin KH et al. Effect of squalene on tissue defense system in isoproterenol-induced myocardial infarction in rats. 2004 Pharmacol. Res. pmid:15225664
Dennis KJ and Shibamoto T Production of malonaldehyde from squalene, a major skin surface lipid, during UV-irradiation. 1989 Photochem. Photobiol. pmid:2756005
Matsuo I et al. Possible involvement of oxidation of lipids in inducing griseofulvin photosensitivity. 1990 Photodermatol Photoimmunol Photomed pmid:2091745
Picardo M et al. Squalene peroxides may contribute to ultraviolet light-induced immunological effects. 1991 Photodermatol Photoimmunol Photomed pmid:1804289
Kawada A et al. In vitro phototoxicity of new quinolones: production of active oxygen species and photosensitized lipid peroxidation. 1999 Photodermatol Photoimmunol Photomed pmid:10599972
Fujita H and Matsuo I In vitro phototoxic activities of new quinolone antibacterial agents: lipid peroxidative potentials. 1994 Photodermatol Photoimmunol Photomed pmid:7880759
Fujita H and Matsuo I Type I lipid photo-oxidation by the nonsteroidal anti-inflammatory drug suprofen: a possible key to its photosensitivity. 1992-1993 Oct Photodermatol Photoimmunol Photomed pmid:1342189
Wilson KR et al. The statistical evolution of multiple generations of oxidation products in the photochemical aging of chemically reduced organic aerosol. 2012 Phys Chem Chem Phys pmid:22158973
King KL et al. Inelastic scattering of OH radicals from organic liquids: isolating the thermal desorption channel. 2013 Phys Chem Chem Phys pmid:23807737
Packwood DM and Phillips LF A stochastic, local mode study of neon-liquid surface collision dynamics. 2011 Phys Chem Chem Phys pmid:21042647
Binks BP et al. How membrane permeation is affected by donor delivery solvent. 2012 Phys Chem Chem Phys pmid:23073464
Liu CL et al. The direct observation of secondary radical chain chemistry in the heterogeneous reaction of chlorine atoms with submicron squalane droplets. 2011 Phys Chem Chem Phys pmid:21455529
Achitouv E et al. C31-C34 methylated squalenes from a Bolivian strain of Botryococcus braunii. 2004 Phytochemistry pmid:15541746
Fernández-Martín R et al. ent-Kaurene and squalene synthesis in Fusarium fujikuroi cell-free extracts. 2000 Phytochemistry pmid:10975508
Metzger P et al. Braunicetals: acetals from condensation of macrocyclic aldehydes and terpene diols in Botryococcus braunii. 2008 Phytochemistry pmid:18639308
Xu R et al. On the origins of triterpenoid skeletal diversity. 2004 Phytochemistry pmid:14751299
Metzger P et al. Botryolins A and B, two tetramethylsqualene triethers from the green microalga Botryococcus braunii. 2002 Phytochemistry pmid:11937163
Quang DN et al. Concentriols B, C and D, three squalene-type triterpenoids from the ascomycete Daldinia concentrica. 2002 Phytochemistry pmid:12359521
Catalán CA et al. A linear sesterterpene, two squalene derivatives and two peptide derivatives from Croton hieronymi. 2003 Phytochemistry pmid:12943786
Flores-Sánchez IJ et al. Biosynthesis of sterols and triterpenes in cell suspension cultures of Uncaria tomentosa. 2002 Plant Cell Physiol. pmid:12514247
Suzuki M et al. Lanosterol synthase in dicotyledonous plants. 2006 Plant Cell Physiol. pmid:16531458
Caligiani A et al. Characterization of a potential nutraceutical ingredient: pomegranate (Punica granatum L.) seed oil unsaponifiable fraction. 2010 Plant Foods Hum Nutr pmid:20607413
Ryan E et al. Phytosterol, squalene, tocopherol content and fatty acid profile of selected seeds, grains, and legumes. 2007 Plant Foods Hum Nutr pmid:17594521
Suzuki M et al. Loss of function of 3-hydroxy-3-methylglutaryl coenzyme A reductase 1 (HMG1) in Arabidopsis leads to dwarfing, early senescence and male sterility, and reduced sterol levels. 2004 Plant J. pmid:14871314
Wentzinger LF et al. Inhibition of squalene synthase and squalene epoxidase in tobacco cells triggers an up-regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase. 2002 Plant Physiol. pmid:12226513
Nguyen HT et al. Molecular characterization of Glycine max squalene synthase genes in seed phytosterol biosynthesis. 2013 Plant Physiol. Biochem. pmid:24036394
Uchida H et al. Cloning and characterization of a squalene synthase gene from a petroleum plant, Euphorbia tirucalli L. 2009 Planta pmid:19283408
Wu S et al. Engineering triterpene metabolism in tobacco. 2012 Planta pmid:22729821
Banzhoff A et al. MF59-adjuvanted H5N1 vaccine induces immunologic memory and heterotypic antibody responses in non-elderly and elderly adults. 2009 PLoS ONE pmid:19197383
Surls J et al. Increased membrane cholesterol in lymphocytes diverts T-cells toward an inflammatory response. 2012 PLoS ONE pmid:22723880
Wijnans L et al. Effectiveness of MF59â„¢ adjuvanted influenza A(H1N1)pdm09 vaccine in risk groups in the Netherlands. 2013 PLoS ONE pmid:23646191
Bischoff AL et al. Altered response to A(H1N1)pnd09 vaccination in pregnant women: a single blinded randomized controlled trial. 2013 PLoS ONE pmid:23637733